Quantitative determination of diterpenoid alkaloid Fuziline by hydrophilic interaction liquid chromatography (HILIC)-electrospray ionization mass spectrometry and its application to pharmacokinetic study in rats

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 913-914, Issue , 2013, Pages 55-60

  Sun, Jianguo ^a   Zhang, Fengyi ^a   Peng, Ying ^a   Liu, Jinghan ^a   Zhong, Yunxi ^a   Wang, Guangji ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Aconitum carmichaeli; Fuziline; Hydrophilic interaction liquid chromatography; LC MS; Pharmacokinetics; Rat

Indexed keywords

ACONITUM CARMICHAELI; ANALYTES; AVERAGE RECOVERY; CLEARANCE RATES; ELECTROSPRAY IONIZATION MASS SPECTROMETRY; ELECTROSPRAYS; ETHYL ACETATES; FREEZE-THAW; FUZILINE; HILIC-MS; HYDROPHILIC INTERACTION LIQUID CHROMATOGRAPHIES; INTERNAL STANDARDS; IONIZATION MASS SPECTROMETRY; ISOCRATIC ELUTION; LC/MS; LIMIT OF DETECTION; LINEAR RELATIONSHIPS; LIQUID-LIQUID EXTRACTION; LOWER LIMIT OF QUANTIFICATIONS; ORAL ADMINISTRATION; PHARMACOKINETIC STUDIES; PROCESSING CONDITION; QUANTITATIVE DETERMINATIONS; RAT PLASMA; RELATIVE STANDARD DEVIATIONS; SAMPLE STORAGE; SELECTED ION MONITORING; SPRAGUE-DAWLEY RATS;

AMIDES; BIOCHEMISTRY; ELECTROSPRAY IONIZATION; MASS SPECTROMETRY; PHARMACOKINETICS; RATS;

CHROMATOGRAPHY;

ACETIC ACID ETHYL ESTER; ALKALOID; FUZILINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; FLOW RATE; FREEZE THAWING; HYDROPHILIC INTERACTION LIQUID CHROMATOGRAPHY ELECTROSPRAY IONIZATION MASS SPECTROMETRY; ION MONITORING; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIQUID LIQUID EXTRACTION; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SENSITIVITY AND SPECIFICITY; STORAGE;

ACONITUM; ALKALOIDS; ANIMALS; CHROMATOGRAPHY, LIQUID; DITERPENES; DRUG STABILITY; FEMALE; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIMIT OF DETECTION; LIQUID-LIQUID EXTRACTION; MALE; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

ACONITUM CARMICHAELI; RATTUS;

EID: 84871658167     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.11.017     Document Type: Article

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