UPLC-TOF/MS based chemical profiling approach to evaluate toxicity-attenuated chemical composition in combination of ginseng and Radix Aconiti Praeparata

Yaoxue Xuebao

Volumn 46, Issue 12, 2011, Pages 1488-1492

  Ma, Zeng Chun ^a   Zhou, Si Si ^a   Liang, Qian De ^a   Huo, Chao ^a   Wang, Yu Guang ^a   Tan, Hong Ling ^a   Xiao, Cheng Rong ^a   Gao, Yue ^a  

^a BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

Author keywords

Compatibility; Ginseng; Radix Aconiti Praeparata

Indexed keywords

ALKALOID; DEOXYACONITINE; DITERPENOID; HYPACONITINE;

ARTICLE; CHEMICAL COMPOSITION; CONTENT ANALYSIS; CONTROLLED STUDY; GINSENG; HERB; MEDICINAL PLANT; NONHUMAN; RADIX ACONITI PRAEPARATA; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ACONITINE; ACONITUM; ALKALOIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG COMBINATIONS; DRUGS, CHINESE HERBAL; PANAX; PLANTS, MEDICINAL; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84863132040     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Zhou H, Hou SZ, Luo P, et al. Ginseng protects rodent hearts from acute myocardial ischemia-reperfusion injury through GR/ER-activated RISK pathway in an endothelial NOS-dependent mechanism [J]. J Ethnopharmacol, 2011, 135: 287-298.
2. Ye R, Yang Q, Kong X, et al. Ginsenoside Rd attenuates early oxidative damage and sequential inflammatory response after transient focal ischemia in rats [J]. Neurochem Int, 2011, 58: 391-398.
3. Yim KM, Tse ML, Lau FL. Reversible intraventricular conduction defect in aconitine poisoning [J]. Singapore Med J, 2009, 50: 302-305.
4. Fujita Y, Terui K, Fujita M, et al. Five cases of aconite poisoning: toxicokinetics of aconitines [J]. J Anal Toxicol, 2007, 31: 132-137. (Pubitemid 46641583)
5. Yue H, Pi ZF, Song FR, et al. Analysis of aconite alkaloids in the combination of Radix Aconiti Praeparata with different herbs by ESI-MS spectrometry [J]. Acta Pharm Sin 2007, 42: 201-205.
6. Qi X, Ignatova S, Luo G, et al. Preparative isolation and purification of ginsenosides Rf, Re, Rd and Rb1 from the roots of Panax ginseng with a salt/containing solvent system and flow step-gradient by high performance counter-current chromatography coupled with an evaporative light scattering detector [J]. J Chromatogr A, 2010, 1217: 1995-2001.
7. Chen JH, Lee CY, Liau BC, et al. Determination of aconitine-type alkaloids as markers in fuzi (Aconitum carmichaeli) by LC/ESI/MS [J]. J Pharm Biomed Anal, 2008, 48: 1105-1111.
8. Li SL, Lai SF, Song JZ, et al. Decocting-induced chemical transformations and global quality of Du-Shen-Tang, the decoction of ginseng evaluated by UPLC-Q-TOF-MS/MS based chemical profiling approach [J]. J Pharm Biomed Anal, 2010, 53: 946-957.
9. Li SL, Song JZ, Qiao CF, et al. UPLC-PDA-TOF MS based chemical profiling approach to rapidly evaluate chemical consistency between traditional and dispensing granule decoctions of traditional medicine combinatorial formulae [J]. J Pharm Biomed Anal, 2010, 52: 468-478.
10. Li L, Luo GA, Liang QL, et al. Rapid qualitative and quantitative analyses of Asian ginseng in adulterated American ginseng preparations by UPLC/Q-TOF-MS [J]. J Pharm Biomed Anal, 2010, 52: 66-72.
11. n [J]. Talanta, 2009, 77: 1800-1807.
12. Zheng XT, Shi PY, Cheng YY, et al. Rapid analysis of a Chinese herbal prescription by liquid chromatography-time-of-flight tandem mass spectrometry [J]. J Chromatogr A, 2008, 1206: 140-146.
13. Singhuber J, Zhu M, Prinz S, et al. Aconitum in traditional Chinese medicine: a valuable drug or an unpredictable risk [J]. J Ethnopharmacol, 2009, 126: 18-30.
14. Wang Y, Shi L, Song F, et al. Exploring the ester-exchange reactions of diester-diterpenoid alkaloids in the aconite decoction process by electrospray ionization tandem mass spectrometry [J]. Rapid Commun Mass Spectrom, 2003, 17: 279-284. (Pubitemid 36193666)
15. Hu R, Zhao J, Qi LW, et al. Structural characterization and identification of C(19)- and C(20)-diterpenoid alkaloids in roots of Aconitum carmichaeli by rapid-resolution liquid chromatography coupled with time-of-flight mass spectrometry [J]. Rapid Commun Mass Spectrom, 2009, 23: 1619-1635.
16. Csupora D, Wenzigb EM, Zupkó I, et al. Qualitative and quantitative analysis of aconitine-type and lipo-alkaloids of Aconitum carmichaelii roots [J]. J Chromatogr A, 2009, 1216: 2079-2086.