Pattern of airway inflammation and remodelling in mild persistent atopic asthma and in mild persistent asthma related to Gastroesophageal Reflux

European Annals of Allergy and Clinical Immunology

Volumn 44, Issue 6, 2012, Pages 236-242

  Dal Negro, R W ^a   Guerriero, M ^b   Micheletto, Claudio ^c  

^a Bussolengo Gen Hospital   (Italy)

^b UNIVERSITY OF VERONA   (Italy)

^c Mater Salutis Hospital   (Italy)

Author keywords

Airway remodelling; Atopic asthma; GER related asthma; Mild asthma

Indexed keywords

INTERLEUKIN 8; LEUKOTRIENE; METHACHOLINE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ALLERGIC ASTHMA; ARTICLE; BASEMENT MEMBRANE; BRONCHUS BIOPSY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE DURATION; FEMALE; FORCED EXPIRATORY VOLUME; GASTROESOPHAGEAL REFLUX; HUMAN; LUNG FUNCTION TEST; MALE; MILD PERSISTENT ASTHMA; NEUTROPHIL; PH MEASUREMENT; RESPIRATORY TRACT INFLAMMATION; URINALYSIS;

ADULT; AGED; AIRWAY REMODELING; ASTHMA; BASEMENT MEMBRANE; BIOPSY; BREATH TESTS; BRONCHIAL PROVOCATION TESTS; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHOSCOPY; EOSINOPHILS; ESOPHAGEAL PH MONITORING; FEMALE; FORCED EXPIRATORY VOLUME; GASTROESOPHAGEAL REFLUX; HUMANS; HYPERSENSITIVITY, IMMEDIATE; INFLAMMATION MEDIATORS; LUNG; MALE; MIDDLE AGED; NEUTROPHILS; PHENOTYPE; PNEUMONIA; SEVERITY OF ILLNESS INDEX;

EID: 84871648167     PISSN: 17641489     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. National Heart Lung and Blood Institute, National Institute of Health. International Consensus Report on the Diagnosis and Management of Asthma. NIH publication number 92-3091, 1992.
2. Bergeron C, Boulet L-P. Structural changes in airway diseases. Chest 2006; 129: 1068-87.
3. Bousquet J, Jeffery PK, Busse WW, Johnson M, Vignola AM. Asthma. From bronchoconstriction to airways inflammation and remodelling. Am J Resp Crit Care Med 2000; 161: 1720-45.
4. Bergeron C, Al-Ramli W, Hamid A. Remodelling in asthma. Proc Am Thorac Soc 2009; 6: 301-5.
5. Amin K, Ludviksdottir D, Janson C, et al. Inflammation and structural changes in the airways of patients with atopic and nonatopic asthma. Am J Resp Crit Care 2000; 162: 2295-301.
6. Jeffery PK. Remodeling in asthma and chronic obstructive lung disease. Am J Respir Crit Care Med 2001; 164: S28-S38.
7. Harding SM, Richter JE. Gastroesophageal reflux disease and asthma. Semin Gastrointest Dis 1992; 3: 139-50.
8. Pope II CE. Acid Reflux disorders. N Engl J Med 1994; 331: 656-60
9. Harding SM, Richter JE. The role of gastroesophageal reflux in chronic cough and asthma. Chest 1997; 111: 1389-402.
10. Sontag SJ, Gastroesophageal reflux and asthma. Am J Med 1997; 103: 84s-90s.
11. Dal Negro RW, Turco P, Micheletto C, et al. Cost analysis of GER-induced asthma: a controlled study vs. atopic asthma of comparable severity. Respir Med 2007; 101 (8): 1814-20.
12. Dal Negro R, Pomari C, Micheletto C, Turco P, Tognella S. Prevalence of gastro-oesophageal reflux in asthmatics: an Italian study. Ital J Gastroenterol Hepatol 1999; 31: 371-5.
13. DeMeester TR, Johnson LF, Joseph GJ, Toscano MS, Hall AW, Skinner DB. Patterns of gastroesophageal reflux in health and disease. Ann Surg 1976; 184: 459-70.
14. Quanjer H, Tammeling GJ, Cotes JE, Pedersen OF, Peslin R, Yernault J-C. Lung volumes and forced ventilatory flows. Official statement of the European Respiratory Society. Eur Respir J 1993; 6, suppl. 16: 5-40.
15. Guidelines for Methacholine and Exercise Challenge testing-1999. Am Rev Respir Crit Care Med 2000; 161: 309-29.
16. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide. Am J Resp Crit care med 2005; 171: 912-30.
17. Workshop summary and guidelines: investigative use of bronchoscopy, lavage and bronchial biopsies in asthma and other airway diseases. J Allergy Clin Immunol 1991; 88: 808-14.
18. Berthier F, Lambert C, Genin C, Bienvenu J. Evaluation of an automated immunoassay method for cytokin measurement using the Immulite Immunoassay system. Clin Chem Lab Med 1999; 37: 593-9.
19. Dal Negro RW, Visconti M, Micheletto C, Tognella S, Guerriero M. Reference urinary LTE4 levels in normal individuals: a pilot study. Eur Ann Allergy Clin Immunol 2011; 43:22-8.
20. Roche WR, Beasley R, Williams JH, Holgate ST. Subepithelial fibrosis in the bronchi of asthmatics. Lancet 1989; 1: 520-4.
21. Hoshino M, Nakamura Y, Sim JJ. Expression of growth factors and remodeling of the airway wall in bronchial asthma. Thorax 1998; 53: 21-7.
22. Beckett PA, Howarth PH. Pharmacotherapy and airway remodelling in asthma? Thorax 2003; 58: 163-74.
23. Bousquet J, Chanez P, Lacoste JY, et al. Asthma: a disease remodeling the airways. Allergy 1992; 47: 3-11.
24. Schachter EN, Doyle CA, Beck GJ. A prospective study of asthma in a rural community. Chest 1984; 85: 623-30.
25. Paet JK, Woolcock AJ, Cullen K. Rate of decline of lung function in subjects with asthma. Eur Resp J 1987; 70: 171-9.
26. Shiba K, Kasahara K, Nakajima H, Adachi M. Structural changes of the airway wall impair respiratory function, even in mild asthma. Chest 2002; 122: 1622-6.
27. Lundgren R, Soderberg M, Horstedt P, Sterling R. Morphological studies of bronchial mucosal biopsies from asthmatics before and after 10 years of treatment with inhaled sterois. Eur Resp J 1988; 1: 883-9.
28. Humbert M, Durham SR, Ying S, et al. IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and non-atopic asthma: evidence against "intrinsic" asthma being a distinct immunopathologic entity. Am J Respir Crit Care Med 1996; 154: 1497-504.
29. Micheletto C, Tognella S, Trevisan F, Visconti M, Dal Negro RW. Eosinophilic inflammation and basement membrane thickness in atopic and ger-related asthma. Chest 2005; 128, 4, 147S.
30. Fixman ED, Stewart A, Martin JG. Basic mechanisms of development of airway structural changes in asthma. Eur Resp J 2007; 29: 379-89.
31. Dal Negro RW, Tognella S, Micheletto C, Sandri M, Guerriero M. A Mch test pre-post esophageal acidification in detecting GER-related asthma. J Asthma 2009; 46: 351-155.
32. Regoli D, Boudon A, Fauchere JL. Receptors and antagonists for substance P and related peptides. Pharmacol Rev 1994; 46: 551-99.
33. Maggi CA, Giacchetti A, Dey RD, Said SI. Neuropeptides as regulators of airway disfunction: vasoactive intestinal petide and the tachykinins. Physil Rev 1995; 75: 277-322.
34. Curran DR, Walsh MT, Costello RW. Interactions between inflammatory cells and nerves. Curr Opin Pharmacol 2002; 2: 243-8.
35. Ricciardolo FLM, Gaston B, Hunt J. Acid stress in the pathology of asthma. J Allergy Clin Immunol 2004; 113: 610-9.
36. Henderson WR Jr, Tang LO, Chu SJ, et al. A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model. Am J Respir Crit Care Med 2002; 165: 108-16.