Coexisting High-grade Vulvar Intraepithelial Neoplasia (VIN) and Condyloma Acuminatum: Independent Lesions Due to Different HPV Types Occurring in Immunocompromised Patients

American Journal of Surgical Pathology

Volumn 37, Issue 1, 2013, Pages 53-60

  Maniar, Kruti P ^a   Ronnett, Brigitte M ^a   Vang, Russell ^a   Yemelyanova, Anna ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

condyloma acuminatum; human papillomavirus; vulvar cancer; vulvar intraepithelial neoplasia

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; KI 67 ANTIGEN; TUMOR MARKER; VIRUS DNA;

ALPHAPAPILLOMAVIRUS; ARTICLE; CARCINOMA IN SITU; CLASSIFICATION; CONDYLOMA ACUMINATUM; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOCOMPROMISED PATIENT; IMMUNOLOGY; IMMUNOSUPPRESSIVE TREATMENT; IN SITU HYBRIDIZATION; METABOLISM; METHODOLOGY; ORGAN TRANSPLANTATION; PAPILLOMAVIRUS INFECTION; PATHOLOGY; POLYMERASE CHAIN REACTION; VIROLOGY; VULVA DISEASE; VULVA TUMOR;

ALPHAPAPILLOMAVIRUS; CARCINOMA IN SITU; CONDYLOMATA ACUMINATA; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA, VIRAL; FEMALE; HIV INFECTIONS; HUMANS; IMMUNOCOMPROMISED HOST; IMMUNOSUPPRESSION; IN SITU HYBRIDIZATION; KI-67 ANTIGEN; ORGAN TRANSPLANTATION; PAPILLOMAVIRUS INFECTIONS; POLYMERASE CHAIN REACTION; TUMOR MARKERS, BIOLOGICAL; VULVAR DISEASES; VULVAR NEOPLASMS;

EID: 84871607240     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e318263cda6     Document Type: Article

References (41)

1. Koutsky L. Epidemiology of genital human papillomavirus infection. Am J Med. 1997;102:3-8.
2. van der Avoort IA, Shirango H, Hoevenaars BM, et al. Vulvar squamous cell carcinoma is a multifactorial disease following two separate and independent pathways. Int J Gynecol Pathol. 2006;25:22-29.
3. Skapa P, Zamecnik J, Hamsikova E, et al. Human papillomavirus (HPV) profiles of vulvar lesions: possible implications for the classification of vulvar squamous cell carcinoma precursors and for the efficacy of prophylactic HPV vaccination. Am J Surg Pathol. 2007;31:1834-1843.
4. Joura EA, Losch A, Haider-Angeler MG, et al. Trends in vulvar neoplasia. Increasing incidence of vulvar intraepithelial neoplasia and squamous cell carcinoma of the vulva in young women. J Reprod Med. 2000;45:613-615.
5. Jones RW, Baranyai J, Stables S. Trends in squamous cell carcinoma of the vulva: the influence of vulvar intraepithelial neoplasia. Obstet Gynecol. 1997;90:448-452.
6. Judson PL, Habermann EB, Baxter NN, et al. Trends in the incidence of invasive and in situ vulvar carcinoma. Obstet Gynecol. 2006;107:1018-1022.
7. Saraiya M, Watson M, Wu X, et al. Incidence of in situ and invasive vulvar cancer in the US, 1998-2003. Cancer. 2008;113:2865-2872.
8. Bodelon C, Madeleine MM, Voigt LF, et al. Is the incidence of invasive vulvar cancer increasing in the United States? Cancer Causes Control. 2009;20:1779-1782.
9. Hoevenaars BM, van der Avoort IA, de Wilde PC, et al. A panel of p16(INK4A), MIB1 and p53 proteins can distinguish between the 2 pathways leading to vulvar squamous cell carcinoma. Int J Cancer. 2008;123:2767-2773.
10. Hording U, Daugaard S, Junge J, et al. Human papillomaviruses and multifocal genital neoplasia. Int J Gynecol Pathol. 1996;15:230-234.
11. Buscema J, Naghashfar Z, Sawada E, et al. The predominance of human papillomavirus type 16 in vulvar neoplasia. Obstet Gynecol. 1988;71:601-606.
12. Gasco M, Sullivan A, Repellin C, et al. Coincident inactivation of 14-3-3sigma and p16INK4a is an early event in vulval squamous neoplasia. Oncogene. 2002;21:1876-1881.
13. van Beurden M, ten Kate FJ, Smits HL, et al. Multifocal vulvar intraepithelial neoplasia grade III and multicentric lower genital tract neoplasia is associated with transcriptionally active human papillomavirus. Cancer. 1995;75:2879-2884.
14. Barzon L, Militello V, Pagni S, et al. Distribution of human papillomavirus types in the anogenital tract of females and males. J Med Virol. 2010;82:1424-1430.
15. Garland SM, Insinga RP, Sings HL, et al. Human papillomavirus infections and vulvar disease development. Cancer Epidemiol Biomarkers Prev. 2009;18:1777-1784.
16. Insinga RP, Liaw KL, Johnson LG, et al. A systematic review of the prevalence and attribution of human papillomavirus types among cervical, vaginal, and vulvar precancers and cancers in the United States. Cancer Epidemiol Biomarkers Prev. 2008;17:1611-1622.
17. Sideri M, Jones RW, Wilkinson EJ, et al. Squamous vulvar intraepithelial neoplasia: 2004 modified terminology, ISSVD Vulvar Oncology Subcommittee. J Reprod Med. 2005;50:807-810.
18. Srodon M, Stoler MH, Baber GB, et al. The distribution of low and high-risk HPV types in vulvar and vaginal intraepithelial neoplasia (VIN and VaIN). Am J Surg Pathol. 2006;30:1513-1518.
19. Garland SM, Steben M, Sings HL, et al. Natural history of genital warts: analysis of the placebo arm of 2 randomized phase III trials of a quadrivalent human papillomavirus (types 6, 11, 16, and 18) vaccine. J Infect Dis. 2009;199:805-814.
20. McLachlin CM, Kozakewich H, Craighill M, et al. Histologic correlates of vulvar human papillomavirus infection in children and young adults. Am J Surg Pathol. 1994;18:728-735.
21. Pirog EC, Chen YT, Isacson C. MIB-1 immunostaining is a beneficial adjunct test for accurate diagnosis of vulvar condyloma acuminatum. Am J Surg Pathol. 2000;24:1393-1399.
22. Hoy T, Singhal PK, Willey VJ, et al. Assessing incidence and economic burden of genital warts with data from a US commercially insured population. Curr Med Res Opin. 2009;25:2343-2351.
23. Logani S, Lu D, Quint WG, et al. Low-grade vulvar and vaginal intraepithelial neoplasia: correlation of histologic features with human papillomavirus DNA detection and MIB-1 immunostaining. Mod Pathol. 2003;16:735-741.
24. Park J, Sun D, Genest DR, et al. Coexistence of low and high grade squamous intraepithelial lesions of the cervix: morphologic progression or multiple papillomaviruses? Gynecol Oncol. 1998;70:386-391.
25. Agorastos T, Miliaras D, Lambropoulos AF, et al. Detection and typing of human papillomavirus DNA in uterine cervices with coexistent grade I and grade III intraepithelial neoplasia: biologic progression or independent lesions? Eur J Obstet Gynecol Reprod Biol. 2005;121:99-103.
26. Mejlhede N, Pedersen BV, Frisch M, et al. Multiple human papilloma virus types in cervical infections: competition or synergy? APMIS. 2010;118:346-352.
27. Rousseau MC, Pereira JS, Prado JC, et al. Cervical coinfection with human papillomavirus (HPV) types as a predictor of acquisition and persistence of HPV infection. J Infect Dis. 2001;184:1508-1517.
28. Hampl M, Sarajuuri H, Wentzensen N, et al. Effect of human papillomavirus vaccines on vulvar, vaginal, and anal intraepithelial lesions and vulvar cancer. Obstet Gynecol. 2006;108:1361-1368.
29. Yemelyanova A, Ji H, Shih I, et al. Utility of p16 expression for distinction of uterine serous carcinomas from endometrial endometrioid and endocervical adenocarcinomas: immunohisto-chemical analysis of 201 cases. Am J Surg Pathol. 2009;33: 1504-1514.
30. Kleter B, van Doorn LJ, Schrauwen L, et al. Development and clinical evaluation of a highly sensitive PCR-reverse hybridization line probe assay for detection and identification of anogenital human papillomavirus. J Clin Microbiol. 1999;37:2508-2517.
31. Kleter B, van Doorn LJ, ter Schegget J, et al. Novel short-fragment PCR assay for highly sensitive broad-spectrum detection of anogenital human papillomaviruses. Am J Pathol. 1998;153:1731-1739.
32. van Hamont D, van Ham MA, Bakkers JM, et al. Evaluation of the SPF10-INNO LiPA human papillomavirus (HPV) genotyping test and the roche linear array HPV genotyping test. J Clin Microbiol. 2006;44:3122-3129.
33. Preti M, Mezzetti M, Robertson C, et al. Inter-observer variation in histopathological diagnosis and grading of vulvar intraepithelial neoplasia: results of a European collaborative study. BJOG. 2000;107:594-599.
34. Conley LJ, Ellerbrock TV, Bush TJ, et al. HIV-1 infection and risk of vulvovaginal and perianal condylomata acuminata and intraepithelial neoplasia: a prospective cohort study. Lancet. 2002;359:108-113.
35. Jamieson DJ, Paramsothy P, Cu-Uvin S, et al. Vulvar, vaginal, and perianal intraepithelial neoplasia in women with or at risk for human immunodeficiency virus. Obstet Gynecol. 2006;107:1023-1028.
36. Chiasson MA, Ellerbrock TV, Bush TJ, et al. Increased prevalence of vulvovaginal condyloma and vulvar intraepithelial neoplasia in women infected with the human immunodeficiency virus. Obstet Gynecol. 1997;89:690-694.
37. Rufforny I, Wilkinson EJ, Liu C, et al. Human papillomavirus infection and p16(INK4a) protein expression in vulvar intra-epithelial neoplasia and invasive squamous cell carcinoma. J Low Genit Tract Dis. 2005;9:108-113.
38. Santos M, Landolfi S, Olivella A, et al. p16 overexpression identifies HPV-positive vulvar squamous cell carcinomas. Am J Surg Pathol. 2006;30:1347-1356.
39. Santos M, Montagut C, Mellado B, et al. Immunohistochemical staining for p16 and p53 in premalignant and malignant epithelial lesions of the vulva. Int J Gynecol Pathol. 2004;23:206-214.
40. Riethdorf S, Neffen EF, Cviko A, et al. p16INK4A expression as biomarker for HPV 16-related vulvar neoplasias. Hum Pathol. 2004;35:1477-1483.
41. Pirog EC, Quint KD, Yantiss RK. P16/CDKN2A and Ki-67 enhance the detection of anal intraepithelial neoplasia and condyloma and correlate with human papillomavirus detection by polymerase chain reaction. Am J Surg Pathol. 2010;34:1449-1455.