Carprofen for perioperative analgesia causes early anastomotic leakage in the rat ileum

BMC Veterinary Research

Volumn 8, Issue , 2012, Pages

  van der Vijver, Rozemarijn J ^a   van Laarhoven, Cees J H M ^a   Lomme, Roger M L M ^a   Hendriks, Thijs ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Anastomosis; Carprofen; Ileum; NSAID; Rat; Wound healing

Indexed keywords

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

CARBAZOLE DERIVATIVE; CARPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT;

ANASTOMOSIS; ANASTOMOSIS LEAKAGE; ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; COHORT ANALYSIS; CYTOCHEMISTRY; DRUG EFFECT; ILEUM; MALE; METHODOLOGY; PATHOLOGY; RANDOMIZATION; RAT; WISTAR RAT; WOUND HEALING;

ANASTOMOSIS, SURGICAL; ANASTOMOTIC LEAK; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARBAZOLES; COHORT STUDIES; HISTOCYTOCHEMISTRY; ILEUM; MALE; RANDOM ALLOCATION; RATS; RATS, WISTAR; WOUND HEALING;

MLCS; MLOWN;

EID: 84871576106     PISSN: None     EISSN: 17466148     Source Type: Journal    
DOI: 10.1186/1746-6148-8-247     Document Type: Article

References (24)

1. Richardson CA, Flecknell PA. Anaesthesia and post-operative analgesia following experimental surgery in laboratory rodents: are we making progress?. Altern Lab Anim 2005, 33(2):119-127.
2. Flecknell P. Analgesia from a veterinary perspective. Br J Anaesth 2008, 101(1):121-124. 10.1093/bja/aen087, 18424804.
3. Livingston A. Pain and analgesia in domestic animals. Handb Exp Pharmacol 2010, 199:159-189. 10.1007/978-3-642-10324-7_7, 20204587.
4. Lees P, Giraudel J, Landoni MF, Toutain PL. PK-PD integration and PK-PD modelling of nonsteroidal anti-inflammatory drugs: principles and applications in veterinary pharmacology. J Vet Pharmacol Ther 2004, 27(6):491-502. 10.1111/j.1365-2885.2004.00618.x, 15601443.
5. van der Vijver RJ, van Laarhoven CJ, de Man BM, Lomme RM, Hendriks T. Perioperative Pain Relief by a COX-2 Inhibitor Affects Ileal Repair and Provides a Model for Anastomotic Leakage in the Intestine. Surg Innov 2012, epub ahead of print.
6. de Hingh I, van Goor H, de Man BM, Lomme RM, Bleichrodt RP, Hendriks T. Selective cyclo-oxygenase 2 inhibition affects ileal but not colonic anastomotic healing in the early postoperative period. Br J Surg 2006, 93(4):489-497. 10.1002/bjs.5288, 16521174.
7. de Waard JW, Wobbes T, de Man BM, van der Linden CJ, Hendriks T. Post-operative levamisole may compromise early healing of experimental intestinal anastomoses. Br J Cancer 1995, 72(2):456-460. 10.1038/bjc.1995.355, 2034010, 7640232.
8. de Hingh I, Lomme RM, van Goor H, Bleichrodt RP, Hendriks T. Changes in gelatinase activity in the gastrointestinal tract after anastomotic construction in the ileum or colon. Dis Colon Rectum 2005, 48(11):2133-2141. 10.1007/s10350-005-0142-5, 16132479.
9. Rao P, Knaus EE. Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyond. J Pharm Pharm Sci 2008, 11(2):81s-110s.
10. Futagami A, Ishizaki M, Fukuda Y, Kawana S, Yamanaka N. Wound healing involves induction of cyclooxygenase-2 expression in rat skin. Lab Invest 2002, 82(11):1503-1513.
11. Kampfer H, Brautigam L, Geisslinger G, Pfeilschifter J, Frank S. Cyclooxygenase-1-coupled prostaglandin biosynthesis constitutes an essential prerequisite for skin repair. J Invest Dermatol 2003, 120(5):880-890. 10.1046/j.1523-1747.2003.12140.x, 12713596.
12. Holte K, Andersen J, Jakobsen DH, Kehlet H. Cyclo-oxygenase 2 inhibitors and the risk of anastomotic leakage after fast-track colonic surgery. Br J Surg 2009, 96(6):650-654. 10.1002/bjs.6598, 19434706.
13. Rushfeldt CF, Sveinbjornsson B, Soreide K, Vonen B. Risk of anastomotic leakage with use of NSAIDs after gastrointestinal surgery. Int J Colorectal Dis 2011, 26(12):1501-1509. 10.1007/s00384-011-1285-6, 21833507.
14. Curry SL, Cogar SM, Cook JL. Nonsteroidal antiinflammatory drugs: a review. J Am Anim Hosp Assoc 2005, 41(5):298-309.
15. Arras M, Rettich A, Cinelli P, Kasermann HP, Burki K. Assessment of post-laparotomy pain in laboratory mice by telemetric recording of heart rate and heart rate variability. BMC Vet Res 2007, 3:16. 10.1186/1746-6148-3-16, 1965463, 17683523.
16. Ochi H, Hara Y, Asou Y, Harada Y, Nezu Y, Yogo T, et al. Effects of long-term administration of carprofen on healing of a tibial osteotomy in dogs. Am J Vet Res 2011, 72(5):634-641. 10.2460/ajvr.72.5.634, 21529215.
17. Mullins KB, Thomason JM, Lunsford KV, Pinchuk LM, Langston VC, Wills RW, et al. Effects of carprofen, meloxicam and deracoxib on platelet function in dogs. Vet Anaesth Analg 2012, 39(2):206-217. 10.1111/j.1467-2995.2011.00684.x, 22248445.
18. Briere CA, Hosgood G, Morgan TW, Hedlund CS, Hicks M, McConnico RS. Effects of carprofen on the integrity and barrier function of canine colonic mucosa. Am J Vet Res 2008, 69(2):174-181. 10.2460/ajvr.69.2.174, 18241012.
19. Kurihara Y, Hatori M, Ando Y, Ito D, Toyoshima T, Tanaka M, et al. Inhibition of cyclooxygenase-2 suppresses the invasiveness of oral squamous cell carcinoma cell lines via down-regulation of matrix metalloproteinase-2 production and activation. Clin Exp Metastasis 2009, 26(5):425-432. 10.1007/s10585-009-9241-3, 19241124.
20. Takeuchi K, Tanaka A, Kato S, Amagase K, Satoh H. Roles of COX inhibition in pathogenesis of NSAID-induced small intestinal damage. Clin Chim Acta 2010, 411(7-8):459-466.
21. Fredenburgh LE, Suarez Velandia MM, Ma J, Olszak T, Cernadas M, Englert JA, et al. Cyclooxygenase-2 Deficiency Leads to Intestinal Barrier Dysfunction and Increased Mortality during Polymicrobial Sepsis. J Immunol 2011, 187(10):5255-5267. 10.4049/jimmunol.1101186, 3208135, 21967897.
22. Haworth R, Oakley K, McCormack N, Pilling A. Differential expression of COX-1 and COX-2 in the gastrointestinal tract of the rat. Toxicol Pathol 2005, 33(2):239-245. 10.1080/01926230590906512, 15902967.
23. Mastboom WJ, Hendriks T, van Elteren P, de Boer HH. The influence of NSAIDs on experimental intestinal anastomoses. Dis Colon Rectum 1991, 34(3):236-243. 10.1007/BF02090163, 1999130.
24. Stokes EL, Flecknell PA, Richardson CA. Reported analgesic and anaesthetic administration to rodents undergoing experimental surgical procedures. Lab Anim 2009, 43(2):149-154. 10.1258/la.2008.008020, 19116297.