Organocatalytic asymmetric michael addition of oxindoles to nitroolefins for the synthesis of 2,2-disubstituted oxindoles bearing adjacent quaternary and tertiary stereocenters

Journal of Organic Chemistry

Volumn 77, Issue 24, 2012, Pages 11307-11312

  Jin, Cheng Yong ^a   Wang, Yao ^a   Liu, Yao Zong ^a   Shen, Chao ^a   Xu, Peng Fei ^a  

^a LANZHOU UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIFUNCTIONAL; HIGH YIELD; MICHAEL ADDITIONS; NITROOLEFINS; ORGANOCATALYTIC; OXINDOLES; STEREOCENTERS; SYNTHETIC ELABORATION; TERTIARY STEREOCENTERS;

THIOUREAS;

ADDITION REACTIONS;

ALKENE; METHYL 1 ACETYL 2 (1 NITROPENTAN 2 YL) 3 OXOINDOLINE 2 CARBOXYLATE; METHYL 1 ACETYL 2 (2 NITRO 1 PHENYLETHYL) 3 OXOINDOLINE 2 CARBOXYLATE; METHYL 1 ACETYL 2 [1 (2 METHOXYPHENYL) 2 NITROETHYL] 3 OXOINDOLINE 2 CARBOXYLATE; METHYL 1 ACETYL 2 [1 (3 BROMOPHENYL) 2 NITROETHYL] 3 OXOINDOLINE 2 CARBOXYLATE; METHYL 1 ACETYL 2 [1 (3 CHLOROPHENYL) 2 NITROETHYL] 3 OXOINDOLINE 2 CARBOXYLATE; METHYL 1 ACETYL 2 [1 (3 METHOXYPHENYL) 2 NITROETHYL] 3 OXOINDOLINE 2 CARBOXYLATE; METHYL 1 ACETYL 2 [1 (3,4 DIMETHYLPHENYL) 2 NITROETHYL] 3 OXOINDOLINE 2 CARBOXYLATE; METHYL 1 ACETYL 2 [1 (4 BROMOPHENYL) 2 NITROETHYL] 3 OXOINDOLINE 2 CARBOXYLATE; METHYL 1 ACETYL 2 [1 (4 CHLOROPHENYL) 2 NITROETHYL] 3 OXOINDOLINE 2 CARBOXYLATE; METHYL 1 ACETYL 2 [1 (4 FLUOROPHENYL) 2 NITROETHYL] 3 OXOINDOLINE 2 CARBOXYLATE; METHYL 1 ACETYL 2 [1 (BENZO[D][1,3]DIOXOL 5 YL) 2 NITROETHYL] 3 OXOINDOLINE 2 CARBOXYLATE; METHYL 1 ACETYL 2 [1 (FURAN 2 YL) 2 NITROETHYL] 3 OXOINDOLINE 2 CARBOXYLATE; METHYL 1 ACETYL 2 [1 (NAPHTHALEN 2 YL) 2 NITROETHYL] 3 OXOINDOLINE 2 CARBOXYLATE; METHYL 1 ACETYL 2 [2 NITRO 1 (3 NITROPHENYL)ETHYL] 3 OXOINDOLINE 2 CARBOXYLATE; METHYL 1 ACETYL 2 [2 NITRO 1 (4 NITROPHENYL)ETHYL] 3 OXOINDOLINE 2 CARBOXYLATE; METHYL 1 ACETYL 2 [2 NITRO 1 (4 TOLYL)ETHYL] 3 OXOINDOLINE 2 CARBOXYLATE; METHYL 1 ACETYL 2 [2 NITRO 1 [4 (TRIFLUOROMETHYL)PHENYL]ETHYL] 3 OXOINDOLINE 2 CARBOXYLATE; METHYL 1 ACETYL 5 BROMO 2 (2 NITRO 1 PHENYLETHYL) 3 OXOINDOLINE 2 CARBOXYLATE; METHYL 1 ACETYL 6 CHLORO 2 (2 NITRO 1 PHENYLETHYL) 3 OXOINDOLINE 2 CARBOXYLATE; METHYL 1 ACETYL 7 METHYL 2 (2 NITRO 1 PHENYLETHYL) 3 OXOINDOLINE 2 CARBOXYLATE; METHYL 1,4 DIACETYL 3 (4 BROMOPHENYL) 1,2,3,3A,4,8B HEXAHYDROPYRROLO[3,2 B]INDOLE 3A CARBOXYLATE; NITROOLEFIN DERIVATIVE; OXINDOLE; THIOUREA; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; ENANTIOSELECTIVITY; MICHAEL ADDITION; STEREOCHEMISTRY; SUBSTITUTION REACTION; SYNTHESIS;

ALKENES; CATALYSIS; CHEMISTRY TECHNIQUES, SYNTHETIC; INDOLES; NITRO COMPOUNDS; STEREOISOMERISM;

EID: 84871571858     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo301886j     Document Type: Article

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