C-Terminal Helical Domains of Dengue Virus Type 4 E Protein Affect the Expression/Stability of prM Protein and Conformation of prM and E Proteins

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Tsai, Wen Yang ^a   Hsieh, Szu Chia ^a   Lai, Chih Yun ^a   Lin, Hong En ^b   Nerurkar, Vivek R ^a   Wang, Wei Kung ^a  

^a UNIVERSITY OF HAWAII   (United States)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; EH2 PROTEIN; ET1 PROTEIN; MONOCLONAL ANTIBODY; PRM PROTEIN; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN; VIRUS PROTEIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DENGUE VIRUS 4; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; NONHUMAN; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY;

ANIMALS; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; ANTIBODIES, VIRAL; ANTIBODY AFFINITY; DENGUE; DENGUE VIRUS; GENE EXPRESSION; GENE EXPRESSION REGULATION, VIRAL; HEK293 CELLS; HUMANS; MICE; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; VIRAL ENVELOPE PROTEINS;

DENGUE VIRUS; DENGUE VIRUS TYPE 4;

EID: 84871532163     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0052600     Document Type: Article

References (48)

1. Gubler DJ, (2002) Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century. Trends Microbiol 10: 100-103.
2. Guzman MG, Halstead SB, Artsob H, Buchy P, Farrar J, et al. (2010) Dengue: a continuing global threat. Nat Rev Microbiol 12 Suppl: S7-S16.
3. World Health Organization (2009) Dengue hemorrhagic fever: Diagnosis, treatment, prevention and control, 3rd ed. Geneva, Switzerland.
4. Lindenbach BD, Thiel HJ, Rice CM (2007) Flaviviridae: the viruses and their replication, p. 1101-1152. In D.M.Knipe and P.M.Howley (eds.), Fields virology. Lippincott William & Wilkins, Philadelphia.
5. Mukhopadhyay S, Kuhn RJ, Rossmann MG, (2005) A structural perspective of the flavivirus life cycle. Nat Rev Microbiol 3: 13-22.
6. Randolph VB, Stollar V, (1990) Low pH-induced cell fusion in flavivirus-infected Aedes albopictus cell cultures. J Gen Virol 71: 1845-1850.
7. Mackenzie JM, Westaway EG, (2001) Assembly and maturation of the flavivirus Kunjin virus appear to occur in the rough endoplasmic reticulum and along the secretory pathway, respectively. J Virol 75: 10787-10799.
8. Welsch S, Miller S, Romero-Brey I, Merz A, Bleck CKE, et al. (2009) Composition and three-dimensional architecture of the dengue virus replication and assembly sites. Cell Host Microbe 5: 365-375.
9. Murray JM, Aaskov JG, Wright PJ, (1993) Processing of the dengue virus type 2 proteins prM and C-prM. J Gen Virol 74: 175-182.
10. Keelapang P, Sriburi R, Supasa S, Panyadee N, Songjaeng A, et al. (2004) Alterations of pr-M cleavage and virus export in pr-M junction chimeric dengue viruses. J Virol 78: 2367-2381.
11. Stadler K, Allison SL, Schalich J, Heinz FX, (1997) Proteolytic activation of tick-borne encephalitis virus by furin. J Virol 71: 8475-8481.
12. Yu IM, Zhang W, Holdaway HA, Li L, Kostyuchenko VA, et al. (2008) Structure of the immature dengue virus at low pH primes proteolytic maturation. Science 319: 1834-1837.
13. Webster DP, Farrar J, Rowland-Jones S, (2009) Progress towards a dengue vaccine. Lancet Infect Dis 9: 678-687.
14. Whitehead SS, Blaney JE, Durbin AP, Murphy BR, (2007) Prospects for a dengue virus vaccine. Nat Rev Microbiol 5: 518-528.
15. Calisher CH, Karabatsos N, Dalrymple JM, Shope RE, Porterfield JS, et al. (1989) Antigenic relationships between flaviviruses as determined by cross-neutralization tests with polyclonal antisera. J Gen Virol 70: 37-43.
16. Modis Y, Ogata S, Clements D, Harrison SC, (2004) Structure of the dengue virus envelope protein after membrane fusion. Nature 427: 313-319.
17. Allison SL, Stiasny K, Stadler K, Mandl CW, Heinz FX, (1999) Mapping of functional elements in the stem-anchor region of tick-borne encephalitis virus envelope protein E. J Virol 73: 5605-5612.
18. Zhang W, Chipman PR, Corver J, Johnson PR, Zhang Y, et al. (2003) Visualization of membrane protein domains by cryo-electron microscopy of dengue virus. Nat Struct Biol 10: 907-912.
19. Fritz R, Blazevic J, Taucher C, Pangerl K, Heinz FX, et al. (2011) The unique transmembrane hairpin of flavivirus fusion protein E is essential for membrane fusion. J Virol 85: 4377-4385.
20. Orlinger KK, Hoenninger VM, Kofler RM, Mandl CW, (2006) Construction and mutagenesis of an artificial bicistronic tick-borne encephalitis virus genome reveals an essential function of the second transmembrane region of protein E in flavivirus assembly. J Virol 80: 12197-12208.
21. Stiasny K, Allison SL, Marchler-Bauer A, Kunz C, Heinz FX, (1996) Structural requirements for low-pH-induced rearrangements in the envelope glycoprotein of tick-borne encephalitis virus. J Virol 70: 8142-8147.
22. Yu IM, Holdaway HA, Chipman PR, Kuhn RJ, Rossmann MG, et al. (2009) Association of the pr peptides with dengue virus at acidic pH blocks membrane fusion. J Virol 83: 12101-12107.
23. Guirakhoo F, Bolin RA, Roehrig JT, (1992) The Murray Valley encephalitis virus prM protein confers acid resistance to virus particles and alters the expression of epitopes within the R2 domain of E glycoprotein. Virology 191: 921-931.
24. Konishi E, Mason PW, (1993) Proper maturation of the Japanese encephalitis virus envelope glycoprotein requires cosynthesis with the premembrane protein. J Virol 67: 1672-1675.
25. Lorenz IC, Allison SL, Heinz FX, Helenius A, (2002) Folding and dimerization of tick-borne encephalitis virus envelope proteins prM and E in the endoplasmic reticulum. J Virol 76: 5480-5491.
26. Bray M, Lai CJ, (1991) Dengue virus premembrane and membrane proteins elicit a protective immune response. Virology 185: 505-508.
27. Huang KJ, Yang YC, Lin Y, Huang JH, Liu HS, et al. (2006) The dual-specific binding of dengue virus and target cells for the antibody-dependent enhancement of dengue virus infection. J Immunol 176: 2825-2832.
28. Rodenhuis-Zybert IA, van der Schaar HM, da Silva Voorham JM, van der Ende-Metselaar H, Lei HY, et al. (2010) Immature dengue virus: a veiled pathogen? PLoS Pathog 6: e1000718.
29. Dejnirattisai W, Jumnainsong A, Onsirisakul N, Fitton P, Vasanawathana S, et al. (2010) Cross-reacting antibodies enhance dengue virus infection in humans. Science 328: 745-748.
30. Hu HP, Hsieh SC, King CC, Wang WK, (2007) Characterization of retrovirus-based reporter viruses pseudotyped with the precursor membrane and envelope glycoproteins of four serotypes of dengue viruses. Virology 368: 376-387.
31. Hsieh SC, Tsai WY, Wang WK, (2010) The length and non-hydrophobic residues in transmembrane domain of dengue virus envelope protein critical for its retention and assembly in endoplasmic reticulum. J Virol 84: 4782-4797.
32. Wang WK, Chen HL, Yang CF, Hsieh SC, Juan CC, et al. (2006) Slower rates of clearance of viral load and virus-containing immune complexes in patients with dengue hemorrhagic fever. Clin Infect Dis 43: 1023-1030.
33. Lin HE, Tsai WY, Liu IJ, Li PC, Liao MY, et al. (2012) Analysis of epitopes on dengue virus envelope protein recognized by monoclonal antibodies and polyclonal human sera by a high throughput assay. PLoS Negl Trop Dis 6: e1447.
34. Beltramello M, Williams KL, Simmons CP, Macagno A, Simonelli L, et al. (2010) The human immune response to dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity. Cell Host Microbe 8: 271-283.
35. de Alwis R, Beltramello M, Messer MB, Sukupolvi-Petty S, Wahala WM, et al. (2011) In-depth analysis of the antibody response of individuals exposed to primary dengue virus infection. PLoS Negl Trop Dis 5: e1188.
36. Vieyres G, Thomas X, Descamps V, Duverlie G, Patel AH, et al. (2010) Characterization of the envelope glycoproteins associated with infectious hepatitis C virus. J Virol 84: 10159-10168.
37. Anelli T, Sitia R, (2008) Protein quality control in the early secretory pathway. EMBO J 27: 315-327.
38. Raviprakash K, Kochel TJ, Ewing D, Simmons M, Phillips I, et al. (2000) Immunogenicity of dengue virus type 1 DNA vaccines expressing truncated and full length envelope protein. Vaccine 18: 2426-2434.
39. Men RH, Bray M, Lai CJ, (1991) Carboxy-terminally truncated dengue virus envelope glycoproteins expressed on the cell surface and secreted extracellularly exhibit increased immunogenicity in mice. J Virol 65: 1400-1407.
40. Bonafé N, Rininger JA, Chubet RG, Foellmer HG, Fader S, et al. (2009) A recombinant West Nile virus envelope protein vaccine candidate produced in Spodoptera frugiperda expresSF+ cells. Vaccine 27: 213-222.
41. Delenda C, Staropoli I, Frenkiel MP, Cabanié L, Deubel V, (1994) Analysis of C-terminally truncated dengue 2 and dengue 3 virus envelope glycoproteins: processing in insect cells and immunogenic properties in mice. J Gen Virol 75: 1569-1578.
42. Guzmán MG, Rodríguez R, Rodríguez R, Hermida L, Alvarez M, et al. (2003) Induction of neutralizing antibodies and partial protection from viral challenge in Macaca fascicularis immunized with recombinant dengue 4 virus envelope glycoprotein expressed in Pichia pastoris. Am J Trop Med Hyg 69: 129-134.
43. Ocazionez Jimenez R, Lopes da Fonseca BA, (2000) Recombinant plasmid expressing a truncated dengue-2 virus E protein without co-expression of prM protein induces partial protection in mice. Vaccine 19: 648-654.
44. Li L, Lok SM, Yu IM, Zhang Y, Kuhn RJ, et al. (2008) The flavivirus precursor membrane-envelope protein complex: structure and maturation. Science 319: 1830-1834.
45. Lin SR, Zou G, Hsieh SC, Qing M, Tsai WY, et al. (2011) The stem region of envelope protein of dengue virus is involved in virus assembly and entry. J Virol 85: 5159-5171.
46. Aberle JH, Aberle SW, Allison SL, Stiasny K, Ecker M, et al. (1999) A DNA immunization model study with constructs expressing the tick-borne encephalitis virus envelope protein E in different physical forms. J Immunol 163: 6756-6761.
47. de Alwis R, Smith SA, Olivarez NP, Messer WB, Huynh JP, et al. (2012) Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions. Proc Natl Acad Sci USA 109: 7439-7444.
48. Guy B, Barban V, Mantel N, Aguirre M, Gulia S, et al. (2009) Evaluation of interferences between dengue vaccine serotypes in a monkey model. Am J Trop Med Hyg 80: 302-311.