The presence of sinusoidal CD163+ macrophages in lymph nodes is associated with favorable nodal status in patients with breast cancer

Virchows Archiv

Volumn 461, Issue 6, 2012, Pages 639-646

  Mansfield, Aaron S ^a   Heikkila, Paivi ^b   Von Smitten, Karl ^b   Vakkila, Jukka ^b   Leidenius, Marjut ^b  

^a MAYO CLINIC   (United States)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Breast cancer; Lymph nodes; Macrophages; Natural killer cells

Indexed keywords

CD163 ANTIGEN; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR;

ADULT; AGED; ARTICLE; ATYPICAL DUCTAL HYPERPLASIA; BREAST CANCER; CANCER GRADING; CANCER PATIENT; CANCER STAGING; CELL COUNT; CLINICAL ARTICLE; CONTROLLED STUDY; GERMINAL CENTER; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; LYMPHOCYTIC INFILTRATION; MACROPHAGE; NATURAL KILLER CELL; PRECANCER; PRIORITY JOURNAL; SENTINEL LYMPH NODE; SINUS VENOSUS; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TUMOR ASSOCIATED LEUKOCYTE; TUMOR VOLUME;

AGED; ANKYRINS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; BREAST NEOPLASMS; FEMALE; HUMANS; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; KILLER CELLS, NATURAL; LYMPH NODES; LYMPHATIC METASTASIS; MACROPHAGES; MIDDLE AGED; RECEPTORS, CELL SURFACE; SENTINEL LYMPH NODE BIOPSY;

EID: 84871526577     PISSN: 09456317     EISSN: 14322307     Source Type: Journal    
DOI: 10.1007/s00428-012-1338-4     Document Type: Article

References (27)

1. Mansfield AS, Heikkila PS, Vaara AT, von Smitten KA, Vakkila JM, Leidenius MH (2009) Simultaneous Foxp3 and IDO expression is associated with sentinel lymph node metastases in breast cancer. BMC Cancer 9:231
2. Mansfield AS, Heikkila P, von Smitten K, Vakkila J, Leidenius M (2011) Metastasis to sentinel lymph nodes in breast cancer is associated with maturation arrest of dendritic cells and poor co-localization of dendritic cells and CD8(+) T cells. Virchows Arch 459:391-398
3. Matsuura K, Yamaguchi Y, Osaki A, Ohara M, Okita R, Emi A, Murakami S, Arihiro K (2009) FOXP3 expression of micrometastasis-positive sentinel nodes in breast cancer patients. Oncol Rep 22:1181-1187
4. Matsuura K, Yamaguchi Y, Ueno H, Osaki A, Arihiro K, Toge T (2006) Maturation of dendritic cells and T-cell responses in sentinel lymph nodes from patients with breast carcinoma. Cancer 106:1227-1236
5. Kohrt HE, Nouri N, Nowels K, Johnson D, Holmes S, Lee PP (2005) Profile of immune cells in axillary lymph nodes predicts disease-free survival in breast cancer. PLoS Med 2:e284
6. Angel CE, Chen CJ, Horlacher OC, Winkler S, John T, Browning J, MacGregor D, Cebon J, Dunbar PR (2009) Distinctive localization of antigen-presenting cells in human lymph nodes. Blood 113:1257-1267
7. Chambers AF, Groom AC, MacDonald IC (2002) Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2:563-572
8. Nathanson SD (2003) Insights into the mechanisms of lymph node metastasis. Cancer 98:413-423
9. Lanier LL (2008) Evolutionary struggles between NK cells and viruses. Nat Rev Immunol 8:259-268
10. Sun JC, Beilke JN, Lanier LL (2009) Adaptive immune features of natural killer cells. Nature 457:557-561
11. Li S, Xu J, Makarenkova VP, Tjandrawan T, Vakkila J, Reichert T, Gooding W, Lagenaur CF, Achim CL, Chambers WH, Herberman RB, Whiteside TL, Vujanovic NL (2004) A novel epitope of N-CAM defines precursors of human adherent NK cells. J Leukoc Biol 76:1187-1199
12. Mansour EG, Ravdin PM, Dressler L (1994) Prognostic factors in early breast carcinoma. Cancer 74:381-400
13. Nemoto T, Vana J, Bedwani RN, Baker HW, McGregor FH, Murphy GP (1980) Management and survival of female breast cancer: results of a national survey by the American College of Surgeons. Cancer 45:2917-2924
14. Rosen PP, Groshen S, Saigo PE, Kinne DW, Hellman S (1989) Pathological prognostic factors in stage I (T1N0M0) and stage II (T1N1M0) breast carcinoma: a study of 644 patients with median follow-up of 18 years. J Clin Oncol 7:1239-1251
15. Leidenius MH, Krogerus LA, Toivonen TS, von Smitten KA (2005) Sentinel node biopsy is not sensible in breast cancer patients with large primary tumours. Eur J Surg Oncol 31:364-368
16. Kristiansen M, Graversen JH, Jacobsen C, Sonne O, Hoffman HJ, Law SK, Moestrup SK (2001) Identification of the haemoglobin scavenger receptor. Nature 409:198-201
17. Martens JH, Kzhyshkowska J, Falkowski-Hansen M, Schledzewski K, Gratchev A, Mansmann U, Schmuttermaier C, Dippel E, Koenen W, Riedel F, Sankala M, Tryggvason K, Kobzik L, Moldenhauer G, Arnold B, Goerdt S (2006) Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in human lymph node sinuses, the primary sites of regional metastasis. J Pathol 208:574-589
18. Leidenius MH, Vironen JH, Heikkila PS, Joensuu H (2010) Influence of isolated tumor cells in sentinel nodes on outcome in small, node-negative (pT1N0M0) breast cancer. Ann Surg Oncol 17:254-262
19. Leidenius MH, Krogerus LA, Toivonen TS, Von Smitten KJ (2003) The feasibility of intraoperative diagnosis of sentinel lymph node metastases in breast cancer. J Surg Oncol 84:68-73
20. Leikola JP, Toivonen TS, Krogerus LA, von Smitten KA, Leidenius MH (2005) Rapid immunohistochemistry enhances the intraoperative diagnosis of sentinel lymph node metastases in invasive lobular breast carcinoma. Cancer 104:14-19
21. Sica A, Schioppa T, Mantovani A, Allavena P (2006) Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy. Eur J Cancer 42:717-727
22. Gordon S (2003) Alternative activation of macrophages. Nat Rev Immunol 3:23-35
23. Mantovani A, Marchesi F, Porta C, Sica A, Allavena P (2007) Inflammation and cancer: breast cancer as a prototype. Breast 16 (Suppl 2):S27-S33
24. Tsutsui S, Yasuda K, Suzuki K, Tahara K, Higashi H, Era S (2005) Macrophage infiltration and its prognostic implications in breast cancer: the relationship with VEGF expression and microvessel density. Oncol Rep 14:425-431
25. Gooden MJ, de Bock GH, Leffers N, Daemen T, Nijman HW (2011) The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis. Br J Cancer 105:93-103
26. Mihm MC Jr, Clemente CG, Cascinelli N (1996) Tumor infiltrating lymphocytes in lymph node melanoma metastases: a histopath-ologic prognostic indicator and an expression of local immune response. Lab Invest 74:43-47
27. Dewan MZ, Takada M, Terunuma H, Deng X, Ahmed S, Yamamoto N, Toi M (2009) Natural killer activity of peripheral-blood mononuclear cells in breast cancer patients. Biomed Pharmac-other 63:703-706