Triboelectric characteristics of mannitol based formulations for the application in dry powder inhalers

Powder Technology

Volumn 235, Issue , 2013, Pages 349-358

  Karner, Stefan ^a   Urbanetz, Nora Anne ^b  

^a GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

^b RESEARCH CENTER PHARMACEUTICAL ENGINEERING GMBH   (Austria)

Author keywords

Adhesive mixtures; Dry powder inhaler; Electrostatic charge; Mannitol; Novolizer ; Open end Faraday cup

Indexed keywords

ACTIVE PHARMACEUTICAL INGREDIENTS; AEROSOLIZATION; AIR FLOW-RATE; CARRIER PARTICLES; CHARGING PROCESS; DRY POWDER INHALER; ELECTROSTATIC CHARGES; FARADAY CUPS; FLOWABILITY; HIGH-IMPACT VELOCITIES; IMPACT VELOCITIES; INTERPARTICLE FORCE; MANNITOL; PARTICLE CHARACTERISTICS; PARTICLE SHAPE; SIZE RANGES; STATISTICAL DESIGN OF EXPERIMENTS; TRIBOCHARGING; TRIBOELECTRIFICATION;

AIR; DESIGN OF EXPERIMENTS; ELECTROSTATICS; FLOW RATE; PARTICLE SIZE;

MIXTURES;

MANNITOL; SALBUTAMOL SULFATE;

AEROSOL; AIRFLOW; ARTICLE; DRUG FORMULATION; DRUG RELEASE; FLOW RATE; HUMIDITY; METERED DOSE INHALER; PARTICLE SIZE; POWDER FLOW; POWDER INHALER; STATIC ELECTRICITY; VELOCITY;

EID: 84871508316     PISSN: 00325910     EISSN: 1873328X     Source Type: Journal    
DOI: 10.1016/j.powtec.2012.10.034     Document Type: Article

References (42)

1. Labiris N.R., Dolovich M.B. Pulmonary drug delivery. Part I: physiological factors affecting therapeutic effectiveness of aerosolized medications. British Journal of Clinical Pharmacology 2003, 56:588-599.
2. Mykhaylova V. Development of Microparticle-Nanoparticle Powder Mixtures for the Use in Dry Powder Inhalers 2009, Heinrich-Heine-Universität Düsseldorf.
3. Steckel H., Bolzen N. Alternative sugars as potential carriers for dry powder inhalations. International Journal of Pharmaceutics 2004, 270:297-306.
4. Huber G., Wirth K.-E. Electrostatically supported surface coating of solid particles in liquid nitrogen for use in dry-powder-inhalers. Powder Technology 2003, 134:181-192.
5. Telko M.J., Kujanpää J., Hickey A.J. Investigation of triboelectric charging in dry powder inhalers using electrical low pressure impactor (ELPI(TM)). International Journal of Pharmaceutics 2007, 336:352-360.
6. Harper W.R. Contact and Frictional Electrification 1967, Clarendon Press, Oxford.
7. Yu Z.-Z.(George), Watson K. Two-step model for contact charge accumulation. Journal of Electrostatics 2001, 51-52:313-318.
8. Diaz A.F., Fenzel-Alexander D. An ion transfer model for contact charging. Langmuir 1993, 9:1009-1015.
9. Castle G.S.P., Schein L.B. General model of sphere-sphere insulator contact electrification. Journal of Electrostatics 1995, 36:165-173.
10. Diaz A.F., Felix-Navarro R.M. A semi-quantitative tribo-electric series for polymeric materials: the influence of chemical structure and properties. Journal of Electrostatics 2004, 62:277-290.
11. Carter P.A., Cassidy O.E., Rowley G., Merrifield D.R. Triboelectrification of fractionated crystalline and spray-dried lactose. Pharmacy and Pharmacology Communications 1998, 4:111-115.
12. Eilbeck J., Rowley G., Fletcher J., Smith I. Investigation of the effects of contact surface on triboelectrification in pharmaceutical powders. 11th Pharmaceutical Technology Conference 1992, 2:358.
13. Vladykina T.N., Deryagin B.V., Toporov Y.P. The effect of surface roughness on triboelectrification of insulators. Physics, Chemistry and Mechanics of Surfaces 1985, 3:2817-2821.
14. Bailey A.G. Electrostatic phenomena during powder handling. Powder Technology 1984, 37:71-81.
15. Eilbeck J., Rowley G., Carter P.A., Fletcher E.J. The effect of materials of construction of pharmaceutical processing equipment and drug delivery devices on the triboelectrification of size fractionated lactose. Pharmacy and Pharmacology Communications 1999, 5:429-433.
16. Eilbeck J., Rowley G., Carter P.A., Fletcher E.J. Effect of contamination of pharmaceutical equipment on powder triboelectrification. International Journal of Pharmaceutics 2000, 195:7-11.
17. Murtomaa M., Laine E. Effect of surface coverage of a glass pipe by small particles on the triboelectrification of glucose powder. Journal of Electrostatics 2001, 54:311-320.
18. Murtomaa M., Harjunen P., Mellin V., Lehto V.-P., Laine E. Effect of amorphicity on the triboelectrification of lactose powder. Journal of Electrostatics 2002, 56:103-110.
19. Elajnaf A., Carter P., Rowley G. Electrostatic characterisation of inhaled powders: effect of contact surface and relative humidity. European Journal of Pharmaceutical Sciences 2006, 29:375-384.
20. Adi H., Chi P., Kwok L.I.P., Crapper J., Young P.M., Traini D., et al. Does electrostatic charge affect powder aerosolisation?. Journal of Pharmaceutical Sciences 2010, 99:2455-2461.
21. Mackin L.A., Rowley G., Fletcher E.J., Marriott R. An investigation of the role of moisture on the charging tendencies of pharmaceutical excipients. Proceedings of the 12th Pharmaceutical Technical Conference 1993, 2:300-317.
22. Watanabe H., Samimi A., Ding Y.L., Ghadiri M., Matsuyama T., Pitt K.G. Measurement of charge transfer due to single particle impact. Particle & Particle Systems Characterization 2006, 23:133-137.
23. Watanabe H., Ghadiri M., Matsuyama T., Ding Y.L., Pitt K.G., Maruyama H., et al. Triboelectrification of pharmaceutical powders by particle impact. International Journal of Pharmaceutics 2007, 334:149-155.
24. Karner S., Anne Urbanetz N. The impact of electrostatic charge in pharmaceutical powders with specific focus on inhalation-powders. Journal of Aerosol Science 2011, 42:428-445.
25. Murtomaa M., Strengell S., Laine E., Bailey A. Measurement of electrostatic charge of an aerosol using a grid-probe. Journal of Electrostatics 2003, 58:197-207.
26. Sung A., Traini D., Kwok P., Chiou H., Chan H.-K., Young P.M. Influence of humidity on the electrostatic charge and aerosol performance of dry powder inhaler carrier based systems. Pharmaceutical Research 2007, 24:963-970.
27. Hoe S., Traini D., Chan H., Young P.M. Measuring charge and mass distributions in dry powder inhalers using the electrical Next Generation Impactor (eNGI). European Journal of Pharmaceutical Sciences 2009, 38:88-94.
28. Hoe S., Traini D., Chan H.-K., Young P.M. The contribution of different formulation components on the aerosol charge in carrier-based dry powder inhaler systems. Pharmaceutical Research 2010, 27:1325-1336.
29. Hoe S., Young P.M., Traini D. Dynamic electrostatic charge of lactose-salbutamol sulphate powder blends dispersed from a Cyclohaler®. Drug Development and Industrial Pharmacy 2011, 37:1365-1375.
30. Hoe S., Young P.M., Traini D. Aerosol tribocharging and its relation to the deposition of Oxis™ Turbuhaler® in the electrical next generation impactor. Journal of Pharmaceutical Sciences 2011, 100:5270-5280.
31. Murtomaa M., Mellin V., Harjunen P., Lankinen T., Laine E., Lehto V.-P. Effect of particle morphology on the triboelectrification in dry powder inhalers. International Journal of Pharmaceutics 2004, 282:107-114.
32. Chow K.T., Zhu K., Tan R.B.H., Heng P.W.S. Investigation of electrostatic behavior of a lactose carrier for dry powder inhalers. Pharmaceutical Research 2008, 25:2822-2834.
33. Karner S., Urbanetz N.A. Arising of electrostatic charge in the mixing process and its influencing factors. Powder Technology 2012, 226:261-268.
34. Zhu K., Tan R.B.H., Chen F., Hadinoto K., Heng P.W.S. Influence of particle wall adhesion on particle electrification in mixers. International Journal of Pharmaceutics 2007, 328:22-34.
35. Rowley G. Quantifying electrostatic interactions in pharmaceutical solid systems. International Journal of Pharmaceutics 2001, 227:47-55.
36. Zeng X.M., Martin G.P., Tee S.-K., Marriott C. The role of fine particle lactose on the dispersion and deaggregation of salbutamol sulphate in an air stream in vitro. International Journal of Pharmaceutics 1998, 176:99-110.
37. Guenette E., Barrett A., Kraus D., Brody R., Harding L., Magee G. Understanding the effect of lactose particle size on the properties of DPI formulations using experimental design. International Journal of Pharmaceutics 2009, 380:80-88.
38. Matsusyama T., Yamamoto H. Impact charging of particulate materials. Chemical Engineering Science 2006, 61:2230-2238.
39. Hoe S., Traini D., Chan H.-K., Young P.M. The influence of flow rate on the aerosol deposition profile and electrostatic charge of single and combination metered dose inhalers. Pharmaceutical Research 2009, 26:2639-2646.
40. Heng D., Lee S.H., Kwek J.W., Ng W.K., Chan H.-K., Tan R.B.H. Assessing the combinatorial influence of climate, formulation and device on powder aerosolization using the Taguchi experimental design. Powder Technology 2012, 226:253-260.
41. De Boer A.H., Hagedoorn P., Gjaltema D., Goede J., Frijlink H.W. Air classifier technology (ACT) in dry powder inhalation. Part 3. Design and development of an air classifier family for the Novolizer ® multi-dose dry powder inhaler. International Journal of Pharmaceutics 2006, 310:72-80.
42. Bennet F.S., Carter P.A., Rowley G., Dandiker Y. Modification of electrostatic charge on inhaled carrier lactose particles by addition of fine particles. Drug Development and Industrial Pharmacy 1999, 25:99-103.