Investigation of electrostatic behavior of a lactose carrier for dry powder inhalers

Pharmaceutical Research

Volumn 25, Issue 12, 2008, Pages 2822-2834

  Chow, Keat Theng ^a,c   Zhu, Kewu ^a   Tan, Reginald B H ^a,b   Heng, Paul W S ^b  

^a INSTITUTE OF CHEMICAL AND ENGINEERING SCIENCES   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Aerosol; Charge; Dry powder inhaler; Electrostatic; Triboelectrification

Indexed keywords

DRUG CARRIER; GELATIN; INHALAC; LACTOSE; UNCLASSIFIED DRUG;

AEROSOL; CONFERENCE PAPER; DRY POWDER; ELECTRIC CONDUCTIVITY; FLOW RATE; HUMIDITY; PARTICLE SIZE; POWDER INHALER; PRIORITY JOURNAL;

DRUG CARRIERS; HUMIDITY; LACTOSE; NEBULIZERS AND VAPORIZERS; STATIC ELECTRICITY;

EID: 57149140308     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-008-9651-y     Document Type: Conference Paper

References (59)

1. S. P. Newman W. W. Busse 2002 Evolution of dry powder inhaler design, formulation, and performance Resp. Med 96 293 304 doi:10.1053/rmed.2001.1276
2. H.-K. Chan 2006 Dry powder aerosol drug delivery-Opportunities for colloid and surface scientists Colloid Surface A 284-285 50 55 doi:10.1016/j.colsurfa.2005.10.091
3. A. G. Bailey 1993 Charging of solid and powders J. Electrostatics 30 167 180 doi:10.1016/0304-3886(93)90072-F
4. J. Eilbeck G. Rowley P. A. Carter E. J. Fletcher 1999 Effect of materials of construction of pharmaceutical processing equipment and drug delivery devices on the triboelectrification of size-fractionated lactose Pharm. Pharmacol. Commun 5 429 433
5. P. R. Byron J. Peart J. N. Staniforth 1997 Aerosol electrostatics I: properties of fine powders before and after aerosolization by dry powder inhalers Pharm. Res 14 6 698 705 doi:10.1023/A:1012181818244
6. M. Murtomaa S. Strengell E. Laine A. Bailey 2003 Measurement of electrostatic charge of an aerosol using a grid-probe J. Electrostatics 58 197 207 doi:10.1016/S0304-3886(03)00048-2
7. W. Li M. Perlz J. Heyder R. Langer J. D. Brain K.-H. Englmeier R. W. Niven D. A. Edwards 1996 Aerodynamics and aerosol particle deaggregation phenomena in model oral-pharyngeal cavities J. Aerosol Sci 27 8 1269 1286 doi:10.1016/0021-8502(96)00046-8
8. A. G. Bailey A. H. Hashish T. J. Williams 1998 Drug delivery by inhalation of charged particles J. Electrostatics 44 3 10 doi:10.1016/S0304- 3886(98)00017-5
9. W. Balachandran W. Machowski E. Gaura C. Hudson 1997 Control of drug aerosol in human airways using electrostatic forces J. Electrostatics 40&41 579 584
10. K. Zhu R. B. H. Tan F. Chen K. Hadinoto P. W. S. Heng 2007 Influence of particle wall adhesion on particle electrification in mixers Int. J. Pharm 328 22 34 doi:10.1016/j.ijpharm.2006.07.041
11. D. A. Engers M. N. Fricke R. P. Storey A. W. Newman K. R. Morris 2006 Triboelectrification of pharmaceutically relevant powders during low-shear tumble blending J. Electrostatics 64 826 835 doi:10.1016/j.elstat.2006.02.003
12. G. Rowley L. A. Mackin 2003 The effect of moisture sorption on electrostatic charging of selected pharmaceutical excipient powders Powder Technol 135-136 50 58 doi:10.1016/j.powtec.2003.08.003
13. M. P. Grosvenor J. N. Staniforth 1996 The influence of water on electrostatic charge retention and dissipation in pharmaceutical compacts for powder coating Pharm. Res 13 11 1725 1729 doi:10.1023/A:1016409227565
14. P. A. Carter O. E. Cassidy G. Rowley D. R. Merrifield 1998 Triboelectrification of fractionated crystalline and spray-dried lactose Pharm. Pharmacol. Commun 4 111 115
15. M. Murtomaa M. Savolainen L. Christiansen J. Rantanen E. Laine J. Yliruusi 2004 Static electrification of powders during spray drying J. Electrostatics 62 63 72 doi:10.1016/j.elstat.2004.05.001
16. M. Murtomaa E. Laine 2000 Electrostatic measurements on lactose-glucose mixtures J. Electrostatics 48 155 162 doi:10.1016/S0304-3886(99)00063-7
17. H. Eliasen H. G. Kristensen T. Schæfer 1999 Electrostatic charging during melt agglomeration process Int. J. Pharm 184 85 96 doi:10.1016/S0378- 5173(99)00102-7
18. A. Elajnaf P. Carter G. Rowley 2007 The effect of relative humidity on electrostatic charge decay of drugs and excipient used in dry powder inhaler formulation Drug Dev. Ind. Pharm 33 967 974 doi:10.1080/03639040601134207
19. J. Peart P. Kulphaisal J. C. Orban 2003 Relevance of electrostatics in respiratory drug delivery Business Briefing Pharmacogenerics 2003 84 87
20. M. Murtomaa V. Mellin P. Harjunen T. Lankinen E. Laine V.-P. Lehto 2004 Effect of particle morphology on the triboelectrification in dry powder inhalers Int. J. Pharm 282 107 114 doi:10.1016/j.ijpharm.2004.06.002
21. F. S. Bennett P. A. Carter G. Rowley Y. Dandiker 1999 Modification of electrostatic charge on inhaled carrier lactose particles by addition of fine particles Drug Dev. Ind. Pharm 25 1 99 103 doi:10.1081/DDC-100102148
22. J. Peart P. R. Byron 1999 Electrostatic properties of metered dose inhalers Inst. Phys. Conf. Ser 163 77 80
23. P. Kulvanich P. J. Stewart 1987 An evaluation of the air stream Faraday cage in the electrostatic charge measurement of interactive drug systems Int. J. Pharm 36 243 252 doi:10.1016/0378-5173(87)90161-X
24. J. Peart J. N. Staniforth B. J. Meakin 1995 Electrostatic charge interactions in pharmaceutical dry powder aerosols Inst. Phys. Conf. Ser 143 271 274
25. P. C. L. Kwok W. Glover H.-K. Chan 2005 Electrostatic charge characteristics of aerosols produced from metered dose inhalers J. Pharm. Sci 94 12 2789 2799 doi:10.1002/jps.20395
26. W. Glover H.-K. Chan 2004 Electrostatic charge characterization of pharmaceutical aerosols using electrical low-pressure impaction (ELPI) J. Aerosol Sci 35 755 764 doi:10.1016/j.jaerosci.2003.12.003
27. A. J. Hickey H. M. Mansour M. J. Telko Z. Xu H. D. C. Smyth T. Mulder R. Mclean J. Langridge D. Papadopoulos 2007 Physical characterization of component particles included in dry powder inhalers. II. Dynamic characteristics J. Pharm. Sci. 96 5 1302 1319 doi:10.1002/jps.20943
28. P. C. L. Kwok H.-K. Chan 2008 Effect of relative humidity on the electrostatic charge properties of dry powder inhaler aerosols Pharm. Res 25 2 277 288 doi:10.1007/s11095-007-9377-2
29. M. K. Mazumder N. Grable Y. Tang S. O Conor R. A. Sims 1999 Real-time particle size and electrostatic charge distribution analysis and its applications to electrostatic processes Inst. Phys. Conf. Ser 163 335 340
30. V. A. Philip R. C. Mehta M. K. Mazumder P. P. DeLuca 1997 Effect of surface treatment on the respirable fractions of PLGA microspheres formulated for dry powder inhalers Int. J. Pharm 151 165 174 doi:10.1016/S0378-5173(96) 04879-X
31. M. K. Mazumder A. S. Biris R. Sharma D. Kumar S. Trigwell R. A. Sims 2001 Measurement of surface topography, packing density, and surface charge distribution of an electrostatically deposited powder layer by image analysis of fluorescent latex spheres Part. Sci. Tech 19 239 256 doi:10.1080/ 02726350290057831
32. J. R. Mountain M. K. Mazumder R. A. Sims D. L. Wankum T. Chasser P. H. Pettit Jr 2001 Triboelectric charging of polymer powders in fluidization and transport processes IEEE T. Ind. Appl 37 3 778 784 doi:10.1109/28.924759
33. G. Rowley 2001 Quantifying electrostatic interactions in pharmaceutical solid systems Int. J. Pharm 227 47 55 doi:10.1016/S0378-5173(01)00784-0
34. L. Yao H. T. Bi A.-H. Park 2002 Characterization of electrostatic charges in freely bubbling fluidized beds with dielectric particles J. Electrostatics 56 183 197 doi:10.1016/S0304-3886(02)00062-1
35. P. M. Young A. Sung D. Traini P. Kwok H. Chiou H.-K. Chan 2007 Influence of humidity on the electrostatic charge and aerosol performance of dry powder inhaler carrier based systems Pharm. Res 24 5 963 970 doi:10.1007/s11095-006- 9218-8
36. M. S. Coates H.-K. Chan D. F. Fletcher J. A. Raper 2005 Influence of air flow on the performance of a dry powder inhaler using computational and experimental analyses Pharm. Res 22 9 1445 1453 doi:10.1007/s11095-005-6155-x
37. M. J. Telko J. Kujanpää A. J. Hickey 2007 Investigation of triboelectric charging in dry powder inhalers using electrical low pressure impactor (ELPIä) Int. J. Pharm 336 352 360 doi:10.1016/j.ijpharm.2006.12. 018
38. M. Lungu 2004 Electrical separation of plastic materials using the triboelectric effect Miner. Eng 17 69 75 doi:10.1016/j.mineng.2003.10.010
39. M. J. Telko A. J. Hickey 2005 Dry powder inhaler formulation Respiratory Care 50 9 1209 1227
40. N. Islam P. Stewart I. Larson P. Hartley 2004 Lactose surface modification by decantation: are drug-fine lactose ratios the key to better dispersion of salmeterol xinafoate from lactose-interactive mixtures? Pharm. Res 21 3 492 499 doi:10.1023/B:PHAM.0000019304.91412.18
41. A. H. de Boer P. Hagedoorn D. Gjaltema J. Goede H. W. Frijlink 2006 Air classifier technology (ACT) in dry powder inhalation Part 4. Performance of air classifier technology in the Novolizer® multi-dose dry powder inhaler Int. J. Pharm 310 81 89 doi:10.1016/j.ijpharm.2005.11.029
42. Meggle Product Overview. InhaLac® 230. http://www.meggle-pharma.de/ en/products/uebersicht/inhalac230/ (accessed 5 December 2006).
43. J. F. Hughes 1989 Powder coating technology J. Electrostatics 23 3 23 doi:10.1016/0304-3886(89)90028-4
44. F. Podczeck M. J. Newton M. B. James 1996 The influence of constant and changing relative humidity of the air on the autoadhesion force between pharmaceutical powder particles Int. J. Pharm 145 221 229 doi:10.1016/S0378- 5173(96)04774-6
45. P. M. Young R. Price M. J. Tobyn M. Buttrum F. Dey 2004 The influence of relative humidity on the cohesion properties of micronized drugs used in inhalation therapy J. Pharm. Sci 93 3 753 761 doi:10.1002/jps.10549
46. T. Nomura T. Satoh H. Masuda 2003 The environment humidity effect on the tribo-charge of powder Powder Technol 135-136 43 49 doi:10.1016/S0032-5910(03) 00157-8
47. T. H. Ibrahim T. R. Burk F. M. Etzler R. D. Neuman 2000 Direct adhesion measurements of pharmaceutical particles to gelatin capsules J. Adhesion Sci. Technol 14 10 1225 1242 doi:10.1163/156856100742177
48. P. J. Mendesa J. F. Pinto J. M. M. Sousa 2007 A non-dimensional functional relationship for the fine particle fraction produced by dry powder inhalers J. Aerosol Sci 38 612 624 doi:10.1016/j.jaerosci.2007.04.001
49. N. Y. K. Chew H.-K. Chan D. F. Bagster J. Mukhraiya 2002 Characterization of pharmaceutical powder inhalers: estimation of energy input for powder dispersion and e&ect of capsule device configuration J. Aerosol Sci 33 999 1008 doi:10.1016/S0021-8502(02)00059-9
50. J. Eilbeck G. Rowley P. A. Carter E. J. Fletcher 2000 Effect of contamination of pharmaceutical equipment on powder triboelectrification Int. J. Pharm 195 7 11 doi:10.1016/S0378-5173(99)00351-8
51. N. Y. K. Chew H.-K. Chan 2002 The role of particle properties in pharmaceutical powder inhalation formulations J. Aerosol Med 15 3 325 330 doi:10.1089/089426802760292672
52. T. Nguyen S. Nieh 1989 The role of water vapor in the charge elimination process for flowing powders J. Electrostatics 22 213 227 doi:10.1016/0304- 3886(89)90086-7
53. R. Sharma S. Trigwell A. S. Biris R. A. Sims M. K. Mazumder 2003 Effect of ambient relative humidity and surface modification on the charge decay properties of polymer powders in powder coating IEEE T. Ind. Appl 39 1 87 95 doi:10.1109/TIA.2002.807234
54. P. Boschung M. Glor 1980 Methods for investigating the electrostatic behaviour of powders J. Electrostatics 8 205 219 doi:10.1016/0304-3886(80)90007- 8
55. D. K. Das-Gupta K. Doughty 1985 Modification of surface conductivity in insulating dielectrics J. Electrostatics 16 165 174 doi:10.1016/0304-3886(85) 90040-3
56. G. A. Turner M. Balasubramanian 1976 The frequency distributions of electrical charges on glass beads J. Electrostatics 2 85 89 doi:10.1016/0304- 3886(76)90018-8
57. J. Coste P. Pechery 1981 Influence of surface profile in polymer-metal contact charging J. Electrostatics 10 129 136 doi:10.1016/0304-3886(81)90032-2
58. P. M. Young R. Price 2004 The influence of humidity on the aerosolisation of micronised and SEDS produced salbutamol sulphate Eur. J. Pharm. Sci 22 235 240 doi:10.1016/j.ejps.2004.03.006
59. A. Elajnaf P. Carter G. Rowley 2006 Electrostatic characterisation of inhaled powders: effect of contact surface and relative humidity Eur. J. Pharm. Sci 29 375 384 doi:10.1016/j.ejps.2006.07.006