Tumor-killing γδ-TCRs take center stage

Blood

Volumn 120, Issue 26, 2012, Pages 5093-5094

  Moser, Bernhard ^a  

^a CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ANTIGEN; GAMMA DELTA T LYMPHOCYTE RECEPTOR; ISOPENTENYL DIPHOSPHATE; PAMIDRONIC ACID; PHOSPHOANTIGEN; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; TUMOR CELL VACCINE; UNCLASSIFIED DRUG; ZOLEDRONIC ACID;

AMINO ACID COMPOSITION; ANTIBODY STRUCTURE; ANTIGEN RECOGNITION; BINDING AFFINITY; CANCER IMMUNOTHERAPY; CELL HOMING; CELL KILLING; CELL SURVIVAL; COMPLEMENTARITY DETERMINING REGION; DRUG ACTIVITY; EFFECTOR CELL; GAMMA DELTA T LYMPHOCYTE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; NOTE; PRIORITY JOURNAL; TUMOR CELL;

EID: 84871507167     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-10-460378     Document Type: Note

References (11)

1. Gründer C, van Dorp S, Hol S, et al. gamma9 and delta2CDR3 domains regulate functional avidity of T-cells harboring gamma9delta2T-cell receptors. Blood. 2012; 120(26):5153-5162.
2. Gomes AQ, Martins DS, Silva-Santos B. Targeting gammadeltaTlymphocytes for cancer immunotherapy: from novel mechanistic insight to clinical application. Cancer Res. 2010;70(24):10024-10027.
3. Morita CT, Jin C, Sarikonda G, Wang H. Nonpeptide antigens, presentation mechanisms, and immunological memory of human Vgamma2Vdelta2 T cells: discriminating friend from foe through the recognition of prenyl pyrophosphate antigens. Immunol Rev. 2007;215:59-76. (Pubitemid 46212230)
4. Gober HJ, Kistowska M, Angman L, et al. Human Tcell receptor gammadelta cells recognize endogenous mevalonate metabolites in tumor cells. J Exp Med. 2003;197(2):163-168. (Pubitemid 36152311)
5. Parker CM, Groh V, Band H, et al. Evidence for extrathymic changes in theTcell receptor gamma/delta repertoire. J Exp Med. 1990;171(5):1597-1612. (Pubitemid 20167553)
6. Hintz M, Reichenberg A, Altincicek B, et al. Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadeltaTcells in Escherichia coli. FEBS Lett. 2001;509(2):317-322. (Pubitemid 34015963)
7. Harly C, Guillaume Y, Nedellec S, et al. Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human gammadelta T-cell subset. Blood. 2012;120(11):2269-2279.
8. Adams EJ, Strop P, Shin S, Chien YH, Garcia KC. An autonomous CDR3delta is sufficient for recognition of the nonclassical MHC class I molecules T10 and T22 by gammadelta T cells. Nat Immunol. 2008;9(7):777-784. (Pubitemid 351859161)
9. D'Asaro M, La Mendola C, Di Liberto D, et al. V gamma 9V delta 2Tlymphocytes efficiently recognize and kill zoledronate-sensitized, imatinib-sensitive, and imatinib-resistant chronic myelogenous leukemia cells. J Immunol. 2010;184(6):3260-3268.
10. Van Laethem F, Sarafova SD, Park JH, et al. Deletion of CD4 and CD8 co-receptors permits generation of alpha-betaT cells that recognize antigens independently of the MHC. Immunity. 2007;27(5):735-750. (Pubitemid 350102257)
11. Moser B, Eberl M. gammadelta T-APCs: a novel tool for immunotherapy? Cell Mol Life Sci. 2011;68(14):2443-2452.