Ceramide synthase

Sphingolipid Biology

Volumn , Issue , 2006, Pages 49-56

  Pankova Kholmyansky, Irene ^a   Futerman, Anthony H ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

ceramide; Dihydroceramide synthase; LASS genes; purification

Indexed keywords

EID: 84871465267     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/4-431-34200-1_3     Document Type: Chapter

References (27)

1. Barz WP, Walter P (1999) Two endoplasmic reticulum (ER) membrane proteins that facilitate ER-to-Golgi transport of glycosylphosphatidylinositol-anchored proteins. Mol Biol Cell, 10, 1043-1059.
2. Boyer J, Pascolo S, Richard GF, Dujon B (1993) Sequence of a 7.8 kb segment on the left arm of yeast chromosome XI reveals four open reading frames, in cluding the CAP1 gene, an intron-containing gene and a gene encoding a homolog to the mammalian UOG-1 gene. Yeast, 9, 279-287.
3. Brandwagt BF, Mesbah LA, Takken FL, Laurent PL, Kneppers TJ, Hille J, Nijkamp HJ (2000) A longevity assurance gene homolog of tomato mediates resistance to Alternaria alternata f. sp. lycopersici toxins and fumonisin B1. Proc Natl Acad Sci USA, 97,4961-4966.
4. D'Mello N P, Childress AM, Franklin DS, Kale SP, Pinswasdi C, Jazwinski SM (1994) Cloning and characterization of LAG1, a |ongevity-assurance gene in yeast. J Biol Chem, 269, 15451-15459.
5. Eto M, Bennouna J, Hunter OC, Hershberger PA, Kanto T, Johnson CS, Lotze MT, Amoscato AA (2003) C16 ceramide accumulates following androgen ablation in LNCaP prostate cancer cells. Prostate, 57, 66-79.
6. Futerman AH, Hannun YA (2004) The complex life of simple sphingolipids. EMBO Rep, 5,777-782.
7. Futerman AH, Riezman H (2005) The ins and outs of sphingolipid synthesis. Trends Cell Biol, 15, 312-318.
8. Guillas I, Jiang JC, Vionnet C, Roubaty C, Uldry D, Chuard R, Wang J, Jazwinski SM, Conzelmann A (2003) Human homologues of LAG1 reconstitute acyl-CoA-dependent ceramide synthesis in yeast. J Biol Chem, 278, 37083-37091.
9. Guillas I, Kirchman PA, Chuard R, Pfefferli M, Jiang JC, Jazwinski SM, Conzelmann A (2001) C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Laglp and Laclp. Embo J, 20, 2655-2665.
10. Jiang JC, Kirchman PA, Zagulski M, Hunt J, Jazwinski SM (1998) Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human. Genome Res, 8, 1259-1272.
11. Kida E, Golabek AA, Wisniewski KE (2001) Cellular pathology and pathogenic aspects of neuronal ceroid lipofuscinoses. Adv Genet, 45, 35-68.
12. Koybasi S, Senkal CE, Sundararaj K, Spassieva S, Bielawski J, Osta W, Day TA, Jiang JC, Jazwinski SM, Hannun YA, Obeid LM, Ogretmen B (2004) Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas. J Biol Chem, 279, 44311-44319.
13. Kroesen BJ, Jacobs S, Pettus BJ, Sietsma H, Kok JW, Hannun YA, de Leij LF (2003) BcR-induced apoptosis involves differential regulation of C16 and C24-ceramide formation and sphingolipid-dependent activation of the proteasome. J Biol Chem, 278, 14723-14731.
14. Lahiri S, Futerman AH (2005) LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl CoA as acyl donor. J Biol Chem, 280, 33735-33738.
15. Merrill AH, Jr. (2002) De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway. J Biol Chem, 277, 25843-25846.
16. Merrill AH, Jr., van Echten G, Wang E, Sandhoff K (1993) Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. J Biol Chem, 268, 27299-27306.
17. Mizutani Y, Kihara A, Igarashi Y (2005) Mammalian longevity assurance homolog LASS6 and its related family members regulate synthesis of specific ceramides. Biochem J, 390, 263-271.
18. Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA, Brenner DA (2005) Roles for C16-ceramide and sphingosine-l-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J Biol Chem, 280, 27879-27887.
19. Ranta S, Zhang Y, Ross B, Lonka L, Takkunen E, Messer A, Sharp J, Wheeler R, Kusumi K, Mole S, Liu W, Soares MB, Bonaldo MF, Hirvasniemi A, de la Chapelle A, Gilliam TC, Lehesjoki AE (1999) The neuronal ceroid lipofuscinoses in human EPMR and mnd mutant mice are associated with mutations in CLN8. Nat Genet, 23, 233-236.
20. Riebeling C, Allegood JC, Wang E, Merrill AH, Jr., Futerman AH (2003) Two mammalian longevity assurance gene (LAG 1) family members, trhl and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. J Biol Chem, 278, 43452-43459.
21. Schorling S, Vallee B, Barz WP, Riezman H, Oesterhelt D (2001) Laglp and Laclp are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae. Mol Biol Cell, 12, 3417-3427.
22. Vallee B, Riezman H (2005) Lip lp: a novel subunit of acyl-CoA ceramide synthase. Embo J, 24, 730-741.
23. Venkataraman K, Futerman AH (2002) Do longevity assurance genes containing Hox domains regulate cell development via ceramide synthesis? FEBS Lett, 528, 3-4.
24. Venkataraman K, Riebeling C, Bodennec J, Riezman H, Allegood JC, Sullards MC, Merrill AH, Jr., Futerman AH (2002) Upstream of growth and differentiation factor 1 (uogl), a mammalian homolog of the yeast longevity assurance gene 1 (LAG 1 ), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin Bl-independent manner in mammalian cells. J Biol Chem, 277, 35642-35649.
25. Wang E, Norred WP, Bacon CW, Riley RT, Merrill AH, Jr. (1991) Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. J Biol Chem, 266, 14486-14490.
26. Watanabe R, Funato K, Venkataraman K, Futerman AH, Riezman H (2002) Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol- anchored proteins in yeast. J Biol Chem, 277, 49538-49544.
27. Winter E, Ponting CP (2002) TRAM, LAG1 and CLN8: members of a novel family of lipid-sensing domains? Trends Biochem Sci, 27, 381-383.