Breast cancer in women 80 years of age and older: A comprehensive analysis of an underreported entity

Acta Oncologica

Volumn 52, Issue 1, 2013, Pages 57-65

  Vetter, Marcus ^a,b   Huang, Dorothy Jane ^a,b   Bosshard, Georg ^c   Güth, Uwe ^a,b,d  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b UHB   (Switzerland)

^c Spital Uster   (Switzerland)

^d CANTONAL HOSPITAL WINTERTHUR   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; HORMONE RECEPTOR;

ADULT; AGED; BREAST CANCER; BREAST METASTASIS; CANCER ADJUVANT THERAPY; CANCER GRADING; CANCER HORMONE THERAPY; CANCER PALLIATIVE THERAPY; CANCER STAGING; CLINICAL EXAMINATION; CONTROLLED STUDY; ECHOMAMMOGRAPHY; FEMALE; HISTOPATHOLOGY; HUMAN; MAJOR CLINICAL STUDY; MASTECTOMY; OVERALL SURVIVAL; PATIENT COMPLIANCE; PRIORITY JOURNAL; REVIEW; TREATMENT REFUSAL; AGE DISTRIBUTION; ARTICLE; CANCER CHEMOTHERAPY; CANCER SURVIVAL; COMPARATIVE STUDY; DISEASE COURSE; ECHOGRAPHY; MAMMOGRAPHY; METASTASIS; MORBIDITY; PROSPECTIVE STUDY; TUMOR VOLUME;

AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, HORMONAL; BREAST NEOPLASMS; CHEMOTHERAPY, ADJUVANT; COHORT STUDIES; DRUG UTILIZATION; FEMALE; HUMANS; MAMMOGRAPHY; MASTECTOMY; MIDDLE AGED; PALLIATIVE CARE; PHYSICAL EXAMINATION; RADIOTHERAPY, ADJUVANT; SURVIVAL ANALYSIS; SWITZERLAND; TREATMENT REFUSAL;

EID: 84871461199     PISSN: 0284186X     EISSN: 1651226X     Source Type: Journal    
DOI: 10.3109/0284186X.2012.731523     Document Type: Review

References (25)

1. Albrand G, T erret C. E arly breast cancer in the elderly: Assessment and management considerations . Drugs Aging 2008; 25 : 35 - 45 .
2. Biganzoli L, W ildiers H, O akman C, M arotti L, L oibl S, Kunkler I, et al . Management of elderly patients with breast cancer: Updated recommendations of the International Society of Geriatric Oncology (SIOG) and European Society of Breast Cancer Specialists (EUSOMA) . Lancet Oncol 2012; 13 : e148 - 60 .
3. Crivellari D, A apro M, L eonard R, v on Minckwitz G, Brain E, Goldhirsch A, et al . Breast cancer in the elderly . J Clin Oncol 2007; 25 : 1882 - 90 . (Pubitemid 46854422)
4. Schonberg MA, Marcantonio ER, Li D, Silliman RA, Ngo L, McCarthy EP . Breast cancer among the oldest old: Tumor characteristics, treatment choices, and survival . J Clin Oncol 2010; 28 : 2038 - 45 .
5. Spazzapan S, C rivellari D, B edard P, L ombardi D, M iolo G, Scalone S, et al . Therapeutic management of breast cancer in the elderly . Expert Opin Pharmacother 2011; 12 : 945 - 60 .
6. Taylor WC, M uss HB. R ecent advances: Adjuvant therapy for older women with breast cancer . Cancer J 2010; 16 : 289 - 93 .
7. World Health Organization. H ealth statistics and health information systems . Defi nition of an older or elderly person. updated 2012; cited 2012 May 27). . Available from: http:// www.who.int/healthinfo/survey/ ageingdefnolder/en/index. html.
8. Hamerman D. T oward an understanding of frailty . A nn Intern Med 1999; 130 : 945 - 50 . (Pubitemid 29239594)
9. Extermann M, H urria A. C omprehensive geriatric assessment for older patients with cancer . J Clin Oncol 2007; 25 : 1824 - 31 . (Pubitemid 46860271)
10. Early Breast Cancer Trialists' Collaborative Group (EBCTCG), Peto R, Davies C, Godwin J, Gray R, Pan H, et al . Comparisons between different polychemotherapy regimens for early breast cancer: Meta-analyses of long-term outcome among 100,000 women in 123 randomised trials . Lancet 2012; 379 : 432 - 44 .
11. Rao V S, J ameel J K, M ahapatra TK, M cManus P L, F ox J N, Drew PJ . Surgery is associated with lower morbidity and longer survival in elderly breast cancer patients over 80 . Breast J 2007; 13 : 368 - 73 . (Pubitemid 46985563)
12. Rosenkranz KM, B edrosian I, Feng L, H unt KK, Hartman K, Lucci A, et al . Breast cancer in the very elderly: Treatment patterns and complications in a tertiary cancer center . Am J Surg 2006; 192 : 541 - 4 . (Pubitemid 44344192)
13. Van Leeuwen BL, R osenkranz KM, F eng LL, B edrosian I, Hartmann K, Hunt KK, et al . The effect of under-treatment of breast cancer in women 80 years of age and older . Crit Rev Oncol Hematol 2011; 79 : 315 - 20 .
14. Schmid SM, M odlasiak AA, M yrick ME, K ilic N, V iehl CT, Schotzau A, et al . Success and failure of primary medical, nonoperative management in breast cancer . Ann Surg Oncol 2011; 18 : 2166 - 72 .
15. Guth U, H uang DJ, S chotzau A, Z anetti-Dallenbach R, Holzgreve W, Bitzer J, et al . Target and reality of adjuvant endocrine therapy in postmenopausal patients with invasive breast cancer . Br J Cancer 2008; 99 : 428 - 33 .
16. Guth U, M yrick M E, K ilic N, E ppenberger-Castori S, Schmid SM . Compliance and persistence of endocrine adjuvant breast cancer therapy . Breast Cancer Res Treat 2012; 131 : 491 - 9 .
17. Bouchardy C, Rapiti E, Blagojevic S, Vlastos A T, Vlastos G . Older female cancer patients: Importance, causes, and consequences of undertreatment . J Clin Oncol 2007; 25 : 1858 - 69 . (Pubitemid 46854419)
18. Litvak DA, A rora R. T reatment of elderly breast cancer patients in a community hospital setting . Arch Surg 2006; 141 : 985 - 90; discussion 990 .
19. Fennessy M, B ates T, M acRae K, R iley D, H oughton J, Baum M . Late follow-up of a randomized trial of surgery plus tamoxifen versus tamoxifen alone in women aged over 70 years with operable breast cancer . Br J Surg 2004; 91 : 699 - 704 . (Pubitemid 38746135)
20. Fentiman IS, C hristiaens MR, P aridaens R, V an Geel A, Rutgers E, Berner J, et al . Treatment of operable breast cancer in the elderly: A randomised clinical trial EORTC 10851 comparing tamoxifen alone with modifi ed radical mastectomy . Eur J Cancer 2003; 39 : 309 - 16 . (Pubitemid 36140047)
21. Mustacchi G, C eccherini R, M ilani S, P luchinotta A, De Matteis A, Maiorino L, et al . Tamoxifen alone versus adjuvant tamoxifen for operable breast cancer of the elderly: Long-term results of the phase III randomized controlled multicenter GRETA trial . Ann Oncol 2003; 14 : 414 - 20 . (Pubitemid 36367419)
22. Yellen SB, C ella DF, L eslie WT. A ge and clinical decision making in oncology patients . J Natl Cancer Inst 1994; 86 : 1766 - 70 . (Pubitemid 24373451)
23. Downey L, L ivingston R, S topeck A. D iagnosing and treating breast cancer in elderly women: A call for improved understanding . J Amer Ger Soc 2007; 55 : 1636 - 44 . (Pubitemid 47508503)
24. Ramirez AJ, W estcombe A M, B urgess CC, S utton S, Littlejohns P, Richards MA . Factors predicting delayed presentation of symptomatic breast cancer: A systematic review . Lancet 1999; 353 : 1127 - 31 . (Pubitemid 29155204)
25. Steinhauser K E, C hristakis N A, C lipp E C, M cNeilly M, McIntyre L, Tulsky JA . Factors considered important at the end of life by patients, family, physicians, and other care providers . JAMA 2000; 284 : 2476 - 82 .