Early changes in serum neutrophil elastase in rats with burn, blast injury or combined burn-blast injury and its significance

National Medical Journal of China

Volumn 90, Issue 24, 2010, Pages 1707-1710

  Cai, Jian Hua ^a   Chai, Jia Ke ^a   Shen, Chuan An ^a   Yin, Hui Nan ^a   Zhou, Xiao Fang ^a   Liu, Wei ^a   Hu, Qing Gang ^a   Chi, Yun Fei ^a   Ma, Li ^a   Deng, Hu Ping ^a   Zhang, Xi Bo ^a   Sun, Tian Jun ^a   Han, Yan Fu ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Blast injuries; Burn blast combined injuries; Burns; Neutrophil elastase; Rat

Indexed keywords

LEUKOCYTE ELASTASE; RINGER SOLUTION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLAST INJURY; BURN; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; LUNG INJURY; LUNG LAVAGE; LUNG PARENCHYMA; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; RAT; WATER CONTENT; ANIMAL; BLOOD; DISEASE MODEL; INJURY; MALE; SPRAGUE DAWLEY RAT;

ANIMALS; BURNS; DISEASE MODELS, ANIMAL; LEUKOCYTE ELASTASE; LUNG INJURY; MALE; RATS; RATS, SPRAGUE-DAWLEY; WOUNDS AND INJURIES;

EID: 84871451312     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0376-2491.2010.24.013     Document Type: Article

References (14)

1. 2008: 751-756.
2. Chai J K, Sheng Z Y, Lu J Y, et al. Characteristics of and strategies for patients with severe burn-blast combined injury. Chin Med J, 2007, 120: 1783-1787.
3. Chai J K, Sheng Z Y, Yang H M, et al. Treatment strategies for mass burn casualties. Chin Med J, 2009, 122: 525-529.
4. Tamakuma S, Ogawa M, Aikawa N, et al. Relationship between neutrophil elastase and acute lung injury in humans. Pulm Pharmacol Ther, 2004, 17: 271-279.
5. Hagio T, Matsumoto S, Nakao S, et al. Elastase inhibition reduced death associated with acid aspiration-induced lung injury in hamsters. Eur J Pharmacol, 2004, 488: 173-180.
6. Inoue Y, Seiyama A, Tanaka H, et al. Protective effects of a selective neutrophil elastase inhibitor (sivelestat) on lipopolysaccharide-induced acute dysfunction of the pulmonary microcirculation. Crit Care Med, 2005, 33: 1814-1822.
7. 2009, 25: 184-187.
8. Carden D, Xiao F, Moak C, et al. Neutrophil elastase promotes lung microvascular injury and proteolysis of endothelial cadherins. Am J Physiol, 1998, 275: H385-H392.
9. Ishihara K, Yamaguchi Y, Uchino S, et al. ICAM-1 signal transduction in cells stimulated with neutrophil elastase. Dig Dis Sci, 2006, 51: 2102-2112.
10. Moraes T J, Chow C W, Downey G P. Proteases and lung injury. Crit Care Med, 2003, 31: S189-194.
11. 2006, 12:3-5.
12. Fujishima S, Morisaki H, Ishizaka A. Neutrophil elastase and systemic inflammatory response syndrome in the initiation and development of acute lung injury among critically ill patients. Biomed Pharmacother, 2008, 62: 333-338.
13. Hayakawa M, Katabami K, Wada T, et al. Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome and disseminated intravascular coagulation patients. Shock, 2010, 33: 14-18.
14. Zeiher B G, Matsuoka S M, Kawabata K, et al. Neutrophil elastase and acute lung injury: Prospects for sivelestat and other neutrophil elastase inhibitors as therapeutics. Critical Care Medicine, 2002, 30: S281-287.