Up-regulated miR155 Reverses the Epithelial-mesenchymal Transition Induced by EGF and Increases Chemo-sensitivity to Cisplatin in Human Caski Cervical Cancer Cells

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Lei, Cui ^a,b,c   Wang, Yanlin ^a,b   Huang, Yurong ^b   Yu, Han ^b   Huang, Yiling ^b   Wu, Liting ^b   Huang, Liming ^b  

^a WUHAN UNIVERSITY   (China)

^b Institute of Molecular Biology of Three Gorges University   (China)

^c CHINA THREE GORGES UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; CYCLIN D1; EPIDERMAL GROWTH FACTOR; GENOMIC DNA; MICRORNA 155; PROTEIN P53; SMAD2 PROTEIN;

ARTICLE; CANCER CELL CULTURE; CELL INVASION; CELL STRAIN CASKI; CONTROLLED STUDY; DRUG SENSITIVITY; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE FUNCTION; GENE OVEREXPRESSION; GENETIC REGULATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MIGRATION INHIBITION; ONCOGENE; PROTEIN EXPRESSION; TUMOR SUPPRESSOR GENE; UTERINE CERVIX CANCER;

BLOTTING, WESTERN; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CISPLATIN; EPIDERMAL GROWTH FACTOR; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MICRORNAS; UTERINE CERVICAL NEOPLASMS;

EID: 84871439027     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0052310     Document Type: Article

References (25)

1. Polyak K, Weinberg RA, (2009) Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits, Nat Rev Cancer. pp. 9265-273.
2. Thiery JP, Acloque H, (2009) Epithelial-mesenchymal transitions in development and disease, Cell. 139: 871-890.
3. Ackland ML, Newgreen DF, Fridman M, Waltham MC, Arvanitis A, et al. (2003) Epidermal growth factor-induced epithelial-mesenchymal transition in human breast carcinoma cells, Lab Invest. 83: 435-448.
4. Shen MR, Hsu YM, Hsu KF, Chen YF, Tang MJ, et al. (2006) Insulin-like growth factor 1 is a potent stimulator of cervical cancer cell invasiveness and proliferation that is modulated by alphavbeta3 integrin signaling, Carcinogenesis. 27: 962-971.
5. Hagemann T, Bozanovic T, Hooper S, Ljubic A, Slettenaar VI, et al. (2007) Molecular profiling of cervical cancer progression, Br J Cancer. 96: 321-328.
6. Moes M, Le Béchec A, Crespo I, Laurini C, Halavatyi A, et al. (2012) A novel network integrating a miRNA-203/SNAI1 feedback loop which regulates epithelial to mesenchymal transition, PLoS One. 7: e35440.
7. Xia H, Hui KM (2012) MicroRNAs involved in regulating epithelial-mesenchymal transition and cancer stem cells as molecular targets for cancer therapeutics, Cancer Gene Ther. doi: 10.1038.
8. Ryu JK, Hong SM, Karikari CA, Hruban RH, Goggins MG, et al. (2010) Aberrant MicroRNA-155 expression is an early event in the multistep progression of pancreatic adenocarcinoma, Pancreatology. 10: 66-73.
9. Greither T, Grochola LF, Udelnow A, Lautenschläger C, Würl P, et al. (2010) Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival, Int J Cancer. 126: 73-80.
10. Castilla MÁ, Moreno-Bueno G, Romero-Pérez L, Van De Vijver K, Biscuola M, et al. (2011) Micro-RNA signature of the epithelial-mesenchymal transition in endometrial carcinosarcoma, J Pathol. 223: 72-80.
11. Songtao Qi. Ye Song, Yuping Peng, Hao Wang, Hao Long (2012) ZEB2 mediates multiple pathways regulating cell proliferation, migration, invasion, and apoptosis in glioma, PLoS One. 7: e 38842.
12. Li QQ, Xu JD, Wang WJ, Cao XX, Chen Q, et al. (2009) Twist1-mediated adriamycin-induced epithelial-mesenchymal transition relates to multidrug resistance and invasive potential in breast cancer cells, Clin Cancer Res. 15: 2657-2665.
13. Lee MY, Chou CY, Tang MJ, Shen MR, (2008) Epithelial-mesenchymal transition in cervical cancer: correlation with tumor progression, epidermal growth factor receptor overexpression, and snail up-regulation, Clin Cancer. Res (15) (): 4743-4750.
14. Iida K, Nakayama K, Rahman MT, Rahman M, Ishikawa M, et al. (2011) EGFR gene amplification is related to adverse clinical outcomes in cervical squamous cell carcinoma, making the EGFR pathway a novel therapeutic target, Br J Cancer. 105: 420-427.
15. Narayanan R, Kim HN, Narayanan NK, Nargi D, Narayanan B, (2012) Epidermal growth factor-stimulated human cervical cancer cell growth is associated with EGFR and cyclin D1 activation, independent of COX-2 expression levels. Int J Oncol. 40: 13-20.
16. Bracken CP, Gregory PA, Kolesnikoff N, Bert AG, Wang J, et al. (2008) A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res. 68: 7846-7854.
17. Ahmad A, Aboukameel A, Kong D, Wang Z, Sethi S, et al. (2011) Phosphoglucose Isomerase/Autocrine Motility Factor Mediates Epithelial-Mesenchymal Transition Regulated by miR-200 in Breast Cancer Cells, Cancer Research. 71: 3400-3409.
18. Kim NH, Kim HS, Li XY, Lee I, Choi HS, et al. (2011) A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition, J Cell Biol. 195: 417-433.
19. Ono Y, Hayashida T, Konagai A, Okazaki H, Miyao K, et al. (2012) Direct inhibition of the transforming growth factor-β pathway by protein-bound polysaccharide through inactivation of Smad2 signaling, Cancer Sci. 103: 317-324.
20. Xiang X, Zhuang X, Ju S, Zhang S, Jiang H, et al. (2011) miR155 promotes macroscopic tumor formation yet inhibits tumor dissemination from mammary fat pads to the lung by preventing EMT, Oncogene. 30: 3440-3453.
21. Gironella M, Seux M, Xie MJ, Cano C, Tomasini R, et al. (2007) Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development, Proc Natl Acad Sci USA. 104: 16170-16175.
22. Jiang S, Zhang HW, Lu MH, He XH, Li Y, et al. (2010) MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene, Cancer Res. 70: 3119-3127.
23. Kong W, Yang H, He L, Zhao JJ, Coppola D, et al. (2008) MicroRNA-155 Is Regulated by the Transforming Growth Factor β/Smad Pathway and Contributes to Epithelial Cell Plasticity by Targeting RhoA, Mol Cell Biol. 28: 6773-6784.
24. Tobin NP, Sims AH, Lundgren KL, Lehn S, Landberg G, (2011) Cyclin D1, Id1 and EMT in breast cancer, BMC Cancer. 11: 417.
25. Zheng L, Foley K, Huang L, Leubner A, Mo G, et al. (2011) Tyrosine 23 phosphorylation-dependent cell-surface localization of annexin A2 is required for invasion and metastases of pancreatic cancer, PLoS One. 6: e19390.