Study on mitochondrial function of ND1 gene with 3316 G → A mutation in human diabetes

National Medical Journal of China

Volumn 89, Issue 40, 2009, Pages 2822-2826

  Deng, Guan Hua ^a   Zhou, Xin ^a   Pang, Zhi Yu ^a   Liu, Song Mei ^a   Xie, Yan ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

Diabetes mellitus; DNA, mitochondria; Genes

Indexed keywords

MITOCHONDRIAL DNA; MITOCHONDRIAL PROTEIN; MT ND1 PROTEIN, HUMAN; MT-ND1 PROTEIN, HUMAN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; SMALL INTERFERING RNA;

ARTICLE; CELL PROLIFERATION; DIABETES MELLITUS; GENE SILENCING; GENETIC TRANSFECTION; GENETICS; HELA CELL; HUMAN; METABOLISM; MUTATION; PATHOLOGY;

CELL PROLIFERATION; DIABETES MELLITUS; DNA, MITOCHONDRIAL; GENE SILENCING; HELA CELLS; HUMANS; MITOCHONDRIAL PROTEINS; MUTATION; NADH DEHYDROGENASE; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84871432938     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0376-2491.2009.40.004     Document Type: Article

References (23)

1. Lindroos MM, Majamaa K, Tura A, et al. m. 3243A > G mutation in mitochondrial DNA leads to decreased insulin sensitivity in skeletal muscle and to progressive beta-cell dysfunction. Diabetes. 2009, 58: 543-549.
2. Berdanier CD, Everts HB. Mitochondrial DNA in aging and degenerative disease. Mutation Research, 2001, 475: 169-184.
3. Van den Ouweland JM, Lemkes HH, Ruitenbeek, et al. Mutation in mitochondrial tRNA(Leu) (UUR) gene in a large pedigree with maternally transmitted type 2 diabetes mellitus and deafness. Nat Genet, 1992, 1: 368-371.
4. Ballinger SW, Shoffner JM, Hedaya EV, et al. Maternally transmitted diabetes and deafness associated with a 10.4kb mitochondrial DNA deletion. Nat Genet, 1992, 1: 11-15.
5. Lowell BB, Shulman GL. Mitochondrial dysfunction and type 2 diabetes. Science, 2005, 307: 384-387.
6. Maassen JA, T Hart LM, Van Essen E, et al. Mitochondrial diabetes: molecular mechanisms and clinical presentation. Diabetes, 2004, 53: S103-109.
7. Rolo AP, Palmeira CM. Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress. Toxicol Appl Pharmacol, 2006, 212: 167-178.
8. Liu SM, Zhou X, Zheng F, et al. Novel mutations found in mitochondrial diabetes in Chinese Han population, Diabetes Res Clin Pract, 2007, 76: 425-435.
9. 2006, 86: 2853-2857.
10. 2005, 85: 1951-1956.
11. Qian J, Zhang LR. Association of the point mutation in mitochondrial DNA ND1 gene with diabetes mellitus. Chin Endocrinol Metab J, 2003, 19: 46-47.
12. Li MZ, Yu DM, Yu P, et al. Mitochondrial gene mutations and type 2 diabetes in Chinese families. Chin Med J, 2008, 121: 682-686.
13. Kong QP, Bandelt HJ, Sun C, et al. Updating the East Asian mtDNA phylogeny: a prerequisite for the identification of pathogenic mutations. Hum Mol Genet, 2006, 15: 2076-2086.
14. Kucera O, Cervinkora Z, Lotkova H, et al. Protective effect of S-adenosylmethionine against Galactosamine-induced injury of rat hepatocytes in primary clutrue. Physiol Res, 2006, 55: 551-560.
15. Funk PE, Pifer J, Kharas M, et al. The avian chB6 alloantigen induces apoptosis in DT40 B cells. Cell Immunol, 2003, 226: 95-104.
16. Kaminker PG, Kim SH, Taylor RD, et al. TANK2, a new TRF1-associated poly (ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression. J Biol Chem, 2001, 276: 35891-35899.
17. Bourges I, Ramus C, Mousson de Camaret B, et al. Structural organization of mitochondrial human complex I: role of the ND4 and ND5 mitochondria-encoded subunits and interaction with prohibitin. Biochem J, 2004, 383: 491-499.
18. Hofhaus G, Attardi G. Efficient selection and characterization of mutants of a human cell line which are defective in mitochondrial DNA-encoded subunits of respiratory NADH dehydrogenase. Cell Mol Biol, 1995, 15: 964-974.
19. Kussmaul L, Judy Hirst J. The mechanism of superoxide production by NADH: ubiquinone oxidoreductase (complex I) from bovine heart mitochondria. Proc Natl Acad Sci, 2006, 103: 7607-7612.
20. Luo KQ, Chang DC. The gene-silencing efficiency of siRNA is strongly dependent on the local structure of mRNA at the targeted region. Biochem Biophys Res Commun, 2004, 318: 303-310.
21. Jeng JY, Yeh TS, Lee JW, et al. Maintenance of mitochondrial DNA copy number and expression are essential for preservation of mitochondrial function and cell growth. J Cell Biochem, 2008, 103: 347-357.
22. Franco M, Johansson M, Karlsson A. Depletion of mitochondrial DNA by down-regulation of deoxyguanosine kinase expression in non-proliferating Hela cells. Exp Cell Res, 2007, 313: 2687-2694.
23. Shin SW, Kil IS, Park JW. Silencing of mitochondrial NADP + - dependent isocitrate dehydrogenase by small interfering RNA enhances heat shock-induced apoptosis. Biochem Biophys Res Commun, 2008, 366: 1012-1018.