Anti-inflammatory therapy in tendinopathy: The role of nonsteroidal drugs and corticosteroid injections

Tendon Injuries: Basic Science and Clinical Medicine

Volumn , Issue , 2005, Pages 211-232

  Leadbetter, Wayne B ^a,b  

^a Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

^b Orthopaedic Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84871422130     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/1-84628-050-8_22     Document Type: Chapter

References (128)

1. Buckwalter JB. (1995) Pharmacological treatment of soft tissue injuries. J Bone Joint Surg. 77-A:1902-1914.
2. O'Connor FG, Sobel JR, Nirschel RP. (1992) Five-step treatment of overuse injuries. Phys Sports Med. 20: 128-142.
3. Petri M, Dobrow R, Neiman R, et al. (1987) Randomized, double-blind, placebo-controlled study of the treatment of the painful shoulder. Arthritis Rheum. 30:1040-1045.
4. Adebajo AO, Nash P, Harleman BL. (1990) A prospective double-blind dummy placebo-controlled study comparing triamcinolone hexacetonide injection with oral diclofenac 50mg TDS in patients with rotator cuff tendinitis. J Rheumatol. 17:1207-1210.
5. Fadale PD,Wiggins ME. (1994) Corticosteroid injections: their use and abuse. J Am Acad Orthop Surg. 2:133-140.
6. Berger RG. (1994) Nonsteroidal anti-inflammatory drugs: making the right choices. J Am Acad Orthop Surg. 4:2: 255-260.
7. Baker BE. (1984) Current concepts in the diagnosis and treatment of musculotendinous injuries. Med Sci Sports Exerc. 16:323-327.
8. West SG. (1997) Nonsteroidal Anti-Inflammatory Drugs: Rheumatologic Secrets. Philadelphia: Heurley and Belfres Inc;465-472.
9. Hill JJ Jr,Trapp RG, Colliver JA. (1989) Survey in the use of corticosteroid injections by orthopaedists. Curr Temp Orthop. 18:39-45.
10. Singh G. (1998) Recent considerations in nonsteroidal anti-inflammatory drug gastropathy. Am J Med. 105: 31-38s.
11. MacFarlane LL, Orak DJ, Snipson WW. (1995) NSAIDs, antihypertensive agents and loss of blood pressure control. Am Fam Physician. 51:849-856.
12. Whelton A, Hamilton CW. (1991) Nonsteroidal antiinflammatory drugs: effects on kidney function. J Clin Pharmacol. 31:588-598.
13. Yost JH, Morgan JG. (1994) Cardiovascular effects of NSAIDs. J Musculoskeletal Med. 11:22-34.
14. Weiler JM. (1992 Jul) Medical modifiers of sports injury: the use of nonsteroidal anti-inflammatory drugs (NSAIDs) in sports soft-tissue injury. Clin Sports Med. 11(3):635-644.
15. LaBelle H, Gilbert R, Joncas J, et al. (1992) Lack of scientific evidence for the treatment of lateral epicondylitis of the elbow - a meta-analysis. J Bone Joint Surg. 74-B: 646-651.
16. Leadbetter WB. (1990) An introduction to sports-induced soft tissue inflammation. In: Leadbetter WB, Buckwalter JB, Gordon SL, eds. Sports-Induced Inflammation. Park Ridge, IL: American Academy of Orthopaedic Surgeons; 3-23.
17. Leadbetter WB. (1993) Aging effects upon the repair and healing of athletic injury. In: Gordon SL, Gonzalez-Mestre X, Garrett WE Jr, eds. Sports and Exercise in Midlife. Rosemont, IL: American Academy of Orthopaedic Surgeons;177-233.
18. Leadbetter WB. (1990) Clinical staging concepts. In: Leadbetter WB, Buckwalter JB, Gordon SL, eds. Sports-Induced Inflammation. Park Ridge, IL: American Academy of Orthopaedic Surgeons;587-595.
19. Fantone J. (1990) Basic concepts of inflammation. In: Leadbetter WB, Buckwalter JB, Gordon SL, eds. Sports-Induced Inflammation. Park Ridge, IL, American Academy of Orthopaedic Surgeons;25-53.
20. Bestwick ES, Maffulli N. (2000) Reactive oxygen species and tendon problems: review and hypothesis. Sports Med Arthroscopy Rev. 8(1):6-16.
21. Kannus P, Jozsa L. (1991) Histopathology preceding spontaneous rupture of a tendon. J Bone Joint Surg. 73a:1507-1525.
22. Järvinen M, Jozsa L, Kannus P, Järvinen TLN, Knist M, Leadbetter WB. (1997) Scand J Med Sci Sports. 7:86-95.
23. Khan KM, Cook JL, Bronar F, Harcourt P, Astroni M. (1999) Histopathology of common tendinopathies update and implications for management. Sports Med. 27:393-408.
24. Tuite DJ, Renstrom PAFH, O'Brien M. (1997) The aging tendon. Scand J Med Sci Sports. 7:72-77.
25. Gallin JL, Goldstein IM, Snyderman R. (1992) Overview. In: Gallin JI, Goldstein IM, Snyderman R, eds. Inflammation: Basic Principles and Clinical Correlates. New York: Raven Press;1-4.
26. Smith DL, McAfee JH, Lucas LM, et al. (1989) Treatment of nonseptic olecranon bursitis: a controlled, blinded prospective trial. Arch Intern Med. 149:2527-2530.
27. Leadbetter WB,Wahl S,Tian H, Cook K. (2001) T-cell infiltration and activation: a possible autoimmune mechanism in chronic sports injury. Proceedings of the Combined Orthopedic Research Societies, Nov. 6-8, 1995, San Diego, 1995:391.
28. Friedlander GE, Jokl P, Horowitz MC. (1990) The autoimmune nature of sports-induced injury: a hypothesis. In: Leadbetter WB, Buckwalter JB, Gordon SL, eds. Sports-Induced Inflammation. Park Ridge, IL: American Academy of Orthopaedic Surgeons;619-627.
29. Fox RI, Lotz M, Carson DA. (1989) Structure and functions of synoviocytes in arthritis and allied conditions. In: McCarty DJ, ed. A Textbook Of Rheumatology. 11th ed. Philadelphia: Lea and Febiger;273-287.
30. Rodosky MW, Fu FH. (1990) Induction of synovial inflammation by matrix molecules, implant particles, and chemical agents. In: Leadbetter WB, Buckwalter JB, Gordon SL, eds. Sports-Induced Inflammation. Park Ridge, IL: American Academy of Orthopaedic Surgeons;357-381.
31. Curwin S. (1990) Models for studying sports-induced soft tissue inflammation. In: Leadbetter WB, Buckwalter JB, Gordon SL, eds. Sports-Induced Inflammation. Park Ridge, IL: American Academy of Orthopaedic Surgeons; 103-121.
32. Jozsa L, Kannus P. (1997) Human Tendons:Anatomy, Physiology and Pathology. Champaign, IL: Human Kinetics.
33. Bachman C, Boquist L, Friden J, et al. (1990) Chronic Achilles paratenonitis with tendinosis: an experimental model in the rabbit. J Orthop Res. 8:541-547.
34. Goldstein RA, Bowen DL, Fauci A. (1992) Adrenal corticosteroids. In: Gallin JI, Goldstein IM, Snyderman R, eds. Inflammation: Basic Principles and Clinical Correlates. New York: Raven Press;1061-1081.
35. Almekinders LC, Banes AJ, Ballinger CA. (1992) Inflammatory response of fibroblasts to repetitive motion. Trans Ortho Res Soc. 17:678.
36. Madden JW, Arem AJ. (1991) Wound healing biologic and clinical features. In: Sabiston DC, ed. Textbook of Surgery. 14th ed. Philadelphia:W.B. Saunders;167.
37. Goldstein IM. (1992) Agents that interfere with arachidonic acid metabolism. In: Gallin JI, Goldstein IM, Snyderman R, eds. Inflammation: Basic Principles and Clinical Correlates. New York: Raven Press;1127-1137.
38. Gray RG, Gottlieb NL. (1984) Corticosteroid injections in RA: how to get best results. In: Dickson RA, Wright V, eds. Musculoskeletal Disease. London: Heinemann Medical Books;48-60.
39. Vane JR. (1971 Jun) Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat N Biol. 231:232-235.
40. Davies P, Macmtyre DE. (1992) Prostaglandins and inflammation. In: Gallin JI, Goldstein IM, Snyderman R, eds. Inflammation: Basic Principles and Clinical Correlates. New York: Raven Press;123-138.
41. Catella-Lawson F, Crofford LJ. (2001) Cyclo-oxygenase initiation and thrombogenecity. Am J Med. 132:134-143.
42. Fantone J. (1990) Basic concepts of inflammation. In: Leadbetter WB, Buckwalter JB, Gordon SL, eds. Sports-Induced Inflammation. Park Ridge, IL: American Academy of Orthopaedic Surgeons;25-53.
43. Goodwin JS. (1987) Mechanism of action of corticosteroids. In: Goodwill IS, ed. Mediguide to Inflammatory Diseases.Vol 16. New York: Pfizer Laboratories;1-5.
44. Elder CL, Dahners LE, Weinhold PS. (2001) A cyclooxygenase-2 inhibitor impairs ligament healing in the rat. Am J Sports Med. 29:801-805.
45. Paulus HE, Furst DE. (1989) Aspirin and other nonsteroidal anti-inflammatory drugs. In: McCarty DJ, ed. Arthritis and Other Allied Conditions. 11th ed. Philadelphia: Lea And Febiger;507-543.
46. Howes EL, Plotz CM, Blunt JW, et al. (1950) Retardation of wound healing by cortisone. Surgery. 28:177-181.
47. Abramson SB. (1990) Nonsteroidal anti-inflammatory drugs: mechanisms of action and therapeutic considerations. In: Leadbetter WB, Buckwalter JB. Gordon SL, eds. Sports-Induced Inflammation. Park Ridge, IL: American Academy of Orthopaedic Surgeons;421-430.
48. Bjork J, Smeadegar DG, Arfors KE. (1985) Methylprednisolone sets at the endothelial cell level reducing inflammatory responses. Acta Physiol Scand. 123:221-224.
49. Almekinders LC. (1990) The efficacy of nonsteroidal antiinflammatory drugs in the treatment of ligament injuries. Sports Med. 9(3):l37-142.
50. Almekinders LL, Banes AJ, Bracey LW. (1995) An in vitro investigation with the effects of repetitive motion and nonsteroidal anti-inflammatory medication on human tendon fibroblasts. Am J Sports Med. 23:119-123.
51. Hart DA, Frauke CB, Bray RC. (1995) Inflammatory processes in repetitive motion and overuse syndromes: potential role of neurogenic mechanisms in tendons and ligaments. In: Gordon SC, Blair SJ, Five LJ, eds. Repetitive Motion Disorders of the Upper Extremity. Rosemont, IL: American Academy of Orthopaedic Surgeons;247-262.
52. Alfredson H, Thomson K, Kroggen S, Lorentson R. (2002) No signs of inflammation but high amounts of the neurotransmitter glutamate in common tendinopathies: an investigation using microdialysis and immunohistochemical techniques. Proc Am Acad Orthop Surg. 10:587.
53. Simpson R, Phillis JW. (1990) The use of nonsteroidal antiinflammatory drugs in sports medicine. Am J Sports Med. 5:107-109.
54. Altman RD. (1990 Feb) Neutrophil activation: An alternative to prostaglandin inhibition as the mechanism of action for NSAIDs. Semin Arthritis Rheum. 19(4):1-5.
55. McCarthy GM, McCarty DJ. (1994) Intrasynovial corticosteroid therapy. Bull Rheum Dis. 43(3):2-4.
56. Hollander JI. (1982) Guidelines for intra-articular steroid therapy. Orthop News. 4(5):2-3.
57. McCarty DJ, Hogan JM. (1964) Inflammatory reaction after intrasynovial injection of microcrystalline adrenocorticosteroid esters. Arthritis Rheum. 7:359-367.
58. Saal J. (1990) The role of inflammation in lumbar pain. Phys Med Rehab: State Art Rev. 4:2.191-199.
59. Baxter JD, Forsham PH. (1972) Tissue effects of glucocorticoids. Am J Med. 53:573-589.
60. Behrens F, Shepard N, Mitchell N. (1976) Metabolic recovery of articular cartilage after intra-articular injections of glucocorticoid. J Bone Joint Surg. 58:1157-1160.
61. Behrens F, Shepard N, Mitchell N. (1975) Alteration of rabbit articular cartilage by intra-articular injections of glucocorticoids. J Bone Joint Surg. (Am) 57:70-76.
62. Ishikawa K. (1981) Effect of intra-articular corticosteroid on the meniscus: a histological and histochemical study in rabbit knees. J Bone Joint Surg. (Am) 63:120-130.
63. Kapetanos G. (1982) The effect of the local corticosteroids on the healing and biomechanical properties of the partially injured tendon. Clin Orthop. 163:170-179.
64. Kennedy JC,Willis RB. (1976) The effects of local steroid injections on tendons: a biomechanical and microscopic correlative study. Am J Sports Med. 4:11-21.
65. Mankin HJ, Conger KA. (1966) The acute effects of intraarticular hydrocortisone on articular cartilage in rabbits. J Bone Joint Surg. (Am) 48:1383-1388.
66. Noyes FR, Nussbaum NS, Torvik PJ, et al. (1975) Biomechanical and ultrastructural changes in ligaments and tendons after local corticosteroid injections. (Abstract) J Bone Joint Surg. 57a:876.
67. Wiggins ME, Fadale PD, Barrach H, et al. (1994) Healing characteristics of a type I collagenous structure treated with corticosteroids. Am J Sports Med. 2:279-288.
68. Wiggins M, Fadale P, Barrach H, et al. (1993) Long-term effects of corticosteroid treatment on a healing rabbit medial collateral ligament. Trans Orthop Res Soc. 18:59.
69. Wrenn RN, Goldner JI, Markee JI. (1954) An experimental study of the effect of cortisone on the healing process and tensile strength of tendons. J Bone Joint Surg. 36a: 588.
70. Matthews LS, Sonstegard DA, Phelps DB. (1974) A biomechanical study of rabbit patellar tendon; effects of steroid injection. J Sports Med. 2:349-357.
71. Vogel HG. (1977) Mechanical and chemical properties of various connective tissue organs in rats as influenced by nonsteroidal antirheumatic drugs. Connect Tissue Res. 5:91-95.
72. Dahners LE, Gilbert JA, Lester GE, Taft TN, Payne LZ. (1988) The effect of nonsteroidal anti-inflammatory drug on the healing of ligaments. Am J Sports Med. 16(6):641-646.
73. Cox JS. (1984) Current concepts in the role of steroids in the treatment of sprains and strains. Med Sci Sports Exerc. 16:216-218.
74. Noyes FR, Keller CS, Grood ES, et al. (1984) Advances in the understanding of knee ligament injury, repair and rehabilitation. Med Sci Sports Exerc. 16:427-443.
75. Noyes FR, Grood ES, Nussbaum NS, et al. (1977) Effect of intra-articular corticosteroids on ligament properties: a biomechanical and histological study in rhesus knees. Clin Orthop. 123:197-209.
76. Kennedy JC,Willis RB. (1976) The effects of local steroid injections on tendons chanical and microscopic correlative study. Am J Sports Med. 4:11-21.
77. Matthews LS, Sonstegard DA, Phelps DB. (1974) A biomechanical study of rabbit tendon: Effects of steroid injection. J Sports Med. 2:349-357.
78. Almekinders LC, Temple JD. (1998) Etiology, diagnosis, and treatment of tendonitis; an analysis of the literature. Med Sci Sports Exerc. 30:1183-1190.
79. Leach RE. (1985) The impingement syndrome. In: Zarins B, Andrews JR, Carson WG Jr, eds. Injuries to the throwing arm. Philadelphia, WB Saunders;121-127.
80. Bono RF, Finkel S, Goodman HF, et al. (1983) A multicenter, double-blind comparison of oxaprozin, phenylbutazone and placebo therapy in patients with tendonitis and bursitis. Clin Ther. 6:79-85.
81. Lopez, JM. (1982) Treatment of acute tendinitis and bursitis with fentiazac; a double-blind comparison with placebo. Clin Ther. 5:79-84.
82. Mena HR, Lomen PL, Turner LF, Lamborn KR, Brin EL. (1986) Treatment of acute shoulder syndrome with fluribiprofen. Am J Med. 80(3A):141-144.
83. Thorling J, Linden B, Berg R, et al. (1990) A double-blind comparison of naproxen gel and placebo in the treatment of soft tissue injuries. Curr Med Res Opin. 12:242-248.
84. Saatok T, Erickson E. (1986) Randomized trial of oral naproxen or local injection of betamthasone in lateral epicondylitis of the humerus. Orthopaedics. 9:192-194.
85. Hollander JL, Brown EM Jr, Jessar RA, et al. (1951) Hydrocortisone and cortisone injected into arthritic joints: comparative effects of and use of hydrocortisone as a local antiarthritic agent. JAMA. 147:1629-1635.
86. White RH, Paull DM, Fleming KW. (1986) Rotator cuff tendinitis: comparison of subacromial injection of a long acting corticosteroid versus oral indomethacin therapy. J Rheumatol. 13:608-613.
87. Day B, Govindasamy HN, Patnaik R. (1978) Corticosteoid injections in the treatment of tennis elbow. Practitioner. 220:459-462.
88. Hollander JL, Brown EM Jr, Jessar RA, et al. (1954) Local antirheumatic effectiveness of higher esters and analogues of hydrocortisone. Ann Rheum Dis. 13:297-301.
89. Hollander JL, Jessar RA, Brown BM. (1961) Intrasynovial corticosteroid therapy: a decade of use. Bull Rheum Dis. 11:239-240.
90. Price R, Sinclair M, Heinrick I, Gibson T. (1991) Local injection treatment of tennis elbow - hydrocortisone, triamcinolone, and lignocaine compared. Br J Rheumatol. 30:39-44.
91. Hollander JL. (1985) Arthrocentesis techniques and intrasynovial therapy. In: McCarty DJ, ed. Arthritis and Allied Conditions: A Textbook of Rheumatology. 10th ed. Philadelphia: Lea & Febiger;541-553.
92. Saartok T, Ericksson E. (1986) Randomized trial of oral naproxen or local injection of betamethasone in lateral epicondylitis of the humerus. Orthopedics. 9:191-194.
93. Highgenboten CL, Jackson AW, Meske NB. (1993) Arthroscopy of the knee: ten-day pain profiles and corticosteroids. Am J Sports Med. 21(4):503-506.
94. Valtonen EJ. (1976) Subacromial triamcinolone mexacetonide and methylprednisolone injections in treatment of supraspinam tendinitis, a comparative trial. Scand J Rheumatol. (Suppl) 16:1-13.
95. Vecchio PC, Hazleman BL, King KM. (1993) A doubleblind trial comparing subacromial methyl prednisolone and lignocaine in acute rotator cuff tendonitis. Br J Rheumatol. 32:743-745.
96. Witherington RH, Girgis FL, Seifert MH. (1985) A placebo-controlled trial and steroid injections in the treatment of supraspinatus tendonitis. Scand J Rheumatol. 14(1):76-78.
97. Hill JJ Jr,Trapp RG, Colliver JA. (1989) Survey on the use of corticosteroid injections by orthopaedists. Contemp Orthop. 18:39-45.
98. Bruno LP, Clarke RP. (1989) The use of local corticosteroid injections in orthopaedic surgery. Presented at the 56th Annual Meeting of the American Academy of Orthopaedic Surgeons, Las Vegas, Feb 9-13.
99. Stahl S, Kaufman T. (1997) The efficacy of an injection of steroids in medial epicondylitis. J Bone Joint Surg. 79-A: 1648-1652.
100. NirschI RP. (1988 Apr) Prevention and treatment of elbow and shoulder injuries in the tennis player. Clin Sports Med. 7(2):289-308.
101. Bowen RE, Doney FY, Shapiro MS. (2001) Efficacy of nonoperative treatment for lateral epicondylitis. Am J Orthop. 30:642-646.
102. Gumher SF, Marks M, Gunther BB. (1989) The efficacy of cortisone injection for trigger fingers and thumbs. Presented at the 56th Annual Meeting of the American Academy of Orthopaedic Surgeons, Las Vegas, Feb 9.
103. Kraemer BA,Young LV,Arfken C. (1990) Stenosing flexor tenosynovitis. S Med J. 83:806-811.
104. Anderson BC, et al. (1991) Treatment of de Quervain's tenosynovitis with corticosteroids: a prospective study of the response to local injection. Arthritis Rheum. 34(7):793-798.
105. Sakai N. (2002) Selective corticosteroid injection into the extensor pollicis brevis tenosynovium for de Quervain's disease. Orthopedics. 25:68-70.
106. Schrier I, et al. (1996) Achilles tendonitis: are corticosteroid injections useful or harmful? Clin J Sports Med. 6:245-250.
107. DaCruz DJ, Geeson M, Alien JM, et al. (1988) Achilles paratendonitis: an evaluation of steroid injection. Br J Sports Med. 22:64-65.
108. Rovere GD,Webb LX, Gristina AG, et al. (1980) Musculoskeletal injuries in theatrical dance students. Am J Sports Med. 11:195-198.
109. Fukuda H, Hamada K, Nakajima T, Tomonaga A. (1994) Pathology and pathogenesis of the intratendinous tearing of the rotator cuff viewed from en bloc histologic sections. Clin Orthop Rel Res. 304:60-67.
110. Finerman GAM, Shapiro MS. (1991) Sports induced soft tissue calcification. In: Leadbetter WB, Buckwalter JA, Gordon SL, eds. Sports-Induced Inflammation: Clinical and Basic Science Concepts. Park Ridge, IL: American Academy of Orthopaedic Surgeons;257-275.
111. Botte MJ, Abrams RA. (1992 Jul) Recognition and treatment of shoulder bursitis. Sports Med Dig. 14(7): 1-3.
112. Leadbetter WB, Mooar PA, Lane GJ, Lee SJ. (1992 Oct) The surgical treatment of tendinitis. Clin Sports Med. 11(4):679-712.
113. Greenfield G, Stanish WD. (1994) Relieving shoulder pain without surgery. Phys Sports Med. 22:67-82.
114. Nirschl RP, Pettronc FA. (1979) Tennis elbow: the surgical treatment of lateral epicondylitis. J Bone Joint Surg. 61A: 832-839.
115. Leadbetter WB. (1983) Corticosteroid injection for the treatment of athletic injury. (Abstract) Med Sci Sports Exerc. 15:103.
116. Leach RE, Miller JK. (1987) Lateral and medial epicondylitis of the elbow. Clin Sports Med. 6:259-272.
117. Amadio P, Cummings DM,Amadio P. (1993) Nonsteroidal anti-inflammatory drugs - tailoring therapy to achieve results and avoid toxicity. Post Graduate Med. 93(4): 73-97.
118. Goss JA, Adams RF. (1993) Local injection of corticosteroids in rheumatic disease. J Musculoskeletal Med. 10(4):93-95.
119. Black HM, Cox JS, Straughn WR. (1980) Use of phenylbutazone in sports medicine: Understanding the risks. Am J Sports Med. 8:270-273.
120. Paget SA. (1994) Nosteroidal anti-inflammatory drugs: uses and misuses. Instructional course presented at the American Orthopedic Society for Sports Medicine 20th Annual Meeting, Palm Desert Ca, June 26-29.
121. Ford LT, DeBender J. (1979) Tendon rupture after local steroid injection. Southern Med J. 72:827-830.
122. Kelly DW, Carter VS, Jobe FW. (1984) Patellar and quadriceps tendon ruptures. Jumper's knee Am J Sports Med. 12:375-380.
123. Kleinman M, Gross AE. (1983) Achilles tendon rupture following steroid injection: Report of three cases. J Bone Joint Surg. 65-A:1345-1347.
124. Neustadt DH. (1980) Tendon rupture and steroid therapy, letter to editor, Southern Med J. 73:271-272.
125. Beskin JL, Sanders RA, Hunter SC. (1987) Surgical repair of Achilles tendon ruptures. Am J of Sports Med. 15: 1-8.
126. Astrom M. (1998) Partial rupture in chronic Achilles tendinopathy. A retrospective analysis of 342 cases. Acta Orthop Scand. 69:404-407.
127. Hollander JL, Jessar RA, Brown EM. (1961) Intr-synovial corticosteroid therapy: A decade of use. Bull Rheum Dis. 11:239-240.
128. Callahan T. (1991) 23 years later, Palmer bird of the same feather.Washington, DC, The Washington Post, February 24.