The ETS Transcription Factors ELK1 and GABPA Regulate Different Gene Networks to Control MCF10A Breast Epithelial Cell Migration

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Odrowaz, Zaneta ^a,b   Sharrocks, Andrew D ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RAC1 PROTEIN; TRANSCRIPTION FACTOR ELK 1; TRANSCRIPTION FACTOR ETS; TRANSCRIPTION FACTOR GABPA; UNCLASSIFIED DRUG;

ARTICLE; BREAST EPITHELIUM; CELL MIGRATION; CONTROLLED STUDY; CYTOSKELETON; ENDOTHELIUM CELL; GENE CONTROL; GENE EXPRESSION; GENE IDENTIFICATION; GENE REGULATORY NETWORK; GENE TARGETING; HUMAN; HUMAN CELL; KIF20A GENE; RAC1 GENE;

CELL LINE; CELL MOVEMENT; CYTOSKELETON; ETS-DOMAIN PROTEIN ELK-1; GA-BINDING PROTEIN TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; HUMANS; MAMMARY GLANDS, HUMAN; TRANSCRIPTION, GENETIC;

EID: 84871421133     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0049892     Document Type: Article

References (20)

1. Wei GH, Badis G, Berger MF, Kivioja T, Palin K, et al. (2010) Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J 29: 2147-2160.
2. Buchwalter G, Gross C, Wasylyk B, (2004) Ets ternary complex transcription factors. Gene 324: 1-14.
3. Hollenhorst PC, McIntosh LP, Graves BJ, (2011) Genomic and biochemical insights into the specificity of ETS transcription factors. Annu Rev Biochem 80: 437-471.
4. Hollenhorst PC, Shah AA, Hopkins C, Graves BJ, (2007) Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family. Genes Dev 21: 1882-1894.
5. Hollenhorst PC, Chandler KJ, Poulsen RL, Johnson WE, Speck NA, et al. (2009) DNA specificity determinants associate with distinct transcription factor functions. PLoS Genet 5: e1000778.
6. Boros J, Donaldson IJ, O'Donnell A, Odrowaz ZA, Zeef L, et al. (2009) Elucidation of the ELK1 target gene network reveals a role in the coordinate regulation of core components of the gene regulation machinery. Genome Res 19: 1963-1973.
7. Odrowaz Z, Sharrocks AD, (2012) ELK1 uses different DNA binding modes to regulate functionally distinct classes of target genes. PLoS Genet 8: e1002694.
8. Yu S, Cui K, Jothi R, Zhao DM, Jing X, et al. (2011) GABP controls a critical transcription regulatory module that is essential for maintenance and differentiation of hematopoietic stem/progenitor cells. Blood 117: 2166-2178.
9. Yang ZF, Mott S, Rosmarin AG, (2007) The Ets transcription factor GABP is required for cell-cycle progression. Nat Cell Biol 9: 339-346.
10. Schaeffer L, Duclert N, Huchet-Dymanus M, Changeux JP, (1998) Implication of a multisubunit Ets-related transcription factor in synaptic expression of the nicotinic acetylcholine receptor. EMBO J 17: 3078-3090.
11. Briguet A, Ruegg MA, (2000) The Ets transcription factor GABP is required for postsynaptic differentiation in vivo. J Neurosci 20: 5989-5996.
12. Valouev A, Johnson DS, Sundquist A, Medina C, Anton E, et al. (2008) Genome-wide analysis of transcription factor binding sites based on ChIP-Seq data. Nat Methods 5: 829-834.
13. Snel B, Lehmann G, Bork P, Huynen MA, (2000) STRING, a web-server to retrieve and display the repeatedly occurring neighbourhood of a gene. Nucleic Acids Res 28: 3442-3444.
14. Crook MF, Olive M, Xue HH, Langenickel TH, Boehm M, et al. (2008) GA-binding protein regulates KIS gene expression, cell migration, and cell cycle progression. FASEB J 22: 225-235.
15. Hollenhorst PC, Ferris MW, Hull MA, Chae H, Kim S, et al. (2011) Oncogenic ETS proteins mimic activated RAS/MAPK signaling in prostate cells. Genes Dev 25: 2147-2157.
16. Carstanjen D, Yamauchi A, Koornneef A, Zang H, Filippi MD, et al. (2005) Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways. J Immunol 174: 4613-4620.
17. Hill E, Clarke M, Barr FA, (2000) The Rab6-binding kinesin, Rab6-KIFL, is required for cytokinesis. EMBO J 19: 5711-5719.
18. Fontijn RD, Goud B, Echard A, Jollivet F, van Marle J, et al. (2001) The human kinesin-like protein RB6K is under tight cell cycle control and is essential for cytokinesis. Mol Cell Biol 21: 2944-2955.
19. Zhao WM, Fang G, (2005) MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis. Proc Natl Acad Sci U S A 102: 13158-13163.
20. Esteller M, (2011) Non-coding RNAs in human disease. Nat Rev Genet 12: 861-874.