An association between -866G/A polymorphism in the promoter of UCP2 and obesity: A meta-analysis

Gene

Volumn 514, Issue 1, 2013, Pages 41-47

  Liu, Lingling ^a   Zhao, Xinxin ^a   Kang, Shan ^a   Zhang, Dongfeng ^a  

^a QINGDAO UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

866G A; Meta analysis; Obesity; Polymorphism; UCP2

Indexed keywords

UNCOUPLING PROTEIN 2;

ALLELE; ARTICLE; ASIAN; CAUCASIAN; DISEASE PREDISPOSITION; DNA POLYMORPHISM; ETHNICITY; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC VARIABILITY; HUMAN; META ANALYSIS; OBESITY; PRIORITY JOURNAL; PUBLISHING; QUANTITATIVE ANALYSIS; SYSTEMATIC REVIEW;

ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; DATABASES, GENETIC; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; ION CHANNELS; MALE; MITOCHONDRIAL PROTEINS; OBESITY; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC;

EID: 84871417302     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2012.11.001     Document Type: Article

References (30)

1. Andersen G., et al. The frequent UCP2 -866G>A polymorphism protects against insulin resistance and is associated with obesity: a study of obesity and related metabolic traits among 17636 Danes. Int. J. Obes. 2012, 1-7.
2. Binh T.Q., et al. Correlations between genetic variance and adiposity measures, and gene × gene interactions for obesity in postmenopausal Vietnamese women. J. Genet. 2011, 90:1-9.
3. Borecki I.B., Blangero J., Rice T., Perusse L., Bouchard C., Rao D.C. Evidence for at least two major loci influencing human fatness. Am. J. Hum. Genet. 1998, 63:831-838.
4. Chagnon Y.C., Peruse L., Bouchard D. Familial aggregation of obesity, candidate genes and quantitative trait loci. Curr. Opin. Lipidol. 1997, 8:205-211.
5. Dalgaard L.T., et al. Mutational analysis of the UCP2 core promoter and relationships of variants with obesity. Obes. Res. 2003, 11:1420-1427.
6. DerSimonian R., Laird N. Meta-analysis in clinical trials. Control. Clin. Trials 1986, 7:177-188.
7. Esterbauer H., et al. A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. Nat. Genet. 2001, 28:178-183.
8. Fabsitz R.R., Sholinsky P., Carmelli D. Genetic influences on adult weight gain and maximum body mass index in male twins. Am. J. Epidemiol. 1994, 140:711-720.
9. Fleury C., et al. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat. Genet. 1997, 15:269-272.
10. Gu G. Relationships between the functional polymorphism in the promoter of uncoupling protein 2 gene and obesity and type 2 diabetes 2005, (D).
11. Heidari J., Akrami S.M., Heshmat R., Amiri P., Fakhrzadeh H., Pajouhi M. Association study of the -866G/A UCP2 gene promoter polymorphism with type 2 diabetes and obesity in a Tehran population: a case control study. Arch. Iran. Med. 2010, 13:384-390.
12. Higgins J.P., Thompson S.G. Quantifying heterogeneity in a meta-analysis. Stat. Med. 2002, 125:549-557.
13. Higgins J.P., Thompson S.G. Controlling the risk of spurious findings from meta-regression. Stat. Med. 2004, 23:1663-1682.
14. International Obesity Taskforce: Obesity the global epidemic http://www.iaso.org/iotf/obesity/obesitytheglobalepidemic.
15. Klingenberg M., et al. Mechanism and evolution of the uncoupling protein of brown adipose tissue. Trends Biochem. Sci. 1990, 15:108-112.
16. Kring S.I., et al. Genotype-phenotype associations in obesity dependent on definition of the obesity phenotype. Obes. Facts 2008, 1:138-145.
17. Mancini F.P., et al. Variants of uncoupling protein-2 gene and obesity: interaction with peroxisome proliferator-activated receptorgamma2. Clin. Endocrinol. 2003, 59:817-822.
18. Mantel N., Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J. Natl. Cancer Inst. 1959, 22:719-748.
19. Munafo M.R., Flint J. Meta-analysis of genetic association studies. Trends Genet. 2004, 20(9):439-444.
20. Ochoa M.C., et al. Association between obesity and insulin resistance with UCP2-UCP3 gene variants in Spanish children and adolescents. Mol. Genet. Metab. 2007, 92:351-358.
21. Oktavianthi S., et al. Uncoupling protein 2 gene polymorphisms are associated with obesity. Cardiovasc. Diabetol. 2012, 11:41.
22. Oppert J.M., et al. DNA polymorphism in the uncoupling protein (UCP) gene and human body fat. Int. J. Obes. 1994, 18:526-531.
23. Patsopoulos N.A., Evangelou E., Ioannidis J.P. Sensitivity of between-study heterogeneity in meta-analysis: proposed metrics and empirical evaluation. Int. J. Epidemiol. 2008, 37(5):1148-1157.
24. Schäuble N., et al. No evidence for involvement of the promoter polymorphism - 866 g/a of the UCP2 gene in childhood-onset obesity in humans. Exp. Clin. Endocrinol. Diabetes 2003, 111:73-76.
25. Shen X. Relationship of uncoupling protein 2 gene -866G/A polymorphism with metabolic syndrome in Chinese Han 2007, (D).
26. Srivastava N., Prakash J., Lakhan R., Agarwal C.G., Pant D.C., Mittal B. A common polymorphism in the promoter of UCP2 is associated with obesity and hyperinsulenemia in northern Indians. Mol. Cell. Biochem. 2010, 337:293-298.
27. Stunkard A.J., Harris J.R., Pedersen N.L., McClearn G.E. The body mass index of twins who have been reared apart. N. Eng. J. Med. 1990, 322:1483-1487.
28. Tobias A. Assessing the influence of a single study in the meta-analysis estimate. Stata Tech. Bull. 1999, 47:15-17.
29. Xu R. Association between uncoupling protein 2 gene polymorphisms and obesity in Japanese 2005, (D).
30. Zou H., Guo D., Li Y., Guo M., Tian Y., Zhang L. The association of uncoupling protein2 -866G/A (UCP2 -866G/A) Polymorphism with obesity. Mol. Cardiol. China 2011, 11(3):158-163.