How many potential drug-drug interactions cause adverse drug reactions in hospitalized patients?

European Journal of Internal Medicine

Volumn 24, Issue 1, 2013, Pages 27-33

  Bucşa, Camelia ^a   Farcaş, Andreea ^a   Cazacu, Irina ^a   Leucuta, Daniel ^a   Achimas Cadariu, Andrei ^a   Mogosan, Cristina ^a   Bojita, Marius ^a  

^a IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

Adverse drug reaction; Drug drug interaction; Hospitalization

Indexed keywords

ACENOCOUMAROL; ACETYLSALICYLIC ACID; AMIODARONE; AMITRIPTYLINE; AMLODIPINE; ANTIDEPRESSANT AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; DICLOFENAC; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FENOFIBRATE; FIBRIC ACID DERIVATIVE; FLUCONAZOLE; GINKGO BILOBA EXTRACT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; KETOPROFEN; METOCLOPRAMIDE; METOPROLOL; NONSTEROID ANTIINFLAMMATORY AGENT; PENTOXIFYLLINE; PERINDOPRIL; RAMIPRIL; SEROTONIN UPTAKE INHIBITOR; SIMVASTATIN; SOTALOL; SPIRONOLACTONE; TRAMADOL;

ABDOMINAL PAIN; ACUTE KIDNEY FAILURE; ADULT; ADVERSE DRUG REACTION; ARTICLE; BRADYCARDIA; CLINICAL TRIAL; CREATININE BLOOD LEVEL; DIZZINESS; DRUG INTERACTION; EPISTAXIS; FEMALE; GASTROINTESTINAL DISEASE; HEADACHE; HEART DISEASE; HEMATOLOGIC DISEASE; HEMATOMA; HOSPITAL PATIENT; HOSPITALIZATION; HUMAN; HYPOTENSION; INTERNATIONAL NORMALIZED RATIO; INTERVIEW; KIDNEY DISEASE; LENGTH OF STAY; LONG QT SYNDROME; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; MYALGIA; NEUROLOGIC DISEASE; PROSPECTIVE STUDY; RESPIRATORY TRACT DISEASE; SIDE EFFECT; URINARY TRACT DISEASE; VOMITING;

AGED; DRUG INTERACTIONS; DRUG TOXICITY; FEMALE; HOSPITALIZATION; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES;

EID: 84871403520     PISSN: 09536205     EISSN: 18790828     Source Type: Journal    
DOI: 10.1016/j.ejim.2012.09.011     Document Type: Article

References (39)

1. D.N. Juurlink, M. Mamdani, A. Kopp, and A. Laupacis Drug-drug interactions among elderly patients hospitalized for drug toxicity JAMA 289 2003 1652 1658 (Pubitemid 37430270)
2. P.J. McDonnell, and M.R. Jacobs Hospital admissions resulting from preventable adverse drug reactions Ann Pharmacother 36 2002 1331 1336 (Pubitemid 34925265)
3. J. Strandell, A. Bate, M. Lindquist, and R.I. Edwards The Swedish, Finnish, INteraction X-referencing drug-drug interaction database (the SFINX group). Drug-drug interactions - a preventable patient safety issue? Br J Clin Pharmacol 65 2007 144 146
4. M. Pirmohamed, S. James, S. Meakin, C. Green, A.K. Scott, and T.J. Walley Adverse drug reaction as cause of admission to hospital: prospective analysis of 18 820 patients BMJ 329 2004 15 19 (Pubitemid 38869995)
5. R. Aparasu, R. Baer, and A. Aparasu Clinically important potential drug-drug interactions in outpatient settings Res Social Adm Pharm 3 2007 426 437
6. D.C. Malone, J. Abarca, P.D. Hansten, A.J. Grizzle, E.P. Armstrong, and R.C. Van Bergen Identification of serious drug-drug interactions: results of the partnership to prevent drug-drug interactions J Am Pharm Assoc 44 2004 142 151
7. I. Grattagliano, P. Portincasa, G. D'Ambrosio, V.O. Palmieri, and G. Palasciano Avoiding drug interactions: here's help J Fam Pract 59 2010 322 329
8. D.S. Sitar Aging issues in drug disposition and efficacy Proc West Pharmacol Soc 50 2007 16 20
9. S.V. Doubova, H. Reyes-Morales, L. del Pilar Torres-Arreola, and M. Suárez-Ortega Potential drug-drug and drug-disease interactions in prescriptions for ambulatory patients over 50 years of age in family medicine clinics in Mexico City BMC Health Serv Res 7 2007 147
10. P. Vonbach, A. Dubied, S. Krähenbühl, and J.H. Beer Prevalence of drug-drug interactions at hospital entry and during hospital stay of patients in internal medicine Eur J Intern Med 19 2008 413 420
11. J.J. Gagne, V. Maio, and C. Rabinowitz Prevalence and predictors of potential drug-drug interactions in Regione Emilia-Romagna, Italy J Clin Pharm Ther 33 2008 141 151 (Pubitemid 351341403)
12. L.R. Tulner, S.V. Frankfort, G. Gijsen, J. van Campen, C. Koks, and J.H. Beijnen Drug-drug interactions in a geriatric outpatient cohort Drugs Aging 25 2008 343 355 (Pubitemid 351440452)
13. B. Janchawee, W. Wongpoowarak, T. Owatranporn, and Chongsuvivatwong Pharmacoepidemiologic study of potential drug interactions in outpatients of a university hospital in Thailand J Clin Pharm Ther 30 2005 13 20 (Pubitemid 41602088)
14. C. Zhan, R. Coreea de Araujo, A.S. Bierman, J. Sangl, M.R. Miller, and S.W. Wickizer Suboptimal prescribing in elderly outpatients: potentially harmful drug-drug and drug-disease combinations J Am Geriatr Soc 53 2005 262 267 (Pubitemid 41632552)
15. M.L. Becker, M. Kallewaard, P. Caspers, L.E. Visser, H. Leufkens, and B. Stricker Hospitalizations and emergency department visits due to drug-drug interactions: a literature review Pharmacoepidemiol Drug Saf 16 2007 641 651 (Pubitemid 47039530)
16. A. Farcas, A. Sanpetrean, C. Mogosan, M. Palage, O. Vostinaru, and M. Bojita Adverse drug reaction detected by stimulated spontaneous reporting in an internal medicine department in Romania Eur J Intern Med 21 2010 453 457
17. Micromedex® Healthcare Series [Internet database]. Greenwood Village, Colo: Thomson Reuters (Healthcare) Inc. Updated periodically.
18. World Health Organization Glossary of terms used in pharmacovigilance Cited at September 13th 2012: http://www.who-umc.org/graphics/25301.pdf
19. F.E. Karch, and E. Lasagna Towards the operational indentification of adverse drug reactions Clin Pharmacol Ther 21 1977 247 254 (Pubitemid 8064243)
20. The R Development Core Team A language and environment for statistical computing R Foundation for Statistical Computing 2012 Available at http://www.R-project.org.
21. WHO Collaborating Center for Drug Statistics Methodology Anatomical therapeutic chemical (ATC) classification index Cited at September 13th 2012: http://www.whocc.no/atc-ddd-index/
22. C.M. Hohl, J. Dankoff, A. Colacone, and M. Afilalo Polypharmacy, adverse drug-related events, and potential adverse drug interactions in elderly patients presenting to an emergency department Ann Emerg Med 38 2001 666 671 (Pubitemid 33131567)
23. B.S. Prince, C.M. Goetz, T.L. Rihn, and M. Olsky Drug-related emergency department visits and hospital admissions Am J Health Syst Pharm 49 1992 1696 1700
24. H. Mok, K. Mulpeter, P. O'Connor, and J. Feely Drug-drug interactions in hospital Ir Med J 84 1991 26
25. H. Peyriere, S. Cassan, E. Floutard, S. Riviere, J.P. Blayac, and D. Hillaire-Buys Adverse drug events associated with hospital admission Ann Pharmacother 37 2003 5 11 (Pubitemid 36068590)
26. S.S. Egger, J. Drewe, and R.G. Schlienger Potential drug-drug interactions in the medication of medical patients at hospital discharge Eur J Clin Pharmacol 58 2003 773 778 (Pubitemid 36399235)
27. J. Abarca, D.C. Malone, E.P. Armstrong, A.J. Grizzle, P.D. Hansten, and R.C. Van Brgen Concordance of severity ratings provided in four drug interaction compendia J Am Pharm Assoc 44 2004 136 141
28. G.I. Kohler, S.M. Bode-Boger, R. Busse, R. Hoopmann, T. Welte, and R.H. Boger Drug-drug interactions in medical patients: effects of in-hospital treatment and relation to multiple drug use Int J Clin Pharmacol Ther 38 2000 504 513
29. A.P. Jonville-Bera, F. Bera, and E. Autret-Leca Are incorrectly used drugs more frequently involved in adverse drug reaction? A prospective study Pharmacoepidemiol Prescript 61 2005 231 236 (Pubitemid 40768557)
30. P.R. Obreli-Neto, A. Nobili, A. de Oliveira Baldoni, C. Molino Guidoni, D. Pereira de Lyra Junior, and D. Pilger Adverse drug reactions caused by drug-drug interactions in elderly outpatients: a prospective cohort study Eur J Clin Pharmacol 2012 10.1007/s00228-012-1309-3
31. K. Baxter Stockley's drug interactions 8th ed. 2008 Pharmaceutical Press London
32. A. Vedamurthy, M. Asghar, A. Oke, A. White, and I. Shah Nephrotoxicity in the elderly due to co-prescription of angiotensin converting enzyme inhibitors and nonsteroidal anti-inflammatory drugs J R Soc Med 94 2001 512 514 (Pubitemid 32959938)
33. K.K. Loboz, and G.M. Shenfield Drug combinations and impaired renal function - the "triple whammy" Br J Clin Pharmacol 59 2005 239 243 (Pubitemid 40208862)
34. R. Bertoli, M. Bissig, D. Caronzolo, M. Odorico, M. Pons, and E. Bernasconi Assessment of potential drug-drug interactions at hospital discharge Swiss Med Wkly 2010 Accessed online at 9/4/2012: http://www.smw.ch/for-readers/ archive/backlinks/?url=/docs/pdfcontent/smw-12979.pdf
35. A.M. Moreira Reis, and S.H. de Bortoli Cassiani Prevalence of potential drug interactions in patients in an intensive care unit of a university hospital in Brazil Clinics 66 2011 9 15
36. R. Lagnaoui, N. Moore, J. Fach, M. Longy-Boursier, and B. Begaud Adverse drug reaction in a department of systemic disease-oriented internal medicine: prevalence, incidence, direct costs and avoidability Eur J Clin Pharmacol 55 2000 181 186 (Pubitemid 30341394)
37. N. Moore, D. Lecointre, C. Noblet, and M. Mabille Frequency and cost of serious adverse drug reaction in a department of general medicine Br J Clin Pharmacol 45 1998 301 308 (Pubitemid 28081927)
38. C.A. Bond, and C.L. Raehl Adverse drug reactions in United States hospitals Pharmacotherapy 26 2006 601 608 (Pubitemid 43673042)
39. C. Catananti, R. Liperoti, S. Settanni, F. Lattanzio, R. Bernabei, and D. Fialova Heart failure and adverse drug reactions among hospitalized older adults Clin Pharmacol Ther 86 2009 307 310