Neurotrophin therapy improves recovery of the neuromuscular continence mechanism following simulated birth injury in rats

Neurourology and Urodynamics

Volumn 32, Issue 1, 2013, Pages 82-87

  Gill, Bradley C ^a,b,c   Balog, Brian M ^c   Dissaranan, Charuspong ^c   Jiang, Hai Hong ^c   Steward, James B ^c   Lin, Dan Li ^c,d   Damaser, Margot S ^a,b,c,d  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b Case Western Reserve University   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

Author keywords

childbirth injury; neurotrophin; pudendal nerve; stress urinary incontinence; vaginal delivery

Indexed keywords

BETA 2 TUBULIN; BETA TUBULIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CYT 207; PLACEBO; RECOMBINANT BRAIN DERIVED NEUROTROPHIC FACTOR; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIRTH INJURY; BLADDER SPHINCTER; CONTINUOUS INFUSION; DRUG INFUSION; ELECTROMYOGRAPHY; NERVE DEGENERATION; NONHUMAN; PROTEIN EXPRESSION; PUDENDAL NERVE; RAT; STRESS INCONTINENCE;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; DELIVERY, OBSTETRIC; DISEASE MODELS, ANIMAL; ELECTROMYOGRAPHY; FEMALE; NERVE CRUSH; PERIPHERAL NERVE INJURIES; PUDENDAL NERVE; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; TREATMENT OUTCOME; URINARY INCONTINENCE, STRESS; VAGINA;

EID: 84871381084     PISSN: 07332467     EISSN: 15206777     Source Type: Journal    
DOI: 10.1002/nau.22264     Document Type: Article

References (27)

1. Gregory W, Nygaard I,. Childbirth and pelvic floor disorders. Clin Obstet Gynecol 2004; 47: 394-403. (Pubitemid 38879092)
2. Rortveit G, Daltveit A, Hannestad Y, et al. Urinary incontinence after vaginal delivery or Cesarean section. New Engl J Med 2003; 348: 900-7. (Pubitemid 36297998)
3. Latthe P, Foon R, Khan K,. Nonsurgical treatment of stress urinary incontinence: Grading of evidence in systematic reviews. BJOG 2008; 115: 435-44. (Pubitemid 351225143)
4. Barber M,. Surgical Treatment of Stress Urinary Incontinence. In:, Bent A, Cundiff G, Swift S, editors. Ostergard's Urogynecology and Pelvic Floor Dysfunction, 6th edition. Philadelphia, PA: Lippincott Williams & Wilkins; 2008. pp 225-62.
5. Phull HS, Pan HQ, Butler RS, et al. Vulnerability of continence structures to injury by simulated childbirth. Am J Physiol Renal Physiol 2011; 301: F641-9.
6. Smith A, Hosker G, Warrell D,. The role of pudendal nerve damage in the aetiology of genuine stress urinary incontinence in women. Br J Obstet Gynaecol 1989; 96: 29-32. (Pubitemid 19046107)
7. Allen R, Hosker G, Smith A, et al. Pelvic floor damage and childbirth: A neurophysiological study. Br J Obstet Gynaecol 1990; 97: 770-9. (Pubitemid 20283313)
8. Snooks S, Swash M, Mathers S, et al. Effect of vaginal delivery on the pelvic floor: A 5-year follow-up. Br J Surg 1990; 77: 1358-60.
9. Omura T, Sano M, Omura K, et al. Different expressions of BDNF, NT3, and NT4 in muscle and nerve after various types of peripheral nerve injuries. JPNS 2005; 10: 293-300. (Pubitemid 41580034)
10. Zhang J, Luo X, Xian C, et al. Endogenous BDNF is required for myelination and regeneration of injured sciatic nerve in rodents. Eur J Neurosci 2000; 12: 4171-80. (Pubitemid 32037828)
11. Wells D, McKechnie B, Kelkar S, et al. Neurotrophins regulate agrin-induced postsynaptic differentiation. Proc Natl Acad Sci 1999; 96: 1112-7. (Pubitemid 29072192)
12. Mousavi K, Jasmin B,. BDNF is expressed in skeletal muscle satellite cells and inhibits myogenic differentiation. J Neurosci 2006; 26: 5739-49. (Pubitemid 44315266)
13. Jiang HH, Pan HQ, Gustilo-Ashby MA, et al. Dual simulated childbirth injuries result in slowed recovery of pudendal nerve and urethral function. Neurourol Urodyn 2009; 28: 229-35.
14. Pan H, Kerns J, Lin D, et al. Dual simulated childbirth injury delays anatomic recovery. Am J Physiol Renal Physiol 2009; 296: F277-83.
15. Kong W, Lin D, Kinley B, et al. Urethral neuromuscular injury following simulated childbirth injury in a rat model. Neurourol Urodyn 2009; 28: 597-8.
16. Sakamoto K, Smith G, Storer P, et al. Neuroregeneration and voiding behavior patterns after pudendal nerve crush in female rats. Neurourol Urodyn 2000; 19: 311-21. (Pubitemid 30253987)
17. Jiang HH, Gustilo-Ashby AM, Salcedo LB, et al. Electrophysiological function during voiding after simulated childbirth injuries. Exp Neurol 2009; 215: 342-8.
18. Hu TW, Wagner TH, Bentkover JD, et al. Costs of urinary incontinence and overactive bladder in the United States: A comparative study. Urology 2004; 63: 461-5.
19. Carr LK, Steele D, Steele S, et al. 1-Year follow-up of autologous muscle-derived stem cell injection pilot study to treat stress urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct 2008; 19: 881-3. (Pubitemid 351597572)
20. Terenghi G,. Peripheral nerve regeneration and neurotrophic factors. J Anat 1999; 194: 1-14. (Pubitemid 29126690)
21. Simon M, Porter R, Brown R, et al. Effect of NT-4 and BDNF deliver to damaged sciatic nerves on phenotypic recover of fast and slow muscle fibers. Eur J Neurosci 2003; 18: 2460-6. (Pubitemid 37452662)
22. Utley D, Lewin S, Cheng E, et al. Brain-derived neurotrophic factor and collagen tubilization enhance functional recovery after peripheral nerve transection and repair. Arch Otolaryngol Head Neck Surg 1996; 122: 407-13. (Pubitemid 26118022)
23. Boyd J, Gordon T,. A dose-dependent facilitation and inhibition of peripheral nerve regeneration by brain-derived neurotrophic factor. Eur J Neurosci 2002; 15: 613-26. (Pubitemid 35471930)
24. Vogelin E, Baker J, Gates J, et al. Effects of local continuous release of brain derived neurotrophic factor (BDNF) on peripheral nerve regeneration in a rat model. Exp Neurol 2006; 199: 348-53. (Pubitemid 43928963)
25. Jiang HH, Gill BC, Salcedo LB, et al. Effects of electrical stimulation on the pudendal nerve on expression of neurotrophins in Onuf's nucleus following simulated childbirth injury. Neurourol Urodyn 2010; 29: 254-5.
26. Lopatina T, Kalinina N, Karagyaur M, et al. Adipose-derived stem cells stimulate regeneration of peripheral nerves: BDNF secreted by these cells promotes nerve healing and axon growth de novo. PLoS One 2011; 6: e17899.
27. Kato R, Wolfe D, Coyle CH, et al. Herpes simplex virus vector-mediated delivery of neurturin rescues erectile dysfunction of cavernous nerve injury. Gene Ther 2009; 16: 26-33.