Nanoparticle Transport from Mouse Vagina to Adjacent Lymph Nodes

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Ballou, Byron ^a   Andreko, Susan K ^a   Osuna Highley, Elvira ^a   McRaven, Michael ^b   Catalone, Tina ^c   Bruchez, Marcel P ^a   Hope, Thomas J ^b   Labib, Mohamed E ^d  

^a CARNEGIE MELLON UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c Northwestern University ^*  (United States)

^d Advanced Biodevices   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NONOXINOL 9; QUANTUM DOT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOFLUORESCENCE IMAGING; CELL AGGREGATION; CERVICAL LYMPH NODE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ELECTRON MICROSCOPY; FEMALE; IN VIVO STUDY; INGUINAL LYMPH NODE; INTRAVAGINAL DRUG ADMINISTRATION; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; PELVIC EXAMINATION; QUANTITATIVE ANALYSIS; TRANSPORT KINETICS; VAGINA MUCOSA; VAGINAL INJURY;

ADMINISTRATION, INTRAVAGINAL; ANIMALS; ANTIGENS; CADMIUM; DRUG DELIVERY SYSTEMS; FEMALE; KINETICS; LUMBAR VERTEBRAE; LYMPH NODES; MICE; MOLECULAR IMAGING; NANOPARTICLES; QUANTUM DOTS; VAGINA;

EID: 84871354629     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051995     Document Type: Article

References (54)

1. Czerkinsky C, Holmgren J, (2010) Topical immunization strategies. Mucosal Immunol 3: 545-555.
2. Czerkinsky C, Holmgren J, (2012) Mucosal delivery routes for optimal immunization: targeting immunity to the right tissues. Curr Top Microbiol Immunol 354: 1-18.
3. Cu Y, Booth CJ, Saltzman WM, (2011) In vivo distribution of surface-modified PLGA nanoparticles following intravaginal delivery. J Control Release 156: 258-264.
4. Ballou B, Lagerholm BC, Ernst LA, Bruchez MP, Waggoner AS, (2004) Noninvasive imaging of quantum dots in mice. Bioconjug Chem 15: 79-86.
5. Lagerholm BC, (2007) Peptide-mediated intracellular delivery of quantum dots. Methods Mol Biol FIELD Full Journal Title:Methods in molecular biology (Clifton, NJ) 374: 105-112.
6. Lagerholm BC, Wang M, Ernst LA, Ly DH, Liu H, et al. (2004) Multicolor Coding of Cells with Cationic Peptide Coated Quantum Dots. Nano Lett 4: 2019-2022.
7. Ballou B, Ernst LA, Andreko S, Harper T, Fitzpatrick JA, et al. (2007) Sentinel lymph node imaging using quantum dots in mouse tumor models. Bioconjug Chem 18: 389-396.
8. Catalone BJ, Kish-Catalone TM, Budgeon LR, Neely EB, Ferguson M, et al. (2004) Mouse model of cervicovaginal toxicity and inflammation for preclinical evaluation of topical vaginal microbicides. Antimicrobial Agents and Chemotherapy 48: 1837-1847.
9. Cone R, Hoen T, Wong X, Abusuwwa R, Anderson D, et al. (2006) Vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmission. BMC Infectious Diseases 6: 90.
10. Fichorova RN, Tucker LD, Anderson DJ, (2001) The molecular basis of nonoxynol-9-induced vaginal inflammation and its possible relevance to human immunodeficiency virus type 1 transmission. J Infect Dis 184: 418-428.
11. Milligan GN, Dudley KL, Bourne N, Reece A, Stanberry LR, (2002) Entry of inflammatory cells into the mouse vagina following application of candidate microbicides- Comparison of detergent-based and sulfated polymer-based agents. Sexually Transmitted Diseases 29: 597-605.
12. Moench TR, Mumper RJ, Hoen TE, Sun M, Cone RA, (2010) Microbicide excipients can greatly increase susceptibility to genital herpes transmission in the mouse. BMC Infect Dis 10: 331.
13. Vargas G, Shilagard T, Johnston R, Bell B, Stegall RL, et al. (2009) Use of High-Resolution Confocal Imaging of the Vaginal Epithelial Microstructure to Detect Microbicide Toxicity. Journal of Infectious Diseases 199: 1546-1552.
14. Vieira OV, Hartmann DO, Cardoso CM, Oberdoerfer D, Baptista M, et al. (2008) Surfactants as microbicides and contraceptive agents: a systematic in vitro study. PLoS One 3: e2913.
15. Grant RM, Hamer D, Hope T, Johnston R, Lange J, et al. (2008) Whither or wither microbicides? Science 321: 532-534.
16. Hillier SL, Moench T, Shattock R, Black R, Reichelderfer P, et al. (2005) In vitro and in vivo: the story of nonoxynol 9. J Acquir Immune Defic Syndr 39: 1-8.
17. Lindqvist M (2010) Mucosal adjuvants and their mode of action in the female genital tract. Gothenburg: University of Gothenburg. Sahlgrenska Academy. 72 p.
18. Fraillery D, Zosso N, Nardelli-Haefliger D, (2009) Rectal and vaginal immunization of mice with human papillomavirus L1 virus-like particles. Vaccine 27: 2326-2334.
19. Hladik F, Hope TJ, (2009) HIV infection of the genital mucosa in women. Curr HIV/AIDS Rep 6: 20-28.
20. Parr MB, Parr EL, (1990) Antigen recognition in the female reproductive tract: I. Uptake of intraluminal protein tracers in the mouse vagina. J Reprod Immunol 17: 101-114.
21. Ibata B, Parr EL, King NJ, Parr MB, (1997) Migration of foreign lymphocytes from the mouse vagina into the cervicovaginal mucosa and to the iliac lymph nodes. Biol Reprod 56: 537-543.
22. King NJ, Parr EL, Parr MB, (1998) Migration of lymphoid cells from vaginal epithelium to iliac lymph nodes in relation to vaginal infection by herpes simplex virus type 2. J Immunol 160: 1173-1180.
23. Mallipeddi R, Rohan LC, (2010) Nanoparticle-based vaginal drug delivery systems for HIV prevention. Expert Opin Drug Deliv 7: 37-48.
24. Whaley KJ, Hanes J, Shattock R, Cone RA, Friend DR, (2010) Novel approaches to vaginal delivery and safety of microbicides: biopharmaceuticals, nanoparticles, and vaccines. Antiviral Res 88Suppl 1: S55-66.
25. Woodrow KA, Cu Y, Booth CJ, Saucier-Sawyer JK, Wood MJ, et al. (2009) Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA. Nat Mater 8: 526-533.
26. Ham AS, Cost MR, Sassi AB, Dezzutti CS, Rohan LC, (2009) Targeted delivery of PSC-RANTES for HIV-1 prevention using biodegradable nanoparticles. Pharm Res 26: 502-511.
27. Saltzman WM, Radomsky ML, Whaley KJ, Cone RA, (1994) Antibody diffusion in human cervical mucus. Biophys J 66: 508-515.
28. Sherwood JK, Zeitlin L, Chen X, Whaley KJ, Cone RA, et al. (1996) Residence half-life of IgG administered topically to the mouse vagina. Biol Reprod 54: 264-269.
29. Cone RA, (2009) Barrier properties of mucus. Adv Drug Deliv Rev 61: 75-85.
30. Lai SK, Hida K, Shukair S, Wang YY, Figueiredo A, et al. (2009) Human immunodeficiency virus type 1 is trapped by acidic but not by neutralized human cervicovaginal mucus. J Virol 83: 11196-11200.
31. Lai SK, O'Hanlon DE, Harrold S, Man ST, Wang YY, et al. (2007) Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus. Proc Natl Acad Sci U S A 104: 1482-1487.
32. Lai SK, Wang YY, Cone R, Wirtz D, Hanes J, (2009) Altering mucus rheology to "solidify" human mucus at the nanoscale. PLoS One 4: e4294.
33. Lai SK, Wang Y-Y, Hida K, Cone R, Hanes J, (2010) Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses. Proceedings of the National Academy of Sciences 107: 598-603.
34. Tang BC, Dawson M, Lai SK, Wang YY, Suk JS, et al. (2009) Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier. Proceedings of the National Academy of Sciences of the United States of America 106: 19268-19273.
35. Hama Y, Koyama Y, Urano Y, Choyke PL, Kobayashi H, (2007) Two-color lymphatic mapping using Ig-conjugated near infrared optical probes. J Invest Dermatol 127: 2351-2356.
36. Hama Y, Koyama Y, Urano Y, Choyke PL, Kobayashi H, (2007) Simultaneous two-color spectral fluorescence lymphangiography with near infrared quantum dots to map two lymphatic flows from the breast and the upper extremity. Breast Cancer Res Treat 103: 23-28.
37. Inoue Y, Kiryu S, Watanabe M, Oyaizu N, Ohtomo K, (2010) Fluorescence lymph node mapping in living mice using quantum dots and a compression technique. J Fluoresc 20: 599-606.
38. Kim S, Lim YT, Soltesz EG, De Grand AM, Lee J, et al. (2004) Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping. Nat Biotechnol 22: 93-97.
39. Parungo CP, Colson YL, Kim SW, Kim S, Cohn LH, et al. (2005) Sentinel lymph node mapping of the pleural space. Chest 127: 1799-1804.
40. Parungo CP, Ohnishi S, Kim SW, Kim S, Laurence RG, et al. (2005) Intraoperative identification of esophageal sentinel lymph nodes with near-infrared fluorescence imaging. J Thorac Cardiovasc Surg 129: 844-850.
41. Parungo CP, Soybel DI, Colson YL, Kim SW, Ohnishi S, et al. (2007) Lymphatic drainage of the peritoneal space: a pattern dependent on bowel lymphatics. Ann Surg Oncol 14: 286-298.
42. Robe A, Pic E, Lassalle HP, Bezdetnaya L, Guillemin F, et al. (2008) Quantum dots in axillary lymph node mapping: biodistribution study in healthy mice. BMC Cancer 8: 111.
43. Soltesz EG, Kim S, Laurence RG, DeGrand AM, Parungo CP, et al. (2005) Intraoperative sentinel lymph node mapping of the lung using near-infrared fluorescent quantum dots. Ann Thorac Surg 79: 269-277; discussion 269-277.
44. Ayehunie S, Cannon C, LaRosa K, Pudney J, Anderson DJ, et al. (2011) Development of an in vitro alternative assay method for vaginal irritation. Toxicology 279: 130-138.
45. Cummins JEJ, Doncel GF (2009) Biomarkers of Cervicovaginal Inflammation for the Assessment of Microbicide Safety. Sexually Transmitted Diseases 36: S84-S91 10.1097/OLQ.1090b1013e3181994191.
46. Chakraborty SK, Fitzpatrick JA, Phillippi JA, Andreko S, Waggoner AS, et al. (2007) Cholera toxin B conjugated quantum dots for live cell labeling. Nano Lett 7: 2618-2626.
47. Dodt HU, Leischner U, Schierloh A, Jahrling N, Mauch CP, et al. (2007) Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain. Nat Methods 4: 331-336.
48. Vinegoni C, Razansky D, Figueiredo J-L, Nahrendorf M, Ntziachristos V, et al. (2009) Normalized Born ratio for fluorescence optical projection tomography. Opt Lett 34: 319-321.
49. Efimova OI, Anokhin KV, (2009) Enhancement of optical transmission capacity of isolated structures in the brain of mature mice. Bull Exp Biol Med 147: 3-6.
50. Bostick RM, Kong KY, Ahearn TU, Chaudry Q, Cohen V, et al. (2006) Detecting and quantifying biomarkers of risk for colorectal cancer using quantum dots and novel image analysis algorithms. Conf Proc IEEE Eng Med Biol Soc 1: 3313-3316.
51. Fogel P, Gobinet C, Young SS, Zugaj D. Evaluation of unmixing methods for the separation of Quantum Dot sources; 2009 26-28 Aug. 2009: 1-4.
52. Genovesio A, Liedl T, Emiliani V, Parak WJ, Coppey-Moisan M, et al. (2006) Multiple particle tracking in 3-D+t microscopy: method and application to the tracking of endocytosed quantum dots. Image Processing, IEEE Transactions on 15: 1062-1070.
53. Paskaleva BS, Hayat MM, Woo-Yong J, Sharma YD, Bender SC, et al. Joint spatio-spectral based edge detection for multispectral infrared imagery; 2010 25-30 July 2010: 2198-2201.
54. Abreu MT, (2010) Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function. Nature Reviews Immunology 10: 131-143.