Polysaccharide from Lentinus edodes Inhibits the Immunosuppressive Function of Myeloid-Derived Suppressor Cells

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Wu, Hao ^a   Tao, Ning ^b   Liu, Xiaoman ^b   Li, Xiao ^b   Tang, Jian ^c   Ma, Chungwah ^c   Xu, Xiaofei ^c   Shao, Haitao ^b   Hou, Baidong ^b   Wang, Hui ^a   Qin, Zhihai ^b  

^a XINXIANG MEDICAL UNIVERSITY   (China)

^b INSTITUTE OF BIOPHYSICS   (China)

^c Infinitus China Company Ltd   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; FUNGAL POLYSACCHARIDE; GALACTOSE; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MANNOSE; MPSSS; MYELOID DIFFERENTIATION FACTOR 88; UNCLASSIFIED DRUG; XYLOSE;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; IN VITRO STUDY; LENTINULA EDODES; MALE; MOUSE; MYELOID DERIVED SUPPRESSOR CELL; NEOPLASM; NONHUMAN; SIGNAL TRANSDUCTION; SPLEEN CELL; SUPPRESSOR CELL; TUMOR CELL; UPREGULATION;

ANIMALS; ANTIGENS, CD11B; ANTIGENS, LY; ANTINEOPLASTIC AGENTS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; FUNGAL POLYSACCHARIDES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MICE; MYELOID CELLS; MYELOID DIFFERENTIATION FACTOR 88; NEOPLASMS; NF-KAPPA B; SHIITAKE MUSHROOMS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TUMOR BURDEN;

LENTINULA EDODES;

EID: 84871341847     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051751     Document Type: Article

References (27)

1. Almand B, Clark JI, Nikitina E, van Beynen J, English NR, et al. (2001) Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer. J Immunol 166: 678-689.
2. Gabrilovich D, (2004) Mechanisms and functional significance of tumour-induced dendritic-cell defects. Nat Rev Immunol 4: 941-952.
3. Gabrilovich DI, Bronte V, Chen SH, Colombo MP, Ochoa A, et al. (2007) The terminology issue for myeloid-derived suppressor cells. Cancer Res 67: 425; author reply 426.
4. Gallina G, Dolcetti L, Serafini P, De Santo C, Marigo I, et al. (2006) Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells. J Clin Invest 116: 2777-2790.
5. Melani C, Chiodoni C, Forni G, Colombo MP, (2003) Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB/c mice suppresses immune reactivity. Blood 102: 2138-2145.
6. Yang L, DeBusk LM, Fukuda K, Fingleton B, Green-Jarvis B, et al. (2004) Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. Cancer Cell 6: 409-421.
7. Chihara G, Maeda Y, Hamuro J, Sasaki T, Fukuoka F, (1969) Inhibition of mouse sarcoma 180 by polysaccharides from Lentinus edodes (Berk.) sing. Nature 222: 687-688.
8. Chihara G, Hamuro J, Maeda Y, Arai Y, Fukuoka F, (1970) Fractionation and purification of the polysaccharides with marked antitumor activity, especially lentinan, from Lentinus edodes (Berk.) Sing. (an edible mushroom). Cancer Res 30: 2776-2781.
9. Hamuro J, Rollinghoff M, Wagner H, (1980) Induction of cytotoxic peritoneal exudate cells by T-cell immune adjuvants of the beta(1 leads to 3) glucan-type lentinan and its analogues. Immunology 39: 551-559.
10. Ladanyi A, Timar J, Lapis K, (1993) Effect of lentinan on macrophage cytotoxicity against metastatic tumor cells. Cancer Immunol Immunother 36: 123-126.
11. Maeda YY, Chihara G, (1973) The effects of neonatal thymectomy on the antitumour activity of lentinan, carboxymethylpachymaran and zymosan, and their effects on various immune responses. Int J Cancer 11: 153-161.
12. Peter G, Karoly V, Imre B, Janos F, Kaneko Y, (1988) Effects of lentinan on cytotoxic functions of human lymphocytes. Immunopharmacol Immunotoxicol 10: 157-163.
13. Solly K, Wang X, Xu X, Strulovici B, Zheng W, (2004) Application of real-time cell electronic sensing (RT-CES) technology to cell-based assays. Assay Drug Dev Technol 2: 363-372.
14. Zhang Y, Li S, Wang X, Zhang L, Cheung PCK, (2011) Advances in lentinan: Isolation, structure, chain conformation and bioactivities. Food hydrocolloids 25: 196-206.
15. Jung HY, Bae IY, Lee S, Lee HG, (2011) Effect of the degree of sulfation on the physicochemical and biological properties of< i>Pleurotus eryngiipolysaccharides. Food hydrocolloids 25: 1291-1295.
16. Qi C, Cai Y, Gunn L, Ding C, Li B, et al. (2011) Differential pathways regulating innate and adaptive antitumor immune responses by particulate and soluble yeast-derived beta-glucans. Blood 117: 6825-6836.
17. Ochoa-Reparaz J, Mielcarz DW, Wang Y, Begum-Haque S, Dasgupta S, et al. (2010) A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease. Mucosal Immunol 3: 487-495.
18. Li XB, He XJ, Liu B, Xu L, Ju DH, et al. (2010) [Immunoregulatory function of Radix Glycyrrhizae polysaccharide in tumor-bearing mice]. Zhong Xi Yi Jie He Xue Bao 8: 363-367.
19. Greifenberg V, Ribechini E, Rossner S, Lutz MB, (2009) Myeloid-derived suppressor cell activation by combined LPS and IFN-gamma treatment impairs DC development. Eur J Immunol 39: 2865-2876.
20. Martinez FO, Gordon S, Locati M, Mantovani A, (2006) Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: New molecules and patterns of gene expression. Journal of Immunology 177: 7303-7311.
21. Lawrence T, Natoli G, (2011) Transcriptional regulation of macrophage polarization: enabling diversity with identity. Nat Rev Immunol 11: 750-761.
22. Wang Z, Jiang J, Li Z, Zhang J, Wang H, et al. (2010) A myeloid cell population induced by Freund adjuvant suppresses T-cell-mediated antitumor immunity. J Immunother 33: 167-177.
23. Jiang J, Wang Z, Li Z, Zhang J, Wang C, et al. (2010) Early exposure of high-dose interleukin-4 to tumor stroma reverses myeloid cell-mediated T-cell suppression. Gene Ther 17: 991-999.
24. Kusmartsev S, Cheng F, Yu B, Nefedova Y, Sotomayor E, et al. (2003) All-trans-retinoic acid eliminates immature myeloid cells from tumor-bearing mice and improves the effect of vaccination. Cancer Res 63: 4441-4449.
25. Mirza N, Fishman M, Fricke I, Dunn M, Neuger AM, et al. (2006) All-trans-retinoic acid improves differentiation of myeloid cells and immune response in cancer patients. Cancer Res 66: 9299.
26. Li Z, Jiang J, Wang Z, Zhang J, Xiao M, et al. (2008) Endogenous interleukin-4 promotes tumor development by increasing tumor cell resistance to apoptosis. Cancer Res 68: 8687-8694.
27. Li Z, Chen L, Qin Z, (2009) Paradoxical roles of IL-4 in tumor immunity. Cell Mol Immunol 6: 415-422.