Liquid chromatography/electrospray ionization tandem mass spectrometric study of milnacipran and its stressed degradation products

Rapid Communications in Mass Spectrometry

Volumn 27, Issue 2, 2013, Pages 369-374

  Borkar, Roshan M ^a   Raju, B ^a   Devrukhakar, Prashant S ^b   Tondepu, Naresh ^b   Rao, Abn Nageswara ^a   Srinivas, R ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b UNITED STATES PHARMACOPEIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

DEGRADATION PRODUCTS; ELECTROSPRAY IONIZATION TANDEM MASS SPECTROMETRIC STUDIES; LIQUID CHROMATOGRAPHY ELECTROSPRAY;

DEGRADATION;

EID: 84871337872     PISSN: 09514198     EISSN: 10970231     Source Type: Journal    
DOI: 10.1002/rcm.6460     Document Type: Letter

References (12)

1. Available: http://www.fda/gov/Safety/MedWatch/SafetyInformation/ ucm203615.htm.
2. K.S. Hale,. Milnacipran: a new treatment for fibromyalgia syndrome. J. Pharm. Technol. 2010, 26, 129.
3. E. Ucakturk, C. Safak,. Determination of milnacipran in human plasma using GC-MS. Chromatographia 2010, 72, 111.
4. P. Mehta, J. D. M. Khatri,. Development and validation of RP-HPLC method for determination of milnacipran hydrochloride in pharmaceutical formulations. Int. J. Pharm. Pharmaceut. Sci. 2010, 2, 137.
5. C. Puozzo, C. Filaquier, G. Zorza,. Determination of milnacipran, a serotonin and noradrenaline reuptake inhibitor, in human plasma using liquid chromatography with spectrofluorimetric detection. J. Chromatogr. B 2004, 806, 221.
6. A. Patti, S. Pedotti, C. Sanfilippo,. Chiral HPLC analysis of milnacipran and its FMOC-derivative on cellulose-based stationary phases. Chirality 2008, 20, 63.
7. C. L. Dias, L. Bajerski, R. C. Rossi, A. M. Bergold, P. E. Fröehlich,. Comparative validation study to assay milnacipran hydrochloride in capsules by a stability-indicating LC and a second order derivative UV spectroscopic method. Pharmaceut. Anal. Acta 2010, 1, 1.
8. N. Tondepu, S. S. Sait, K. V. Surendranath, R. K. Kaja, S. Kumar,. A stability indicating U-HPLC method for milnacipran in bulk drugs and pharmaceutical dosage forms. Am. J. Anal. Chem. 2012, 3, 40.
9. n experiments. Biomed.Chromatogr. 2012, 26, 720.
10. Stability testing of new drug substances and products, ICH guideline, Q1A (R2). International Conference on Harmonization, Food and Drug Administration, USA, February, 2003.
11. Photostability testing on new drug substances and products, ICH guideline, Q1B. International Conference on Harmonization, Food and Drug Administration, USA, 1996.
12. Validation of analytical procedures: text and methodology, ICH guideline, Q2 (R1). International Conference on Harmonization, Food and Drug Administration, USA, November, 2005.