Identification and characterization of stressed degradation products of metoprolol using LC/Q-TOF-ESI-MS/MS and MSn experiments

Biomedical Chromatography

Volumn 26, Issue 6, 2012, Pages 720-736

  Borkar, Roshan M ^a,b   Raju, B ^a   Srinivas, R ^a,b   Patel, Prashant ^b   Shetty, Satheesh Kumar ^c  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^c UNITED STATES PHARMACOPEIA   (United States)

Author keywords

Accurate mass measurements; Degradation products; LC ESI MS MS; Metoprolol

Indexed keywords

DEGRADATION; DRUG PRODUCTS; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; MASS SPECTROMETRY;

ACCURATE MASS MEASUREMENTS; DEGRADATION PRODUCTS; ESI-MS-MS; FRAGMENTATIONS PATTERN; ISOCRATIC; LC MS/MS(ESI); LC-ESI-MS/MS; LC/ESI-MS/MS; METOPROLOL; STRESS CONDITION;

PHOTOLYSIS;

METOPROLOL;

ACCURACY; ARTICLE; CONTROLLED STUDY; DRUG DEGRADATION; DRUG HYDROLYSIS; DRUG IMPURITY; DRUG OXIDATION; DRUG STABILITY; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PHOTOLYSIS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; THERMOSTABILITY; TIME OF FLIGHT MASS SPECTROMETRY;

EID: 84860492759     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1721     Document Type: Article

References (13)

1. Albers S, Elshoff JP, Völker C, Richter A and Läer S. HPLC quantification of metoprolol with solid-phase extraction for the drug monitoring of pediatric patients. Biomedical Chromatography 2005; 19(3): 202-207.
2. Balmér K, Zhang YY, Lagerström PO and Persson BA. Determination of metoprolol and two major metabolites in plasma and urine by column liquid chromatography and fluorometric detection. Journal of Chromatography. B: Biomedical Sciences and Applications 1987; 417(2): 357-365.
3. Baranowska I and Wilczek A. Simultaneous RP-HPLC determination of sotolol, metoprolol, alpha- hydroxymetoprolol, paracetamol and its glucuronide and sulfate metabolite in human urine. Analytical Science 2009; 25(6): 769-772.
4. British Pharmacopoeia, medicinal and pharmaceutical substances. 2009; I and II 3933-3936.
5. thEdition, 2005; 5: 2032-2033.
6. ICH. Stability Testing: Photostability Testing of New Drug Substances and Products. Q1B. International Conference on Harmonization, IFPMA: Geneva, 1996.
7. ICH. Stability Testing of New Drug Substances and Products. Q1A (R2). International Conference on Harmonization, IFPMA: Geneva, 2003.
8. ICH. Q2 (R1). Validation of analytical procedure: text and methodology. International Conference on Harmonization, IFPMA: Geneva, 2005.
9. Jasińska M, Karwowski B, Orszulak-Michalak D and Kurczewska U. Stability studies of expired Tablets of metoprolol tartrate and propranolol hydrochloride. Part 1. Content determination. Acta Poloniae Pharmaceutica 2009; 66(6): 697-701.
10. Johnson RD and Lewis RJ. Quantitation of atenolol, metoprolol, and propranolol in postmortem human fluid and tissue specimens via LC/APCI-MS. Forensic Science International 2006; 156: 106-117.
11. Swedberg K, Hjalmarson A, Waagstein F and Wallentin I. Prolongation of survival in congestive cardiomyopathy by beta-receptor blockade. Lancet 1979; 1: 1374-1376.
12. United States Pharmacopeia. 32nd edn, Vol. 3. The United States Pharmacopeial Convention: Rockville, MD, 2009; 2963-2970.
13. Yilmaz B, Asci A and Arslan S. Detection. Journal of Separation Science 2010; 33(13): 1904-1908.