The effect of losartan and carvedilol on renal haemodynamics and altered metabolism in fructose-fed Sprague-Dawley rats

Journal of Physiology and Biochemistry

Volumn 68, Issue 3, 2012, Pages 353-363

  Abdulla, Mohammed H ^a,c   Sattar, Munavvar A ^a   Abdullah, Nor A ^b   Johns, Edward J ^c  

^a SCHOOL OF PHARMACEUTICAL SCIENCES   (Malaysia)

^b UNIVERSITY OF MALAYA   (Malaysia)

^c UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Angiotensin II; Carvedilol; Fructose; Losartan; Sprague Dawley rat

Indexed keywords

ANGIOTENSIN II; CARVEDILOL; FRUCTOSE; LOSARTAN; LOSARTAN POTASSIUM; METHOXAMINE; NORADRENALIN; PHENYLEPHRINE; TAP WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD PRESSURE REGULATION; BLOOD VESSEL REACTIVITY; BODY WEIGHT; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG EFFECT; EPIDIDYMIS FAT; EXPERIMENTAL MODEL; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; HEMODYNAMIC PARAMETERS; HYPERTENSION; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; KIDNEY BLOOD FLOW; KIDNEY CIRCULATION; MALE; MEAN ARTERIAL PRESSURE; METABOLIC PARAMETERS; METABOLIC SYNDROME X; METABOLISM; NONHUMAN; RAT; RETROPERITONEAL FAT; SPRAGUE DAWLEY RAT; SYSTOLIC BLOOD PRESSURE; VASOCONSTRICTION;

ANGIOTENSIN II; ANIMALS; BODY WEIGHT; CARBAZOLES; FRUCTOSE; GLUCOSE TOLERANCE TEST; HEMODYNAMICS; INSULIN RESISTANCE; KIDNEY; LOSARTAN; MALE; NOREPINEPHRINE; PHENYLEPHRINE; PROPANOLAMINES; RATS; RATS, SPRAGUE-DAWLEY; VASOCONSTRICTOR AGENTS;

FELINE CALICIVIRUS; RATTUS;

EID: 84871315503     PISSN: 11387548     EISSN: 18778755     Source Type: Journal    
DOI: 10.1007/s13105-012-0147-1     Document Type: Article

References (62)

1. Abbas SA, Munavvar AS, Abdullah NA, Johns EJ (2006) Involvement of a1-adrenoceptor subtypes in the cardiac failure in spontaneously hypertensive rats. J Basic & Applied Sci 2:59-69
2. Abdulla MH, Sattar MA, Abdullah NA, Hazim AI, Anand Swarup KR, Rathore HA, Khan MA, Johns EJ (2008) Inhibition of Ang II and renal sympathetic nerve influence dopamine-and isoprenaline-induced renal haemodynamic changes in normal Wistar-Kyoto and spontaneously hypertensive rats. Auton Autacoid Pharmacol 28(4):95-101
3. Abdulla MH, Sattar MA, Abdullah NA, Khan AH, Anand Swarup KR, Rathore HA, Kazi RN, Basri F, Johns EJ (2011) Effect of renal sympathetic nerve on adrenergically and angiotensin II-induced renal vasoconstriction in normal Wistar-Kyoto rats. Ups J Med Sci 116(1):18-25
4. Abdulla MH, Sattar MA, Abdullah NA, Khan MA, Abdallah HH, Johns EJ (2009) Chronic treatment with losartan and carvedilol differentially modulates renal vascular responses to sympathomimetics compared to treatment with individual agents in normal Wistar Kyoto and spontaneously hypertensive rats. Eur J Pharmacol 612(1-3):69-74
5. Abdulla MH, Sattar MA, Abdullah NA, Khan MA, Anand Swarup KR, Johns EJ (2011) The contribution of alpha(1B)-adrenoceptor subtype in the renal vasculature of fructose-fed Sprague-Dawley rats. Eur J Nutr 50:251-260
6. Abdulla MH, Sattar MA, Abdullah NA, Khan MA, Anand Swarup KR, Johns EJ (2011) The effect of losartan and carvedilol on vasopressor responses to adrenergic agonists and angiotensin II in the systemic circulation of Sprague Dawley rats. Auton Autacoid Pharmacol 31(1-2):13-20
7. Abdulla MH, Sattar MA, Johns EJ, Abdullah NA, Khan MA (2011) Evidence for the role of alpha(1A)-adrenoceptor subtype in the control of renal haemodynamics in fructosefed Sprague-Dawley rat. Eur J Nutr 50(8):689-697
8. Abdulla MH, Sattar MA, Johns EJ, Abdullah NA, Khan MA, Rathore HA (2011) High-fructose feeding impacts on the adrenergic control of renal haemodynamics in the rat. Br J Nutr. doi:10.1017/S0007114511002716
9. Abdulla MH, Sattar MA, Khan MA, Abdullah NA, Johns EJ (2009) Influence of sympathetic and AT-receptor blockade on angiotensin II and adrenergic agonist-induced renal vasoconstrictions in spontaneously hypertensive rats. Acta Physiol (Oxf) 195(3):397-404
10. Armenia A, Munavvar AS, Abdullah NA, Helmi A, Johns EJ (2004) The contribution of adrenoceptor subtype(s) in the renal vasculature of diabetic spontaneously hypertensive rats. Br J Pharmacol 142(4):719-726
11. Bakris GL, Fonseca V, Katholi RE, McGill JB, Messerli FH, Phillips RA, Raskin P, Wright JT Jr, Oakes R, Lukas MA, Anderson KM, Bell DS (2004) Metabolic effects of carvedilol vs metoprolol in patients with type 2 diabetes mellitus and hypertension: A randomized controlled trial. JAMA 292 (18):2227-2236
12. Basat O, Ucak S, Seber S, Oztekin E, Altuntas Y (2006) After myocardial infarction carvedilol improves insulin resistance compared to metoprolol. Clin Res Cardiol 95 (2):99-104
13. Batenburg WW, van Esch JH, Garrelds IM, Jorde U, Lamers JM, Dekkers DH, Walther T, Kellett E, Milligan G, van Kats JP, Danser AH (2006) Carvedilol-induced antagonism of angiotensin II: A matter of alpha1-adrenoceptor blockade. J Hypertens 24(7):1355-1363
14. Bayorh MA, Ganafa AA, Eatman D, Walton M, Feuerstein GZ (2005) Simvastatin and losartan enhance nitric oxide and reduce oxidative stress in salt-induced hypertension. Am J Hypertens 18(11):1496-1502
15. Bell DS (2004) Advantages of a third-generation betablocker in patients with diabetes mellitus. Am J Cardiol 93(9A):49B-52B
16. Bhatt P, Makwana D, Santani D, Goyal R (2007) Comparative effectiveness of carvedilol and propranolol on glycemic control and insulin resistance associated with Lthyroxin-induced hyperthyroidism-an experimental study. Can J Physiol Pharmacol 85(5):514-520
17. Boustany CM, Brown DR, Randall DC, Cassis LA (2005) AT1-receptor antagonism reverses the blood pressure elevation associated with diet-induced obesity. Am J Physiol Regul Integr Comp Physiol 289(1):R181-R186
18. Brooks DP, Short BG, Cyronak MJ, Contino LC, DiCristo M, Wang YX, Ruffolo RR Jr (1993) Comparison between carvedilol and captopril in rats with partial ablation-induced chronic renal failure. Br J Pharmacol 109(2):581-586
19. Bunnag P, Hori MT, Ormsby B, Berger ME, Golub MS, Tuck ML (1997) Impaired in vivo adrenergic responses in diet-induced hypertensive rats. Hypertens Res 20 (1):17-21
20. Cabassi A, Coghi P, Govoni P, Barouhiel E, Speroni E, Cavazzini S, Cantoni AM, Scandroglio R, Fiaccadori E (2005) Sympathetic modulation by carvedilol and losartan reduces angiotensin II-mediated lipolysis in subcutaneous and visceral fat. J Clin Endocrinol Metab 90(5):2888-2897
21. Cotter MA, Cameron NE (1995) Neuroprotective effects of carvedilol in diabetic rats: Prevention of defective peripheral nerve perfusion and conduction velocity. Naunyn Schmiedebergs Arch Pharmacol 351(6):630-635
22. de Zeeuw D, Gansevoort RT, Dullaart RP, de Jong PE (1995) Angiotensin II antagonism improves the lipoprotein profile in patients with nephrotic syndrome. J Hypertens Suppl 13(1):S53-S58
23. Ferrannini E, Natali A, Capaldo B, Lehtovirta M, Jacob S, Yki-Jarvinen H (1997) Insulin resistance, hyperinsulinemia, and blood pressure: Role of age and obesity. European Group for the Study of Insulin Resistance (EGIR). Hypertension 30(5):1144-1149
24. Fonseca V, Sharma PP, Shah M, Deedwania P (2011) Risk of new-onset diabetes mellitus associated with beta-blocker treatment for hypertension. Curr Med Res Opin 27(4):799-807
25. Garcia-Sainz JA (1993) Alpha 1-adrenergic action: Receptor subtypes, signal transduction and regulation. Cell Signal 5 (5):539-547
26. Gardiner SM, Kemp PA, March JE, Bennett T (1993) Regional haemodynamic effects of angiotensin II (3-8) in conscious rats. Br J Pharmacol 110(1):159-162
27. Gellai M, DeWolf R, Ruffolo RR Jr (1990) Effect of carvedilol on renal hemodynamics and renal excretory function in spontaneously hypertensive rats. Pharmacology 41(4):200-206
28. Hryniewicz K, Androne AS, Hudaihed A, Katz SD (2003) Comparative effects of carvedilol and metoprolol on regional vascular responses to adrenergic stimuli in normal subjects and patients with chronic heart failure. Circulation 108 (8):971-976
29. Hsieh PS, Tai YH, Loh CH, Shih KC, Cheng WT, Chu CH (2005) Functional interaction of AT1 and AT2 receptors in fructose-induced insulin resistance and hypertension in rats. Metabolism 54(2):157-164
30. Huang CL, Davis G, Johns EJ (1991) A study of the action of angiotensin II on perfusion through the cortex and papilla of the rat kidney. Exp Physiol 76(5):787-798
31. Huang F, Lezama MA, Ontiveros JA, Bravo G, Villafana S, del-Rio-Navarro BE, Hong E (2010) Effect of losartan on vascular function in fructose-fed rats: The role of perivascular adipose tissue. Clin Exp Hypertens 32(2):98-104
32. Isganaitis E, Lustig RH (2005) Fast food, central nervous system insulin resistance, and obesity. Arterioscler Thromb Vasc Biol 25(12):2451-2462
33. Iyer SN, Katovich MJ (1996) Effect of acute and chronic losartan treatment on glucose tolerance and insulin sensitivity in fructose-fed rats. Am J Hypertens 9(7):662-668
34. Jurgens H, HaassW, Castaneda TR, Schurmann A, Koebnick C, Dombrowski F, Otto B, Nawrocki AR, Scherer PE, Spranger J, Ristow M, Joost HG, Havel PJ, Tschop MH (2005) Consuming fructose-sweetened beverages increases body adiposity in mice. Obes Res 13(7):1146-1156
35. Just A, Olson AJ, Whitten CL, Arendshorst WJ (2007) Superoxide mediates acute renal vasoconstriction produced by angiotensin II and catecholamines by a mechanism independent of nitric oxide. Am J Physiol Heart Circ Physiol 292(1):H83-H92
36. Kalinowski L, Dobrucki LW, Szczepanska-Konkel M, Jankowski M, Martyniec L, Angielski S, Malinski T (2003) Third-generation beta-blockers stimulate nitric oxide release from endothelial cells throughATP efflux: A novelmechanism for antihypertensive action. Circulation 107(21):2747-2752
37. Khan AH, Sattar MA, Abdullah NA, Johns EJ (2009) Effect of calcium channel blockade on adrenergically induced renal vasoconstriction in rat models of renal impairment. Clin Exp Pharmacol Physiol 36(5-6):501-508
38. Khan MA, Sattar MA, Abdullah NA, Johns EJ (2008) Alpha1B-adrenoceptors mediate adrenergically-induced renal vasoconstrictions in rats with renal impairment. Acta Pharmacol Sin 29(2):193-203
39. Kline RL, Liu F (1994) Modification of pressure natriuresis by long-term losartan in spontaneously hypertensive rats. Hypertension 24(4):467-473
40. Li XC, Campbell DJ, Ohishi M, Yuan S, Zhuo JL (2006) AT1 receptor-activated signaling mediates angiotensin IVinduced renal cortical vasoconstriction in rats. Am J Physiol Renal Physiol 290(5):F1024-F1033
41. Matsukawa T, Gotoh E, Minamisawa K, Kihara M, Ueda S, Shionoiri H, Ishii M (1991) Effects of intravenous infusions of angiotensin II on muscle sympathetic nerve activity in humans. Am J Physiol 261(3 Pt 2):R690-R696
42. Mattson DL, Roman RJ (1991) Role of kinins and angiotensin II in the renal hemodynamic response to captopril. Am J Physiol 260(5 Pt 2):F670-F679
43. Miao Y, Dobre D, Heerspink HJ, Brenner BM, Cooper ME, Parving HH, Shahinfar S, Grobbee D, de Zeeuw D (2011) Increased serum potassium affects renal outcomes: A post hoc analysis of the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) trial. Diabetologia 54(1):44-50
44. Morioka Y, Koike H, Ikezumi Y, Ito Y, Oyanagi A, Gejyo F, Shimizu F, Kawachi H (2001) Podocyte injuries exacerbate mesangial proliferative glomerulonephritis. Kidney Int 60 (6):2192-2204
45. Navarro-Cid J, Maeso R, Perez-Vizcaino F, Cachofeiro V, Ruilope LM, Tamargo J, Lahera V (1995) Effects of losartan on blood pressure, metabolic alterations, and vascular reactivity in the fructose-induced hypertensive rat. Hypertension 26(6 Pt 2):1074-1078
46. Navarro-Cid J, Maeso R, Perez-Vizcaino F, Casal MC, Cachofeiro V, Ruilope LM, Tamargo J, Lahera V (1996) Effects of antihypertensive drugs on blood pressure and metabolic alterations in the fructose-induced hypertensive rat. Am J Hypertens 9(7):669-674
47. Rodriguez-Perez JC, Losada A, Anabitarte A, Cabrera J, Llobet J, Palop L, Plaza C (1997) Effects of the novel multiple-action agent carvedilol on severe nephrosclerosis in renal ablated rats. J Pharmacol Exp Ther 283(1):336-344
48. Rodriguez Perez JC, Cabrera JJ, Anabitarte A, Plaza ML, Losada A, Garcia Suarez P, Afonso JL (2001) Effects of carvedilol in rats with induced chronic kidney failure. Nefrologia 21(1):52-58
49. Roman RJ, Mattson DL, Cowley AW Jr (2001) Measurement of regional blood flow in the kidney using laser-Doppler flowmetry. Methods Mol Med 51:407-426
50. Rosen P, Ohly P, Gleichmann H (1997) Experimental benefit ofmoxonidine on glucose metabolism and insulin secretion in the fructose-fed rat. J Hypertens Suppl 15(1):S31-S38
51. Sattar MA, Johns EJ (1994) Evidence for an alpha 1-adrenoceptor subtype mediating adrenergic vasoconstriction in Wistar normotensive and stroke-prone spontaneously hypertensive rat kidney. J Cardiovasc Pharmacol 23(2):232-239
52. Schnabel P, Maack C, Mies F, Tyroller S, Scheer A, Bohm M (2000) Binding properties of beta-blockers at recombinant beta1-, beta2-, and beta3-adrenoceptors. J Cardiovasc Pharmacol 36(4):466-471
53. Soltis EE, Jewell AL, Dwoskin LP, Cassis LA (1993) Acute and chronic effects of losartan (DuP 753) on blood pressure and vascular reactivity in normotensive rats. Clin Exp Hypertens 15(1):171-184
54. Taylor BA, Phillips SJ (1996) Detection of obesity QTLs on mouse chromosomes 1 and 7 by selective DNA pooling. Genomics 34(3):389-398
55. Teff KL, Elliott SS, Tschop M, Kieffer TJ, Rader D, Heiman M, Townsend RR, Keim NL, D'Alessio D, Havel PJ (2004) Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. J Clin Endocrinol Metab 89 (6):2963-2972
56. Tran LT, MacLeod KM, McNeill JH (2009) Chronic etanercept treatment prevents the development of hypertension in fructose-fed rats. Mol Cell Biochem 330(1-2):219-228
57. Verma S, Bhanot S, McNeill JH (1999) Sympathectomy prevents fructose-induced hyperinsulinemia and hypertension. Eur J Pharmacol 373(2-3):R1-R4
58. Viswanad B, Srinivasan K, Kaul CL, Ramarao P (2006) Effect of tempol on altered angiotensin II and acetylcholinemediated vascular responses in thoracic aorta isolated from rats with insulin resistance. Pharmacol Res 53(3):209-215
59. Wong VY, Laping NJ, Nelson AH, Contino LC, Olson BA, Gygielko E, Campbell WG Jr, Barone F, Brooks DP (2001) Renoprotective effects of carvedilol in hypertensive-stroke prone rats may involve inhibition of TGF beta expression. Br J Pharmacol 134(5):977-984
60. Xu L, Brooks VL (1996) ANG II chronically supports renal and lumbar sympathetic activity in sodium-deprived, conscious rats. Am J Physiol 271(6 Pt 2):H2591-H2598
61. Ye S, Zhong H, Duong VN, Campese VM (2002) Losartan reduces central and peripheral sympathetic nerve activity in a rat model of neurogenic hypertension. Hypertension 39 (6):1101-1106
62. Yue TL, Cheng HY, Lysko PG, McKenna PJ, Feuerstein R, Gu JL, Lysko KA, Davis LL, Feuerstein G (1992) Carvedilol, a new vasodilator and beta adrenoceptor antagonist, is an antioxidant and free radical scavenger. J Pharmacol Exp Ther 263(1):92-98