Donor specific transplant tolerance is dependent on complement receptors

Transplant International

Volumn 26, Issue 1, 2013, Pages 99-108

  Bartel, Gregor ^a   Brown, Kathryn ^a   Phillips, Richards ^a   Peng, Qi ^a   Zhou, Wuding ^a   Sacks, Steven H ^a   Wong, Wilson ^a  

^a GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Complement receptors; Complement system; T regulatory cells; Tolerance

Indexed keywords

COMPLEMENT COMPONENT 3A RECEPTOR; COMPLEMENT RECEPTOR; COMPLEMENT RECEPTOR 3; HISTOCOMPATIBILITY ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD8+ T LYMPHOCYTE; COMPLEMENT COMPONENT 3A RECEPTOR DEFICIENCY; COMPLEMENT DEFICIENCY; CONTROLLED STUDY; DENDRITIC CELL; GRAFT RECIPIENT; IMMUNE RESPONSE; MALE; MOUSE; NONHUMAN; ORGAN DONOR; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SKIN GRAFT; SPLEEN; SPLEEN CELL;

ANIMALS; COMPLEMENT C3; FEMALE; IMMUNE TOLERANCE; INTERFERON-GAMMA; MALE; MICE; MICE, INBRED STRAINS; RECEPTORS, G-PROTEIN-COUPLED; SKIN TRANSPLANTATION; T-LYMPHOCYTES, REGULATORY; TISSUE DONORS;

EID: 84871302123     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/tri.12006     Document Type: Article

References (30)

1. Kingsley CI, Nadig SN, Wood KJ,. Transplantation tolerance: lessons from experimental rodent models. Transpl Int 2007: 20: 828.
2. Orlando G, Hematti P, Stratta RJ, etal. Clinical operational tolerance after renal transplantation: current status and future challenges. Ann Surg 2010: 252: 915.
3. Carroll MC,. Complement and humoral immunity. Vaccine 2008: 26 (Suppl. 8): I28.
4. Kemper C, Atkinson JP,. T-cell regulation: with complements from innate immunity. Nat Rev Immunol 2007: 7: 9.
5. Sohn JH, Bora PS, Suk HJ, Molina H, Kaplan HJ, Bora NS,. Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells. Nat Med 2003: 9: 206.
6. Hammerberg C, Katiyar SK, Carroll MC, Cooper KD,. Activated complement component 3 (C3) is required for ultraviolet induction of immunosuppression and antigenic tolerance. J Exp Med 1998: 187: 1133.
7. Schmidt J, Klempp C, Buchler MW, Marten A,. Release of iC3b from apoptotic tumor cells induces tolerance by binding to immature dendritic cells in vitro and in vivo. Cancer Immunol Immunother 2006: 55: 31.
8. Sacks S, Lee Q, Wong W, Zhou W,. The role of complement in regulating the alloresponse. Curr Opin Organ Transplant 2009: 14: 10.
9. Baruah P, Simpson E, Dumitriu IE, etal. Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance. Eur J Immunol 2010: 40: 1758.
10. Stegall M, Tayyab D, Lynn C, Justin B, Patrick D, Gloor JM,. Terminal complement inhibition decreases early acute humoral rejection in sensitized renal transplant recipients. AJT 2010; 10: 39.
11. Patel H, Smith RA, Sacks SH, Zhou W,. Therapeutic strategy with a membrane-localizing complement regulator to increase the number of usable donor organs after prolonged cold storage. J Am Soc Nephrol 2006: 17: 1102.
12. Billingham RE, Medawar PB,. Desensitization to skin homografts by injections of donor skin extracts. Ann Surg 1953: 137: 444.
13. Yamaguchi Y, Tsumura H, Miwa M, Inaba K,. Contrasting effects of TGF-beta 1 and TNF-alpha on the development of dendritic cells from progenitors in mouse bone marrow. Stem Cells 1997: 15: 144.
14. Feng G, Gao W, Strom TB, etal. Exogenous IFN-gamma ex vivo shapes the alloreactive T-cell repertoire by inhibition of Th17 responses and generation of functional Foxp3+ regulatory T cells. Eur J Immunol 2008: 38: 2512.
15. Brown K, Moxham V, Karegli J, Phillips R, Sacks SH, Wong W,. Ultra-localization of Foxp3+ T cells within renal allografts shows infiltration of tubules mimicking rejection. Am J Pathol 2007: 171: 1915.
16. Phillips RE, Sacks SH, Wong W,. Critical role of C3 in transplant tolerance. AJT 2006: 6: 892.
17. Zheng XX, Sanchez-Fueyo A, Sho M, Domenig C, Sayegh MH, Strom TB,. Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance. Immunity 2003: 19: 503.
18. Heeger PS, Lalli PN, Lin F, etal. Decay-accelerating factor modulates induction of T cell immunity. J Exp Med 2005: 201: 1523.
19. Pavlov V, Raedler H, Yuan S, etal. Donor deficiency of decay-accelerating factor accelerates murine T cell-mediated cardiac allograft rejection. J Immunol 2008: 181: 4580.
20. Esposito A, Suedekum B, Liu J, etal. Decay accelerating factor is essential for successful corneal engraftment. Am J Transplant 2010: 10: 527.
21. Strainic MG, Liu J, Huang D, etal. Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells. Immunity 2008: 28: 425.
22. Li K, Anderson KJ, Peng Q, etal. Cyclic AMP plays a critical role in C3a-receptor-mediated regulation of dendritic cells in antigen uptake and T-cell stimulation. Blood 2008: 112: 5084.
23. Peng Q, Li K, Anderson K, etal. Local production and activation of complement up-regulates the allostimulatory function of dendritic cells through C3a-C3aR interaction. Blood 2008: 111: 2452.
24. Peng Q, Li K, Patel H, Sacks SH, Zhou W,. Dendritic cell synthesis of C3 is required for full T cell activation and development of a Th1 phenotype. J Immunol 2006: 176: 3330.
25. Kemper C, Chan AC, Green JM, Brett KA, Murphy KM, Atkinson JP,. Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature 2003: 421: 388.
26. Brennan DC, Mohanakumar T, Flye MW,. Donor-specific transfusion and donor bone marrow infusion in renal transplantation tolerance: a review of efficacy and mechanisms. Am J Kidney Dis 1995: 26: 701.
27. Werfel T, Kirchhoff K, Wittmann M, etal. Activated human T lymphocytes express a functional C3a receptor. J Immunol 2000: 165: 6599.
28. Kishimoto K, Yuan X, Auchincloss H Jr, Sharpe AH, Mandelbrot DA, Sayegh MH,. Mechanism of action of donor-specific transfusion in inducing tolerance: role of donor MHC molecules, donor co-stimulatory molecules, and indirect antigen presentation. J Am Soc Nephrol 2004: 15: 2423.
29. Bushell A, Karim M, Kingsley CI, Wood KJ,. Pretransplant blood transfusion without additional immunotherapy generates CD25+CD4+ regulatory T cells: a potential explanation for the blood-transfusion effect. Transplantation 2003: 76: 449.
30. Benghiat FS, Graca L, Braun MY, etal. Critical influence of natural regulatory CD25+ T cells on the fate of allografts in the absence of immunosuppression. Transplantation 2005: 79: 648.