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Volumn 14, Issue 1, 2009, Pages 10-15

The role of complement in regulating the alloresponse

Author keywords

Anaphylatoxins; Rejection; Reperfusion

Indexed keywords

ANAPHYLATOXIN; COMPLEMENT; IMMUNOSUPPRESSIVE AGENT;

EID: 67649198980     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/MOT.0b013e32831ec551     Document Type: Review
Times cited : (22)

References (60)
  • 1
    • 0035810399 scopus 로고    scopus 로고
    • Complement. First of two parts
    • Walport MJ. Complement. First of two parts. N Engl J Med 2001; 344:1058-1066.
    • (2001) N Engl J Med , vol.344 , pp. 1058-1066
    • Walport, M.J.1
  • 2
    • 0035849176 scopus 로고    scopus 로고
    • Complement. Second of two parts
    • Walport MJ. Complement. Second of two parts. N Engl J Med 2001; 344:1140-1144.
    • (2001) N Engl J Med , vol.344 , pp. 1140-1144
    • Walport, M.J.1
  • 3
    • 33646404373 scopus 로고    scopus 로고
    • Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2
    • Selander B, Martensson U, Weintraub A, et al. Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2. J Clin Invest 2006; 116:1425-1434.
    • (2006) J Clin Invest , vol.116 , pp. 1425-1434
    • Selander, B.1    Martensson, U.2    Weintraub, A.3
  • 5
    • 34250347689 scopus 로고    scopus 로고
    • Complement factor H and the hemolytic uremic syndrome
    • DOI 10.1084/jem.20070664
    • Atkinson JP, Goodship TH. Complement factor H and the hemolytic uremic syndrome. J Exp Med 2007; 204:1245-1248. (Pubitemid 46919860)
    • (2007) Journal of Experimental Medicine , vol.204 , Issue.6 , pp. 1245-1248
    • Atkinson, J.P.1    Goodship, T.H.J.2
  • 8
    • 17244379811 scopus 로고    scopus 로고
    • Complement factor H polymorphism and age-related macular degeneration
    • DOI 10.1126/science.1110189
    • Edwards AO, Ritter R III, Abel KJ, et al. Complement factor H polymorphism and age-related macular degeneration. Science 2005; 308:421-424. (Pubitemid 40530082)
    • (2005) Science , vol.308 , Issue.5720 , pp. 421-424
    • Edwards, A.O.1    Ritter III, R.2    Abel, K.J.3    Manning, A.4    Panhuysen, C.5    Farrer, L.A.6
  • 12
    • 33750859976 scopus 로고    scopus 로고
    • Structure of C3b reveals conformational changes that underlie complement activity
    • DOI 10.1038/nature05172, PII NATURE05172
    • Janssen BJ, Christodoulidou A, McCarthy A, et al. Structure of C3b reveals conformational changes that underlie complement activity. Nature 2006; 444:213-216. (Pubitemid 44722062)
    • (2006) Nature , vol.444 , Issue.7116 , pp. 213-216
    • Janssen, B.J.C.1    Christodoulidou, A.2    McCarthy, A.3    Lambris, J.D.4    Gros, P.5
  • 13
    • 34547763220 scopus 로고    scopus 로고
    • Crystallography: Crystallographic evidence for deviating C3b structure
    • DOI 10.1038/nature06102, PII NATURE06102
    • Janssen BJ, Read RJ, Brünger AT, Gros P. Crystallography: crystallographic evidence for deviating C3b structure. Nature 2007; 448:E1-E2. (Pubitemid 47236866)
    • (2007) Nature , vol.448 , Issue.7154
    • Janssen, B.J.C.1    Read, R.J.2    Brunger, A.T.3    Gros, P.4
  • 14
    • 34548282471 scopus 로고    scopus 로고
    • The relative importance of local and systemic complement production in ischaemia, transplantation and other pathologies
    • DOI 10.1016/j.molimm.2007.06.006, PII S016158900700257X, XIth European meeting on Complement in Human Disease
    • Li K, Sacks SH, Zhou W. The relative importance of local and systemic complement production in ischaemia, transplantation and other pathologies. Mol Immunol 2007; 44:3866-3874. (Pubitemid 47332623)
    • (2007) Molecular Immunology , vol.44 , Issue.16 , pp. 3866-3874
    • Li, K.1    Sacks, S.H.2    Zhou, W.3
  • 16
    • 0033120556 scopus 로고    scopus 로고
    • Contribution of renal secreted complement C3 to the circulating pool in humans
    • Tang S, Zhou W, Sheerin NS, et al. Contribution of renal secreted complement C3 to the circulating pool in humans. J Immunol 1999; 162:4336-4341. (Pubitemid 29314826)
    • (1999) Journal of Immunology , vol.162 , Issue.7 , pp. 4336-4341
    • Tang, S.1    Zhou, W.2    Sheerin, N.S.3    Vaughan, R.W.4    Sacks, S.H.5
  • 17
    • 0028961964 scopus 로고
    • Delayed graft function, acute rejection, and outcome after cadaver renal transplantation. The multivariate analysis
    • Troppmann C, Gillingham KJ, Benedetti E, et al. Delayed graft function, acute rejection, and outcome after cadaver renal transplantation. The multivariate analysis. Transplantation 1995; 59:962-968.
    • (1995) Transplantation , vol.59 , pp. 962-968
    • Troppmann, C.1    Gillingham, K.J.2    Benedetti, E.3
  • 19
    • 0037219239 scopus 로고    scopus 로고
    • Do alloreactivity and prolonged cold ischemia cause different elementary lesions in chronic allograft nephropathy?
    • Herrero-Fresneda I, Torras J, Cruzado JM, et al. Do alloreactivity and prolonged cold ischemia cause different elementary lesions in chronic allograft nephropathy? Am J Pathol 2003; 162:127-137.
    • (2003) Am J Pathol , vol.162 , pp. 127-137
    • Herrero-Fresneda, I.1    Torras, J.2    Cruzado, J.M.3
  • 20
    • 33644928993 scopus 로고    scopus 로고
    • Local extravascular pool of C3 is a determinant of postischemic acute renal failure
    • DOI 10.1096/fj.05-4747com
    • Farrar CA, Zhou W, Lin T, Sacks SH. Local extravascular pool of C3 is a determinant of postischemic acute renal failure. FASEB J 2006; 20:217-226. (Pubitemid 44933168)
    • (2006) FASEB Journal , vol.20 , Issue.2 , pp. 217-226
    • Farrar, C.A.1    Zhou, W.2    Lin, T.3    Sacks, S.H.4
  • 21
    • 33645473397 scopus 로고    scopus 로고
    • Therapeutic strategy with a membrane- Localizing complement regulator to increase the number of usable donor organs after prolonged cold storage
    • Patel H, Smith RA, Sacks SH, Zhou W. Therapeutic strategy with a membrane- localizing complement regulator to increase the number of usable donor organs after prolonged cold storage. J Am Soc Nephrol 2006; 17:1102-1111.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 1102-1111
    • Patel, H.1    Smith, R.A.2    Sacks, S.H.3    Zhou, W.4
  • 29
    • 18844420498 scopus 로고    scopus 로고
    • Complement and glomerulonephritis: New insights
    • Turnberg D, Cook HT. Complement and glomerulonephritis: new insights. Curr Opin Nephrol Hypertens 2005; 14:223-228.
    • (2005) Curr Opin Nephrol Hypertens , vol.14 , pp. 223-228
    • Turnberg, D.1    Cook, H.T.2
  • 30
    • 0037213077 scopus 로고    scopus 로고
    • A small molecule C5a receptor antagonist protects kidneys from ischemia/reperfusion injury in rats
    • Arumugam TV, Shiels IA, Strachan AJ, et al. A small molecule C5a receptor antagonist protects kidneys from ischemia/reperfusion injury in rats. Kidney Int 2003; 63:134-142.
    • (2003) Kidney Int , vol.63 , pp. 134-142
    • Arumugam, T.V.1    Shiels, I.A.2    Strachan, A.J.3
  • 32
    • 0028239796 scopus 로고
    • Localization of the complement regulatory proteins in the normal human kidney
    • Ichida S, Yuzawa Y, Okada H, et al. Localization of the complement regulatory proteins in the normal human kidney. Kidney Int 1994; 46:89-96. (Pubitemid 24210439)
    • (1994) Kidney International , vol.46 , Issue.1 , pp. 89-96
    • Ichida, S.1    Yuzawa, Y.2    Okada, H.3    Yoshioka, K.4    Matsuo, S.5
  • 33
    • 12344333421 scopus 로고    scopus 로고
    • Acute tubular necrosis is characterized by activation of the alternative pathway of complement
    • DOI 10.1111/j.1523-1755.2005.67109.x
    • Thurman JM, Lucia MS, Ljubanovic D, Holers VM. Acute tubular necrosis is characterized by activation of the alternative pathway of complement. Kidney Int 2005; 67:524-530. (Pubitemid 40139844)
    • (2005) Kidney International , vol.67 , Issue.2 , pp. 524-530
    • Thurman, J.M.1    Lucia, M.S.2    Ljubanovic, D.3    Holers, V.M.4
  • 35
    • 0035886199 scopus 로고    scopus 로고
    • The allogeneic T and B cell response is strongly dependent on complement components C3 and C4
    • Marsh JE, Farmer CK, Jurcevic S, et al. The allogeneic T and B cell response is strongly dependent on complement components C3 and C4. Transplantation 2001; 72:1310-1318. (Pubitemid 33026614)
    • (2001) Transplantation , vol.72 , Issue.7 , pp. 1310-1318
    • Marsh, J.E.1    Farmer, C.K.T.2    Jurcevic, S.3    Wang, Y.4    Carroll, M.C.5    Sacks, S.H.6
  • 36
    • 0017265647 scopus 로고
    • Immunosuppression by cobra factor: Distribution, antigen-induced blast transformation and trapping of lymphocytes during in vivo complement depletion
    • Pepys MB, Mirjah DD, Dash AC, Wansbrough-Jones MH. Immunosuppression by cobra factor: distribution, antigen-induced blast transformation and trapping of lymphocytes during in vivo complement depletion. Cell Immunol 1976; 21:327-336.
    • (1976) Cell Immunol , vol.21 , pp. 327-336
    • Pepys, M.B.1    Mirjah, D.D.2    Dash, A.C.3    Wansbrough-Jones, M.H.4
  • 37
    • 0034097043 scopus 로고    scopus 로고
    • Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex
    • Fearon DT, Carroll MC. Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex. Annu Rev Immunol 2000; 18:393-422.
    • (2000) Annu Rev Immunol , vol.18 , pp. 393-422
    • Fearon, D.T.1    Carroll, M.C.2
  • 38
    • 0036284207 scopus 로고    scopus 로고
    • Local synthesis of complement component C3 regulates acute renal transplant rejection
    • Pratt JR, Basheer SA, Sacks SH. Local synthesis of complement component C3 regulates acute renal transplant rejection. Nat Med 2002; 8:582-587.
    • (2002) Nat Med , vol.8 , pp. 582-587
    • Pratt, J.R.1    Basheer, S.A.2    Sacks, S.H.3
  • 39
    • 33644745156 scopus 로고    scopus 로고
    • Macrophages from C3-deficient mice have impaired potency to stimulate alloreactive T cells
    • DOI 10.1182/blood-2005-08-3144
    • Zhou W, Patel H, Li K, et al. Macrophages from C3-deficient mice have impaired potency to stimulate alloreactive T cells. Blood 2006; 107:2461-2469. (Pubitemid 43345568)
    • (2006) Blood , vol.107 , Issue.6 , pp. 2461-2469
    • Zhou, W.1    Patel, H.2    Li, K.3    Peng, Q.4    Villiers, M.-B.5    Sacks, S.H.6
  • 40
    • 33644845646 scopus 로고    scopus 로고
    • Dendritic cell synthesis of C3 is required for full T cell activation and development of a Th1 phenotype
    • Peng Q, Li K, Patel H, et al. Dendritic cell synthesis of C3 is required for full T cell activation and development of a Th1 phenotype. J Immunol 2006; 176:3330-3341. (Pubitemid 43363979)
    • (2006) Journal of Immunology , vol.176 , Issue.6 , pp. 3330-3341
    • Peng, Q.1    Li, K.2    Patel, H.3    Sacks, S.H.4    Zhou, W.5
  • 41
    • 41349100253 scopus 로고    scopus 로고
    • Local production and activation of complement up-regulates the allostimulatory function of dendritic cells through C3a-C3aR interaction
    • This study investigated the mechanism by which C3 modulates dendritic cell function in allostimulation. Authors demonstrated that dendritic cells are able to secrete a wide range of complement proteins leading to C3a generation and C3aR expression in the local environment. Dendritic cells lacking receptor for C3a elicited defective T-cell priming against alloantigen expressed on those cells, in vivo and in vitro. The suggestion from this study is that the anaphylatoxin C3a and its corresponding receptor on dendritic cells play a significant role in allostimulation
    • Peng Q, Li K, Anderson K, et al. Local production and activation of complement up-regulates the allostimulatory function of dendritic cells through C3a-C3aR interaction. Blood 2008; 111:2452-2461. This study investigated the mechanism by which C3 modulates dendritic cell function in allostimulation. Authors demonstrated that dendritic cells are able to secrete a wide range of complement proteins leading to C3a generation and C3aR expression in the local environment. Dendritic cells lacking receptor for C3a elicited defective T-cell priming against alloantigen expressed on those cells, in vivo and in vitro. The suggestion from this study is that the anaphylatoxin C3a and its corresponding receptor on dendritic cells play a significant role in allostimulation.
    • (2008) Blood , vol.111 , pp. 2452-2461
    • Peng, Q.1    Li, K.2    Anderson, K.3
  • 42
    • 58149393171 scopus 로고    scopus 로고
    • Cyclic AMP plays a critical role in C3a-receptor-mediated regulation of dendritic cells in antigen uptake and T cell stimulation
    • [Epub ahead of print]. Authors found that engagement of C3a receptor (C3aR) on the surface of dendritic cells leads to alterations in the level of intracellular cAMP, a potent negative regulator of inflammatory responses. C3aR activation-induced depression of cAMP was associated with enhanced capacity of dendritic cells for antigen uptake and T-cell stimulation. The finding of a link between complement and adaptive immune stimulation through cAMP offers new insight into how innate and adaptive immunity combines to generate efficient effector and memory responses
    • Li K, Anderson KJ, Peng Q, et al. Cyclic AMP plays a critical role in C3a-receptor-mediated regulation of dendritic cells in antigen uptake and T cell stimulation. Blood 2008 [Epub ahead of print]. Authors found that engagement of C3a receptor (C3aR) on the surface of dendritic cells leads to alterations in the level of intracellular cAMP, a potent negative regulator of inflammatory responses. C3aR activation-induced depression of cAMP was associated with enhanced capacity of dendritic cells for antigen uptake and T-cell stimulation. The finding of a link between complement and adaptive immune stimulation through cAMP offers new insight into how innate and adaptive immunity combines to generate efficient effector and memory responses.
    • (2008) Blood
    • Li, K.1    Anderson, K.J.2    Peng, Q.3
  • 44
    • 57149103158 scopus 로고    scopus 로고
    • Donor deficiency of decay-accelerating factor accelerates murine T cell-mediated cardiac allograft rejection
    • Pavlov V, Raedler H, Yuan S, et al. Donor deficiency of decay-accelerating factor accelerates murine T cell-mediated cardiac allograft rejection. J Immunol 2008; 181:4580-4589.
    • (2008) J Immunol , vol.181 , pp. 4580-4589
    • Pavlov, V.1    Raedler, H.2    Yuan, S.3
  • 45
    • 40249116606 scopus 로고    scopus 로고
    • Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells
    • This study demonstrated that locally produced C5a and C3a anaphylatoxins interacting with their G protein-coupled receptors (GPCRs), C5aR and C3aR, on APCs and T cells both upstream and downstream of CD28 and CD40L signalling are integrally involved in T-cell proliferation and differentiation. C5aR and C3aR mediated their effects through PI-3 kinase-gamma-dependent AKT phosphorylation, providing a link between GPCR signalling, CD28 costimulation and T-cell survival
    • Strainic MG, Liu J, Huang D, et al. Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells. Immunity 2008; 28:425-435. This study demonstrated that locally produced C5a and C3a anaphylatoxins interacting with their G protein-coupled receptors (GPCRs), C5aR and C3aR, on APCs and T cells both upstream and downstream of CD28 and CD40L signalling are integrally involved in T-cell proliferation and differentiation. C5aR and C3aR mediated their effects through PI-3 kinase-gamma-dependent AKT phosphorylation, providing a link between GPCR signalling, CD28 costimulation and T-cell survival.
    • (2008) Immunity , vol.28 , pp. 425-435
    • Strainic, M.G.1    Liu, J.2    Huang, D.3
  • 46
    • 52649176344 scopus 로고    scopus 로고
    • Locally produced C5a binds to T cell-expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis
    • + T cells. Authors demonstrated that T-cell expansion induced by DAF-deficient APCs was augmented with diminished T-cell apoptosis, whereas T-cell expansion induced by C3-/- APCs was reduced because of enhanced T-cell apoptosis. These effects were traced to locally produced C5a, which through binding to T-cell-expressed C5aR, enhanced expression of Bcl-2 and prevented Fas upregulation. The results show that C5aR signal transduction in T cells is important to allow optimal T-cell expansion, as well as to maintain naive cell viability, and does so by suppressing programmed cell death
    • + T cells. Authors demonstrated that T-cell expansion induced by DAF-deficient APCs was augmented with diminished T-cell apoptosis, whereas T-cell expansion induced by C3-/- APCs was reduced because of enhanced T-cell apoptosis. These effects were traced to locally produced C5a, which through binding to T-cell-expressed C5aR, enhanced expression of Bcl-2 and prevented Fas upregulation. The results show that C5aR signal transduction in T cells is important to allow optimal T-cell expansion, as well as to maintain naive cell viability, and does so by suppressing programmed cell death.
    • (2008) Blood , vol.112 , pp. 1759-1766
    • Lalli, P.N.1    Strainic, M.G.2    Yang, M.3
  • 47
    • 0036284207 scopus 로고    scopus 로고
    • Local synthesis of complement component C3 regulates acute renal transplant rejection
    • Pratt JR, Basheer SA, Sacks SH. Local synthesis of complement component C3 regulates acute renal transplant rejection. Nat Med 2002; 8:582-587.
    • (2002) Nat Med , vol.8 , pp. 582-587
    • Pratt, J.R.1    Basheer, S.A.2    Sacks, S.H.3
  • 48
  • 49
    • 33646486869 scopus 로고    scopus 로고
    • Influence of donor C3 allotype on late renal-transplantation outcome
    • Brown KM, Kondeatis E, Vaughan RW, et al. Influence of donor C3 allotype on late renal-transplantation outcome. N Engl J Med 2006; 354:2014-2023.
    • (2006) N Engl J Med , vol.354 , pp. 2014-2023
    • Brown, K.M.1    Kondeatis, E.2    Vaughan, R.W.3
  • 51
    • 33845462462 scopus 로고    scopus 로고
    • In vivo regulation of neutrophil apoptosis by C5a during sepsis
    • Guo RF, Sun L, Gao H, et al. In vivo regulation of neutrophil apoptosis by C5a during sepsis. J Leukoc Biol 2006; 80:1575-1583.
    • (2006) J Leukoc Biol , vol.80 , pp. 1575-1583
    • Guo, R.F.1    Sun, L.2    Gao, H.3
  • 52
    • 53149141785 scopus 로고    scopus 로고
    • CD46-induced immunomodulatory CD4+ T cells express the adhesion molecule and chemokine receptor pattern of intestinal T cells
    • + T lymphocytes isolated from the lectin pathway of patients undergoing bariatric surgery contain T cells that spontaneously secrete a cytokine pattern consistent with that from CD46-activated T cells. Authors suggest thatCD46-induced Tregs might play a role in intestinal immune homeostasis in which they could dampen unwanted effector T-cell responses
    • + T lymphocytes isolated from the lectin pathway of patients undergoing bariatric surgery contain T cells that spontaneously secrete a cytokine pattern consistent with that from CD46-activated T cells. Authors suggest thatCD46-induced Tregs might play a role in intestinal immune homeostasis in which they could dampen unwanted effector T-cell responses.
    • (2008) J Immunol , vol.181 , pp. 2544-2555
    • Alford, S.K.1    Longmore, G.D.2    Stenson, W.F.3    Kemper, C.4
  • 53
    • 48349087311 scopus 로고    scopus 로고
    • The classical complement pathway in transplantation: Unanticipated protective effects of C1q and role in inductive antibody therapy
    • In this study, authors observed that mouse cardiac allograft rejection is accelerated in C1q-/- recipients compared with wild-type recipients, suggesting a protective role for C1q in the rejection process. Although the mechanisms by which C1q mediates the protective effects in allograft rejection are not clear, it seems not due to the alteration of allospecific T-cell response, instead the C1q may help recipient macrophages/dendritic cells to phagocytose apoptotic bodies within the graft to render the graft less inflammation
    • Csencsits K, Burrell BE, Lu G, et al. The classical complement pathway in transplantation: unanticipated protective effects of C1q and role in inductive antibody therapy. Am J Transplant 2008; 8:1622-1630. In this study, authors observed that mouse cardiac allograft rejection is accelerated in C1q-/- recipients compared with wild-type recipients, suggesting a protective role for C1q in the rejection process. Although the mechanisms by which C1q mediates the protective effects in allograft rejection are not clear, it seems not due to the alteration of allospecific T-cell response, instead the C1q may help recipient macrophages/dendritic cells to phagocytose apoptotic bodies within the graft to render the graft less inflammation.
    • (2008) Am J Transplant , vol.8 , pp. 1622-1630
    • Csencsits, K.1    Burrell, B.E.2    Lu, G.3
  • 54
    • 0034495107 scopus 로고    scopus 로고
    • In situ localization of C3 synthesis in experimental acute renal allograft rejection
    • Pratt JR, Abe K, Miyazaki M, et al. In situ localization of C3 synthesis in experimental acute renal allograft rejection. Am J Pathol 2000; 157:825-831.
    • (2000) Am J Pathol , vol.157 , pp. 825-831
    • Pratt, J.R.1    Abe, K.2    Miyazaki, M.3
  • 55
    • 46249086018 scopus 로고    scopus 로고
    • C5 blockade with conventional immunosuppression induces long-term graft survival in presensitized recipients
    • Rother RP, Arp J, Jiang J, et al. C5 blockade with conventional immunosuppression induces long-term graft survival in presensitized recipients. Am J Transplant 2008; 8:1129-1142.
    • (2008) Am J Transplant , vol.8 , pp. 1129-1142
    • Rother, R.P.1    Arp, J.2    Jiang, J.3
  • 56
    • 40649099165 scopus 로고    scopus 로고
    • Inhibition of terminal complement components in presensitized transplant recipients prevents antibody-mediated rejection leading to long-term graft survival and accommodation
    • Wang H, Arp J, Liu W, et al. Inhibition of terminal complement components in presensitized transplant recipients prevents antibody-mediated rejection leading to long-term graft survival and accommodation. J Immunol 2007; 179:4451-4463.
    • (2007) J Immunol , vol.179 , pp. 4451-4463
    • Wang, H.1    Arp, J.2    Liu, W.3
  • 59
    • 0141844659 scopus 로고    scopus 로고
    • Nontransgenic hyperexpression of a complement regulator in donor kidney modulates transplant ischemia/reperfusion damage, acute rejection, and chronic nephropathy
    • Pratt JR, Jones ME, Dong J, et al. Nontransgenic hyperexpression of a complement regulator in donor kidney modulates transplant ischemia/reperfusion damage, acute rejection, and chronic nephropathy. Am J Pathol 2003; 163:1457-1465. (Pubitemid 37175093)
    • (2003) American Journal of Pathology , vol.163 , Issue.4 , pp. 1457-1465
    • Pratt, J.R.1    Jones, M.E.2    Dong, J.3    Zhou, W.4    Chowdhury, P.5    Smith, R.A.G.6    Sacks, S.H.7
  • 60
    • 54949088913 scopus 로고    scopus 로고
    • 11th European Meeting on Complement in Human Diseases
    • Smith R, Koffman G, Chowdhury P, et al. 11th European Meeting on Complement in Human Diseases. Mol Immunol 2007; 44:3915.
    • (2007) Mol Immunol , vol.44 , pp. 3915
    • Smith, R.1    Koffman, G.2    Chowdhury, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.