Identifying patients harboring extended-spectrum-β-lactamase-producing Enterobacteriaceae on hospital admission: Derivation and validation of a scoring system

Antimicrobial Agents and Chemotherapy

Volumn 55, Issue 7, 2011, Pages 3485-3490

  Tumbarello, Mario ^a   Trecarichi, Enrico Maria ^a   Bassetti, Matteo ^b   De Rosa, Francesco Giuseppe ^c   Spanu, Teresa ^a   Di Meco, Eugenia ^a   Losito, Angela Raffaella ^a   Parisini, Andrea ^b   Pagani, Nicole ^c   Cauda, Roberto ^a  

^a FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAM; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

AGED; ARTICLE; BACTERIUM CULTURE; BACTERIUM IDENTIFICATION; BLADDER CATHETERIZATION; CALIBRATION; ESCHERICHIA COLI; FEMALE; GROUPS BY AGE; HOSPITAL ADMISSION; HOSPITAL PATIENT; HOSPITALIZATION; HUMAN; ITALY; KLEBSIELLA; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; PATIENT TRANSPORT; PRIORITY JOURNAL; PROTEUS MIRABILIS; RETROSPECTIVE STUDY; SCORING SYSTEM; VALIDATION STUDY;

AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; COMMUNITY-ACQUIRED INFECTIONS; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTIONS; FEMALE; HUMANS; KLEBSIELLA; MALE; MIDDLE AGED; PROTEUS MIRABILIS; RETROSPECTIVE STUDIES;

EID: 79959206438     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00009-11     Document Type: Article

References (35)

1. Apisarnthanarak, A., P. Kiratisin, and L. M. Mundy. 2008. Predictors of mortality from community-onset bloodstream infections due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae. Infect. Control Hosp. Epidemiol. 29:671-674.
2. Azap, O. K., et al. 2010. Risk factors for extended-spectrum beta-lactamase positivity in uropathogenic Escherichia coli isolated from community-acquired urinary tract infections. Clin. Microbiol. Infect. 16:147-151.
3. Ben-Ami, R., et al. 2009. A multinational survey of risk factors for infection with extended-spectrum beta-lactamase-producing enterobacteriaceae in nonhospitalized patients. Clin. Infect. Dis. 49:682-690.
4. Ben-Ami, R., et al. 2006. Influx of extended-spectrum beta-lactamase-producing Enterobacteriaceae into the hospital. Clin. Infect. Dis. 42:925-934.
5. Charlson, M. E., P. Pompei, K. L. Ales, and C. R. MacKenzie. 1987. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J. Chronic Dis. 40:373-383.
6. Clinical and Laboratory Standards Institute. 2009. Performance standards for antimicrobial susceptibility testing; 19th informational supplement. M100-S19. Clinical and Laboratory Standards Institute, Wayne, PA.
7. Coque, T. M., F. Baquero, and R. Canton. 2008. Increasing prevalence of ESBL-producing Enterobacteriaceae in Europe. Eur. Surveill. 13.
8. Cosgrove, S. E. 2006. The relationship between antimicrobial resistance and patient outcomes: mortality, length of hospital stay, and health care costs. Clin. Infect. Dis. 42(Suppl. 2):S82-S89.
9. Falagas, M. E., and D. E. Karageorgopoulos. 2009. Extended-spectrum beta-lactamase- producing organisms. J. Hosp. Infect. 73:345-354.
10. Friedmann, R., et al. 2009. Prospective evaluation of colonization with extended-spectrum beta-lactamase (ESBL)-producing enterobacteriaceae among patients at hospital admission and of subsequent colonization with ESBL-producing enterobacteriaceae among patients during hospitalization. Infect. Control Hosp. Epidemiol. 30:534-542.
11. Furuno, J. P., et al. 2004. Prediction rules to identify patients with methicillin- resistant Staphylococcus aureus and vancomycin-resistant enterococci upon hospital admission. Am. J. Infect. Control. 32:436-440.
12. Giske, C. G., et al. 2008. Clinical and economic impact of common multidrug- resistant gram-negative bacilli. Antimicrob. Agents Chemother. 52: 813-821.
13. Harbarth, S., et al. 2006. Evaluating the probability of previously unknown carriage of MRSA at hospital admission. Am. J. Med. 119:275.e15-275.e23.
14. Hawser, S. P., et al. 2010. Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrobial Resistance Trends (SMART). Antimicrob. Agents Chemother. 54:3043-3046.
15. Kader, A. A., A. Kumar, and K. A. Kamath. 2007. Fecal carriage of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in patients and asymptomatic healthy individuals. Infect. Control Hosp. Epidemiol. 28:1114-1116.
16. Kang, C. I., et al. 2008. Clinical features and outcome of community-onset bloodstream infections caused by extended-spectrum beta-lactamase-producing Escherichia coli. Eur. J. Clin. Microbiol. Infect. Dis. 27:85-88.
17. Laupacis, A., N. Sekar, and I. G. Stiell. 1997. Clinical prediction rules. A review and suggested modifications of methodological standards. JAMA 277:488-494.
18. Laupland, K. B., D. L. Church, J. Vidakovich, M. Mucenski, and J. D. Pitout. 2008. Community-onset extended-spectrum beta-lactamase (ESBL) producing Escherichia coli: importance of international travel. J. Infect. 57:441-448.
19. Mesa, R. J., et al. 2006. Extended-spectrum beta-lactamase-producing Enterobacteriaceae in different environments (humans, food, animal farms and sewage). J. Antimicrob. Chemother. 58:211-215. (Pubitemid 44295011)
20. Ortega, M., et al. 2009. Analysis of 4758 Escherichia coli bacteraemia episodes: predictive factors for isolation of an antibiotic-resistant strain and their impact on the outcome. J. Antimicrob. Chemother. 63:568-574.
21. Peralta, G., et al. 2007. Impact of antibiotic resistance and of adequate empirical antibiotic treatment in the prognosis of patients with Escherichia coli bacteraemia. J. Antimicrob. Chemother. 60:855-863.
22. Pitout, J. D., and K. B. Laupland. 2008. Extended-spectrum beta-lactamase-producing Enterobacteriaceae: an emerging public-health concern. Lancet Infect. Dis. 8:159-166.
23. Rodríguez-Baño, J., et al. 2010. Community-onset bacteremia due to extended-spectrum beta-lactamase-producing Escherichia coli: risk factors and prognosis. Clin. Infect. Dis. 50:40-48.
24. Rodríguez-Baño, J., et al. 2008. Community infections caused by extended-spectrum beta-lactamase-producing Escherichia coli. Arch. Intern. Med. 168: 1897-1902.
25. Rodríguez-Baño, J., L. López-Cerero, M. D. Navarro, P. Díaz de Alba, and A. Pascual. 2008. Faecal carriage of extended-spectrum beta-lactamase-producing Escherichia coli: prevalence, risk factors and molecular epidemiology. J. Antimicrob. Chemother. 62:1142-1149.
26. Schwaber, M. J., and Y. Carmeli. 2007. Mortality and delay in effective therapy associated with extended-spectrum beta-lactamase production in Enterobacteriaceae bacteraemia: a systematic review and meta-analysis. J. Antimicrob. Chemother. 60:913-920.
27. Song, K. H., et al. 2009. Clinical outcomes of spontaneous bacterial peritonitis due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species: a retrospective matched case-control study. BMC Infect. Dis. 9:41.
28. Sullivan, L. M., J. M. Massaro, and R. B. D'Agostino Sr. 2004. Presentation of multivariate data for clinical use: the Framingham Study risk score functions. Stat. Med. 23:1631-1660.
29. Tacconelli, E., A. W. Karchmer, D. Yokoe, and E. M. D'Agata. 2004. Preventing the influx of vancomycin-resistant enterococci into health care institutions, by use of a simple validated prediction rule. Clin. Infect. Dis. 39: 964-970.
30. Tacconelli, E., M. A. Cataldo, G. De Angelis, and R. Cauda. 2007. Risk scoring and bloodstream infections. Int. J. Antimicrob. Agents 30(Suppl. 1):S88-S92.
31. Tumbarello, M., et al. 2008. Bloodstream infections caused by extended-spectrum- beta-lactamase-producing Escherichia coli: risk factors for inadequate initial antimicrobial therapy. Antimicrob. Agents Chemother. 52: 3244-3252.
32. Tumbarello, M., et al. 2007. Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-beta-lactamase-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment. Antimicrob. Agents Chemother. 51:1987-1994.
33. Tumbarello, M., et al. 2006. Bloodstream infections caused by extended-spectrum- beta-lactamase-producing Klebsiella pneumoniae: risk factors, molecular epidemiology, and clinical outcome. Antimicrob. Agents Chemother. 50:498-504.
34. Tumbarello, M., et al. 2010. Costs of bloodstream infections caused by Escherichia coli and influence of extended-spectrum-beta-lactamase production and inadequate initial antibiotic therapy. Antimicrob. Agents Chemother. 54:4085-4091.
35. Valverde, A., et al. 2004. Dramatic increase in prevalence of fecal carriage of extended-spectrum beta-lactamase-producing Enterobacteriaceae during non-outbreak situations in Spain. J. Clin. Microbiol. 42:4769-4775.