Alveolar epithelial stem and progenitor cells: Emerging evidence for their role in lung regeneration

Current Medicinal Chemistry

Volumn 19, Issue 35, 2012, Pages 6003-6008

  Hoffman, A M ^a   Ingenito, E P ^b  

^a TUFTS UNIVERSITY   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Alveolar multiplication; Compensatory lung growth; Epithelialization; Lung stem cell

Indexed keywords

ARTICLE; BASEMENT MEMBRANE; CELL DIFFERENTIATION; CELL FUNCTION; CELL ISOLATION; CELL MIGRATION; CELL POPULATION; ENDOTHELIUM CELL; FIBROBLAST; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LUNG ALVEOLUS EPITHELIUM; LUNG INJURY; LUNG REGENERATION; LUNG RESECTION; MESENCHYMAL STROMA CELL; NONHUMAN; STEM CELL; TISSUE REGENERATION;

ANIMALS; BRONCHIOLES; EPITHELIAL CELLS; LUNG; PULMONARY ALVEOLI; REGENERATION; STEM CELLS;

EID: 84871290912     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986712804485872     Document Type: Article

References (64)

1. Xian W, McKeon F. Adult stem cells underlying lung regeneration. Cell Cycle. 2012 Mar. 1;11 (5).
2. Bertoncello I, McQualter J. Isolation and clonal assay of adult lung epithelial stem/progenitor cells. Curr Protoc Stem Cell Biol. 2011 Jan; Chapter 2: Unit 2G 1.
3. Weiss DJ, Bertoncello I, Borok Z, Kim C, Panoskaltsis-Mortari A, Reynolds S, et al. Stem cells and cell therapies in lung biology and lung diseases. Proc Am Thorac Soc. 2011 Jun; 8(3):223-72.
4. Beers MF, Morrisey EE. The three R's of lung health and disease: repair, remodeling, and regeneration. J Clin Invest. 2011 Jun; 121(6):2065-73.
5. Kubo H. Molecular basis of lung tissue regeneration. Gen Thorac Cardiovasc Surg. 2011 Apr; 59(4):231-44.
6. Stripp BR. Hierarchical organization of lung progenitor cells: is there an adult lung tissue stem cell? Proc Am Thorac Soc. 2008 Aug. 15;5(6):695-8.
7. Warburton D, Perin L, Defilippo R, Bellusci S, Shi W, Driscoll B. Stem/progenitor cells in lung development, injury repair, and regeneration. Proc Am Thorac Soc. 2008 Aug. 15;5(6):703-6.
8. Kajstura J, Rota M, Hall SR, Hosoda T, D'Amario D, Sanada F, et al. Evidence for human lung stem cells. N Engl J Med. 2011 May 12;364(19):1795-806.
9. Hutchison C, Pilote M, Roy S. The axolotl limb: a model for bone development, regeneration and fracture healing. Bone. 2007 Jan; 40(1):45-56.
10. Campbell LJ, Suarez-Castillo EC, Ortiz-Zuazaga H, Knapp D, Tanaka EM, Crews CM. Gene expression profile of the regeneration epithelium during axolotl limb regeneration. Dev Dyn. 2011 Jul; 240(7):1826-40.
11. Satoh A, Cummings GM, Bryant SV, Gardiner DM. Regulation of proximaldistal intercalation during limb regeneration in the axolotl (Ambystoma mexicanum). Dev Growth Differ. 2010 Dec; 52(9):785-98.
12. Menger B, Reimers K, Kuhbier J W, Vogt PM. Lessons from the Mexican axolotl: amphibian limb regeneration and its impact on plastic surgery. Plast Reconstr Surg. 2010 Jun; 125(6):260e-1e.
13. Satoh A, Cummings GM, Bryant SV, Gardiner DM. Neurotrophic regulation of fibroblast dedifferentiation during limb skeletal regeneration in the axolotl (Ambystoma mexicanum). Dev Biol. 2010 Jan 15;337(2):444-57.
14. Satoh A, James MA, Gardiner DM. The role of nerve signaling in limb genesis and agenesis during axolotl limb regeneration. J Bone Joint Surg Am. 2009 Jul; 91 Suppl 4:90-8.
15. Kragl M, Knapp D, Nacu E, Khattak S, Maden M, Epperlein HH, et al. Cells keep a memory of their tissue origin during axolotl limb regeneration. Nature. 2009 Jul. 2;460(7251):60-5.
16. Satoh A, Graham GM, Bryant S V, Gardiner DM. Neurotrophic regulation of epidermal dedifferentiation during wound healing and limb regeneration in the axolotl (Ambystoma mexicanum). Dev Biol. 2008 Jul. 15;319(2):321-35.
17. Brown LM, Rannels SR, Rannels DE. Implications of post-pneumonectomy compensatory lung growth in pulmonary physiology and disease. Respir Res. 2001;2(6):340-7.
18. Voswinckel R, Motejl V, Fehrenbach A, Wegmann M, Mehling T, Fehrenbach H, et al. Characterisation of post-pneumonectomy lung growth in adult mice. Eur Respir J. 2004 Oct; 24(4):524-32.
19. Ravikumar P, Yilmaz C, Dane DM, Johnson RL, Jr., Estrera AS, Hsia CC. Developmental signals do not further accentuate nonuniform postpneumonectomy compensatory lung growth. J Appl Physiol. 2007 Mar; 102(3):1170-7.
20. Konerding MA, Gibney BC, Houdek JP, Chamoto K, Ackermann M, Lee GS, et al. Spatial dependence of alveolar angiogenesis in postpneumonectomy lung growth. Angiogenesis. 2012 Mar; 15(1):23-32.
21. Fehrenbach H, Voswinckel R, Michl V, Mehling T, Fehrenbach A, Seeger W, et al. Neoalveolarization contributes to compensatory lung growth following pneumonectomy in mice. Eur Respir J. 2007 Nov. 21.
22. Foster DJ, Yan X, Bellotto DJ, Moe O W, Hagler HK, Estrera AS, et al. Expression of epidermal growth factor and surfactant proteins during postnatal and compensatory lung growth. Am J Physiol Lung Cell Mol Physiol. 2002 Nov; 283(5): L981-90.
23. Zhang L, Li T, Yu D, Forman BM, Huang W. FXR protects lung from lipopolysaccharide-induced acute injury. Mol Endocrinol. 2012 Jan; 26(1):27-36.
24. Kumar PA, Hu Y, Yamamoto Y, Hoe NB, Wei TS, Mu D, et al. Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection. Cell. 2011 Oct. 28;147(3):525-38.
25. Ishizawa K, Kubo H, Yamada M, Kobayashi S, Numasaki M, Ueda S, et al. Bone marrow-derived cells contribute to lung regeneration after elastaseinduced pulmonary emphysema. FEBS Lett. 2004 Jan 2;556(1-3):249-52.
26. Massaro D, Massaro GD, Baras A, Hoffman EP, Clerch LB. Calorie-related rapid onset of alveolar loss, regeneration, and changes in mouse lung gene expression. Am J Physiol Lung Cell Mol Physiol. 2004 May; 286(5): L896-906.
27. Lee JM, Kwon HJ, Bae SC, Jung HS. Lung tissue regeneration after induced injury in Runx3 KO mice. Cell Tissue Res. 2010 Sep; 341(3):465-70.
28. Hsia CC. Lessons from a canine model of compensatory lung growth. Curr Top Dev Biol. 2004;64:17-32.
29. Holmes C, Thurlbeck WM. Normal lung growth and response after pneumonectomy in rats at various ages. Am Rev Respir Dis. 1979 Nov; 120(5):1125-36.
30. Cagle PT, Thurlbeck WM. Postpneumonectomy compensatory lung growth. Am Rev Respir Dis. 1988 Nov; 138(5):1314-26.
31. Hoffman AM, Paxson JA, Mazan MR, Davis AM, Tyagi S, Murthy S, et al. Lung derived mesenchymal stromal cell post-transplantation survival, persistence, paracrine expression, and repair of elastase injured lung. Stem Cells Dev. 2011 May 17.
32. Paxson JA, Gruntman A, Parkin CD, Mazan MR, Davis A, Ingenito E P, et al. Age-dependent decline in mouse lung regeneration with loss of lung fibroblast clonogenicity and increased myofibroblastic differentiation. PLoS One. 2011;6(8):e23232.
33. Hoffman AM, Shifren A, Mazan MR, Gruntman AM, Lascola KM, Nolen-Walston RD, et al. Matrix modulation of compensatory lung regrowth and progenitor cell proliferation in mice. Am J Physiol Lung Cell Mol Physiol. 2010 Feb; 298(2): L158-68.
34. Nolen-Waltson R. D. KCF, Mazan M. R., Ingenito E. P., Gruntman A. M., Tsai L., Boston R., Woolfenden A. E., Jacks T., and Hoffman A. M., Cellular kinetics and modeling of bronchioalveolar stem cell response during lung regeneration. Am J Physiol Lung Cell Mol Physiol. 2008 March 28;294:L1158-65.
35. Brody JS, Burki R, Kaplan N. Deoxyribonucleic acid synthesis in lung cells during compensatory lung growth after pneumonectomy. Am Rev Respir Dis. 1978 Feb; 117(2):307-16.
36. Simnett JD, Fisher JM. Cell division and tissue repair following localized damage to the mammalian lung. J Morphol. 1976 Feb; 148(2):177-84.
37. Rannels SR, Rannels DE. Alterations in type II pneumocytes cultured after partial pneumonectomy. Am J Physiol. 1988 May; 254(5 Pt 1):C684-90.
38. Sakurai MK, Lee S, Arsenault DA, Nose V, Wilson JM, Heymach JV, et al. Vascular endothelial growth factor accelerates compensatory lung growth after unilateral pneumonectomy. Am J Physiol Lung Cell Mol Physiol. 2007 Mar; 292(3): L742-7.
39. Voswinckel R, Ziegelhoeffer T, Heil M, Kostin S, Breier G, Mehling T, et al. Circulating vascular progenitor cells do not contribute to compensatory lung growth. Circ Res. 2003 Aug. 22;93(4):372-9.
40. Paxson JA, Parkin CD, Iyer LK, Mazan MR, Ingenito EP, Hoffman AM. Global gene expression patterns in the post-pneumonectomy lung of adult mice. Respir Res. 2009;10:92.
41. Chamoto K, Gibney BC, Ackermann M, Lee GS, Lin M, Konerding MA, et al. Alveolar macrophage dynamics in murine lung regeneration. J Cell Physiol. 2011 Nov. 21.
42. Kim CF, Jackson EL, Woolfenden AE, Lawrence S, Babar I, Vogel S, et al. Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell. 2005 Jun. 17;121(6):823-35.
43. Nolen-Walston RD, Kim CF, Mazan MR, Ingenito E P, Gruntman AM, Tsai L, et al. Cellular kinetics and modeling of bronchioalveolar stem cell response during lung regeneration. Am J Physiol Lung Cell Mol Physiol. 2008 Jun; 294(6): L1158-65.
44. Rawlins EL, Okubo T, Xue Y, Brass DM, Auten RL, Hasegawa H, et al. The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium. Cell Stem Cell. 2009 Jun. 5;4(6):525-34.
45. Nolen-Walston RD, Kim CF, Mazan MR, Ingenito EP, Gruntman AM, Tsai L, et al. Cellular kinetics and modeling of bronchioalveolar stem cell response during lung regeneration. Am J Physiol Lung Cell Mol Physiol. 2008 Mar. 28.
46. Evans MJ, Cabral LJ, Stephens RJ, Freeman G. Renewal of alveolar epithelium in the rat following exposure to NO2. Am J Pathol. 1973 Feb; 70(2):175-98.
47. Rock JR, Barkauskas CE, Cronce MJ, Xue Y, Harris JR, Liang J, et al. Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition. Proc Natl Acad Sci U S A. 2011 Dec. 27;108(52):E1475-83.
48. McQualter JL, Yuen K, Williams B, Bertoncello I. Evidence of an epithelial stem/progenitor cell hierarchy in the adult mouse lung. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1414-9.
49. McQualter JL, Brouard N, Williams B, Baird BN, Sims-Lucas S, Yuen K, et al. Endogenous fibroblastic progenitor cells in the adult mouse lung are highly enriched in the sca-1 positive cell fraction. Stem Cells. 2009 Mar; 27(3):623-33.
50. Ding BS, Nolan DJ, Guo P, Babazadeh AO, Cao Z, Rosenwaks Z, et al. Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization. Cell. 2011 Oct. 28;147(3):539-53.
51. Chapman HA, Li X, Alexander JP, Brumwell A, Lorizio W, Tan K, et al. Integrin alpha6beta4 identifies an adult distal lung epithelial population with regenerative potential in mice. J Clin Invest. 2011 Jul; 121(7):2855-62.
52. Ghosh M, Helm KM, Smith RW, Giordanengo MS, Li B, Shen H, et al. A single cell functions as a tissue-specific stem cell and the in vitro nicheforming cell. Am J Respir Cell Mol Biol. 2011 Sep; 45(3):459-69.
53. Croagh D, Phillips WA, Redvers R, Thomas RJ, Kaur P. Identification of candidate murine esophageal stem cells using a combination of cell kinetic studies and cell surface markers. Stem Cells. 2007 Feb; 25(2):313-8.
54. Terunuma A, Kapoor V, Yee C, Telford WG, Udey MC, Vogel JC. Stem cell activity of human side population and alpha6 integrin-bright keratinocytes defined by a quantitative in vivo assay. Stem Cells. 2007 Mar; 25(3):664-9.
55. Flanagan LA, Rebaza LM, Derzic S, Schwartz PH, Monuki ES. Regulation of human neural precursor cells by laminin and integrins. J Neurosci Res. 2006 Apr; 83(5):845-56.
56. Lung stem cells: looking beyond the hype. Nat Med. 2011 Jul; 17(7):788-9.
57. Downs CA, Montgomery DW, Merkle CJ. Cell culture models using rat primary alveolar type I cells. Pulm Pharmacol Ther. 2011 Oct; 24(5):577-86.
58. Wang S, Hubmayr RD. Type I alveolar epithelial phenotype in primary culture. Am J Respir Cell Mol Biol. 2011 May; 44(5):692-9.
59. Dobbs LG, Johnson MD, Vanderbilt J, Allen L, Gonzalez R. The great big alveolar TI cell: evolving concepts and paradigms. Cell Physiol Biochem. 2010;25(1):55-62.
60. Gonzalez RF, Allen L, Dobbs LG. Rat alveolar type I cells proliferate, express OCT-4, and exhibit phenotypic plasticity in vitro. Am J Physiol Lung Cell Mol Physiol. 2009 Dec; 297(6): L1045-55.
61. Delgado O, Kaisani AA, Spinola M, Xie XJ, Batten KG, Minna JD, et al. Multipotent capacity of immortalized human bronchial epithelial cells. PLoS One. 2011;6(7):e22023.
62. Ling T Y, Kuo MD, Li CL, Yu AL, Huang YH, Wu TJ, et al. Identification of pulmonary Oct-4+ stem/progenitor cells and demonstration of their susceptibility to SARS coronavirus (SARS-CoV) infection in vitro. Proc Natl Acad Sci U S A. 2006 Jun. 20;103(25):9530-5.
63. Hegab AE, Kubo H, Fujino N, Suzuki T, He M, Kato H, et al. Isolation and characterization of murine multipotent lung stem cells. Stem Cells Dev. 2010 Apr; 19(4):523-36.
64. Fujino N, Kubo H, Suzuki T, Ota C, Hegab AE, He M, et al. Isolation of alveolar epithelial type II progenitor cells from adult human lungs. Lab Invest. 2011 Mar; 91(3):363-78.