메뉴 건너뛰기




Volumn 70, Issue 6, 2012, Pages 861-873

Fixed-dose rate infusion and standard rate infusion of gemcitabine in patients with advanced non-small-cell lung cancer: A meta-analysis of six trials

Author keywords

Fixed dose rate; Gemcitabine; Non small cell lung cancer; Toxicities

Indexed keywords

CARBOPLATIN; CISPLATIN; GEMCITABINE; ROFECOXIB;

EID: 84871252027     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-012-1974-z     Document Type: Article
Times cited : (10)

References (35)
  • 2
    • 0028843552 scopus 로고
    • Chemotherapy in non-small cell lung cancer: A meta-analysis using updated data on individual patients from 52 randomized clinical trials
    • Non-small Cell Lung Cancer Collaborative Group
    • Alberti W (1995) Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomized clinical trials. Non-small Cell Lung Cancer Collaborative Group. BMJ 311(7010):899-909
    • (1995) BMJ , vol.311 , Issue.7010 , pp. 899-909
    • Alberti, W.1
  • 3
    • 0345148774 scopus 로고    scopus 로고
    • Randomized phase III study of gemcitabine-cisplatin versus etoposide- cisplatin in the treatment of locally advanced or metastatic non-small-cell lung cancer
    • Cardenal F, López-Cabrerizo MP, Antón A et al (1999) Randomized phase III study of gemcitabine-cisplatin versus etoposide- cisplatin in the treatment of locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 17(1):12-18
    • (1999) J Clin Oncol , vol.17 , Issue.1 , pp. 12-18
    • Cardenal, F.1    López-Cabrerizo, M.P.2    Antón, A.3
  • 5
    • 0346560025 scopus 로고    scopus 로고
    • Three-arm randomized study of two cisplatin- based regimens and paclitaxel plus gemcitabine in advanced non-small-cell lung cancer: A phase III trial of the European Organization for Research and Treatment of Cancer Lung Cancer Group-EORTC 08975
    • Smit EF, van Meerbeeck JP, Lianes P, Debruyne C, Legrand C, Schramel F, Smit H, Gaafar R, Biesma B, Manegold C, Neymark N, Giaccone G (2003) Three-arm randomized study of two cisplatin- based regimens and paclitaxel plus gemcitabine in advanced non-small-cell lung cancer: a phase III trial of the European Organization for Research and Treatment of Cancer Lung Cancer Group-EORTC 08975. J Clin Oncol 21(21):3909-3917
    • (2003) J Clin Oncol , vol.21 , Issue.21 , pp. 3909-3917
    • Smit, E.F.1    Van Meerbeeck, J.P.2    Lianes, P.3    Debruyne, C.4    Legrand, C.5    Schramel, F.6    Smit, H.7    Gaafar, R.8    Biesma, B.9    Manegold, C.10    Neymark, N.11    Giaccone, G.12
  • 7
    • 33847276516 scopus 로고    scopus 로고
    • Randomized phase III study of cisplatin plus irinotecan versus carboplatin plus paclitaxel, cisplatin plus gemcitabine, and cisplatin plus vinorelbine for advanced non-small-cell lung cancer: Four-arm cooperative study in Japan
    • Ohe Y, Ohashi Y, Kubota K, Tamura T, Nakagawa K, Negoro S, Nishiwaki Y, Saijo N, Ariyoshi Y, Fukuoka M (2007) Randomized phase III study of cisplatin plus irinotecan versus carboplatin plus paclitaxel, cisplatin plus gemcitabine, and cisplatin plus vinorelbine for advanced non-small-cell lung cancer: four-arm cooperative study in Japan. Ann Oncol 18(2):317-323
    • (2007) Ann Oncol , vol.18 , Issue.2 , pp. 317-323
    • Ohe, Y.1    Ohashi, Y.2    Kubota, K.3    Tamura, T.4    Nakagawa, K.5    Negoro, S.6    Nishiwaki, Y.7    Saijo, N.8    Ariyoshi, Y.9    Fukuoka, M.10
  • 9
    • 33747607482 scopus 로고    scopus 로고
    • Non-small cell lung cancer clinical practice guidelines in oncology
    • Ettinger DS, Bepler G, Bueno R et al (2006) Non-small cell lung cancer clinical practice guidelines in oncology. J Natl Compr Canc Netw 4(6):548-582
    • (2006) J Natl Compr Canc Netw , vol.4 , Issue.6 , pp. 548-582
    • Ettinger, D.S.1    Bepler, G.2    Bueno, R.3
  • 10
    • 0023783698 scopus 로고    scopus 로고
    • Comparison of the cellular pharmacokinetics and toxicity of 20,20- difluorodeoxycytidine and 1-D-arabinofuranosylcytosine
    • Heinemann V, Hertel LW, Grindey GB, Plunkett W (1998) Comparison of the cellular pharmacokinetics and toxicity of 20,20- difluorodeoxycytidine and 1-D-arabinofuranosylcytosine. Cancer Res 48(14):4024-4031
    • (1998) Cancer Res , vol.48 , Issue.14 , pp. 4024-4031
    • Heinemann, V.1    Hertel, L.W.2    Grindey, G.B.3    Plunkett, W.4
  • 12
    • 0029060757 scopus 로고
    • Fludarabine and gemcitabineinduced apoptosis: Incorporation of analogs into DNA is a critical event
    • Huang P, Plunkett W (1995) Fludarabine and gemcitabineinduced apoptosis: incorporation of analogs into DNA is a critical event. Cancer Chemother Pharmacol 36(3):181-188
    • (1995) Cancer Chemother Pharmacol , vol.36 , Issue.3 , pp. 181-188
    • Huang, P.1    Plunkett, W.2
  • 13
    • 0025089191 scopus 로고
    • Pharmacologically directed design of the dose rate and schedule of 2,2-difluorodeoxycytidine (Gemcitabine) administration in leukemia
    • Grunewald R, Kantarjian H, Keating MJ, Abbruzzese J, Tarassoff P, Plunkett W (1990) Pharmacologically directed design of the dose rate and schedule of 2,2-difluorodeoxycytidine (Gemcitabine) administration in leukemia. Cancer Res 50(21):6823-6826
    • (1990) Cancer Res , vol.50 , Issue.21 , pp. 6823-6826
    • Grunewald, R.1    Kantarjian, H.2    Keating, M.J.3    Abbruzzese, J.4    Tarassoff, P.5    Plunkett, W.6
  • 14
    • 0142121290 scopus 로고    scopus 로고
    • Randomized phase II comparison of dose-intense gemcitabine: Thirty-minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma
    • Tempero M, Plunkett W, Ruiz Van Haperen V, Hainsworth J, Hochster H, Lenzi R, Abbruzzese J (2003) Randomized phase II comparison of dose-intense gemcitabine: thirty-minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma. J Clin Oncol 21(18):3402-3408
    • (2003) J Clin Oncol , vol.21 , Issue.18 , pp. 3402-3408
    • Tempero, M.1    Plunkett, W.2    Ruiz Van Haperen, V.3    Hainsworth, J.4    Hochster, H.5    Lenzi, R.6    Abbruzzese, J.7
  • 16
    • 33747780795 scopus 로고    scopus 로고
    • A randomized phase II trial evaluating standard (50 mg/min) versus low (10 mg/min) infusion duration of gemcitabine as first-line treatment in advanced non-small-cell lung cancer patients who are not eligible for platinum-based chemotherapy
    • Cappuzzo F, Novello S, De Marinis F, Selvaggi G, Scagliotti GV, Barbieri F, Maur M, Papi M, Pasquini E, Bartolini S, Marini L, Crino (2006) A randomized phase II trial evaluating standard (50 mg/min) versus low (10 mg/min) infusion duration of gemcitabine as first-line treatment in advanced non-small-cell lung cancer patients who are not eligible for platinum-based chemotherapy. Lung Cancer 52(3):319-325
    • (2006) Lung Cancer , vol.52 , Issue.3 , pp. 319-325
    • Cappuzzo, F.1    Novello, S.2    De Marinis, F.3    Selvaggi, G.4    Scagliotti, G.V.5    Barbieri, F.6    Maur, M.7    Papi, M.8    Pasquini, E.9    Bartolini, S.10    Marini, L.11    Crino12
  • 17
    • 33745601697 scopus 로고    scopus 로고
    • A multicentre randomised phase II study of carboplatin in combination with gemcitabine at standard rate or fixed dose rate infusion in patients with advanced stage non-small-cell lung cancer
    • Soo RA, Wang LZ, Tham LS, Yong WP, Boyer M, Lim HL, Lee HS, Millward M, Liang S, Beale P, Lee SC, Goh BC (2006) A multicentre randomised phase II study of carboplatin in combination with gemcitabine at standard rate or fixed dose rate infusion in patients with advanced stage non-small-cell lung cancer. Ann Oncol 17(7):1128-1133
    • (2006) Ann Oncol , vol.17 , Issue.7 , pp. 1128-1133
    • Soo, R.A.1    Wang, L.Z.2    Tham, L.S.3    Yong, W.P.4    Boyer, M.5    Lim, H.L.6    Lee, H.S.7    Millward, M.8    Liang, S.9    Beale, P.10    Lee, S.C.11    Goh, B.C.12
  • 18
    • 34249320128 scopus 로고    scopus 로고
    • Factorial phase III randomised trial of rofecoxib and prolonged constant infusion of gemcitabine in advanced non-small-cell lung cancer: The GEmcitabine- COxib in NSCLC (GECO) study
    • Gridelli C, Gallo C, Ceribelli A et al (2007) Factorial phase III randomised trial of rofecoxib and prolonged constant infusion of gemcitabine in advanced non-small-cell lung cancer: the GEmcitabine- COxib in NSCLC (GECO) study. Lancet Oncol 8(6): 500-512
    • (2007) Lancet Oncol , vol.8 , Issue.6 , pp. 500-512
    • Gridelli, C.1    Gallo, C.2    Ceribelli, A.3
  • 19
    • 34447532355 scopus 로고    scopus 로고
    • Phase II study of gemcitabine and carboplatin in patients with advanced non-small-cell lung cancer
    • Wang LR, Huang MZ, Zhang GB, Xu N, Wu XH (2007) Phase II study of gemcitabine and carboplatin in patients with advanced non-small-cell lung cancer. Cancer Chemother Pharmacol 60(4): 601-607
    • (2007) Cancer Chemother Pharmacol , vol.60 , Issue.4 , pp. 601-607
    • Wang, L.R.1    Huang, M.Z.2    Zhang, G.B.3    Xu, N.4    Wu, X.H.5
  • 20
    • 34548514268 scopus 로고    scopus 로고
    • Gemcitabine administered as a short infusion versus a fixed dose rate in combination with cisplatin for the treatment of patients with advanced non-small cell lung cancer
    • Pereira JR, Fein L, Del Giglio A, Blajman CR, Richardet E, Schwartsmann G, Orlando M, Hall BJ, West TM, van Kooten M (2007) Gemcitabine administered as a short infusion versus a fixed dose rate in combination with cisplatin for the treatment of patients with advanced non-small cell lung cancer. Lung Cancer 58(1):80-87
    • (2007) Lung Cancer , vol.58 , Issue.1 , pp. 80-87
    • Pereira, J.R.1    Fein, L.2    Del Giglio, A.3    Blajman, C.R.4    Richardet, E.5    Schwartsmann, G.6    Orlando, M.7    Hall, B.J.8    West, T.M.9    Van Kooten, M.10
  • 21
    • 34447309352 scopus 로고    scopus 로고
    • Comparison of pharmacokinetics, efficacy and toxicity profile of gemcitabine using two different administration regimens in Chinese patients with non-small-cell lung cancer
    • Wang LR, Liu J, Huang MZ, Xu N (2007) Comparison of pharmacokinetics, efficacy and toxicity profile of gemcitabine using two different administration regimens in Chinese patients with non-small-cell lung cancer. J Zhejiang Univ Sci B 8(5): 307-313
    • (2007) J Zhejiang Univ Sci B , vol.8 , Issue.5 , pp. 307-313
    • Wang, L.R.1    Liu, J.2    Huang, M.Z.3    Xu, N.4
  • 25
    • 34248396059 scopus 로고    scopus 로고
    • The efficacy and relationship between peak concentration and toxicity profile of fixed-dose-rate gemcitabine plus carboplatin in patients with advanced non-small-cell lung cancer
    • Wang L, Wu X, Huang M, Cai J, Xu N, Liu J (2007) The efficacy and relationship between peak concentration and toxicity profile of fixed-dose-rate gemcitabine plus carboplatin in patients with advanced non-small-cell lung cancer. Cancer Chemother Pharmacol 60(2):211-218
    • (2007) Cancer Chemother Pharmacol , vol.60 , Issue.2 , pp. 211-218
    • Wang, L.1    Wu, X.2    Huang, M.3    Cai, J.4    Xu, N.5    Liu, J.6
  • 27
    • 0026101039 scopus 로고
    • Saturation of 20,20-difluorodeoxycytidine 50-triphosphate accumulation by mononuclear cells during a phase i trial of gemcitabine
    • Grunewald R, Abbruzzese JL, Tarassoff P, Plunkett W (1991) Saturation of 20,20-difluorodeoxycytidine 50-triphosphate accumulation by mononuclear cells during a phase I trial of gemcitabine. Cancer Chemother Pharmacol 27(4):258-262
    • (1991) Cancer Chemother Pharmacol , vol.27 , Issue.4 , pp. 258-262
    • Grunewald, R.1    Abbruzzese, J.L.2    Tarassoff, P.3    Plunkett, W.4
  • 28
    • 0035424877 scopus 로고    scopus 로고
    • Phase II clinical investigation of gemcitabine in advanced soft tissue sarcomas and window evaluation of dose rate on gemcitabine accumulation
    • Patel SR, Gandhi V, Jenkins J, Papadopolous N, Burgess MA, Plager C, Plunkett W, Benjamin RS (2001) Phase II clinical investigation of gemcitabine in advanced soft tissue sarcomas and window evaluation of dose rate on gemcitabine accumulation. J Clin Oncol 19(15):3483-3489
    • (2001) J Clin Oncol , vol.19 , Issue.15 , pp. 3483-3489
    • Patel, S.R.1    Gandhi, V.2    Jenkins, J.3    Papadopolous, N.4    Burgess, M.A.5    Plager, C.6    Plunkett, W.7    Benjamin, R.S.8
  • 29
    • 73949094909 scopus 로고    scopus 로고
    • Randomized phase II study of gemcitabine administered at a fixed dose rate or in combination with cisplatin, docetaxel, or irinotecan in patients with metastatic pancreatic cancer: CALGB 89904
    • Kulke MH, Tempero MA, Niedzwiecki D, Hollis DR, Kindler HL, Cusnir M, Enzinger PC, Gorsch SM, Goldberg RM, Mayer RJ (2009) Randomized phase II study of gemcitabine administered at a fixed dose rate or in combination with cisplatin, docetaxel, or irinotecan in patients with metastatic pancreatic cancer: CALGB 89904. J Clin Oncol 27(33):5506-5512
    • (2009) J Clin Oncol , vol.27 , Issue.33 , pp. 5506-5512
    • Kulke, M.H.1    Tempero, M.A.2    Niedzwiecki, D.3    Hollis, D.R.4    Kindler, H.L.5    Cusnir, M.6    Enzinger, P.C.7    Gorsch, S.M.8    Goldberg, R.M.9    Mayer, R.J.10
  • 30
    • 68949114505 scopus 로고    scopus 로고
    • Phase III, randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed-dose rate infusion) compared with gemcitabine (30-minute infusion) in patients with pancreatic Carcinoma E6201: A trial of the Eastern Cooperative Oncology Group
    • Poplin E, Feng Y, Berlin J, Rothenberg ML, Hochster H, Mitchell E, Alberts S, O'Dwyer P, Haller D, Catalano P, Cella D, Benson AB (2009) Phase III, randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed-dose rate infusion) compared with gemcitabine (30-minute infusion) in patients with pancreatic Carcinoma E6201: a trial of the Eastern Cooperative Oncology Group. J Clin Oncol 27(23):3778-3785
    • (2009) J Clin Oncol , vol.27 , Issue.23 , pp. 3778-3785
    • Poplin, E.1    Feng, Y.2    Berlin, J.3    Rothenberg, M.L.4    Hochster, H.5    Mitchell, E.6    Alberts, S.7    O'Dwyer, P.8    Haller, D.9    Catalano, P.10    Cella, D.11    Benson, A.B.12
  • 32
    • 69549116226 scopus 로고    scopus 로고
    • Gemcitabine in brief versus prolonged low-dose infusion, both combined with cisplatin, for advanced non-small cell lung cancer: A randomized phase II clinical trial
    • Zwitter M, Kovac V, Smrdel U, Vrankar M, Zadnik V (2009) Gemcitabine in brief versus prolonged low-dose infusion, both combined with cisplatin, for advanced non-small cell lung cancer: a randomized phase II clinical trial. J Thorac Oncol 4(9):1148-1155
    • (2009) J Thorac Oncol , vol.4 , Issue.9 , pp. 1148-1155
    • Zwitter, M.1    Kovac, V.2    Smrdel, U.3    Vrankar, M.4    Zadnik, V.5
  • 33
    • 84855210829 scopus 로고    scopus 로고
    • A phase II trial of low-dose gemcitabine in a prolonged infusion and cisplatin for malignant pleural mesothelioma
    • Kovac V, Zwitter M, Rajer M, Marin A, Debeljak A, Smrdel U, Vrankar M (2012) A phase II trial of low-dose gemcitabine in a prolonged infusion and cisplatin for malignant pleural mesothelioma. Anticancer Drugs 23(2):230-238
    • (2012) Anticancer Drugs , vol.23 , Issue.2 , pp. 230-238
    • Kovac, V.1    Zwitter, M.2    Rajer, M.3    Marin, A.4    Debeljak, A.5    Smrdel, U.6    Vrankar, M.7
  • 34
    • 0034823867 scopus 로고    scopus 로고
    • Funnel plots for detecting bias in meta-analysis: Guidelines on choice of axis
    • Sterne JA, Egger M (2001) Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J Clin Epidemiol 54(10):1046-1055
    • (2001) J Clin Epidemiol , vol.54 , Issue.10 , pp. 1046-1055
    • Sterne, J.A.1    Egger, M.2
  • 35
    • 49049089802 scopus 로고    scopus 로고
    • Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer
    • Scagliotti GV, Parikh P, von Pawel J et al (2008) Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol 26(21):3543-3551
    • (2008) J Clin Oncol , vol.26 , Issue.21 , pp. 3543-3551
    • Scagliotti, G.V.1    Parikh, P.2    Von Pawel, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.