Molecular Sex Differences in Human Serum

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Ramsey, Jordan M ^a   Schwarz, Emanuel ^a   Guest, Paul C ^a   van Beveren, Nico J M ^b   Leweke, F Markus ^c,d   Rothermundt, Matthias ^e   Bogerts, Bernhard ^f   Steiner, Johann ^f   Ruta, Liliana ^g   Baron Cohen, Simon ^g   Bahn, Sabine ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF COLOGNE   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e UNIVERSITY OF MÜNSTER   (Germany)

^f OTTO VON GUERICKE UNIVERSITY   (Germany)

^g UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; ASPERGER SYNDROME; BLOOD ANALYSIS; CELL ACTIVATION; CELL DEATH; CELL GROWTH; CHEMOTAXIS; CLINICAL ARTICLE; CLUSTER ANALYSIS; COHORT ANALYSIS; CONTROLLED STUDY; FATTY ACID OXIDATION; FEMALE; HORMONAL REGULATION; HUMAN; IMMUNE RESPONSE; IMMUNOASSAY; IMMUNOCOMPETENT CELL; MALE; METABOLISM; NUCLEOTIDE SEQUENCE; REPRODUCIBILITY; SEX DIFFERENCE; UNINDEXED SEQUENCE;

ADULT; ASPERGER SYNDROME; CLUSTER ANALYSIS; FEMALE; GENE REGULATORY NETWORKS; HUMANS; MALE; META-ANALYSIS AS TOPIC; MIDDLE AGED; PRINCIPAL COMPONENT ANALYSIS; SERUM; SEX CHARACTERISTICS; YOUNG ADULT;

EID: 84871236669     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051504     Document Type: Article

References (50)

1. Pelfrey CM, (2001) Sexual dimorphism in autoimmunity?: a focus on Th1/Th2 cytokines and multiple sclerosis. Clin Appl Immunol Rev 1: 331-345.
2. Miller VM, (2012) Family matters: sexual dimorphism in cardiovascular disease. Lancet 379: 873-875 doi:10.1016/S0140-6736(12)60200-1.
3. Czlonkowska A, Ciesielska A, Gromadzka G, (2006) Gender Differences in Neurological Disease. Endocrine 29: 243-256.
4. Tingen CM, Kim AM, Wu P-H, Woodruff TK, (2010) Sex and sensitivity: the continued need for sex-based biomedical research and implementation. Women's Health 6: 511-516 doi:10.2217/whe.10.45.
5. Verthelyi D, (2001) Sex hormones as immunomodulators in health and disease. Int Immunopharmacol 1: 983-993.
6. Mahr S, Menard J, Krenn V, Muller B, (2003) Sexual dimorphism in the osteoarthritis of STR/ort mice may be linked to articular cytokines. Ann Rheum Dis 62: 1234-1237 doi:10.1136/ard.2002.005041.
7. Denton K, Baylis C, (2007) Physiological and molecular mechanisms governing sexual dimorphism of kidney, cardiac, and vascular function. Am J Physiol Regul Integr Comp Physiol 292: R697-R699 doi:10.1152/ajpregu.00766.2006.
8. Penaloza C, Estevez B, Orlanski S, Sikorska M, Walker R, et al. (2009) Sex of the cell dictates its response: differential gene expression and sensitivity to cell death inducing stress in male and female cells. FASEB J 23: 1869-1879 doi:10.1096/fj.08-119388.
9. Vamvakopoulos NV, (1995) Sexual dimorphism of stress response and immune/inflammatory reaction: the corticotropin releasing hormone perspective. Mediators Inflammation 4: 163-174.
10. Thangavel C, Shapiro BH, (2007) A molecular basis for the sexually dimorphic response to growth hormone. Endocrinology 148: 2894-2903 doi:10.1210/en.2006-1333.
11. Thorand B, Baumert J, Kolb H, Meisinger C, Chambless L, et al. (2007) Sex differences in the prediction of type 2 diabetes by inflammatory markers: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002. Diabetes Care 30: 854-860 doi:10.2337/dc06-1693.
12. Beasley LE, Koster A, Newman AB, Javaid MK, Ferrucci L, et al. (2009) Inflammation and race and gender differences in computerized tomography-measured adipose depots. Obesity 17: 1062-1069 doi:10.1038/oby.2008.627.
13. Wang M, Zhang W, Crisostomo P, Markel T, Meldrum KK, et al. (2007) Sex differences in endothelial STAT3 mediate sex differences in myocardial inflammation. Am J Physiol Endocrinol Metab 293: E872-E877 doi:10.1152/ajpendo.00251.2007.
14. Da Silva J, Larbre J, Seed M, Cutolo M, Villaggio B, et al. (1994) Sex differences in inflammation induced cartilage damage in rodents. The influence of sex steroids. J Rheumatol 21: 330-337.
15. Delaleu N, Immervoll H, Cornelius J, Jonsson R, (2008) Biomarker profiles in serum and saliva of experimental Sjögren's syndrome: associations with specific autoimmune manifestations. Arthritis Res Ther 10: R22 doi:10.1186/ar2375.
16. Umstead TM, Lu C-jung K, Freeman WM, Myers JL, Clark JB, et al. (2012) The kinetics of cardiopulmonary bypass: a dual-platform proteomics study of plasma biomarkers in pediatric patients undergoing cardiopulmonary bypass. Artif Organs 36: E1-E20 doi:10.1111/j.1525-1594.2011.01412.x.
17. Kang K, Schmahl J, Lee J-M, Garcia K, Patil K, et al. (2012) Mouse ghrelin-O-acyltransferase (GOAT) plays a critical role in bile acid reabsorption. FASEB J 26: 259-271 doi:10.1096/fj.11-191460.
18. Schwarz E, Guest PC, Rahmoune H, Harris LW, Wang L, et al. (2012) Identification of a biological signature for schizophrenia in serum. Mol Psychiatry 17: 494-502 doi:10.1038/mp.2011.42.
19. Bertenshaw GP, Yip P, Seshaiah P, Zhao J, Chen T-H, et al. (2008) Multianalyte profiling of serum antigens and autoimmune and infectious disease molecules to identify biomarkers dysregulated in epithelial ovarian cancer. Cancer Epidemiol Biomarkers Prev 17: 2872-2881 doi:10.1158/1055-9965.EPI-08-0464.
20. Ghobrial IM, Munshi NC, Harris BN, Shi P, Porter NM, et al. (2011) A phase I safety study of enzastaurin plus bortezomib in the treatment of relapsed or refractory multiple myeloma. Am J Hematol 86: 573-578 doi:10.1002/ajh.22048.
21. Baron-Cohen S, Lombardo MV, Auyeung B, Ashwin E, Chakrabarti B, et al. (2011) Why are autism spectrum conditions more prevalent in males? PLoS Biol 9: e1001081 doi:10.1371/journal.pbio.1001081.
22. Cliff N (1996) Alternatives to mean comparisons. In: Ordinal methods for behavioral data analysis. Mahwah: Lawrence Erlbaum Associates, Inc. 123-157.
23. Feng D, Cliff N, (2004) Monte Carlo evaluation of ordinal d with improved confidence interval. J Mod App Stat Meth 3: 322-332.
24. Kromrey JD, Hogarty KY, Ferron JM, Hines CV, Hess MR, et al. (2005) Robustness in meta-analysis: An empirical comparison of point and interval estimates of standardized mean differences and Cliff's delta. In: Joint Statistical Meetings. Minneapolis, MN.
25. Hess MR, Kromrey JD (2004) Robust confidence intervals for effect sizes: A comparative study of Cohen's d and Cliff's delta under non-normality and heterogeneous variances. In: Annual Meeting of the American Education Research Association. San Diego, CA.
26. Sutton A (2000) Methods for meta-analysis in medical research. Chichester: John Wiley & Sons Ltd. 317 p.
27. McMahon FJ, Akula N, Schulze TG, Muglia P, Tozzi F, et al. (2010) Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1. Nat Gen 42: 128-131 doi:10.1038/ng.523.
28. Chen DT, Jiang X, Akula N, Shugart YY, Wendland JR, et al. (2011) Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder. Mol Psychiatry: 1-11. doi:10.1038/mp.2011.157.
29. Fabricatore A, Wadden T, Higginbotham A, Faulconbridge L, Nguyen A, et al. (2011) Intentional weight loss and changes in symptoms of depression: a systematic review and meta-analysis. Int J Obes 35: 1363-1376 doi:10.1038/ijo.2011.2.
30. Wolin K, Yan Y, Colditz G, (2011) Physical activity and risk of colon adenoma: a meta-analysis. Br J Cancer 104: 882-885 doi:10.1038/sj.bjc.6606045.
31. Benjamini Y, Hochberg Y, (1995) Controlling the false discovery rate: A practical and powerful approach to multiple testing. J R Stat Soc Ser B Stat Methodol 57: 289-300.
32. Huang D, Sherman B, Lempicki R, (2009) Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 37: 1-13.
33. Huang D, Sherman B, Lempicki R, (2009) Systematic and integrative analysis of large gene lists using DAVID Bioinformatics Resources. Nat Protoc 4: 44-57.
34. Schwarz E, Guest PC, Rahmoune H, Wang L, Levin Y, et al. (2011) Sex-specific serum biomarker patterns in adults with Asperger's syndrome. Mol Psychiatry 16: 1213-1220 doi:10.1038/mp.2010.102.
35. Mittendorfer B, (2005) Sexual dimorphism in human lipid metabolism. J Nutr 135: 681-686.
36. McCullough A, (2002) Update on nonalcoholic fatty liver disease. J Clin Gastroenterol 34: 255-262.
37. Spitzer J, (1999) Gender differences in some host defense mechanisms. Lupus 8: 380-383.
38. Casimir GJ, Duchateau J, (2011) Gender differences in inflammatory processes could explain poorer prognosis for males. J Clin Microbiol 49: 478-479 doi:10.1128/JCM.02096-10.
39. Grossman C, (1989) Possible underlying mechanisms of sexual dimorphism in the immune response, fact and hypothesis. J Steroid Biochem 34: 241-251.
40. Nalbandian G, Kovats S, (2005) Estrogen, immunity & autoimmune disease. Curr Med Chem- Immun, Endoc & Metab Agents 5: 85-91 doi:10.2174/1568013053005418.
41. Cannon JG, St. Pierre B, (1997) Gender differences in host defense mechanisms. J Psychiat Res 31: 99-113.
42. Luster AD, Hospital MG (2001) Chemotaxis?: Role in immune response. Encyclopedia of Life Sciences: 1-12.
43. Fish EN, (2008) The X-files in immunity: Sex-based differences predispose immune responses. Nat Rev Immunol 8: 737-744.
44. Saltevo J, Kautiainen H, Vanhala M, (2009) Gender differences in adiponectin and low-grade inflammation among individuals with normal glucose tolerance, prediabetes, and type 2 diabetes. Gender Med 6: 463-470 doi:10.1016/j.genm.2009.09.006.
45. Devaraj S, Torok N, Dasu MR, Samols D, Jialal I, (2008) Adiponectin decreases C-reactive protein synthesis and secretion from endothelial cells: evidence for an adipose tissue-vascular loop. Arterioscler Throm Vas Biol 28: 1368-1374 doi:10.1161/ATVBAHA.108.163303.
46. Regitz-Zagrosek V, Lehmkuhl E, Weickert M, (2006) Gender differences in the metabolic syndrome and their role for cardiovascular disease. Clin Res Cardiol 95: 136-147 doi:10.1007/s00392-006-0351-5.
47. Saad F, Gooren LJ (2011) The role of testosterone in the etiology and treatment of obesity, the metabolic syndrome, and diabetes mellitus type 2. J Obes 2011. doi:10.1155/2011/471584.
48. Staprans I, Rapp JH, Pan XM, Ong DL, Feingold KR, (1990) Testosterone regulates metabolism of plasma chylomicrons in rats. Arterioscler Throm Vas Biol 10: 591-596 doi:10.1161/01.ATV.10.4.591.
49. von Eckardstein A, Kliesch S, Nieschlag E, Chirazi A, Assmann G, et al. (1997) Suppression of endogenous testosterone in young men increases serum levels of high density lipoprotein subclass lipoprotein A-I and lipoprotein(a)*. J Clin Endocrinol Metab 82: 3367-3372.
50. Lai M-C, Lombardo MV, Pasco G, Ruigrok ANV, Wheelwright SJ, et al. (2011) A behavioral comparison of male and female adults with high functioning autism spectrum conditions. PLoS ONE 6: e20835 doi:10.1371/journal.pone.0020835.