Fingolimod and multiple sclerosis: Four cautionary tales

Neurology

Volumn 79, Issue 19, 2012, Pages 1942-1943

  Bourdette, Dennis ^a,b,c   Gilden, Don ^d  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b MS Center of Excellence West   (United States)

^c PORTLAND VA MEDICAL CENTER   (United States)

^d UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FINGOLIMOD; NATALIZUMAB;

CHICKENPOX; COMORBIDITY; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE EXACERBATION; DISEASE SEVERITY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; EDITORIAL; ENCEPHALITIS; HERPES ZOSTER; HUMAN; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; MIXED INFECTION; MULTIPLE SCLEROSIS; NEUROPROTECTION; PRIORITY JOURNAL; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; TREATMENT DURATION; VARICELLA ZOSTER VIRUS; VIRUS ACTIVATION;

EID: 84871228180     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e3182735edf     Document Type: Editorial

References (12)

1. Pelletier D, Hafler DA. Fingolimod for multiple sclerosis. N Engl J Med 2012;366:339-347.
2. Centonze D, Rossi S, Rinaldi F, Gallo P. Severe relapses under fingolimod treatment prescribed after natalizumab. Neurology 2012;79:2004-2006.
3. Visser F, Wattjes MP, Pouwels PJW, Linssen WHJP, van Oosten BW. Tumefactive multiple sclerosis lesions under fingolimod treatment. Neurology 2012;79:2000-2002.
4. Gross CM, Baumgartner A, Rauer S, Stich O. Multiple sclerosis rebound following herpes zoster infection and suspension of fingolimod. Neurology 2012;79:2006-2007.
5. Ratchford JN, Costello K, Reich DS, Calabresi PA. Varicella-zoster virus encephalitis and vasculopathy in a patient treated with fingolimod. Neurology 2012;79: 2002-2004.
6. Miravalle A, Jensen R, Kinkel RP. Immune reconstitution inflammatory syndrome in patients with multiple sclerosis following cessation of natalizumab. Arch Neurol 2011;68: 186-191.
7. Castrop F, Kowarik MS, Albrecht H, et al. Severe multiple sclerosis relapse under fingolimod therapy: incident or coincidence? Neurology 2012;78:928-930.
8. Leypoldt F, Munchau A, Moeller F et al. Hemorrhaging focal encephalitis under fingolimod (FTY720) treatment: a case report. Neurology 2009;72:1022-1024.
9. Havia JB, Pellkofer HL, Meini L, et al. Rebound of disease activity after withdrawal of fingolimod (FTY720) treatment. Arch Neurol 2012;69:262-264.
10. Kappos L, Radue EW, O'Connor P, et al. A placebocontrolled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med 2010;362:387-401.
11. Cohen JA, Barkhof F, Comi G, et al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med 2010;362:402-415.
12. Conzett KB, Kolm I, Jelcic I, et al. Melanoma occurring during treatment with fingolimod for multiple sclerosis: a case report. Arch Dermatol 2011;147:991-992.