Improvement of dissolution and bioavailability of Ginsenosides by hot melt extrusion and cogrinding

Drug Development and Industrial Pharmacy

Volumn 39, Issue 1, 2013, Pages 109-116

  Luo, Yanfei ^a   Xu, Lishuang ^a   Xu, Ming ^a   Tao, Xiaoguang ^a   Ai, Ruiting ^b   Tang, Xing ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b China National Center for Biotechnology Development   (China)

Author keywords

Bioavailability; Cogrinding; Dissolution; Ginsenosides; Hot melt extrusion

Indexed keywords

20 PROTOPANAXADIOL; 20 PROTOPANAXATRIOL; DODECYL SULFATE SODIUM; GINSENOSIDE; PANAXSAPONIN RG1; PHOSPHOLIPID; SAPONIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; CHEMICAL COMPOSITION; COGRINDING; CONTROLLED STUDY; DISPERSION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG SOLUBILITY; DRUG STABILITY; FEMALE; GRINDING; HOT MELT EXTRUSION; IN VITRO STUDY; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PARTICLE SIZE; PELLET EXTRUSION; SINGLE DRUG DOSE; SOLID DISPERSION; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; BIOLOGICAL AVAILABILITY; DOGS; DRUG COMPOUNDING; FEMALE; GINSENOSIDES; HOT TEMPERATURE; MALE; SOLUBILITY;

EID: 84871203333     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2012.659189     Document Type: Article

References (25)

1. Mizuno M, Yamada J, Terai H, Kozukue N, Lee YS, Tsuchida H. (1994). Differences in immunomodulating effect between wild and cultured panax ginseng. Biochem Biophys Res Commun, 200:1672-1678. (Pubitemid 24181845)
2. Kim HS, Lee JH, Goo YS, Nah SY. (1998). Effects of ginsenosides on Ca2+ channels and membrane capacitance in rat adrenal chromaffin cells. Brain Res Bull, 46:245-251.
3. Ro JY, Ahn YS, Kim KH. (1998). Inhibitory effect of ginsenoside on the mediator release in the guinea pig lung mast cells activated by specific antigen-Antibody reactions. Int J Immunopharmacol, 20:625-641. (Pubitemid 28535146)
4. Surh YJ, Na HK, Lee JY, Keum YS. (2001). Molecular mechanisms underlying anti-Tumor promoting activities of heat-Processed Panax ginseng C.A. Meyer. J Korean Med Sci, 16 Suppl:S38-S41.
5. Kaneko H, Nakanishi K. (2004). Proof of the mysterious efficacy of ginseng: Basic and clinical trials: Clinical effects of medical ginseng, korean red ginseng: Specifically, its anti-Stress action for prevention of disease. J Pharmacol Sci, 95:158-162. (Pubitemid 38899684)
6. Yue PY, Mak NK, Cheng YK, Leung KW, Ng TB, Fan DT et al. (2007). Pharmacogenomics and the Yin/Yang actions of ginseng: Anti-Tumor, angiomodulating and steroid-like activities of ginsenosides. Chin Med, 2:6.
7. Gang L, Zhenhua W, Yaxuan S, Ke L, Ziren W. (2006). Ginsenoside 20(S)-Protopanaxadiol inhibits the proliferation and invasion of human fibrosarcoma HT1080 cells. Basic Clin Pharmacol Toxicol, 98:588-592.
8. Liu GY, Bu X, Yan H, Jia WW. (2007). 20S-Protopanaxadiolinduced programmed cell death in glioma cells through caspase-Dependent and -Independent pathways. J Nat Prod, 70:259-264. (Pubitemid 46447640)
9. Popovich DG, Kitts DD. (2004). Mechanistic studies on protopanaxadiol, Rh2, and ginseng (Panax quinquefolius) extract induced cytotoxicity in intestinal Caco-2 cells. J Biochem Mol Toxicol, 18:143-149. (Pubitemid 39069608)
10. Chen SE, Sawchuk RJ, Staba EJ. (1980). American ginseng III Pharmacokinetics of ginsenosides in the rabbit. Eur J Drug Metab Pharmacokinet, 5:161-168. (Pubitemid 11252888)
11. Hasegawa H, Sung JH, Benno Y. (1997). Role of human intestinal Prevotella oris in hydrolyzing ginseng saponins. Planta Med, 63:436-440. (Pubitemid 27399983)
12. Hasegawa H, Sung JH, Matsumiya S. (1996). Main ginseng saponin metabolites formed by intestinal bacteria. Planta Med, 62:453-457. (Pubitemid 26370341)
13. Kubo H, Osawa T, Takashima K, Mizobe M. (1996). Enhancement of oral bioavailability and pharmacological effect of 1-(3,4-Dimethoxyphenyl)-2,3- bis(methoxycarbonyl)-4-Hydroxy-6,7,8- Trimethoxynaphthalene (TA-7552), a new hypocholesterolemic agent, by micronization in co-Ground mixture with D-mannitol. Biol Pharm Bull, 19:741-747.
14. Martis L, Hall NA, Thakkar AL. (1972). Micelle formation and testosterone solubilization by sodium glycocholate. J Pharm Sci, 61:1757-1761.
15. Rees JA, Collett JH. (1974). The dissolution of salicylic acid in micellar solutions of polysorbate 20. J Pharm Pharmacol, 26:956-960.
16. Cassella R, Williams DA, Jambhekar SS. (1998). Solidstate-Cyclodextrin complexes containing indomethacin, ammonia and water. II. Solubility studies. Int J Pharm, 165:15-22. (Pubitemid 28218340)
17. Trapani G, Latrofa A, Franco M, Lopedota A, Maciocco E, Liso G. (1998). Water-Soluble salts of aminoacid esters of the anaesthetic agent propofol. Int J Pharm, 175:195-204. (Pubitemid 28517975)
18. Suleiman MS, Najib N, el-Sayed Y, Hasan M, Abdulahameed M. (1989). A study on the relative bioavailability of a sustainedrelease formulation of diclofenac sodium. Int J Clin Pharmacol Ther Toxicol, 27:276-279. (Pubitemid 19147147)
19. Dammann HG, Simon-Schultz J, Steinhoff I, Damaschke A, Schmoldt A, Sallowsky E. (1993). Differential effects of misoprostol and ranitidine on the pharmacokinetics of diclofenac and gastrointestinal symptoms. Br J Clin Pharmacol, 36:345-349. (Pubitemid 23303532)
20. Dhirendra K, Lewis S, Udupa N, Atin K. (2009). Solid dispersions: A review. Pak J Pharm Sci, 22:234-246.
21. Jennifer BD, Christos R. (2000). In vitro-In vivo correlations for lipophilic, poorly water-Soluble drugs. Eur J Pharm Sci, 2:73-80.
22. Paek IB, Moon Y, Kim J, Ji HY, Kim SA, Sohn DH et al. (2006). Pharmacokinetics of a ginseng saponin metabolite compound K in rats. Biopharm Drug Dispos, 27:39-45. (Pubitemid 43173973)
23. Bruce JA, Hiroshi S, Deborah LB, Shiew-Mei H, Shaker AM, Munir A. (1996). Hussain Enhancement of the intestinal absorption of peptides and nonpeptides. J Control Release, 41:19-31.
24. Kaus LC, Gillespie WR, Hussain AS, Amidon GL. (1999). The effect of in vivo dissolution, gastric emptying rate, and intestinal transit time on the peak concentration and area-under-The-Curve of drugs with different gastrointestinal permeabilities. Pharm Res, 16:272-280. (Pubitemid 29135133)
25. Meihua H, Jing C, Shilin C, Xiangtao W. (2010). Development of a UPLC-ESI-MS/MS Assay for 20(S)-Protopanaxadiol and Pharmacokinetic Application of Its Two Formulations in Rats. Anal Sci, 26:749-753.