Enhancement of oral bioavailability and pharmacological effect of 1-(3,4-dimethoxyphenyl)-2,3-bis(methoxycarbonyl)-4-hydroxy-6,7,8- trimethoxynaphthalene (TA-7552), a new hypocholesterolemic agent, by micronization in co-ground mixture with D-mannitol

Biological and Pharmaceutical Bulletin

Volumn 19, Issue 5, 1996, Pages 741-747

  Kubo, Hiroaki ^a   Osawa, Takashi ^a   Takashima, Kohki ^a   Mizobe, Masakazu ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Bioavailability; Co ground mixture; D mannitol; Hypocholesterolemic agent; Particle size; Sparingly water soluble drug

Indexed keywords

1 (3,4 DIMETHOXYPHENYL) 4 HYDROXY 6,7,8 TRIMETHOXY 2,3 NAPHTHALENEDICARBOXYLIC ACID DIMETHYL ESTER; CHOLESTEROL; HYPOCHOLESTEROLEMIC AGENT; MANNITOL; TA 7552; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG MIXTURE; HYPOCHOLESTEROLEMIA; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PARTICLE SIZE; POWDER; RAT;

ANIMALS; ANTICHOLESTEREMIC AGENTS; BIOLOGICAL AVAILABILITY; DOGS; INTESTINAL ABSORPTION; MALE; MANNITOL; NAPHTHOLS; POWDERS; SOLUBILITY; VEHICLES;

EID: 0029898991     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.19.741     Document Type: Article

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