Treatment with adjunctive N-acetylcysteine in an adolescent with selective serotonin reuptake inhibitor-resistant anxiety

Journal of Child and Adolescent Psychopharmacology

Volumn 22, Issue 6, 2012, Pages 472-473

  Strawn, Jeffrey R ^a   Saldaña, Shannon N ^b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b PRIMARY CHILDREN'S MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; FLUOXETINE; SEROTONIN UPTAKE INHIBITOR; SERTRALINE;

ADOLESCENT; CASE REPORT; CLINICAL FEATURE; CLINICAL GLOBAL IMPRESSION SCALE; COGNITIVE THERAPY; DRUG DOSE TITRATION; DRUG MEGADOSE; DRUG WITHDRAWAL; FEAR; GENERALIZED ANXIETY DISORDER; HUMAN; LETTER; MALE; MONOTHERAPY; PSYCHOTHERAPY; SOCIAL AVOIDANCE BEHAVIOR; SOCIAL BEHAVIOR; SOCIAL PHOBIA; TREATMENT OUTCOME; TREATMENT RESPONSE;

ACETYLCYSTEINE; ADOLESCENT; ANTIOXIDANTS; ANXIETY DISORDERS; DRUG THERAPY, COMBINATION; HUMANS; MALE; PHOBIC DISORDERS; SEROTONIN UPTAKE INHIBITORS; SERTRALINE; TREATMENT OUTCOME;

EID: 84871198759     PISSN: 10445463     EISSN: 15578992     Source Type: Journal    
DOI: 10.1089/cap.2012.0066     Document Type: Letter

References (7)

1. Grant JE, Odlaug BL, Kim SW: N-acetylcysteine, a glutamate modulator, in the treatment of trichotillomania: A double-blind, placebocontrolled study. Arch Gen Psychiatry 66:756-763, 2009.
2. Gray M, Carpenter MJ, Baker NL, Desantis SM, Kryway E, Hartwell KJ, McRae-Clark AL, Brady KT:A double-blind randomized controlled trial of N-acetylcysteine in cannabis-dependent adolescents. Am J Psychiatry 169:805-812, 2012.
3. Hardan AY, Fung LK, Libove RA, Obukhanych TV, Nair S, Herzenberg LA, Frazier TW, Tirouvanziam R:A randomized controlled pilot trial of oral N-acetylcysteine in children with autism. Biol Psychiatry71:956-961, 2012.
4. Lafleur DL, Pittenger C, Kelmendi B, Gardner T, Wasylink S, Malison RT, Sanacora G, Krystal JH, Coric V:N-acetylcysteine augmentation in serotonin reuptake inhibitor refractory obsessive-compulsive disorder. Psychopharmacology (Berl) 184:254-256, 2006. (Pubitemid 43084809)
5. Phan KL, Fitzgerald DA, Cortese BM, Seraji-Bozorgzad N, Tancer ME, Moore GJ: Anterior cingulate neurochemistry in social anxiety disorder: 1H-MRS at 4 Tesla. Neuroreport 16:183-186, 2005. (Pubitemid 40250397)
6. Strawn JR, Sakolsky DJ, Rynn MA: Psychopharmacologic treatment of children and adolescents with anxiety disorders. Child Adolesc Psychiatr Clin N Am 21:527-539, 2012.
7. Walkup JT, Albano AM, Piacentini J, Birmaher B, Compton SN, Sherrill JT, Ginsburg GS, Rynn MA, McCracken J, Waslick B, Iyengar S, March JS, Kendall PC: Cognitive behavioral therapy, sertraline, or a combination in childhood anxiety. N Engl J Med 359:2753-2766, 2008.