Production of 1,3-PDO and butanol by a mutant strain of Clostridium pasteurianum with increased tolerance towards crude glycerol

AMB Express

Volumn 2, Issue 1, 2012, Pages 1-7

  Jensen, Torbjørn Ølshøj ^a   Kvist, Thomas ^b   Mikkelsen, Marie Just ^b   Westermann, Peter ^a  

^a AALBORG UNIVERSITY   (Denmark)

^b Biogasol ApS   (Denmark)

Author keywords

Anaerobic fermentation; Biofuel; Chemical mutagenesis; Crude glycerol; Glycerol

Indexed keywords

1,3 PROPANEDIOL; ALCOHOL; BUTANOL; GLYCEROL;

ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BATCH FERMENTATION; CLOSTRIDIUM PASTEURIANUM; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MUTAGENESIS; NONHUMAN; REACTOR; TOXICITY TESTING;

EID: 84871171633     PISSN: None     EISSN: 21910855     Source Type: Journal    
DOI: 10.1186/2191-0855-2-44     Document Type: Article

References (38)

1. Annous BA, Blaschek HP (1991) Isolation and characterization of Clostridium acetobutylicum with enhanced amylolytic activity. Appl Environ Microbiol 57(9):2544-2548
2. Biebl H (1991) Glycerol fermentation of 1,3-propanediol by Clostridium butyricum-Measurement of product inhibition by use of a pH-autostat. Appl Microbiol Biotechnol 35(6):701-705
3. Biebl H (2001) Fermentation of glycerol by Clostridium pasteurianum-batch and continuous culture studies. J Ind Microbiol & Biotechnol 27(1):18-26
4. Biebl H, Menzel K, Zeng AP, Deckwer WD (1999) Microbial production of 1,3-propanediol. Appl Microbiol Biotechnol 52(3):289-297
5. Borden JR, Papoutsakis ET (2007) Dynamics of genomic-library enrichment and identification of solvent tolerance genes for Clostridium acetobutylicum. Appl Environ Microbiol 73(9):3061-3068
6. Chatzifragkou A, Papanikolaou S, Dietz D, Doulgeraki AI, Nychas GJE, Zeng AP (2011) Production of 1,3-propanediol by Clostridium butyricum growing on biodiesel-derived crude glycerol through a non-sterilized fermentation process. Appl Microbiol Biotechnol 91(1):101-112
7. Dabrock B, Bahl H, Gottschalk G (1992) Parameters affecting solvent production by Clostridium pasteurianum. Appl Environ Microbiol 58(4):1233-1239
8. Demirbas A (2007) Importance of biodiesel as transportation fuel. Energy Policy 35(9):4661-4670
9. Dobson R, Gray V, Rumbold K (2012) Microbial utilization of crude glycerol for the production of value-added products. J Ind Microbiol Biotechnol 39(2):217-226
10. Sorona W (2011), http://www2.dupont.com/Sorona_Consumer/en_US/ index.html. Accessed 12-Dec-2011
11. Dürre P (2008) Fermentative butanol production-Bulk chemical and biofuel. Ann N Y Acad Sci 1125:353-362
12. Elkanouni A, Junelles AM, Janatiidrissi R, Petitdemange H, Gay R (1989) Clostridium acetobutylicum mutants isolated for resistance to the pyruvate halogen analogs. Curr Microbiol 18(3):139-144
13. Ezeji TC, Qureshi N, Blaschek HP (2004) Acetone butanol ethanol (ABE) production from concentrated substrate: reduction in substrate inhibition by fed-batch technique and product inhibition by gas stripping. Appl Microbiol Biotechnol 63(6):653-658
14. Girbal L, Croux C, Vasconcelos I, Soucaille P (1995) Regulation of metabolic shifts in Clostridium acetobutylicum ATCC-824. FEMS Microbiol Rev 17(3):287-297
15. Gonzalez-Pajuelo M, Meynial-Salles I, Mendes F, Andrade JC, Vasconcelos I, Soucaille P (2005) Metabolic engineering of Clostridium acetobutylicum for the industrial production of 1,3-propanediol from glycerol. Metab Eng 7(5-6):329-336
16. Groot WJ, Luyben K (1986) In situ product recovery by adsorption in the butanol/ isopropanol batch fermentation. Appl Microbiol Biotechnol 25(1):29-31
17. Hild HM, Stuckey DC, Leak DJ (2003) Effect of nutrient limitation on product formation during continuous fermentation of xylose with Thermoanaerobacter ethanolicus JW200 Fe(7). Appl Microbiol Biotechnol 60(6):679-686
18. Jensen T, Kvist T, Mikkelsen M, Christensen P, Westermann P (2012) Fermentation of crude glycerol from biodiesel production by Clostridium pasteurianum. J Ind Microbiol Biotechnol 39(5):709-717
19. Johnson DT, Taconi KA (2007) The glycerin glut: Options for the value-added conversion of crude glycerol resulting from biodiesel production. Environ Prog 26(4):338-348
20. Lee SY, Lee DY, Kim TY (2005) Systems biotechnology for strain improvement. Trends Biotechnol 23(7):349-358
21. Lee SY, Park JH, Jang SH, Nielsen LK, Kim J, Jung KS (2008) Fermentative butanol production by clostridia. Biotechnol Bioeng 101(2):209-228
22. Lemmel SA (1985) Mutagenesis in Clostridium acetobutylicum. Biotechnol Lett 7(10):711-716
23. Malaviya A, Jang Y-S, Lee S (2012) Continuous butanol production with reduced byproducts formation from glycerol by a hyper producing mutant of Clostridium pasteurianum. Appl Microbiol Biotechnol 93(4):1485-1494
24. Nakas JP, Schaedle M, Parkinson CM, Coonley CE, Tanenbaum SW (1983) Systemdevelopment for linked-fermentation production of solvents from algal biomass. Appl Environ Microbiol 46(5):1017-1023
25. Pagliaro M, Ciriminna R, Kimura H, Rossi M, Della Pina C (2007) From glycerol to value-added products. Angew Chem Int Ed 46(24):4434-4440
26. Pyle DJ, Garcia RA, Wen ZY (2008) Producing docosahexaenoic acid (DHA)-rich algae from biodiesel-derived crude glycerol: Effects of impurities on DHA production and algal biomass composition. J Agric Food Chem 56(11):3933-3939
27. Qureshi N, Hughes S, Maddox IS, Cotta MA (2005) Energy-efficient recovery of butanol from model solutions and fermentation broth by adsorption. Bioprocess Biosystems Eng 27(4):215-222
28. Reimann A, Biebl H (1996) Production of 1,3-propanediol by Clostridium butyricum DSM 5431 and product tolerant mutants in fedbatch culture: Feeding strategy for glycerol and ammonium. Biotechnol Lett 18(7):827-832
29. Rossi DM, da Costa JB, de Souza EA, Peralba MDR, Ayub MAZ (2012) Bioconversion of residual glycerol from biodiesel synthesis into 1,3-propanediol and ethanol by isolated bacteria from environmental consortia. Renew Energ 39(1):223-227
30. Syed QUA, Nadeem M, Nelofer R (2008) Enhanced butanol production by mutant strains of Clostridium acetobutylicum in molasses medium. Turk J Biochem 33(1):25-30
31. Taconi KA, Venkataramanan KP, Johnson DT (2009) Growth and solvent production by Clostridium pasteurianum ATCC (R) 6013 (TM) utilizing biodiesel-derived crude glycerol as the sole carbon source. Environ Prog Sustainable Energy 28(1):100-110
32. Venkataramanan KP, Boatman JJ, Kurniawan Y, Taconi KA, Bothun GD, Scholz C (2012) Impact of impurities in biodiesel-derived crude glycerol on the fermentation by Clostridium pasteurianum ATCC 6013. Appl Microbiol Biotechnol 93(3):1325-1335
33. Wilkens E, Ringel AK, Hortig D, Willke T, Vorlop KD (2012) High-level production of 1,3-propanediol from crude glycerol by Clostridium butyricum AKR102a. Appl Microbiol Biotechnol 93(3):1057-1063
34. Willke T, Vorlop K (2008) Biotransformation of glycerol into 1,3-propanediol. Eur J Lipid Sci Technol 110(9):831-840
35. Yazdani SS, Gonzalez R (2007) Anaerobic fermentation of glycerol: a path to economic viability for the biofuels industry. Curr Opin Biotechnol 18(3):213-219
36. Zeng A-P (1996) Pathway and kinetic analysis of 1,3-propanediol production from glycerol fermentation by Clostridium butyricum. Bioprocess Eng 14(4):169-175
37. Zeng A-P, Biebl H (2002) Bulk Chemicals from Biotechnology: The Case of 1,3-Propanediol Production and the New Trends. Adv Biochem Eng Biotechnol 74:239-259
38. Zeng A-P, Ross A, Biebl H, Tag C, Gunzel B, Deckwer WD (1994) Multiple product inhibition and growth modeling of Clostridium butyricum and Klebsiella pneumoniae in glycerol fermentation. Biotechnol Bioeng 44(8):902-911