Body mass index and the efficacy of needle-free jet injection for the administration of rapid-acting insulin analogs, a post hoc analysis

Diabetes, Obesity and Metabolism

Volumn 15, Issue 1, 2013, Pages 84-86

  De Galan, B E ^a   Engwerda, E E C ^a   Abbink, E J ^a   Tack, C J ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Body mass index obesity indices; Euglycaemic glucose clamp; Insulin administration; Insulin analogs; Insulin aspart; Jet injector; Pharmacodynamics; Pharmacokinetics

Indexed keywords

INSULIN ASPART; PLACEBO;

ADULT; BODY MASS; BODY WEIGHT; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; HUMAN; HUMAN EXPERIMENT; JET INJECTION; JET INJECTOR; LETTER; MALE; NORMAL HUMAN; OBESITY; RANDOMIZED CONTROLLED TRIAL; TIME TO MAXIMUM PLASMA CONCENTRATION; WAIST CIRCUMFERENCE; WAIST HIP RATIO;

EID: 84871133684     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2012.01666.x     Document Type: Letter

References (8)

1. Vora JP, Burch A, Peters JR, Owens DR. Absorption of radiolabelled soluble insulin in type 1 (insulin-dependent) diabetes: influence of subcutaneous blood flow and anthropometry. Diabet Med 1993; 10: 736-743.
2. Vora JP, Burch A, Peters JR, Owens DR. Relationship between absorption of radiolabeled soluble insulin, subcutaneous blood flow, and anthropometry. Diabetes Care 1992; 15: 1484-1493.
3. Sindelka G, Heinemann L, Berger M, Frenck W, Chantelau E. Effect of insulin concentration, subcutaneous fat thickness and skin temperature on subcutaneous insulin absorption in healthy subjects. Diabetologia 1994; 37: 377-380.
4. Gagnon-Auger M, du Souich P, Baillargeon JP et al. Dose-dependent delay of the hypoglycemic effect of short-acting insulin analogs in obese subjects with type 2 diabetes: a pharmacokinetic and pharmacodynamic study. Diabetes Care 2010; 33: 2502-2507.
5. Monnier L, Lapinski H, Colette C. Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients: variations with increasing levels of HbA(1c). Diabetes Care 2003; 26: 881-885.
6. Engwerda EE, Abbink EJ, Tack CJ, de Galan BE. Improved pharmacokinetic and pharmacodynamic profile of rapid-acting insulin using needle-free jet injection technology. Diabetes Care 2011; 34: 1804-1808.
7. Mitragotri S. Current status and future prospects of needle-free liquid jet injectors. Nat Rev Drug Discov 2006; 5: 543-548.
8. Abbink EJ, Walker AJ, van der Sluijs HA, Tack CJ, Smits P. No role of calcium- and ATP-dependent potassium channels in insulin-induced vasodilation in humans in vivo. Diabetes Metab Res Rev 2002; 18: 143-148.