The effect of pH, dilution, and temperature on the viscosity of ocular lubricants-shift in rheological parameters and potential clinical significance

Eye (Basingstoke)

Volumn 26, Issue 12, 2012, Pages 1579-1584

  Rahman, M Q ^a   Chuah, K S ^b   MacDonald, E C A ^a   Trusler, J P M ^b   Ramaesh, K ^a  

^a GARTNAVEL GENERAL HOSPITAL   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

lubricant; rheology; viscosity

Indexed keywords

CARBOXYMETHYLCELLULOSE; CROSCARMELLOSE SODIUM; EYE DROPS; GLYCEROL; HYALURONIC ACID; HYDROXYPROPYLMETHYLCELLULOSE; LUBRICATING AGENT;

ARTICLE; CAPILLARY TUBE; CORNEA; DILUTION; DRUG BIOAVAILABILITY; DRUG EFFICACY; FLOW KINETICS; KINEMATICS; LABORATORY TEST; OUTCOME ASSESSMENT; PH; QUANTITATIVE ANALYSIS; TEMPERATURE; VISCOMETER; VISCOSITY;

EID: 84871094063     PISSN: 0950222X     EISSN: 14765454     Source Type: Journal    
DOI: 10.1038/eye.2012.211     Document Type: Article

References (16)

1. Brewitt H, Sistani F. Dry eye disease: the scale of the problem. Surv Ophthalmol 2001; 45(Suppl 2): S199-S202.
2. Dohlman CH. Punctal occlusion in keratoconjunctivitis sicca. Ophthalmology 1978; 85(12): 1277-1281.
3. Werblin TP, Rheinstrom SD, Kaufman HE. The use of slow-release artificial tears in the long-term management of keratitis sicca. Ophthalmology 1981; 88(1): 78-81.
4. Maurice DM. The dynamics and drainage of tears. Int Ophthalmol Clin 1973; 13(1): 103-116.
5. Snibson GR, Greaves JL, Soper ND, Prydal JI, Wilson CG, Bron AJ et al. Precorneal residence times of sodium hyaluronate solutions studied by quantitative gamma scintigraphy. Eye 1990; 4(Pt 4): 594-602.
6. Yokoi N, Komuro A. Non-invasive methods of assessing the tear film. Exp Eye Res 2004; 78(3): 399-407.
7. Meadows DL, Paugh JR, Joshi A, Mordaunt J. A novel method to evaluate residence time in humans using a nonpenetrating fluorescent tracer. Invest Ophthalmol Vis Sci 2002; 43(4): 1032-1039.
8. Barnes HA. An Introduction to Rheology. Elsevier International: Oxford, UK, 1993.
9. Purslow C, Wolffsohn JS. Ocular surface temperature: A review. Eye Contact Lens 2005; 31(3): 117-123.
10. Chrai SS, Robinson Jr. Ocular evaluation of methylcellulose vehicle in albino rabbits. J Pharm Sci 1974; 63(8): 1218-1223.
11. Bach FC, Adam JB, McWhirter HC, Johnson JE. Ocular retention of artificial tear solutions. Comparison of hydroxypropyl methylcellulose and polyvinyl alcohol vehicles using an argyrol marker. Ann Ophthalmol 1972; 4(2): 116-119.
12. Zaki I, Fitzgerald P, Hardy JG, Wilson CG. A comparison of the effect of viscosity on the precorneal residence of solutions in rabbit and man. J Pharm Pharmacol 1986; 38(6): 463-466.
13. Gayton JL. Etiology, prevalence, and treatment of dry eye disease. Clin Ophthalmol 2009; 3: 405-412.
14. Doughty MJ, Glavin S. Efficacy of different dry eye treatments with artificial tears or ocular lubricants: A systematic review. Ophthalmic Physiol Opt 2009; 29(6): 573-583.
15. Forrester J. The Eye: Basic Sciences in Practise. WB Saunders: London, 2002.
16. Snibson GR, Fitzgerald P, Hardy JG, Wilson CG. Ocular surface residence times of artificial tear solutions. Cornea 1992; 11(4): 288-293.