-
1
-
-
37049183697
-
Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
-
Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL: Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987; 235:177-82.
-
(1987)
Science
, vol.235
, pp. 177-182
-
-
Slamon, D.J.1
Clark, G.M.2
Wong, S.G.3
Levin, W.J.4
Ullrich, A.5
McGuire, W.L.6
-
2
-
-
0038010542
-
Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma
-
Bendell JC, Domchek SM, Burstein HJ, Harris L, Younger J, Kuter I, Bunnell C, Rue M, Gelman R, Winer E: Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma. Cancer 2003;97:2972-7.
-
(2003)
Cancer
, vol.97
, pp. 2972-2977
-
-
Bendell, J.C.1
Domchek, S.M.2
Burstein, H.J.3
Harris, L.4
Younger, J.5
Kuter, I.6
Bunnell, C.7
Rue, M.8
Gelman, R.9
Winer, E.10
-
3
-
-
4344691784
-
Incidence of cerebral metastases in patients treated with trastuzumab for metastatic breast cancer
-
Clayton AJ, Danson S, Jolly S, Ryder WD, Burt PA, Stewart AL, Wilkinson PM, Welch RS, Magee B, Wilson G, Howell A, Wardley AM: Incidence of cerebral metastases in patients treated with trastuzumab for metastatic breast cancer. Br J Cancer 2004;91:639-43.
-
(2004)
Br J Cancer
, vol.91
, pp. 639-643
-
-
Clayton, A.J.1
Danson, S.2
Jolly, S.3
Ryder, W.D.4
Burt, P.A.5
Stewart, A.L.6
Wilkinson, P.M.7
Welch, R.S.8
Magee, B.9
Wilson, G.10
Howell, A.11
Wardley, A.M.12
-
5
-
-
33845599378
-
Ratio of trastuzumab levels in serum and cerebrospinal fluid is altered in HER2-positive breast cancer patients with brain metastases and impairment of blood-brain barrier
-
Stemmler HJ, Schmitt M, Willems A, Bernhard H, Harbeck N, Heinemann V: Ratio of trastuzumab levels in serum and cerebrospinal fluid is altered in HER2-positive breast cancer patients with brain metastases and impairment of blood-brain barrier. Anticancer Drugs 2007;18:23-8.
-
(2007)
Anticancer Drugs
, vol.18
, pp. 23-28
-
-
Stemmler, H.J.1
Schmitt, M.2
Willems, A.3
Bernhard, H.4
Harbeck, N.5
Heinemann, V.6
-
6
-
-
38549134656
-
Cardiotoxicity and incidence of brain metastases after adjuvant trastuzumab for early breast cancer: The dark side of the moon? A metaanalysis of the randomized trials
-
Bria E, Cuppone F, Fornier M, Nisticò C, Carlini P, Milella M, Sperduti I, Terzoli E, Cognetti F, Giannarelli D: Cardiotoxicity and incidence of brain metastases after adjuvant trastuzumab for early breast cancer: the dark side of the moon? A metaanalysis of the randomized trials. Breast Cancer Res Treat 2008;109:231-9.
-
(2008)
Breast Cancer Res Treat
, vol.109
, pp. 231-239
-
-
Bria, E.1
Cuppone, F.2
Fornier, M.3
Nisticò, C.4
Carlini, P.5
Milella, M.6
Sperduti, I.7
Terzoli, E.8
Cognetti, F.9
Giannarelli, D.10
-
7
-
-
33646869211
-
Temozolomide in metastatic breast cancer (MBC): A phase II trial of the National Cancer Institute of Canada-Clinical Trials Group (NCIC-CTG)
-
Trudeau ME, Crump M, Charpentier D, Yelle L, Bordeleau L, Matthews S, Eisenhauer E: Temozolomide in metastatic breast cancer (MBC): a phase II trial of the National Cancer Institute of Canada-Clinical Trials Group (NCIC-CTG). Ann Oncol 2006;17:952-6.
-
(2006)
Ann Oncol
, vol.17
, pp. 952-956
-
-
Trudeau, M.E.1
Crump, M.2
Charpentier, D.3
Yelle, L.4
Bordeleau, L.5
Matthews, S.6
Eisenhauer, E.7
-
8
-
-
33749026073
-
Phase i study of capecitabine in combination with temozolomide in the treatment of patients with brain metastases from breast carcinoma
-
Rivera E, Meyers C, Groves M, Valero V, Francis D, Arun B, Broglio K, Yin G, Hortobagyi GN, Buchholz T: Phase I study of capecitabine in combination with temozolomide in the treatment of patients with brain metastases from breast carcinoma. Cancer 2006;107:1348-54.
-
(2006)
Cancer
, vol.107
, pp. 1348-1354
-
-
Rivera, E.1
Meyers, C.2
Groves, M.3
Valero, V.4
Francis, D.5
Arun, B.6
Broglio, K.7
Yin, G.8
Hortobagyi, G.N.9
Buchholz, T.10
-
9
-
-
33845886440
-
Lapatinib plus capecitabine for HER2-positive advanced breast cancer
-
Geyer CE, Forster J, Lindquist D, Chan S, Romieu CG, Pienkowski T, Jagiello-Gruszfeld A, Crown J, Chan A, Kaufman B, Skarlos D, Campone M, Davidson N, Berger M, Oliva C, Rubin SD, Stein S, Cameron D: Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 2006;355:2733-43.
-
(2006)
N Engl J Med
, vol.355
, pp. 2733-2743
-
-
Geyer, C.E.1
Forster, J.2
Lindquist, D.3
Chan, S.4
Romieu, C.G.5
Pienkowski, T.6
Jagiello-Gruszfeld, A.7
Crown, J.8
Chan, A.9
Kaufman, B.10
Skarlos, D.11
Campone, M.12
Davidson, N.13
Berger, M.14
Oliva, C.15
Rubin, S.D.16
Stein, S.17
Cameron, D.18
-
10
-
-
41549138328
-
The role of efflux and uptake transporters in [N-{3-chloro-4-[(3- fluorobenzyl) oxy]phenyl}-6-[5-({[2-(methylsulfonyl) ethyl]amino} methyl)-2-furyl]-4-quinazolinamine (GW572016, lapatinib) disposition and drug interactions
-
Polli J, Humphreys JE, Harmon KA, Castellino S, O'Mara MJ, Olson KL, John-Williams LS, Koch KM, Serabjit-Singh CJ: The role of efflux and uptake transporters in [N-{3-chloro-4-[(3-fluorobenzyl) oxy]phenyl}-6-[5-({[2- (methylsulfonyl) ethyl]amino} methyl)-2-furyl]-4-quinazolinamine (GW572016, lapatinib) disposition and drug interactions. Drug Metable Dispos 2008;36:695-701.
-
(2008)
Drug Metable Dispos
, vol.36
, pp. 695-701
-
-
Polli, J.1
Humphreys, J.E.2
Harmon, K.A.3
Castellino, S.4
O'mara, M.J.5
Olson, K.L.6
John-Williams, L.S.7
Koch, K.M.8
Serabjit-Singh, C.J.9
-
11
-
-
56549113680
-
A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: Updated efficacy and biomarker analyses
-
Cameron D, Casey M, Press M, Lindquist D, Pienkowski T, Romieu CG, Chan S, Jagiello-Gruszfeld A, Kaufman B, Crown J, Chan A, Campone M, Viens P, Davidson N, Gorbounova V, Raats JI, Skarlos D, Newstat B, Roychowdhury D, Paoletti P, Oliva C, Rubin S, Stein S, Geyer CE: A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses. Breast Cancer Res Treat 2008; 112:533-43.
-
(2008)
Breast Cancer Res Treat
, vol.112
, pp. 533-543
-
-
Cameron, D.1
Casey, M.2
Press, M.3
Lindquist, D.4
Pienkowski, T.5
Romieu, C.G.6
Chan, S.7
Jagiello-Gruszfeld, A.8
Kaufman, B.9
Crown, J.10
Chan, A.11
Campone, M.12
Viens, P.13
Davidson, N.14
Gorbounova, V.15
Raats, J.I.16
Skarlos, D.17
Newstat, B.18
Roychowdhury, D.19
Paoletti, P.20
Oliva, C.21
Rubin, S.22
Stein, S.23
Geyer, C.E.24
more..
-
12
-
-
42949112556
-
Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer
-
Lin NU, Carey LA, Liu MC, Younger J, Come SE, Ewend M, Harris GJ, Bullitt E, Van den Abbeele AD, Henson JW, Li X, Gelman R, Burstein HJ, Kasparian E, Kirsch DG, Crawford A, Hochberg F, Winer EP: Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol 2008; 26:1993-9.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1993-1999
-
-
Lin, N.U.1
Carey, L.A.2
Liu, M.C.3
Younger, J.4
Come, S.E.5
Ewend, M.6
Harris, G.J.7
Bullitt, E.8
Van Den Abbeele, A.D.9
Henson, J.W.10
Li, X.11
Gelman, R.12
Burstein, H.J.13
Kasparian, E.14
Kirsch, D.G.15
Crawford, A.16
Hochberg, F.17
Winer, E.P.18
-
13
-
-
59149099189
-
Evaluation of lapatinib plus capecitabine in patients with brain metastases from HER2+ breast cancer enrolled in the Lapatinib Expanded Access Program (LEAP) and French Authorisation Temporaire d'Utilization (ATU)
-
Boccardo F, Kaufman B, Baselga J, Dieras J, Link J, Casey MA, Fittipaldo A, Oliva C, Zembryki D, Rubin SD: Evaluation of lapatinib plus capecitabine in patients with brain metastases from HER2+ breast cancer enrolled in the Lapatinib Expanded Access Program (LEAP) and French Authorisation Temporaire d'Utilization (ATU). J Clin Oncol 2008;26(suppl):abstr 1094.
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL.
, pp. 1094
-
-
Boccardo, F.1
Kaufman, B.2
Baselga, J.3
Dieras, J.4
Link, J.5
Casey, M.A.6
Fittipaldo, A.7
Oliva, C.8
Zembryki, D.9
Rubin, S.D.10
-
14
-
-
63149110733
-
Multicenter phase II study of lapatinib in patients with brain metastases from HER2-positive breast cancer
-
Lin NU, Dieras V, Paul D, Lossignol D, Christodoulou C, Stemmler HJ, Roché H, Liu MC, Greil R, Ciruelos E, Loibl S, Gori S, Wardley A, Yardley D, Brufsky A, Blum JL, Rubin SD, Dharan B, Steplewski K, Zembryki D, Oliva C, Roychowdhury D, Paoletti P, Winer EP: Multicenter phase II study of lapatinib in patients with brain metastases from HER2-positive breast cancer. Clin Cancer Res 2009;15:1452-9.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 1452-1459
-
-
Lin, N.U.1
Dieras, V.2
Paul, D.3
Lossignol, D.4
Christodoulou, C.5
Stemmler, H.J.6
Roché, H.7
Liu, M.C.8
Greil, R.9
Ciruelos, E.10
Loibl, S.11
Gori, S.12
Wardley, A.13
Yardley, D.14
Brufsky, A.15
Blum, J.L.16
Rubin, S.D.17
Dharan, B.18
Steplewski, K.19
Zembryki, D.20
Oliva, C.21
Roychowdhury, D.22
Paoletti, P.23
Winer, E.P.24
more..
-
15
-
-
77949542447
-
Treatment of HER2-positive metastatic breast cancer with lapatinib and capecitabine in the lapatinib expanded access programme, including efficacy in brain metastases -The UK experience
-
Sutherland S, Ashley S, Miles D, Chan S, Wardley A, Davidson N, Bhatti R, Shehata M, Nouras H, Camburn T, Johnston SRD: Treatment of HER2-positive metastatic breast cancer with lapatinib and capecitabine in the lapatinib expanded access programme, including efficacy in brain metastases -the UK experience. Br J Cancer 2010;102:995-1002.
-
(2010)
Br J Cancer
, vol.102
, pp. 995-1002
-
-
Sutherland, S.1
Ashley, S.2
Miles, D.3
Chan, S.4
Wardley, A.5
Davidson, N.6
Bhatti, R.7
Shehata, M.8
Nouras, H.9
Camburn, T.10
Johnston, S.R.D.11
-
16
-
-
79952017724
-
Clinical outcome of patients with brain metastases from HER2-positive breast cancer treated with lapatinib and capecitabine
-
Metro G, Foglietta J, Russillo M, Stocchi L, Vidiri A, Giannarelli D, Crino L, Papoldo P, Mottolese M, Cognetti F, Fabi A, Gori S: Clinical outcome of patients with brain metastases from HER2-positive breast cancer treated with lapatinib and capecitabine. Ann Oncol 2011;22:625-30.
-
(2011)
Ann Oncol
, vol.22
, pp. 625-630
-
-
Metro, G.1
Foglietta, J.2
Russillo, M.3
Stocchi, L.4
Vidiri, A.5
Giannarelli, D.6
Crino, L.7
Papoldo, P.8
Mottolese, M.9
Cognetti, F.10
Fabi, A.11
Gori, S.12
-
17
-
-
84855218212
-
LANDSCAPE: An FNCLCC phase II study with lapatinib and capecitabine in patients with brain metastases from HER2-positive metastatic breast cancer before whole brain radiotherapy
-
abstr 509
-
Bachelot TD, Romieu, G, Campone, M, Dieras V, Cropet C, Roche HH, Jimenez M, Le Rhun E, Pierga J, Gonçalves A, Leheurteur M, Domont J, Gutierrez M,Cure H,Ferrero C, Labbe C: LANDSCAPE: an FNCLCC phase II study with lapatinib and capecitabine in patients with brain metastases from HER2-positive metastatic breast cancer before whole brain radiotherapy. J Clin Oncol 2011; 29:47s(abstr 509).
-
(2011)
J Clin Oncol
, vol.29
-
-
Bachelot, T.D.1
Romieu, G.2
Campone, M.3
Dieras, V.4
Cropet, C.5
Roche, H.H.6
Jimenez, M.7
Le Rhun, E.8
Pierga, J.9
Gonçalves, A.10
Leheurteur, M.11
Domont, J.12
Gutierrez McUre Hferrero, C.13
Labbe, C.14
-
18
-
-
49349117401
-
Lapatinib prevents the metastatic colonization of EGFR+ and Her-2+ breast cancer cells in the brain
-
abstr 210
-
Palmieri D, Gril BM, Herring J, et al.: Lapatinib prevents the metastatic colonization of EGFR+ and Her-2+ breast cancer cells in the brain. Breast Cancer Res Treat 2007;106(suppl 1):S30(abstr 210).
-
(2007)
Breast Cancer Res Treat
, vol.106
, Issue.SUPPL. 1
-
-
Palmieri, D.1
Gril, B.M.2
Herring, J.3
-
19
-
-
0942268145
-
Effects of the EGFR/HER2 kinase inhibitor GW572016 on EGFR-and HER2-overexpressing breast cancer cell line proliferation, radiosensitization, and resistance
-
Zhou H, Kim YS, Peletier A, McCall W, Earp HS, Sartor CI: Effects of the EGFR/HER2 kinase inhibitor GW572016 on EGFR-and HER2-overexpressing breast cancer cell line proliferation, radiosensitization, and resistance. Int J Radiat Oncol Biol Phys 2004;58:344-52.
-
(2004)
Int J Radiat Oncol Biol Phys
, vol.58
, pp. 344-352
-
-
Zhou, H.1
Kim, Y.S.2
Peletier, A.3
McCall, W.4
Earp, H.S.5
Sartor, C.I.6
|