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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 1, 2013, Pages 169-173

Sulfonylpiperidines as novel, antibacterial inhibitors of Gram-positive thymidylate kinase (TMK)

(7) Martínez Botella, Gabriel a,b Loch, James T a Green, Oluyinka M a Kawatkar, Sameer P a Olivier, Nelson B a Boriack Sjodin, P Ann a Keating, Thomas A a

a ASTRAZENECA (United Kingdom)

b Sage Therapeutics Inc (United States)

Author keywords

Antibacterials; Antibiotics; Nucleotide kinase; Structure based drug discovery; Thymidylate kinase; TMK

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL ENZYME; BENZYLPIPERIDINE; CARBENE; LEVOFLOXACIN; PHENOL DERIVATIVE; SULFONAMIDE; SULFONYLPIPERIDINE DERIVATIVE; THYMIDINE DIPHOSPHATE; THYMIDINE PHOSPHATE; THYMIDYLATE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTALLOGRAPHY; DRUG BINDING; DRUG STRUCTURE; ENTEROCOCCUS; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; HUMAN; HUMAN CELL; HYDROGEN BOND; IN VIVO STUDY; NONHUMAN; RAT; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STAPHYLOCOCCUS HAEMOLYTICUS; STAPHYLOCOCCUS LUGDUNENSIS; STREPTOCOCCUS AGALACTIAE; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; MOLECULAR DOCKING SIMULATION; NUCLEOSIDE-PHOSPHATE KINASE; PIPERIDINES; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 84871030780 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.10.128 Document Type: Article

Times cited : (24)

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