The discovery of potent and selective 4-aminothienopyridines as B-Raf kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 1, 2013, Pages 66-70

  Tang, Jun ^a   Lackey, Karen E ^a   Dickerson, Scott H ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

B Raf inhibitor; Knowledge based design

Indexed keywords

2 [4 (2 DIMETHYLAMINOETHOXY)PHENYL] 4 (1 HYDROXYIMINO 5 INDANYL) 5 (4 PYRIDINYL) 1H IMIDAZOLE; 3 (4,4,5,5 TETRAMETHYL 1,3,2 DIOXABOROLAN 2 YL)ANILINE; 3 BROMO 7 IODOTHIENO[3,2 C]PYRIDIN 4 AMINE; 4 AMINOTHIENOPYRIDINE DERIVATIVE; B RAF KINASE INHIBITOR; CYTOCHROME P450; N [3 (5 CHLORO 1H PYRROLO[2,3 B]PYRIDINE 3 CARBONYL) 2,4 DIFLUOROPHENYL]PROPANESULFONAMIDE; THIENOPYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL ASSAY; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ASSAY; IC 50; PHARMACOPHORE;

AMINOPYRIDINES; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; PHENYLUREA COMPOUNDS; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS B-RAF; STRUCTURE-ACTIVITY RELATIONSHIP; THIENOPYRIDINES;

EID: 84871017608     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.11.020     Document Type: Article

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