Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin- 5(9bH)-ones as 5-HT2C receptor agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 1, 2013, Pages 330-335

  Fevig, John M ^a   Feng, Jianxin ^a   Rossi, Karen A ^a   Miller, Keith J ^a   Wu, Ginger ^a   Hung, Chen Pin ^a   Ung, Thao ^a   Malmstrom, Sarah E ^a   Zhang, Ge ^a   Keim, William J ^a   Cullen, Mary Jane ^a   Rohrbach, Kenneth W ^a   Qu, Qinling ^a   Gan, Jinping ^a   Pelleymounter, Mary Ann ^a   Robl, Jeffrey A ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

5 HT2c receptor agonist; Obesity; Serotonin

Indexed keywords

2,3,3A,4 TETRAHYDRO 1H PYRROLO[3,4 C]ISOQUINOLIN 5(9BH) ONE DERIVATIVE; SEROTONIN 2A RECEPTOR; SEROTONIN 2B RECEPTOR; SEROTONIN 2C AGONIST; SEROTONIN 2C RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; FEEDING; FOOD INTAKE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; HALF-LIFE; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; ISOQUINOLINES; MALE; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTOR, SEROTONIN, 5-HT2B; RECEPTOR, SEROTONIN, 5-HT2C; SEROTONIN 5-HT2 RECEPTOR AGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 84870991177     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.10.091     Document Type: Article

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