Inhibitors of HIV-1 attachment. Part 7: Indole-7-carboxamides as potent and orally bioavailable antiviral agents

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 1, 2013, Pages 198-202

  Yeung, Kap Sun ^a   Qiu, Zhilei ^a   Xue, Quifen ^a   Fang, Haiquan ^a   Yang, Zheng ^a   Zadjura, Lisa ^a   D'Arienzo, Celia J ^a   Eggers, Betsy J ^a   Riccardi, Keith ^a   Shi, Pei Yong ^a   Gong, Yi Fei ^a   Browning, Marc R ^a   Gao, Qi ^a   Hansel, Steven ^a   Santone, Kenneth ^a   Lin, Ping Fang ^a   Meanwell, Nicholas A ^a   Kadow, John F ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Amides; Antivirals; HIV 1 attachment inhibitors; Indole glyoxamide; Molecular conformation

Indexed keywords

1 BENZOYL 4 [(4,7 DIMETHOXY 1H PYRROLO[2,3 C]PYRIDIN 3 YL)OXOACETYL]PIPERAZINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ENVELOPE PROTEIN; INDOLE 7 CARBOXAMIDE DERIVATIVE; PROTEIN JRFL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG CONFORMATION; DRUG HALF LIFE; DRUG POTENCY; DRUG STABILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HYDROGEN BOND; IN VITRO STUDY; LIVER MICROSOME; MAXIMUM PLASMA CONCENTRATION; MEMBRANE PERMEABILITY; NONHUMAN; PROTEIN EXPRESSION; RAT; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; SUSPENSION; VIRUS ATTACHMENT;

AMIDES; ANIMALS; ANTI-HIV AGENTS; BIOLOGICAL AVAILABILITY; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; CRYSTALLOGRAPHY, X-RAY; DOGS; HALF-LIFE; HAPLORHINI; HIV-1; HUMANS; INDOLES; MICROSOMES, LIVER; MOLECULAR CONFORMATION; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS ATTACHMENT;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84870988523     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.10.115     Document Type: Article

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