-
2
-
-
84860773361
-
Risk categories and refractory CLL in the era of chemoimmunotherapy
-
Zenz T, Gribben JG, Hallek M, Döhner H, Keating MJ, Stilgenbauer S. Risk categories and refractory CLL in the era of chemoimmunotherapy. Blood 119(18), 4101-4107 (2012).
-
(2012)
Blood
, vol.119
, Issue.18
, pp. 4101-4107
-
-
Zenz, T.1
Gribben, J.G.2
Hallek, M.3
Döhner, H.4
Keating, M.J.5
Stilgenbauer, S.6
-
3
-
-
33845543049
-
Indications for allogeneic stem cell transplantation in chronic lymphocytic leukemia: The EBMT transplant consensus
-
Chronic Leukemia Working Party of the EBMT
-
Dreger P, Corradini P, Kimby E et al.; Chronic Leukemia Working Party of the EBMT. Indications for allogeneic stem cell transplantation in chronic lymphocytic leukemia: the EBMT transplant consensus. Leukemia 21(1), 12-17 (2007).
-
(2007)
Leukemia
, vol.21
, Issue.1
, pp. 12-17
-
-
Dreger, P.1
Corradini, P.2
Kimby, E.3
-
4
-
-
77957664665
-
Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised open-label phase 3 trial
-
International Group Of Investigators; German Chronic Lymphocytic Leukaemia Study Group
-
Hallek M, Fischer K, Fingerle-Rowson G et al.; International Group of Investigators; German Chronic Lymphocytic Leukaemia Study Group. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, Phase 3 trial. Lancet 376(9747), 1164-1174 (2010).
-
(2010)
Lancet
, vol.376
, Issue.9747
, pp. 1164-1174
-
-
Hallek, M.1
Fischer, K.2
Fingerle-Rowson, G.3
-
5
-
-
79551504914
-
TP53 mutation and survival in chronic lymphocytic leukemia
-
Zenz T, Eichhorst B, Busch R et al. TP53 mutation and survival in chronic lymphocytic leukemia. J. Clin. Oncol. 28(29), 4473-4479 (2010).
-
(2010)
J. Clin. Oncol.
, vol.28
, Issue.29
, pp. 4473-4479
-
-
Zenz, T.1
Eichhorst, B.2
Busch, R.3
-
6
-
-
34447530283
-
Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): A randomised controlled trial
-
UK National Cancer Research Institute (NCRI) Haematological Oncology Clinical Studies Group; NCRI Chronic Lymphocytic Leukaemia Working Group
-
Catovsky D, Richards S, Matutes E et al. UK National Cancer Research Institute (NCRI) Haematological Oncology Clinical Studies Group; NCRI Chronic Lymphocytic Leukaemia Working Group. Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): a randomised controlled trial. Lancet 370(9583), 230-239 (2007).
-
(2007)
Lancet
, vol.370
, Issue.9583
, pp. 230-239
-
-
Catovsky, D.1
Richards, S.2
Matutes, E.3
-
7
-
-
79957949229
-
Mutational status of the TP53 gene as a predictor of response and survival in patients with chronic lymphocytic leukemia: Results from the LRF CLL4 Trial
-
Gonzalez D, Martinez P, Wade R et al. Mutational status of the TP53 gene as a predictor of response and survival in patients with chronic lymphocytic leukemia: results from the LRF CLL4 Trial. J. Clin. Oncol. 29(16), 2223-2229 (2011).
-
(2011)
J. Clin. Oncol.
, vol.29
, Issue.16
, pp. 2223-2229
-
-
Gonzalez, D.1
Martinez, P.2
Wade, R.3
-
8
-
-
69849107362
-
Subcutaneous alemtuzumab in fludarabine-refractory chronic lymphocytic leukemia: Clinical results and prognostic marker analyses from the CLL2H study of the German Chronic Lymphocytic Leukemia Study Group
-
German Chronic Lymphocytic Leukemia Study Group
-
Stilgenbauer S, Zenz T, Winkler D et al. German Chronic Lymphocytic Leukemia Study Group. Subcutaneous alemtuzumab in fludarabine-refractory chronic lymphocytic leukemia: clinical results and prognostic marker analyses from the CLL2H study of the German Chronic Lymphocytic Leukemia Study Group. J. Clin. Oncol. 27(24), 3994-4001 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, Issue.24
, pp. 3994-4001
-
-
Stilgenbauer, S.1
Zenz, T.2
Winkler, D.3
-
9
-
-
70350511471
-
Detailed analysis of p53 pathway defects in fludarabine-refractory chronic lymphocytic leukemia (CLL): Dissecting the contribution of 17p deletion, TP53 mutation, p53-p21 dysfunction, and miR34a in a prospective clinical trial
-
Zenz T, Häbe S, Denzel T et al. Detailed analysis of p53 pathway defects in fludarabine-refractory chronic lymphocytic leukemia (CLL): dissecting the contribution of 17p deletion, TP53 mutation, p53-p21 dysfunction, and miR34a in a prospective clinical trial. Blood 114(13), 2589-2597 (2009).
-
(2009)
Blood
, vol.114
, Issue.13
, pp. 2589-2597
-
-
Zenz, T.1
Häbe, S.2
Denzel, T.3
-
10
-
-
79960353160
-
Analysis of the chronic lymphocytic leukemia coding genome: Role of NOTCH1 mutational activation
-
Fabbri G, Rasi S, Rossi D et al. Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation. J. Exp. Med. 208(7), 1389-1401 (2011).
-
(2011)
J. Exp. Med.
, vol.208
, Issue.7
, pp. 1389-1401
-
-
Fabbri, G.1
Rasi, S.2
Rossi, D.3
-
11
-
-
79960036578
-
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
-
Puente XS, Pinyol M, Quesada V et al. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature 475(7354), 101-105 (2011).
-
(2011)
Nature
, vol.475
, Issue.7354
, pp. 101-105
-
-
Puente, X.S.1
Pinyol, M.2
Quesada, V.3
-
12
-
-
84555171449
-
Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia
-
Quesada V, Conde L, Villamor N et al. Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. Nat. Genet. 44(1), 47-52 (2012).
-
(2012)
Nat. Genet.
, vol.44
, Issue.1
, pp. 47-52
-
-
Quesada, V.1
Conde, L.2
Villamor, N.3
-
13
-
-
84255160977
-
Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: Association with progression and fludarabine-refractoriness
-
Rossi D, Bruscaggin A, Spina V et al. Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness. Blood 118(26), 6904-6908 (2011).
-
(2011)
Blood
, vol.118
, Issue.26
, pp. 6904-6908
-
-
Rossi, D.1
Bruscaggin, A.2
Spina, V.3
-
14
-
-
84855370035
-
SF3B1 and other novel cancer genes in chronic lymphocytic leukemia
-
Wang L, Lawrence MS, Wan Y et al. SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N. Engl. J. Med. 365(26), 2497-2506 (2011).
-
(2011)
N. Engl. J. Med.
, vol.365
, Issue.26
, pp. 2497-2506
-
-
Wang, L.1
Lawrence, M.S.2
Wan, Y.3
-
15
-
-
77958567414
-
NOTCH1 PEST domain mutation is an adverse prognostic factor in B-CLL
-
Sportoletti P, Baldoni S, Cavalli L et al. NOTCH1 PEST domain mutation is an adverse prognostic factor in B-CLL. Br. J. Haematol. 151(4), 404-406 (2010).
-
(2010)
Br. J. Haematol.
, vol.151
, Issue.4
, pp. 404-406
-
-
Sportoletti, P.1
Baldoni, S.2
Cavalli, L.3
-
16
-
-
84855854025
-
Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia
-
Rossi D, Rasi S, Fabbri G et al. Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia. Blood 119(2), 521-529 (2012).
-
(2012)
Blood
, vol.119
, Issue.2
, pp. 521-529
-
-
Rossi, D.1
Rasi, S.2
Fabbri, G.3
-
17
-
-
84858859064
-
Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia
-
Rossi D, Fangazio M, Rasi S et al. Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia. Blood 119(12), 2854-2862 (2012).
-
(2012)
Blood
, vol.119
, Issue.12
, pp. 2854-2862
-
-
Rossi, D.1
Fangazio, M.2
Rasi, S.3
-
18
-
-
70450270900
-
Awakening guardian angels: Drugging the p53 pathway
-
Brown CJ, Lain S, Verma CS, Fersht AR, Lane DP. Awakening guardian angels: drugging the p53 pathway. Nat. Rev. Cancer 9(12), 862-873 (2009).
-
(2009)
Nat. Rev. Cancer
, vol.9
, Issue.12
, pp. 862-873
-
-
Brown, C.J.1
Lain, S.2
Verma, C.S.3
Fersht, A.R.4
Lane, D.P.5
-
19
-
-
0034727833
-
Genomic aberrations and survival in chronic lymphocytic leukemia
-
Döhner H, Stilgenbauer S, Benner A et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N. Engl. J. Med. 343(26), 1910-1916 (2000).
-
(2000)
N. Engl. J. Med.
, vol.343
, Issue.26
, pp. 1910-1916
-
-
Döhner, H.1
Stilgenbauer, S.2
Benner, A.3
-
20
-
-
54049141334
-
Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: Results from a detailed genetic characterization with long-term follow-up
-
Zenz T, Kröber A, Scherer K et al. Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: results from a detailed genetic characterization with long-term follow-up. Blood 112(8), 3322-3329 (2008).
-
(2008)
Blood
, vol.112
, Issue.8
, pp. 3322-3329
-
-
Zenz, T.1
Kröber, A.2
Scherer, K.3
-
21
-
-
58249117812
-
The detection of TP53 mutations in chronic lymphocytic leukemia independently predicts rapid disease progression and is highly correlated with a complex aberrant karyotype
-
Dicker F, Herholz H, Schnittger S et al. The detection of TP53 mutations in chronic lymphocytic leukemia independently predicts rapid disease progression and is highly correlated with a complex aberrant karyotype. Leukemia 23(1), 117-124 (2009).
-
(2009)
Leukemia
, vol.23
, Issue.1
, pp. 117-124
-
-
Dicker, F.1
Herholz, H.2
Schnittger, S.3
-
22
-
-
73949135028
-
Monoallelic and biallelic inactivation of TP53 gene in chronic lymphocytic leukemia: Selection, impact on survival, and response to DNA damage
-
Malcikova J, Smardova J, Rocnova L et al. Monoallelic and biallelic inactivation of TP53 gene in chronic lymphocytic leukemia: selection, impact on survival, and response to DNA damage. Blood 114(26), 5307-5314 (2009).
-
(2009)
Blood
, vol.114
, Issue.26
, pp. 5307-5314
-
-
Malcikova, J.1
Smardova, J.2
Rocnova, L.3
-
23
-
-
61549089361
-
The prognostic value of TP53 mutations in chronic lymphocytic leukemia is independent of Del17p13: Implications for overall survival and chemorefractoriness
-
Rossi D, Cerri M, Deambrogi C et al. The prognostic value of TP53 mutations in chronic lymphocytic leukemia is independent of Del17p13: implications for overall survival and chemorefractoriness. Clin. Cancer Res. 15(3), 995-1004 (2009).
-
(2009)
Clin. Cancer Res.
, vol.15
, Issue.3
, pp. 995-1004
-
-
Rossi, D.1
Cerri, M.2
Deambrogi, C.3
-
24
-
-
79953117852
-
The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation
-
Rossi D, Spina V, Deambrogi C et al. The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation. Blood 117(12), 3391-3401 (2011).
-
(2011)
Blood
, vol.117
, Issue.12
, pp. 3391-3401
-
-
Rossi, D.1
Spina, V.2
Deambrogi, C.3
-
25
-
-
78751702338
-
TP53 mutations are infrequent in newly diagnosed chronic lymphocytic leukemia
-
Zainuddin N, Murray F, Kanduri M et al. TP53 mutations are infrequent in newly diagnosed chronic lymphocytic leukemia. Leuk. Res. 35(2), 272-274 (2011).
-
(2011)
Leuk. Res.
, vol.35
, Issue.2
, pp. 272-274
-
-
Zainuddin, N.1
Murray, F.2
Kanduri, M.3
-
26
-
-
78650307334
-
TP53 mutation profile in chronic lymphocytic leukemia: Evidence for a disease specific profile from a comprehensive analysis of 268 mutations
-
European Research Initiative on CLL (ERIC)
-
Zenz T, Vollmer D, Trbusek M et al. European Research Initiative on CLL (ERIC). TP53 mutation profile in chronic lymphocytic leukemia: evidence for a disease specific profile from a comprehensive analysis of 268 mutations. Leukemia 24(12), 2072-2079 (2010).
-
(2010)
Leukemia
, vol.24
, Issue.12
, pp. 2072-2079
-
-
Zenz, T.1
Vollmer, D.2
Trbusek, M.3
-
27
-
-
70349231440
-
De novo deletion 17p13.1 chronic lymphocytic leukemia shows significant clinical heterogeneity: The M. D. Anderson and Mayo Clinic experience
-
Tam CS, Shanafelt TD, Wierda WG et al. De novo deletion 17p13.1 chronic lymphocytic leukemia shows significant clinical heterogeneity: the M. D. Anderson and Mayo Clinic experience. Blood 114(5), 957-964 (2009).
-
(2009)
Blood
, vol.114
, Issue.5
, pp. 957-964
-
-
Tam, C.S.1
Shanafelt, T.D.2
Wierda, W.G.3
-
28
-
-
31544434508
-
Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia
-
German CLL Study Group
-
Eichhorst BF, Busch R, Hopfinger G et al. German CLL Study Group. Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia. Blood 107(3), 885-891 (2006).
-
(2006)
Blood
, vol.107
, Issue.3
, pp. 885-891
-
-
Eichhorst, B.F.1
Busch, R.2
Hopfinger, G.3
-
29
-
-
74549145611
-
Rituximab, fludarabine, cyclophosphamide, and mitoxantrone: A new, highly active chemoimmunotherapy regimen for chronic lymphocytic leukemia
-
Bosch F, Abrisqueta P, Villamor N et al. Rituximab, fludarabine, cyclophosphamide, and mitoxantrone: a new, highly active chemoimmunotherapy regimen for chronic lymphocytic leukemia. J. Clin. Oncol. 27(27), 4578-4584 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, Issue.27
, pp. 4578-4584
-
-
Bosch, F.1
Abrisqueta, P.2
Villamor, N.3
-
30
-
-
70350784064
-
P53 expression by immunohistochemistry is an important determinant of survival in patients with chronic lymphocytic leukemia receiving frontline chemo-immunotherapy
-
Schlette EJ, Admirand J, Wierda W et al. p53 expression by immunohistochemistry is an important determinant of survival in patients with chronic lymphocytic leukemia receiving frontline chemo-immunotherapy. Leuk. Lymphoma 50(10), 1597-1605 (2009).
-
(2009)
Leuk. Lymphoma
, vol.50
, Issue.10
, pp. 1597-1605
-
-
Schlette, E.J.1
Admirand, J.2
Wierda, W.3
-
31
-
-
79960116871
-
Missense mutations located in structural p53 DNA-binding motifs are associated with extremely poor survival in chronic lymphocytic leukemia
-
Trbusek M, Smardova J, Malcikova J et al. Missense mutations located in structural p53 DNA-binding motifs are associated with extremely poor survival in chronic lymphocytic leukemia. J. Clin. Oncol. 29(19), 2703-2708 (2011).
-
(2011)
J. Clin. Oncol.
, vol.29
, Issue.19
, pp. 2703-2708
-
-
Trbusek, M.1
Smardova, J.2
Malcikova, J.3
-
32
-
-
79251504278
-
Is the aberrant expression of p53 by immunocytochemistry a surrogate marker of TP53 mutation and/or deletion in chronic lymphocytic leukemia?
-
Marinelli M, Raponi S, Del Giudice I et al. Is the aberrant expression of p53 by immunocytochemistry a surrogate marker of TP53 mutation and/or deletion in chronic lymphocytic leukemia? Am. J. Clin. Pathol. 135(1), 173-174 (2011).
-
(2011)
Am. J. Clin. Pathol.
, vol.135
, Issue.1
, pp. 173-174
-
-
Marinelli, M.1
Raponi, S.2
Del Giudice, I.3
-
33
-
-
45149100665
-
Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute - Working Group 1996 guidelines
-
International Workshop on Chronic Lymphocytic Leukemia
-
Hallek M, Cheson BD, Catovsky D et al.; International Workshop on Chronic Lymphocytic Leukemia. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute - Working Group 1996 guidelines. Blood 111(12), 5446-5456 (2008).
-
(2008)
Blood
, vol.111
, Issue.12
, pp. 5446-5456
-
-
Hallek, M.1
Cheson, B.D.2
Catovsky, D.3
-
34
-
-
84863778287
-
ERIC recommendations on TP53 mutation analysis in chronic lymphocytic leukemia
-
European Research Initiative on CLL (ERIC)
-
Pospisilova S, Gonzalez D, Malcikova J et al. European Research Initiative on CLL (ERIC). ERIC recommendations on TP53 mutation analysis in chronic lymphocytic leukemia. Leukemia 26(7), 1458-1461 (2012).
-
(2012)
Leukemia
, vol.26
, Issue.7
, pp. 1458-1461
-
-
Pospisilova, S.1
Gonzalez, D.2
Malcikova, J.3
-
35
-
-
77957743452
-
Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: Long-term clinical and MRD results of the German CLL Study Group CLL3X trial
-
German CLL Study Group
-
Dreger P, Döhner H, Ritgen M et al. German CLL Study Group. Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the German CLL Study Group CLL3X trial. Blood 116(14), 2438-2447 (2010).
-
(2010)
Blood
, vol.116
, Issue.14
, pp. 2438-2447
-
-
Dreger, P.1
Döhner, H.2
Ritgen, M.3
-
36
-
-
84863769805
-
Alemtuzumab in combination with methylprednisolone is a highly effective induction regimen for patients with chronic lymphocytic leukemia and deletion of TP53: Final results of the National Cancer
-
Research Institute CLL206 trial
-
Pettitt AR, Jackson R, Carruthers S et al. Alemtuzumab in combination with methylprednisolone is a highly effective induction regimen for patients with chronic lymphocytic leukemia and deletion of TP53: final results of the National Cancer Research Institute CLL206 trial. J. Clin. Oncol. 30(14), 1647-1655 (2012).
-
(2012)
J. Clin. Oncol.
, vol.30
, Issue.14
, pp. 1647-1655
-
-
Pettitt, A.R.1
Jackson, R.2
Carruthers, S.3
-
37
-
-
80555129351
-
Oncogenic and tumor suppressor functions of Notch in cancer: It's NOTCH what you think
-
Lobry C, Oh P, Aifantis I. Oncogenic and tumor suppressor functions of Notch in cancer: it's NOTCH what you think. J. Exp. Med. 208(10), 1931-1935 (2011).
-
(2011)
J. Exp. Med.
, vol.208
, Issue.10
, pp. 1931-1935
-
-
Lobry, C.1
Oh, P.2
Aifantis, I.3
-
38
-
-
77952316273
-
Functions of notch signaling in the immune system: Consensus and controversies
-
Yuan JS, Kousis PC, Suliman S, Visan I, Guidos CJ. Functions of notch signaling in the immune system: consensus and controversies. Annu. Rev. Immunol. 28, 343-365 (2010).
-
(2010)
Annu. Rev. Immunol.
, vol.28
, pp. 343-365
-
-
Yuan, J.S.1
Kousis, P.C.2
Suliman, S.3
Visan, I.4
Guidos, C.J.5
-
39
-
-
79959549536
-
T cell lineage commitment: Identity and renunciation
-
Rothenberg EV. T cell lineage commitment: identity and renunciation. J. Immunol. 186(12), 6649-6655 (2011).
-
(2011)
J. Immunol.
, vol.186
, Issue.12
, pp. 6649-6655
-
-
Rothenberg, E.V.1
-
40
-
-
34848842174
-
Notch1 engagement by Delta-like-1 promotes differentiation of B lymphocytes to antibody-secreting cells
-
Santos MA, Sarmento LM, Rebelo M et al. Notch1 engagement by Delta-like-1 promotes differentiation of B lymphocytes to antibody-secreting cells. Proc. Natl Acad. Sci. USA 104(39), 15454-15459 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, Issue.39
, pp. 15454-15459
-
-
Santos, M.A.1
Sarmento, L.M.2
Rebelo, M.3
-
41
-
-
78649991073
-
Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies
-
Aster JC, Blacklow SC, Pear WS. Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies. J. Pathol. 223(2), 262-273 (2011).
-
(2011)
J. Pathol.
, vol.223
, Issue.2
, pp. 262-273
-
-
Aster, J.C.1
Blacklow, S.C.2
Pear, W.S.3
-
42
-
-
79951516547
-
Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia
-
Paganin M, Ferrando A. Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia. Blood Rev. 25(2), 83-90 (2011).
-
(2011)
Blood Rev.
, vol.25
, Issue.2
, pp. 83-90
-
-
Paganin, M.1
Ferrando, A.2
-
43
-
-
84855860383
-
NOTCH1 mutations in CLL associated with trisomy 12
-
Balatti V, Bottoni A, Palamarchuk A et al. NOTCH1 mutations in CLL associated with trisomy 12. Blood 119(2), 329-331 (2012).
-
(2012)
Blood
, vol.119
, Issue.2
, pp. 329-331
-
-
Balatti, V.1
Bottoni, A.2
Palamarchuk, A.3
-
44
-
-
84857739865
-
NOTCH1 mutations in +12 chronic lymphocytic leukemia (CLL) confer an unfavorable prognosis, induce a distinctive transcriptional profiling and refine the intermediate prognosis of +12 CLL
-
Del Giudice I, Rossi D, Chiaretti S et al. NOTCH1 mutations in +12 chronic lymphocytic leukemia (CLL) confer an unfavorable prognosis, induce a distinctive transcriptional profiling and refine the intermediate prognosis of +12 CLL. Haematologica 97(3), 437-441 (2012).
-
(2012)
Haematologica
, vol.97
, Issue.3
, pp. 437-441
-
-
Del Giudice, I.1
Rossi, D.2
Chiaretti, S.3
-
45
-
-
84863580564
-
Different distribution of NOTCH1 mutations in chronic lymphocytic leukemia with isolated trisomy 12 or associated with other chromosomal alterations
-
López C, Delgado J, Costa D et al. Different distribution of NOTCH1 mutations in chronic lymphocytic leukemia with isolated trisomy 12 or associated with other chromosomal alterations. Genes Chromosomes Cancer 51(9), 881-889 (2012).
-
(2012)
Genes Chromosomes Cancer
, vol.51
, Issue.9
, pp. 881-889
-
-
López, C.1
Delgado, J.2
Costa, D.3
-
46
-
-
59649083306
-
Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells
-
Rosati E, Sabatini R, Rampino G et al. Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells. Blood 113(4), 856-865 (2009).
-
(2009)
Blood
, vol.113
, Issue.4
, pp. 856-865
-
-
Rosati, E.1
Sabatini, R.2
Rampino, G.3
-
47
-
-
84855243926
-
Analysis of NOTCH1 mutations in monoclonal B-cell lymphocytosis
-
Rasi S, Monti S, Spina V, Foà R, Gaidano G, Rossi D. Analysis of NOTCH1 mutations in monoclonal B-cell lymphocytosis. Haematologica 97(1), 153-154 (2012).
-
(2012)
Haematologica
, vol.97
, Issue.1
, pp. 153-154
-
-
Rasi, S.1
Monti, S.2
Spina, V.3
Foà, R.4
Gaidano, G.5
Rossi, D.6
-
48
-
-
84863833162
-
Different impact of NOTCH1 and SF3B1 mutations on the risk of chronic lymphocytic leukemia transformation to Richter syndrome
-
Rossi D, Rasi S, Spina V et al. Different impact of NOTCH1 and SF3B1 mutations on the risk of chronic lymphocytic leukemia transformation to Richter syndrome. Br. J. Haematol. 158(3), 426-429 (2012).
-
(2012)
Br. J. Haematol.
, vol.158
, Issue.3
, pp. 426-429
-
-
Rossi, D.1
Rasi, S.2
Spina, V.3
-
49
-
-
84861968011
-
Therapeutic approaches to modulating Notch signaling: Current challenges and future prospects
-
Groth C, Fortini ME. Therapeutic approaches to modulating Notch signaling: current challenges and future prospects. Semin. Cell Dev. Biol. 23(4), 465-472 (2012).
-
(2012)
Semin. Cell Dev. Biol.
, vol.23
, Issue.4
, pp. 465-472
-
-
Groth, C.1
Fortini, M.E.2
-
51
-
-
78049416081
-
Alternative pre-mRNA splicing regulation in cancer: Pathways and programs unhinged
-
David CJ, Manley JL. Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged. Genes Dev. 24(21), 2343-2364 (2010).
-
(2010)
Genes Dev.
, vol.24
, Issue.21
, pp. 2343-2364
-
-
David, C.J.1
Manley, J.L.2
-
52
-
-
0029664530
-
The SAP, a new family of proteins, associate and function positively with the SIT4 phosphatase
-
Luke MM, Della Seta F, Di Como CJ, Sugimoto H, Kobayashi R, Arndt KT. The SAP, a new family of proteins, associate and function positively with the SIT4 phosphatase. Mol. Cell. Biol. 16(6), 2744-2755 (1996).
-
(1996)
Mol. Cell. Biol.
, vol.16
, Issue.6
, pp. 2744-2755
-
-
Luke, M.M.1
Della Seta, F.2
Di Como, C.J.3
Sugimoto, H.4
Kobayashi, R.5
Arndt, K.T.6
-
53
-
-
0032523934
-
Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysis
-
Wang C, Chua K, Seghezzi W, Lees E, Gozani O, Reed R. Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysis. Genes Dev. 12(10), 1409-1414 (1998).
-
(1998)
Genes Dev.
, vol.12
, Issue.10
, pp. 1409-1414
-
-
Wang, C.1
Chua, K.2
Seghezzi, W.3
Lees, E.4
Gozani, O.5
Reed, R.6
-
54
-
-
0032880119
-
Characterization of a protein complex containing spliceosomal proteins SAPs 49, 130, 145, and 155
-
Das BK, Xia L, Palandjian L, Gozani O, Chyung Y, Reed R. Characterization of a protein complex containing spliceosomal proteins SAPs 49, 130, 145, and 155. Mol. Cell. Biol. 19(10), 6796-6802 (1999).
-
(1999)
Mol. Cell. Biol.
, vol.19
, Issue.10
, pp. 6796-6802
-
-
Das, B.K.1
Xia, L.2
Palandjian, L.3
Gozani, O.4
Chyung, Y.5
Reed, R.6
-
55
-
-
60349104299
-
The spliceosome: Design principles of a dynamic RNP machine
-
Wahl MC, Will CL, Lührmann R. The spliceosome: design principles of a dynamic RNP machine. Cell 136(4), 701-718 (2009).
-
(2009)
Cell
, vol.136
, Issue.4
, pp. 701-718
-
-
Wahl, M.C.1
Will, C.L.2
Lührmann, R.3
-
56
-
-
80054010617
-
Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts
-
Chronic Myeloid Disorders Working Group of the International Cancer Genome Consortium
-
Papaemmanuil E, Cazzola M, Boultwood J et al. Chronic Myeloid Disorders Working Group of the International Cancer Genome Consortium. Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. N. Engl. J. Med. 365(15), 1384-1395 (2011).
-
(2011)
N. Engl. J. Med.
, vol.365
, Issue.15
, pp. 1384-1395
-
-
Papaemmanuil, E.1
Cazzola, M.2
Boultwood, J.3
-
57
-
-
80053900941
-
Frequent pathway mutations of splicing machinery in myelodysplasia
-
Yoshida K, Sanada M, Shiraishi Y et al. Frequent pathway mutations of splicing machinery in myelodysplasia. Nature 478(7367), 64-69 (2011).
-
(2011)
Nature
, vol.478
, Issue.7367
, pp. 64-69
-
-
Yoshida, K.1
Sanada, M.2
Shiraishi, Y.3
-
58
-
-
84874929638
-
Analysis of SF3B1 mutations in monoclonal B-cell lymphocytosis
-
doi: 10.1002/hon.2013 Epub ahead of print).
-
Greco M, Capello D, Bruscaggin A et al. Analysis of SF3B1 mutations in monoclonal B-cell lymphocytosis. Hematol. Oncol. doi: 10.1002/hon.2013 (2012) (Epub ahead of print).
-
(2012)
Hematol. Oncol.
-
-
Greco, M.1
Capello, D.2
Bruscaggin, A.3
-
59
-
-
84858405200
-
Splice modulating therapies for human disease
-
Spitali P, Aartsma-Rus A. Splice modulating therapies for human disease. Cell 148(6), 1085-1088 (2012).
-
(2012)
Cell
, vol.148
, Issue.6
, pp. 1085-1088
-
-
Spitali, P.1
Aartsma-Rus, A.2
-
60
-
-
9144220762
-
Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway
-
Kern C, Cornuel JF, Billard C et al. Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway. Blood 103(2), 679-688 (2004).
-
(2004)
Blood
, vol.103
, Issue.2
, pp. 679-688
-
-
Kern, C.1
Cornuel, J.F.2
Billard, C.3
-
61
-
-
33846258010
-
BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-κB pathway
-
Endo T, Nishio M, Enzler T et al. BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-κB pathway. Blood 109(2), 703-710 (2007).
-
(2007)
Blood
, vol.109
, Issue.2
, pp. 703-710
-
-
Endo, T.1
Nishio, M.2
Enzler, T.3
-
62
-
-
47149090375
-
The NF-κB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target
-
Hewamana S, Alghazal S, Lin TT et al. The NF-κB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target. Blood 111(9), 4681-4689 (2008).
-
(2008)
Blood
, vol.111
, Issue.9
, pp. 4681-4689
-
-
Hewamana, S.1
Alghazal, S.2
Lin, T.T.3
-
63
-
-
77957366071
-
Interaction with vascular endothelium enhances survival in primary chronic lymphocytic leukemia cells via NF-κB activation and de novo gene transcription
-
Buggins AG, Pepper C, Patten PE et al. Interaction with vascular endothelium enhances survival in primary chronic lymphocytic leukemia cells via NF-κB activation and de novo gene transcription. Cancer Res. 70(19), 7523-7533 (2010).
-
(2010)
Cancer Res.
, vol.70
, Issue.19
, pp. 7523-7533
-
-
Buggins, A.G.1
Pepper, C.2
Patten, P.E.3
-
64
-
-
78751549662
-
The lymph node microenvironment promotes B-cell receptor signaling, NF-κB activation, and tumor proliferation in chronic lymphocytic leukemia
-
Herishanu Y, Pérez-Galán P, Liu D et al. The lymph node microenvironment promotes B-cell receptor signaling, NF-κB activation, and tumor proliferation in chronic lymphocytic leukemia. Blood 117(2), 563-574 (2011).
-
(2011)
Blood
, vol.117
, Issue.2
, pp. 563-574
-
-
Herishanu, Y.1
Pérez-Galán, P.2
Liu, D.3
-
65
-
-
67650724069
-
Regulation and function of NF-κB transcription factors in the immune system
-
Vallabhapurapu S, Karin M. Regulation and function of NF-κB transcription factors in the immune system. Annu. Rev. Immunol. 27, 693-733 (2009).
-
(2009)
Annu. Rev. Immunol.
, vol.27
, pp. 693-733
-
-
Vallabhapurapu, S.1
Karin, M.2
-
66
-
-
0037149542
-
TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
-
Li X, Yang Y, Ashwell JD. TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. Nature 416(6878), 345-347 (2002).
-
(2002)
Nature
, vol.416
, Issue.6878
, pp. 345-347
-
-
Li, X.1
Yang, Y.2
Ashwell, J.D.3
-
67
-
-
56349164239
-
Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK
-
Zarnegar BJ, Wang Y, Mahoney DJ et al. Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. Nat. Immunol. 9(12), 1371-1378 (2008).
-
(2008)
Nat. Immunol.
, vol.9
, Issue.12
, pp. 1371-1378
-
-
Zarnegar, B.J.1
Wang, Y.2
Mahoney, D.J.3
-
68
-
-
78149369048
-
Noncanonical NF-κB activation and abnormal B cell accumulation in mice expressing ubiquitin protein ligase-inactive c-IAP2
-
Conze DB, Zhao Y, Ashwell JD. Noncanonical NF-κB activation and abnormal B cell accumulation in mice expressing ubiquitin protein ligase-inactive c-IAP2. PLoS Biol. 8(10), e1000518 (2010).
-
(2010)
PLoS Biol
, vol.8
, Issue.10
-
-
Conze, D.B.1
Zhao, Y.2
Ashwell, J.D.3
-
69
-
-
80855133512
-
Alteration of BIRC3 and multiple other NF-κB pathway genes in splenic marginal zone lymphoma
-
Rossi D, Deaglio S, Dominguez-Sola D et al. Alteration of BIRC3 and multiple other NF-κB pathway genes in splenic marginal zone lymphoma. Blood 118(18), 4930-4934 (2011).
-
(2011)
Blood
, vol.118
, Issue.18
, pp. 4930-4934
-
-
Rossi, D.1
Deaglio, S.2
Dominguez-Sola, D.3
-
70
-
-
0029969111
-
Molecular cytogenetic delineation of a novel critical genomic region in chromosome bands 11q22.3-923.1 in lymphoproliferative disorders
-
Stilgenbauer S, Liebisch P, James MR et al. Molecular cytogenetic delineation of a novel critical genomic region in chromosome bands 11q22.3-923.1 in lymphoproliferative disorders. Proc. Natl Acad. Sci. USA 93(21), 11837-11841 (1996).
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, Issue.21
, pp. 11837-11841
-
-
Stilgenbauer, S.1
Liebisch, P.2
James, M.R.3
-
71
-
-
0033566329
-
Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia
-
Schaffner C, Stilgenbauer S, Rappold GA, Döhner H, Lichter P. Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia. Blood 94(2), 748-753 (1999).
-
(1999)
Blood
, vol.94
, Issue.2
, pp. 748-753
-
-
Schaffner, C.1
Stilgenbauer, S.2
Rappold, G.A.3
Döhner, H.4
Lichter, P.5
-
72
-
-
27644450586
-
Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL
-
Austen B, Powell JE, Alvi A et al. Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL. Blood 106(9), 3175-3182 (2005).
-
(2005)
Blood
, vol.106
, Issue.9
, pp. 3175-3182
-
-
Austen, B.1
Powell, J.E.2
Alvi, A.3
-
73
-
-
84855231198
-
ATM gene alterations in chronic lymphocytic leukemia patients induce a distinct gene expression profile and predict disease progression
-
Guarini A, Marinelli M, Tavolaro S et al. ATM gene alterations in chronic lymphocytic leukemia patients induce a distinct gene expression profile and predict disease progression. Haematologica 97(1), 47-55 (2012).
-
(2012)
Haematologica
, vol.97
, Issue.1
, pp. 47-55
-
-
Guarini, A.1
Marinelli, M.2
Tavolaro, S.3
-
74
-
-
84855211959
-
ATM germline heterozygosity does not play a role in chronic lymphocytic leukemia initiation but influences rapid disease progression through loss of the remaining ATM allele
-
Skowronska A, Austen B, Powell JE et al. ATM germline heterozygosity does not play a role in chronic lymphocytic leukemia initiation but influences rapid disease progression through loss of the remaining ATM allele. Haematologica 97(1), 142-146 (2012).
-
(2012)
Haematologica
, vol.97
, Issue.1
, pp. 142-146
-
-
Skowronska, A.1
Austen, B.2
Powell, J.E.3
-
75
-
-
58149355768
-
The novel nuclear factor-κB inhibitor LC-1 is equipotent in poor prognostic subsets of chronic lymphocytic leukemia and shows strong synergy with fludarabine
-
Hewamana S, Lin TT, Jenkins C et al. The novel nuclear factor-κB inhibitor LC-1 is equipotent in poor prognostic subsets of chronic lymphocytic leukemia and shows strong synergy with fludarabine. Clin. Cancer Res. 14(24), 8102-8111 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, Issue.24
, pp. 8102-8111
-
-
Hewamana, S.1
Lin, T.T.2
Jenkins, C.3
-
76
-
-
77955870224
-
17-DMAG targets the nuclear factor-κB family of proteins to induce apoptosis in chronic lymphocytic leukemia: Clinical implications of HSP90 inhibition
-
Hertlein E, Wagner AJ, Jones J et al. 17-DMAG targets the nuclear factor-κB family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition. Blood 116(1), 45-53 (2010).
-
(2010)
Blood
, vol.116
, Issue.1
, pp. 45-53
-
-
Hertlein, E.1
Wagner, A.J.2
Jones, J.3
-
77
-
-
84865176364
-
The B-cell receptor signaling pathway as a therapeutic target in CLL
-
Woyach JA, Johnson AJ, Byrd JC. The B-cell receptor signaling pathway as a therapeutic target in CLL. Blood 120(6), 1175-1184 (2012).
-
(2012)
Blood
, vol.120
, Issue.6
, pp. 1175-1184
-
-
Woyach, J.A.1
Johnson, A.J.2
Byrd, J.C.3
-
78
-
-
84865082196
-
Novel targeted agents and the need to refine clinical end points in chronic lymphocytic leukemia
-
Cheson BD, Byrd JC, Rai KR et al. Novel targeted agents and the need to refine clinical end points in chronic lymphocytic leukemia. J. Clin. Oncol. 30(23), 2820-2822 (2012).
-
(2012)
J. Clin. Oncol.
, vol.30
, Issue.23
, pp. 2820-2822
-
-
Cheson, B.D.1
Byrd, J.C.2
Rai, K.R.3
|