Using the time-to-event continual reassessment method in the presence of partial orders

Statistics in Medicine

Volumn 32, Issue 1, 2013, Pages 131-141

  Wages, Nolan A ^a   Conaway, Mark R ^a   O'Quigley, John ^b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b SORBONNE UNIVERSITÉ   (France)

Author keywords

Continual reassessment method; Dose finding; Drug combination; Partial order; Phase1 trials; Time to event

Indexed keywords

LOMEGUATRIB; TEMOZOLOMIDE;

ARTICLE; DOSE CALCULATION; DOSE TIME EFFECT RELATION; DRUG COMBINATION; DRUG TOXICITY; INTERMETHOD COMPARISON; MAXIMUM TOLERATED DOSE; PARTIAL ORDER; PHASE 1 CLINICAL TRIAL (TOPIC); SIMULATION; STATISTICAL ANALYSIS; STATISTICAL PARAMETERS; STUDY DESIGN; TIME TO EVENT CONTINUAL REASSESSMENT METHOD; TREATMENT DURATION;

CLINICAL TRIALS, PHASE I AS TOPIC; COMPUTER SIMULATION; DATA INTERPRETATION, STATISTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MAXIMUM TOLERATED DOSE;

EID: 84870953927     PISSN: 02776715     EISSN: 10970258     Source Type: Journal    
DOI: 10.1002/sim.5491     Document Type: Article

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