Elevated IGF2 prevents leptin induction and terminal adipocyte differentiation in hemangioma stem cells

Experimental and Molecular Pathology

Volumn 94, Issue 1, 2013, Pages 126-136

  Kleiman, Alexandra ^a   Keats, Emily C ^a   Chan, Nancy G ^a,b   Khan, Zia A ^a,c  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b LONDON HEALTH SCIENCES CENTRE   (Canada)

^c LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

Author keywords

Angiogenesis; Blood vessels; Differentiation; Endothelial cells; Insulin like growth factor 2; Plasticity; Proliferation; Recruitment; Stem cells; Tumor

Indexed keywords

CD133 ANTIGEN; LEPTIN; MITOGENIC AGENT; SOMATOMEDIN;

ADIPOCYTE; ARTICLE; CAPILLARY HEMANGIOMA; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PLASTICITY; REMISSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STEM CELL;

ADIPOCYTES; ADIPOGENESIS; ANTIGENS, CD; CELL DIFFERENTIATION; CELL PROLIFERATION; GLYCOPROTEINS; HEMANGIOMA; HUMANS; INSULIN-LIKE GROWTH FACTOR II; LEPTIN; MITOGENS; NEOPLASTIC STEM CELLS; PEPTIDES; RNA INTERFERENCE; RNA, SMALL INTERFERING; TUMOR CELLS, CULTURED;

EID: 84870943097     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2012.09.023     Document Type: Article

References (38)

1. Baker J., Liu J.P., Robertson E.J., Efstratiadis A. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 1993, 75:73-82.
2. Bendall S.C., Stewart M.H., Menendez P., George D., Vijayaragavan K., Werbowetski-Ogilvie T., Ramos-Mejia V., Rouleau A., Yang J., Bosse M., Lajoie G., Bhatia M. IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro. Nature 2007, 448:1015-1021.
3. Brendel C., Kuklick L., Hartmann O., Kim T.D., Boudriot U., Schwell D., Neubauer A. Distinct gene expression profile of human mesenchymal stem cells in comparison to skin fibroblasts employing cDNA microarray analysis of 9600 genes. Gene Expression 2005, 12:245-257.
4. Byrd J.C., MacDonald R.G. Mechanisms for high affinity mannose 6-phosphate ligand binding to the insulin-like growth factor II/mannose 6-phosphate receptor. The Journal of Biological Chemistry 2000, 275:18638-18646.
5. Byrd J.C., Park J.H., Schaffer B.S., Garmroudi F., MacDonald R.G. Dimerization of the insulin-like growth factor II/mannose 6-phosphate receptor. The Journal of Biological Chemistry 2000, 275:18647-18656.
6. Cristancho A.G., Lazar M.A. Forming functional fat: a growing understanding of adipocyte differentiation. Nature Reviews Molecular Cell Biology 2011, 12:722-734.
7. Donzelli E., Lucchini C., Ballarini E., Scuteri A., Carini F., Tredici G., Miloso M. ERK1 and ERK2 are involved in recruitment and maturation of human mesenchymal stem cells induced to adipogenic differentiation. Journal of Molecular Cell Biology 2011, 3:123-131.
8. El-Shewy H.M., Luttrell L.M. Insulin-like growth factor-2/mannose-6 phosphate receptors. Vitamins and Hormones 2009, 80:667-697.
9. Forbes K., Westwood M. The IGF axis and placental function. A mini review. Hormone Research 2008, 69:129-137.
10. Gao D., Nolan D.J., Mellick A.S., Bambino K., McDonnell K., Mittal V. Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. Science 2008, 319:195-198.
11. Gregoire F.M., Smas C.M., Sul H.S. Understanding adipocyte differentiation. Physiological Reviews 1998, 78:783-809.
12. Hopkins A., Crowe P.J., Yang J.L. Effect of type 1 insulin-like growth factor receptor targeted therapy on chemotherapy in human cancer and the mechanisms involved. Journal of Cancer Research and Clinical Oncology 2010, 136:639-650.
13. Hu Y., Tan R., MacCalman C.D., Eastabrook G., Park S.H., Dutz J.P., von Dadelszen P. IFN-gamma-mediated extravillous trophoblast outgrowth inhibition in first trimester explant culture: a role for insulin-like growth factors. Molecular Human Reproduction 2008, 14:281-289.
14. Hwang C.S., Loftus T.M., Mandrup S., Lane M.D. Adipocyte differentiation and leptin expression. Annual Review of Cell and Developmental Biology 1997, 13:231-259.
15. Kasuga M., Karlsson F.A., Kahn C.R. Insulin stimulates the phosphorylation of the 95,000-Dalton subunit of its own receptor. Science 1982, 215:185-187.
16. Keats E., Khan Z.A. Unique responses of stem cell-derived vascular endothelial and mesenchymal cells to high levels of glucose. PLoS One 2012, 7:e38752.
17. Khan Z.A., Melero-Martin J.M., Wu X., Paruchuri S., Boscolo E., Mulliken J.B., Bischoff J. Endothelial progenitor cells from infantile hemangioma and umbilical cord blood display unique cellular responses to endostatin. Blood 2006, 108:915-921.
18. Khan Z.A., Boscolo E., Picard A., Psutka S., Melero-Martin J.M., Bartch T.C., Mulliken J.B., Bischoff J. Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice. The Journal of Clinical Investigation 2008, 118:2592-2599.
19. Kim K.W., Bae S.K., Lee O.H., Bae M.H., Lee M.J., Park B.C. Insulin-like growth factor II induced by hypoxia may contribute to angiogenesis of human hepatocellular carcinoma. Cancer Research 1998, 58:348-351.
20. Kleiman A., Keats E.C., Chan N.G., Khan Z.A. Evolution of hemangioma endothelium. Experimental and Molecular Pathology 2012, 93:264-272.
21. Kleinman M.E., Tepper O.M., Capla J.M., Bhatt K.A., Ceradini D.J., Galiano R.D., Blei F., Levine J.P., Gurtner G.C. Increased circulating AC133+ CD34+ endothelial progenitor cells in children with hemangioma. Lymphatic Research and Biology 2003, 1:301-307.
22. Lee O.H., Bae S.K., Bae M.H., Lee Y.M., Moon E.J., Cha H.J., Kwon Y.G., Kim K.W. Identification of angiogenic properties of insulin-like growth factor II in in vitro angiogenesis models. British Journal of Cancer 2000, 82:385-391.
23. LeRoith D., Werner H., Beitner-Johnson D., Roberts C.T. Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocrine Reviews 1995, 16:143-163.
24. Maeng Y.S., Choi H.J., Kwon J.Y., Park Y.W., Choi K.S., Min J.K., Kim Y.H., Suh P.G., Kang K.S., Won M.H., Kim Y.M., Kwon Y.G. Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLCbeta2 axis. Blood 2009, 113:233-243.
25. Massague J. Subunit structure of a high-affinity receptor for type beta-transforming growth factor. Evidence for a disulfide-linked glycosylated receptor complex. The Journal of Biological Chemistry 1985, 260:7059-7066.
26. Melero-Martin J.M., Khan Z.A., Picard A., Wu X., Paruchuri S., Bischoff J. In vivo vasculogenic potential of human blood-derived endothelial progenitor cells. Blood 2007, 109:4761-4768.
27. Mulliken J.B., Glowacki J. Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plastic and Reconstructive Surgery 1982, 69:412-422.
28. Nolan D.J., Ciarrocchi A., Mellick A.S., Jaggi J.S., Bambino K., Gupta S., Heikamp E., McDevitt M.R., Scheinberg D.A., Benezra R., Mittal V. Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization. Genes & Development 2007, 21:1546-1558.
29. North P.E., Waner M., Mizeracki A., Mrak R.E., Nicholas R., Kincannon J., Suen J.Y., Mihm M.C. A unique microvascular phenotype shared by juvenile hemangiomas and human placenta. Archives of Dermatology 2001, 137:559-570.
30. Pavelic J., Matijevic T., Knezevic J. Biological & physiological aspects of action of insulin-like growth factor peptide family. The Indian Journal of Medical Research 2007, 125:511-522.
31. Picard A., Boscolo E., Khan Z.A., Bartch T.C., Mulliken J.B., Vazquez M.P., Bischoff J. IGF-2 and FLT-1/VEGF-R1 mRNA levels reveal distinctions and similarities between congenital and common infantile hemangioma. Pediatric Research 2008, 63:263-267.
32. Rentsch J., Chiesi M. Regulation of ob gene mRNA levels in cultured adipocytes. FEBS Letters 1996, 379:55-59.
33. Ritter M.R., Dorrell M.I., Edmonds J., Friedlander S.F., Friedlander M. Insulin-like growth factor 2 and potential regulators of hemangioma growth and involution identified by large-scale expression analysis. Proceedings of the National Academy of Sciences of the United States of America 2002, 99:7455-7460.
34. Ritter M.R., Moreno S.K., Dorrell M.I., Rubens J., Ney J., Friedlander D.F., Bergman J., Cunningham B.B., Eichenfield L., Reinisch J., Cohen S., Veccione T., Holmes R., Friedlander S.F., Friedlander M. Identifying potential regulators of infantile hemangioma progression through large-scale expression analysis: a possible role for the immune system and indoleamine 2,3 dioxygenase (IDO) during involution. Lymphatic Research and Biology 2003, 1:291-299.
35. Roach E.E., Chakrabarti R., Park N.I., Keats E.C., Yip J., Chan N.G., Khan Z.A. Intrinsic regulation of hemangioma involution by platelet-derived growth factor. Cell Death and Disease 2012, 3:e328.
36. Rubin J.B., Shia M.A., Pilch P.F. Stimulation of tyrosine-specific phosphorylation in vitro by insulin-like growth factor I. Nature 1983, 305:438-440.
37. Taura D., Noguchi M., Sone M., Hosoda K., Mori E., Okada Y., Takahashi K., Homma K., Oyamada N., Inuzuka M., Sonoyama T., Ebihara K., Tamura N., Itoh H., Suemori H., Nakatsuji N., Okano H., Yamanaka S., Nakao K. Adipogenic differentiation of human induced pluripotent stem cells: comparison with that of human embryonic stem cells. FEBS Letters 2009, 583:1029-1033.
38. Yu Y., Wylie-Sears J., Boscolo E., Mulliken J.B., Bischoff J. Genomic imprinting of IGF2 is maintained in infantile hemangioma despite its high level of expression. Molecular Medicine 2004, 10:117-123.