Isolation and characterization of degradation products of moxidectin using LC, LTQ FT-MS, H/D exchange and NMR

Analytical and Bioanalytical Chemistry

Volumn 404, Issue 8, 2012, Pages 2203-2222

  Awasthi, Atul ^a   Razzak, Majid ^b   Al Kassas, Raida ^a   Greenwood, David R ^c,d   Harvey, Joanne ^e   Garg, Sanjay ^a,f  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b Ancare Scientific Ltd Auckland   (New Zealand)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

^d THE NEW ZEALAND INSTITUTE FOR PLANT AND FOOD RESEARCH LIMITED   (New Zealand)

^e VICTORIA UNIVERSITY OF WELLINGTON   (New Zealand)

^f UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

Author keywords

H D exchange; High resolution FT MS andMSn; Macrocyclic lactone; Moxidectin degradation product; NMR; Stress study

Indexed keywords

ACCURATE MASS; ACID HYDROLYSIS; CHROMATOGRAPHIC PROFILES; DEGRADATION PRODUCTS; DEGRADATION PROFILES; FINISHED PRODUCTS; FT-ICR MS; GOOD STABILITY; H/D EXCHANGE; HIGH RESOLUTION; HYDROGEN/DEUTERIUM EXCHANGE; ISOLATION AND CHARACTERIZATION; MACROCYCLIC LACTONES; MOLECULAR ION PEAKS; SAMPLE MATRIX; STRESS CONDITION;

DEGRADATION; ESTERS; EXPERIMENTS; ISOMERS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

IMPURITIES;

MACROLIDE; MILBEMYCIN;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG CONTAMINATION; DRUG STABILITY; HEAT; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; PHARMACEUTICS;

CHROMATOGRAPHY, LIQUID; DRUG CONTAMINATION; DRUG STABILITY; HOT TEMPERATURE; HYDROGEN-ION CONCENTRATION; MACROLIDES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MODELS, MOLECULAR; TECHNOLOGY, PHARMACEUTICAL;

EID: 84870903950     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-012-6393-9     Document Type: Article

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