Optimal design of multi-arm multi-stage trials

Statistics in Medicine

Volumn 31, Issue 30, 2012, Pages 4269-4279

  Wason, James M S ^a   Jaki, Thomas ^b  

^a MRC BIOSTATISTICS UNIT   (United Kingdom)

^b LANCASTER UNIVERSITY   (United Kingdom)

Author keywords

Multi arm multi stage trials; Optimal allocation, optimal design; Simulated annealing

Indexed keywords

TELMISARTAN;

ANALYTICAL ERROR; ARTICLE; CALCULATION; CLINICAL TRIAL (TOPIC); DRUG EFFICACY; HUMAN; INSULIN RESISTANCE; METHODOLOGY; PHASE 2 CLINICAL TRIAL (TOPIC); PROBABILITY; SAMPLE SIZE; SIMULATION; STATISTICAL PARAMETERS;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANTI-RETROVIRAL AGENTS; BENZIMIDAZOLES; BENZOATES; BIAS (EPIDEMIOLOGY); CLINICAL TRIALS AS TOPIC; COMPUTER SIMULATION; DRUG THERAPY, COMBINATION; ENDPOINT DETERMINATION; HIV INFECTIONS; HUMANS; INSULIN RESISTANCE; RESEARCH DESIGN; SAMPLE SIZE;

EID: 84870901532     PISSN: 02776715     EISSN: 10970258     Source Type: Journal    
DOI: 10.1002/sim.5513     Document Type: Article

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