Neuropilin-2 as a useful marker in the differentiation between Spitzoid malignant melanoma and Spitz nevus

Journal of the American Academy of Dermatology

Volumn 68, Issue 1, 2013, Pages 129-137

  Wititsuwannakul, Jade ^a,b   Mason, Ashley R ^a   Klump, Vincent R ^a   Lazova, Rossitza ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

immunohistochemical staining; melanoma; neuropilin; Spitz nevus; Spitzoid malignant melanoma

Indexed keywords

NEUROPILIN 2;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; JUVENILE MELANOMA; MALE; MELANOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPITZOID MALIGNANT MELANOMA; TUMOR DIFFERENTIATION;

ADOLESCENT; ADULT; AGED; CHILD; CHILD, PRESCHOOL; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MELANOMA; MIDDLE AGED; NEUROPILIN-2; NEVUS, EPITHELIOID AND SPINDLE CELL; SKIN NEOPLASMS; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84870898417     PISSN: 01909622     EISSN: 10976787     Source Type: Journal    
DOI: 10.1016/j.jaad.2012.07.009     Document Type: Article

References (44)

1. M. Miteva, and R. Lazova Spitz nevus and atypical Spitzoid neoplasm Semin Cutan Med Surg 29 2010 165 173
2. K.A. Crotty, R.A. Scolyer, L. Li, A.A. Palmer, L. Wang, and S.W. McCarthy Spitz nevus versus Spitzoid melanoma: when and how can they be distinguished? Pathology 34 2002 6 12
3. R.L. Barnhill The Spitzoid lesion: rethinking Spitz tumors, atypical variants, "Spitzoid melanoma" and risk assessment Mod Pathol 19 Suppl 2006 S21 S33
4. R.L. Barnhill, Z.B. Argenyi, L. From, L.F. Glass, J.C. Maize, and M.C. Mihm Jr. Atypical Spitz nevi/tumors: lack of consensus for diagnosis, discrimination from melanoma, and prediction of outcome Hum Pathol 30 1999 513 520
5. S. Spitz Melanomas of childhood Am J Pathol 24 1948 591 609
6. R.P. Rapini Spitz nevus or melanoma? Semin Cutan Med Surg 18 1999 56 63
7. A. Spatz, and R.L. Barnhill The Spitz tumor 50 years later: revisiting a landmark contribution and unresolved controversy J Am Acad Dermatol 40 1999 223 228
8. N. Walsh, K. Crotty, A. Palmer, and S. McCarthy Spitz nevus versus Spitzoid malignant melanoma: an evaluation of the current distinguishing histopathologic criteria Hum Pathol 29 1998 1105 1112
9. A. Spatz, E. Calonje, S. Handfield-Jones, and R.L. Barnhill Spitz tumors in children: a grading system for risk stratification Arch Dermatol 135 1999 282 285
10. C.A. Staton, I. Kumar, M.W. Reed, and N.J. Brown Neuropilins in physiological and pathological angiogenesis J Pathol 212 2007 237 248
11. D.R. Bielenberg, C.A. Pettaway, S. Takashima, and M. Klagsbrun Neuropilins in neoplasms: expression, regulation, and function Exp Cell Res 312 2006 584 593
12. C. Chen, M. Li, H. Chai, H. Yang, W.E. Fisher, and Q. Yao Roles of neuropilins in neuronal development, angiogenesis, and cancers World J Surg 29 2005 271 275
13. L.M. Ellis The role of neuropilins in cancer Mol Cancer Ther 5 2006 1099 1107
14. L. Yuan, D. Moyon, L. Pardanaud, C. Breant, M.J. Karkkainen, and K. Alitalo Abnormal lymphatic vessel development in neuropilin 2 mutant mice Development 129 2002 4797 4806
15. M. Caunt, J. Mak, W.C. Liang, S. Stawicki, Q. Pan, and R.K. Tong Blocking neuropilin-2 function inhibits tumor cell metastasis Cancer Cell 13 2008 331 342
16. E.C. Rushing, M.J. Stine, S.J. Hahn, S. Shea, M.S. Eller, and A. Naif Neuropilin-2: a novel biomarker for malignant melanoma? Hum Pathol 43 2012 381 389
17. M.J. Stine, C.J. Wang, W.F. Moriarty, B. Ryu, R. Cheong, and W.H. Westra Integration of genotypic and phenotypic screening reveals molecular mediators of melanoma-stromal interaction Cancer Res 71 2011 2433 2444
18. D.C. Zedek, and T.H. McCalmont Spitz nevi, atypical Spitzoid neoplasms, and Spitzoid melanoma Clin Lab Med 31 2011 311 320
19. M. Kashani-Sabet, R.W. Sagebiel, C.M. Ferreira, M. Nosrati, and J.R. Miller III Tumor vascularity in the prognostic assessment of primary cutaneous melanoma J Clin Oncol 20 2002 1826 1831
20. R. Bergman, R. Dromi, H. Trau, I. Cohen, and C. Lichtig The pattern of HMB-45 antibody staining in compound Spitz nevi Am J Dermatopathol 17 1995 542 546
21. J.D. Harvell, B.C. Bastian, and P.E. LeBoit Persistent (recurrent) Spitz nevi: a histopathologic, immunohistochemical, and molecular pathologic study of 22 cases Am J Surg Pathol 26 2002 654 661
22. A. Ribe, and N.S. McNutt S100A6 protein expression is different in Spitz nevi and melanomas Mod Pathol 16 2003 505 511
23. P. Kapur, M.A. Selim, L.C. Roy, M. Yegappan, A.G. Weinberg, and M.P. Hoang Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis Mod Pathol 18 2005 197 204
24. D. Innocenzi, P.L. Alo, A. Balzani, V. Sebastiani, V. Silipo, and G. La Torre Fatty acid synthase expression in melanoma J Cutan Pathol 30 2003 23 28
25. Z. Kaleem, A.C. Lind, P.A. Humphrey, R.H. Sueper, P.E. Swanson, and J.H. Ritter Concurrent Ki-67 and p53 immunolabeling in cutaneous melanocytic neoplasms: an adjunct for recognition of the vertical growth phase in malignant melanomas? Mod Pathol 13 2000 217 222
26. R. Bergman, A. Shemer, R. Levy, R. Friedman-Birnbaum, H. Trau, and C. Lichtig Immunohistochemical study of p53 protein expression in Spitz nevus as compared with other melanocytic lesions Am J Dermatopathol 17 1995 547 550
27. L.E. Sparrow, M.J. Eldon, D.R. English, and P.J. Heenan p16 and p21WAF1 protein expression in melanocytic tumors by immunohistochemistry Am J Dermatopathol 20 1998 255 261
28. E. George, N.L. Polissar, and M. Wick Immunohistochemical evaluation of p16INK4A, E-cadherin, and cyclin D1 expression in melanoma and Spitz tumors Am J Clin Pathol 133 2010 370 379
29. R. Al Dhaybi, M. Agoumi, I. Gagne, C. McCuaig, J. Powell, and V. Kokta p16 expression: a marker of differentiation between childhood malignant melanomas and Spitz nevi J Am Acad Dermatol 65 2011 357 363
30. G. Rappa, O. Fodstad, and A. Lorico The stem cell-Associated antigen CD133 (Prominin-1) is a molecular therapeutic target for metastatic melanoma Stem Cells 26 2008 3008 3017
31. + cancer stem cells in childhood malignant melanoma and its correlation with metastasis Mod Pathol 23 2010 376 380
32. M.S. King, S.J. Porchia, and K.M. Hiatt Differentiating Spitzoid melanomas from Spitz nevi through CD99 expression J Cutan Pathol 34 2007 576 580
33. B.C. Bastian, U. Wesselmann, D. Pinkel, and P.E. Leboit Molecular cytogenetic analysis of Spitz nevi shows clear differences to melanoma J Invest Dermatol 113 1999 1065 1069
34. B.C. Bastian, P.E. LeBoit, and D. Pinkel Mutations and copy number increase of HRAS in Spitz nevi with distinctive histopathological features Am J Pathol 157 2000 967 972
35. J.A. Curtin, J. Fridlyand, T. Kageshita, H.N. Patel, K.J. Busam, and H. Kutzner Distinct sets of genetic alterations in melanoma N Engl J Med 353 2005 2135 2147
36. B.C. Bastian, P.E. LeBoit, H. Hamm, E.B. Brocker, and D. Pinkel Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization Cancer Res 58 1998 2170 2175
37. J.D. Harvell, S. Kohler, S. Zhu, T. Hernandez-Boussard, J.R. Pollack, and M. van de Rijn High-resolution array-based comparative genomic hybridization for distinguishing paraffin-embedded Spitz nevi and melanomas Diagn Mol Pathol 13 2004 22 25
38. A.C. van Engen-van Grunsven, M.C. van Dijk, D.J. Ruiter, A. Klaasen, W.J. Mooi, and W.A. Blokx HRAS-mutated Spitz tumors: a subtype of Spitz tumors with distinct features Am J Surg Pathol 34 2010 1436 1441
39. D.R. Fullen, J.N. Poynter, L. Lowe, L.D. Su, J.T. Elder, and R.P. Nair BRAF and NRAS mutations in Spitzoid melanocytic lesions Mod Pathol 19 2006 1324 1332
40. M. Gill, J. Cohen, N. Renwick, J.M. Mones, D.N. Silvers, and J.T. Celebi Genetic similarities between Spitz nevus and Spitzoid melanoma in children Cancer 101 2004 2636 2640
41. D.A. Lee, J.A. Cohen, W.S. Twaddell, G. Palacios, M. Gill, and E. Levit Are all melanomas the same? Spitzoid melanoma is a distinct subtype of melanoma Cancer 106 2006 907 913
42. T. Gaiser, H. Kutzner, G. Palmedo, M.D. Siegelin, T. Wiesner, and T. Bruckner Classifying ambiguous melanocytic lesions with FISH and correlation with clinical long-term follow up Mod Pathol 23 2010 413 419
43. L. Raskin, M. Ludgate, R.K. Iyer, T.E. Ackley, C.R. Bradford, and T.M. Johnson Copy number variations and clinical outcome in atypical Spitz tumors Am J Surg Pathol 35 2011 243 252
44. R. Lazova, E.H. Seeley, M. Keenan, R. Gueorguieva, and R.M. Caprioli Imaging mass spectrometry-A new and promising method to differentiate Spitz nevi from Spitzoid malignant melanomas Am J Dermatopathol 34 2012 82 90